ATE241012T1 - Verfahren zur herstellung von humanen relaxin - Google Patents

Verfahren zur herstellung von humanen relaxin

Info

Publication number: ATE241012T1
Authority: AT; Austria
Prior art keywords: producing human; human relaxin; relaxin; prorelaxin; naturally occurring
Prior art date: 1993-06-21

Application number

AT94920786T

Other languages

English (en)

Inventor

Tim Breece

Kirk Hayenga

Ernst Rinderknecht

Richard Vandlen

Daniel Yansura

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-21

Filing date

1994-06-20

Publication date

2003-06-15

1994-06-20 Application filed by Genentech Inc filed Critical Genentech Inc

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241012T1 publication Critical patent/ATE241012T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title 1
108010087851 prorelaxin Proteins 0.000 abstract 2
108090000103 Relaxin Proteins 0.000 abstract 1
102000003743 Relaxin Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Reproductive Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

AT94920786T 1993-06-21 1994-06-20 Verfahren zur herstellung von humanen relaxin ATE241012T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8035493A	1993-06-21	1993-06-21
PCT/US1994/006997 WO1995000645A2 (en)	1993-06-21	1994-06-20	Process for producing relaxin

Publications (1)

Publication Number	Publication Date
ATE241012T1 true ATE241012T1 (de)	2003-06-15

Family

ID=22156855

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94920786T ATE241012T1 (de)	1993-06-21	1994-06-20	Verfahren zur herstellung von humanen relaxin

Country Status (8)

Country	Link
US (1)	US5759807A (de)
EP (1)	EP0707650B1 (de)
JP (2)	JP3954091B2 (de)
AT (1)	ATE241012T1 (de)
AU (1)	AU691189B2 (de)
CA (1)	CA2165781C (de)
DE (1)	DE69432704T2 (de)
WO (1)	WO1995000645A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
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KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US5612051A (en) *	1995-11-17	1997-03-18	Yue; Samuel K.	Method of treating involuntary muscle dysfunction with relaxin hormone
US6709659B1 (en)	1996-08-02	2004-03-23	Zymogenetics, Inc.	Antibodies that bind testis-specific insulin homolog polypeptides
AU3972797A (en) *	1996-08-02	1998-02-25	Zymogenetics Inc.	Testis-specific insulin homolog polypeptides
US6251863B1 (en)	1998-09-08	2001-06-26	Samuel K. Yue	Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
HK1048828A1 (zh) *	1999-11-19	2003-04-17	Transkaryotic Therapies, Inc.	可令生产优化的核酸构造
US20050032683A1 (en)	2000-10-04	2005-02-10	Amento Edward P.	Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20040006205A1 (en) *	2001-04-03	2004-01-08	Li Li	Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20050186526A1 (en) *	2002-11-01	2005-08-25	Bas Medical, Inc.	Methods and systems for enabling and stabilizing tooth movement
US7878978B2 (en) *	2004-03-18	2011-02-01	University Of Pittsburgh- Of The Commonwealth System Of Higher Education	Use of relaxin to increase arterial compliance
US20050287519A1 (en) *	2004-05-12	2005-12-29	Merchiers Pascal G	Methods, compositions and compound assays for inhibiting amyloid-beta protein production
MX2007001589A (es) *	2004-08-09	2007-08-02	Alios Biopharma Inc	Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas.
US7597884B2 (en) *	2004-08-09	2009-10-06	Alios Biopharma, Inc.	Hyperglycosylated polypeptide variants and methods of use
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US20080260820A1 (en) *	2007-04-19	2008-10-23	Gilles Borrelly	Oral dosage formulations of protease-resistant polypeptides
US8415301B2 (en)	2008-05-16	2013-04-09	Corthera, Inc.	Method of treating dyspnea associated with acute heart failure by administering H2 relaxin
AU2009246112B2 (en)	2008-05-16	2013-05-02	Corthera, Inc.	Method of treating chronic heart failure
US9052304B2 (en)	2009-03-13	2015-06-09	Terrasep, Llc	Methods and apparatus for centrifugal liquid chromatography
GR1006941B (el) *	2009-06-01	2010-08-27	Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),	Πεπτιδικη συνθεση (peptide synthesis)
KR101800040B1 (ko)	2010-03-10	2017-11-21	유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드	릴랙신을 사용한 아쿠아포린의 조절
PE20140160A1 (es)	2010-08-17	2014-02-08	Ambrx Inc	Polipeptidos de relaxina modificados y sus usos
AU2012291972B2 (en)	2011-08-04	2017-03-09	Pharis Biotec Gmbh	Process for preparing human relaxin-2
CN102643825A (zh) *	2011-11-18	2012-08-22	上海佑科生物技术有限公司	松弛素野生型和突变体的制备方法及其所制备的松弛素野生型和突变体
EP2630964A1 (de)	2012-02-22	2013-08-28	Immundiagnostik AG	Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes
CN102603888B (zh) *	2012-04-11	2013-11-20	黑龙江八一农垦大学	一种人松弛素2前体及其制备方法
US9393288B2 (en)	2012-05-29	2016-07-19	The University Of Vermont And State Agricultural College	Methods of treating diseases associated with PPARγ
US9907833B2 (en)	2013-07-25	2018-03-06	University Of Florida Research Foundation, Incorporated	Use of relaxin to treat placental syndromes
WO2015038938A1 (en)	2013-09-13	2015-03-19	The California Institute For Biomedical Research	Modified therapeutic agents and compositions thereof
WO2015073727A1 (en)	2013-11-13	2015-05-21	Aequus Biopharma, Inc.	Engineered glycoproteins and uses thereof
US10039809B2 (en)	2013-12-18	2018-08-07	The California Institute For Biomedical Research	Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
HK1226581A1 (zh) *	2014-02-03	2017-09-29	Novartis Ag	用於输液器上的过滤器
EP3204405B1 (de) *	2014-10-09	2020-12-02	Cathay Biotech Inc.	Expression von rekombinanten tetrazyklin-effluxpumpen zur herstellung von lysin oder lysin-abgeleiteten produkten sowie verfahren und anwendungen davon
CN107417787B (zh) *	2016-05-23	2020-11-17	江苏恒瑞医药股份有限公司	一种人松弛素2类似物的制备方法
SG10201912034UA (en)	2017-02-08	2020-02-27	Bristol Myers Squibb Co	Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
EP4069726A4 (de)	2019-12-04	2024-03-20	The Scripps Research Institute	Glp2-rezeptoragonisten und verfahren zur verwendung
AU2022289610A1 (en)	2021-06-09	2024-01-25	The Scripps Research Institute	Long-acting dual gip/glp-1 peptide conjugates and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0068375A3 (de) *	1981-06-22	1983-04-13	G.D. Searle & Co.	Rekombinante DNS Technik zur Herstellung von Relaxin
AU561670B2 (en) *	1982-06-10	1987-05-14	Howard Florey Institute Of Experimental Physiology And Medicine	Peptides with relaxin activity
US4656249A (en) *	1982-06-10	1987-04-07	Howard Florey Institute Of Experimental Physiology And Medicine	Peptides with relaxin activity
US5145962A (en) *	1982-08-12	1992-09-08	Howard Florey Institute Of Experimental Physiology And Medicine	Human pro relaxin polypeptides
EP0101309B1 (de) *	1982-08-12	1991-01-16	Howard Florey Institute Of Experimental Physiology And Medicine	Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz
US5179195A (en) *	1982-12-13	1993-01-12	Howard Florey Institute Of Experimental Physiology And Medicine	Human relaxin polypeptides
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
US4518526A (en) *	1982-12-22	1985-05-21	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
JPS63230089A (ja) *	1987-03-18	1988-09-26	Takeda Chem Ind Ltd	分泌発現による蛋白質の製造法
US5304473A (en) *	1991-06-11	1994-04-19	Eli Lilly And Company	A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy

1994
- 1994-06-20 CA CA002165781A patent/CA2165781C/en not_active Expired - Lifetime
- 1994-06-20 EP EP94920786A patent/EP0707650B1/de not_active Expired - Lifetime
- 1994-06-20 WO PCT/US1994/006997 patent/WO1995000645A2/en not_active Ceased
- 1994-06-20 AT AT94920786T patent/ATE241012T1/de active
- 1994-06-20 AU AU71765/94A patent/AU691189B2/en not_active Expired
- 1994-06-20 JP JP50303695A patent/JP3954091B2/ja not_active Expired - Lifetime
- 1994-06-20 DE DE69432704T patent/DE69432704T2/de not_active Expired - Lifetime
1995
- 1995-05-22 US US08/443,568 patent/US5759807A/en not_active Expired - Lifetime
2006
- 2006-07-31 JP JP2006208539A patent/JP2007014342A/ja active Pending

Also Published As

Publication number	Publication date
EP0707650A1 (de)	1996-04-24
CA2165781A1 (en)	1995-01-05
JPH09501911A (ja)	1997-02-25
JP2007014342A (ja)	2007-01-25
CA2165781C (en)	2007-02-13
JP3954091B2 (ja)	2007-08-08
AU7176594A (en)	1995-01-17
AU691189B2 (en)	1998-05-14
DE69432704D1 (de)	2003-06-26
EP0707650B1 (de)	2003-05-21
DE69432704T2 (de)	2004-02-26
WO1995000645A3 (en)	1995-02-09
WO1995000645A2 (en)	1995-01-05
US5759807A (en)	1998-06-02

Legal Events

Date

Code

Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

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