ATE241807T1 - Immunoassay zum nachweis des mutanten p53 polypeptids in biologischen flüssigkeiten - Google Patents

Immunoassay zum nachweis des mutanten p53 polypeptids in biologischen flüssigkeiten

Info

Publication number
ATE241807T1
ATE241807T1 AT92906415T AT92906415T ATE241807T1 AT E241807 T1 ATE241807 T1 AT E241807T1 AT 92906415 T AT92906415 T AT 92906415T AT 92906415 T AT92906415 T AT 92906415T AT E241807 T1 ATE241807 T1 AT E241807T1
Authority
AT
Austria
Prior art keywords
mutant
polypeptide
immunoassay
detection
biological liquids
Prior art date
Application number
AT92906415T
Other languages
English (en)
Inventor
Frederick H Reynolds Jr
Ron Zeheb
John R Stephenson
John M Sorvillo
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Application granted granted Critical
Publication of ATE241807T1 publication Critical patent/ATE241807T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57575—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT92906415T 1991-02-01 1992-01-31 Immunoassay zum nachweis des mutanten p53 polypeptids in biologischen flüssigkeiten ATE241807T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64956691A 1991-02-01 1991-02-01
US71917291A 1991-06-21 1991-06-21
PCT/US1992/000878 WO1992013970A1 (en) 1991-02-01 1992-01-31 Immunoassay for detection of mutant p53 polypeptide in biological fluids

Publications (1)

Publication Number Publication Date
ATE241807T1 true ATE241807T1 (de) 2003-06-15

Family

ID=27095640

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92906415T ATE241807T1 (de) 1991-02-01 1992-01-31 Immunoassay zum nachweis des mutanten p53 polypeptids in biologischen flüssigkeiten

Country Status (5)

Country Link
EP (2) EP1006364A1 (de)
AT (1) ATE241807T1 (de)
AU (1) AU1370592A (de)
DE (1) DE69233079T2 (de)
WO (1) WO1992013970A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505719A (ja) * 1992-04-14 1995-06-22 デューク・ユニバーシティー ｐ５３及びＨＳＰ７０のコンプレックスを含む腫瘍の検出方法
CA2124595A1 (en) * 1992-09-30 1994-04-14 Hanswalter Zentgraf Process for detecting p53-specific antibodies
US5747650A (en) * 1993-08-02 1998-05-05 Health Research, Inc. P53AS protein and antibody therefor
US5726024A (en) * 1993-08-02 1998-03-10 Health Research, Inc. p53as protein and antibody therefor
US7238523B1 (en) 1993-08-02 2007-07-03 Health Research, Inc. p53as protein and antibody therefor
US6965009B1 (en) 1993-08-02 2005-11-15 Health Research, Inc. p53 as protein and antibody therefor
DE69433274T2 (de) * 1993-08-02 2004-08-05 Health Research Inc. Protein P53as sowie Plasmide und virale Vektoren, die eine zu der das Protein codierende DNA-Sequenz komplementäre cDNA-Sequence enthalten
US5688918A (en) * 1993-08-02 1997-11-18 Health Research, Inc. p53as protein and antibody therefor
SE9403953D0 (sv) * 1994-07-15 1994-11-16 Pharmacia Biotech Ab Sequence-based diagnosis
US6350615B1 (en) 1996-11-22 2002-02-26 Duke University Gene product over expressed in cancer cells
US5912142A (en) * 1996-11-22 1999-06-15 Duke University Gene product over expressed in cancer cells
US6072034A (en) * 1997-11-22 2000-06-06 Duke University Gene product over expressed in cancer cells
IL121041A0 (en) * 1997-06-09 1997-11-20 Yeda Res & Dev Immunogenic compositions for induction of anti-tumor immunity
WO1999002682A1 (en) * 1997-07-09 1999-01-21 Affymetrix, Inc. p53 MUTANTS FOUND IN TUMORS
CA2214461A1 (en) 1997-09-02 1999-03-02 Mcgill University Screening method for determining individuals at risk of developing diseases associated with different polymorphic forms of wildtype p53
JP4678882B2 (ja) * 2004-10-14 2011-04-27 ジェネンテック， インコーポレイテッド Ｃｏｐ１分子およびその使用
GB201617564D0 (en) * 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4699877A (en) * 1982-11-04 1987-10-13 The Regents Of The University Of California Methods and compositions for detecting human tumors
US4798787A (en) * 1984-09-19 1989-01-17 Cetus Corporation Peptide antibodies and their use in detecting oncogene products
DE4444969C1 (de) * 1994-12-16 1996-10-24 Orga Med Dr Med Erwin Klopfer Nachweis von Antikörpern gegen p53 in Körperflüssigkeiten

Also Published As

Publication number Publication date
EP0576476B1 (de) 2003-05-28
EP0576476A1 (de) 1994-01-05
DE69233079T2 (de) 2004-04-01
WO1992013970A1 (en) 1992-08-20
AU1370592A (en) 1992-09-07
EP0576476A4 (en) 1994-06-29
DE69233079D1 (de) 2003-07-03
EP1006364A1 (de) 2000-06-07

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Legal Events

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