ATE241012T1 - Verfahren zur herstellung von humanen relaxin - Google Patents

Verfahren zur herstellung von humanen relaxin

Info

Publication number: ATE241012T1
Authority: AT; Austria
Prior art keywords: producing human; human relaxin; relaxin; prorelaxin; naturally occurring
Prior art date: 1993-06-21

Application number

AT94920786T

Other languages

English (en)

Inventor

Tim Breece

Kirk Hayenga

Ernst Rinderknecht

Richard Vandlen

Daniel Yansura

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-21

Filing date

1994-06-20

Publication date

2003-06-15

1994-06-20 Application filed by Genentech Inc filed Critical Genentech Inc

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241012T1 publication Critical patent/ATE241012T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title 1
108010087851 prorelaxin Proteins 0.000 abstract 2
108090000103 Relaxin Proteins 0.000 abstract 1
102000003743 Relaxin Human genes 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Reproductive Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94920786T 1993-06-21 1994-06-20 Verfahren zur herstellung von humanen relaxin ATE241012T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8035493A	1993-06-21	1993-06-21
PCT/US1994/006997 WO1995000645A2 (en)	1993-06-21	1994-06-20	Process for producing relaxin

Publications (1)

Publication Number	Publication Date
ATE241012T1 true ATE241012T1 (de)	2003-06-15

Family

ID=22156855

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94920786T ATE241012T1 (de)	1993-06-21	1994-06-20	Verfahren zur herstellung von humanen relaxin

Country Status (8)

Country	Link
US (1)	US5759807A (de)
EP (1)	EP0707650B1 (de)
JP (2)	JP3954091B2 (de)
AT (1)	ATE241012T1 (de)
AU (1)	AU691189B2 (de)
CA (1)	CA2165781C (de)
DE (1)	DE69432704T2 (de)
WO (1)	WO1995000645A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US5612051A (en) *	1995-11-17	1997-03-18	Yue; Samuel K.	Method of treating involuntary muscle dysfunction with relaxin hormone
US6709659B1 (en)	1996-08-02	2004-03-23	Zymogenetics, Inc.	Antibodies that bind testis-specific insulin homolog polypeptides
WO1998005782A1 (en) *	1996-08-02	1998-02-12	Zymogenetics, Inc.	Testis-specific insulin homolog polypeptides
US6251863B1 (en)	1998-09-08	2001-06-26	Samuel K. Yue	Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
MXPA02005014A (es) *	1999-11-19	2003-02-27	Transkaryotic Therapies Inc	Constructo de acido nucleico para produccion optimizada de productos.
US20050032683A1 (en)	2000-10-04	2005-02-10	Amento Edward P.	Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20040006205A1 (en) *	2001-04-03	2004-01-08	Li Li	Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US20050186526A1 (en) *	2002-11-01	2005-08-25	Bas Medical, Inc.	Methods and systems for enabling and stabilizing tooth movement
US7878978B2 (en) *	2004-03-18	2011-02-01	University Of Pittsburgh- Of The Commonwealth System Of Higher Education	Use of relaxin to increase arterial compliance
US20060281699A1 (en) *	2004-05-12	2006-12-14	Merchiers Pascal G	Methods, compositions and compound assays for inhibiting amyloid-beta protein production
WO2006020580A2 (en) *	2004-08-09	2006-02-23	Alios Biopharma Inc.	Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US7597884B2 (en) *	2004-08-09	2009-10-06	Alios Biopharma, Inc.	Hyperglycosylated polypeptide variants and methods of use
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US20080260820A1 (en) *	2007-04-19	2008-10-23	Gilles Borrelly	Oral dosage formulations of protease-resistant polypeptides
BRPI0912559A2 (pt)	2008-05-16	2015-10-13	Corthera Inc	método de tratar insuficiência cardíaca crônica
CA2724540C (en)	2008-05-16	2014-07-08	Corthera, Inc.	Treating dyspnea associated with acute heart failure with relaxin
US9052304B2 (en)	2009-03-13	2015-06-09	Terrasep, Llc	Methods and apparatus for centrifugal liquid chromatography
GR1006941B (el)	2009-06-01	2010-08-27	Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),	Πεπτιδικη συνθεση (peptide synthesis)
EP2544706B1 (de)	2010-03-10	2015-06-17	The University Of Melbourne	Modulierung von aquaporinen mit relaxin
EA030886B1 (ru)	2010-08-17	2018-10-31	Амбркс, Инк.	Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение
JP6276690B2 (ja)	2011-08-04	2018-02-07	ファリスバイオテックゲーエムベーハー	ヒトリラキシン−２を調製する方法
CN102643825A (zh) *	2011-11-18	2012-08-22	上海佑科生物技术有限公司	松弛素野生型和突变体的制备方法及其所制备的松弛素野生型和突变体
EP2630964A1 (de)	2012-02-22	2013-08-28	Immundiagnostik AG	Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes
CN102603888B (zh) *	2012-04-11	2013-11-20	黑龙江八一农垦大学	一种人松弛素2前体及其制备方法
US9393288B2 (en)	2012-05-29	2016-07-19	The University Of Vermont And State Agricultural College	Methods of treating diseases associated with PPARγ
US9907833B2 (en)	2013-07-25	2018-03-06	University Of Florida Research Foundation, Incorporated	Use of relaxin to treat placental syndromes
JP6822839B2 (ja)	2013-09-13	2021-01-27	ザ・スクリップス・リサーチ・インスティテュート	修飾された治療剤、及びその組成物
EP3068891A1 (de)	2013-11-13	2016-09-21	Aequus Biopharma Inc.	Manipulierte glycoproteine und verwendungen davon
KR102455171B1 (ko)	2013-12-18	2022-10-14	더 스크립스 리서치 인스티튜트	변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물
MX2016010087A (es) *	2014-02-03	2016-10-07	Novartis Ag	Filtros para equipos de infusion.
WO2016054792A1 (en) *	2014-10-09	2016-04-14	Cathay R&D Center Co., Ltd.	Expression of recombinant tetracycline efflux pumps for the production of lysine or lysine-derived products, and methods and applications thereof
CN107417787B (zh) *	2016-05-23	2020-11-17	江苏恒瑞医药股份有限公司	一种人松弛素2类似物的制备方法
PE20191716A1 (es)	2017-02-08	2019-12-05	Bristol Myers Squibb Co	Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
MX2022006861A (es)	2019-12-04	2022-07-11	Scripps Research Inst	Agonistas del receptor glp2 y metodos de uso.
KR20240032010A (ko)	2021-06-09	2024-03-08	더 스크립스 리서치 인스티튜트	장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0068375A3 (de) *	1981-06-22	1983-04-13	G.D. Searle & Co.	Rekombinante DNS Technik zur Herstellung von Relaxin
AU561670B2 (en) *	1982-06-10	1987-05-14	Howard Florey Institute Of Experimental Physiology And Medicine	Peptides with relaxin activity
US4656249A (en) *	1982-06-10	1987-04-07	Howard Florey Institute Of Experimental Physiology And Medicine	Peptides with relaxin activity
US5145962A (en) *	1982-08-12	1992-09-08	Howard Florey Institute Of Experimental Physiology And Medicine	Human pro relaxin polypeptides
EP0101309B1 (de) *	1982-08-12	1991-01-16	Howard Florey Institute Of Experimental Physiology And Medicine	Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
US5179195A (en) *	1982-12-13	1993-01-12	Howard Florey Institute Of Experimental Physiology And Medicine	Human relaxin polypeptides
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US4518526A (en) *	1982-12-22	1985-05-21	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
JPS63230089A (ja) *	1987-03-18	1988-09-26	Takeda Chem Ind Ltd	分泌発現による蛋白質の製造法
US5304473A (en) *	1991-06-11	1994-04-19	Eli Lilly And Company	A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy

1994
- 1994-06-20 WO PCT/US1994/006997 patent/WO1995000645A2/en not_active Ceased
- 1994-06-20 AU AU71765/94A patent/AU691189B2/en not_active Expired
- 1994-06-20 DE DE69432704T patent/DE69432704T2/de not_active Expired - Lifetime
- 1994-06-20 JP JP50303695A patent/JP3954091B2/ja not_active Expired - Lifetime
- 1994-06-20 CA CA002165781A patent/CA2165781C/en not_active Expired - Lifetime
- 1994-06-20 AT AT94920786T patent/ATE241012T1/de active
- 1994-06-20 EP EP94920786A patent/EP0707650B1/de not_active Expired - Lifetime
1995
- 1995-05-22 US US08/443,568 patent/US5759807A/en not_active Expired - Lifetime
2006
- 2006-07-31 JP JP2006208539A patent/JP2007014342A/ja active Pending

Also Published As

Publication number	Publication date
US5759807A (en)	1998-06-02
EP0707650A1 (de)	1996-04-24
CA2165781C (en)	2007-02-13
AU691189B2 (en)	1998-05-14
CA2165781A1 (en)	1995-01-05
JP2007014342A (ja)	2007-01-25
JP3954091B2 (ja)	2007-08-08
DE69432704D1 (de)	2003-06-26
EP0707650B1 (de)	2003-05-21
WO1995000645A3 (en)	1995-02-09
JPH09501911A (ja)	1997-02-25
DE69432704T2 (de)	2004-02-26
WO1995000645A2 (en)	1995-01-05
AU7176594A (en)	1995-01-17

Legal Events

Date

Code

Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0707650

Country of ref document: EP

Publication	Publication Date	Title
ATE241012T1 (de)	2003-06-15	Verfahren zur herstellung von humanen relaxin
ATE226949T1 (de)	2002-11-15	Verfahren zur herstellung von tolterodin
DE69101775D1 (de)	1994-05-26	Verfahren zur Herstellung von Wasserstoffperoxid.
DE58908534D1 (de)	1994-11-24	Verfahren zur Herstellung von doppelt-haploiden Gurken.
DE69409148D1 (de)	1998-04-30	Verfahren zur Herstellung von Wasserstoffperoxid
DE69611658D1 (de)	2001-03-01	Verfahren zur Herstellung von Ethylenglykol
DE69606495D1 (de)	2000-03-09	Verfahren zur Herstellung von depolymerisiertem Naturkautschuk
DE69407653D1 (de)	1998-02-12	Verfahren zur Herstellung von Wasserstoffsuperoxyd
ATE81339T1 (de)	1992-10-15	Verfahren zur herstellung von zyklischen sulfaten.
DE69424024D1 (de)	2000-05-25	Verfahren zur Herstellung von Laktamen
DE69429316D1 (de)	2002-01-17	Verfahren zur Herstellung von oxydierter Weisslauge
DE69414211D1 (de)	1998-12-03	Verfahren zur Herstellung von Fluorchemikalien
DE59003282D1 (de)	1993-12-09	Verfahren zur Herstellung von Dawsonit.
DE59300418D1 (de)	1995-09-07	Verfahren zur Herstellung von natürlichen Antioxidantien.
DE69314445D1 (de)	1997-11-13	Verfahren zur Herstellung von Wasserstoffperoxyd
DE69605064T3 (de)	2004-01-29	Verfahren zur Herstellung von Wasserstoffperoxid
DE69023991D1 (de)	1996-01-18	Verfahren zur Herstellung von Chlortrifluorethylen.
DE69609882D1 (de)	2000-09-28	Verfahren zur Herstellung von normalen und überbasischen Phenolaten
DE69015814D1 (de)	1995-02-16	Verfahren zur Herstellung von Calciumhypochlorit.
DE69015152D1 (de)	1995-01-26	Verfahren zur Herstellung von Chlordioxyd.
ATE67986T1 (de)	1991-10-15	Verfahren zur herstellung von wasserstoffperoxid.
DE69611331D1 (de)	2001-02-01	Verfahren zur Herstellung von S-Phenyl-L-Cystein
DE69603243D1 (de)	1999-08-19	Verfahren zur Herstellung von Ethenylamiden
DE69611505D1 (de)	2001-02-15	Verfahren zur Herstellung von all-trans Polyprenolen
DE58909821D1 (de)	1997-11-20	Verfahren zur Herstellung von Diaphragmen