ATE242778T1 - Verfahren für die herstellung von methylenbisphosphonsäure und deren salze - Google Patents

Verfahren für die herstellung von methylenbisphosphonsäure und deren salze

Info

Publication number: ATE242778T1
Authority: AT; Austria
Prior art keywords: salts; production; bisphosphonic acid; methylene bisphosphonic; methylene
Prior art date: 1999-09-17

Application number

AT00958856T

Other languages

English (en)

Inventor

Mark Purdie

Original Assignee

Astrazeneca Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-17

Filing date

2000-09-11

Publication date

2003-06-15

2000-09-11 Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE242778T1 publication Critical patent/ATE242778T1/de

Links

MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3856—Polyphosphonic acids containing halogen or nitro(so) substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3843—Polyphosphonic acids containing no further substituents than -PO3H2 groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT00958856T 1999-09-17 2000-09-11 Verfahren für die herstellung von methylenbisphosphonsäure und deren salze ATE242778T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9903345A SE9903345D0 (sv)	1999-09-17	1999-09-17	Novel process
PCT/GB2000/003473 WO2001021629A1 (en)	1999-09-17	2000-09-11	Process for preparing methylene bisphosphonic and salts

Publications (1)

Publication Number	Publication Date
ATE242778T1 true ATE242778T1 (de)	2003-06-15

Family

ID=20417040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00958856T ATE242778T1 (de)	1999-09-17	2000-09-11	Verfahren für die herstellung von methylenbisphosphonsäure und deren salze

Country Status (24)

Country	Link
US (2)	US6657076B1 (de)
EP (1)	EP1216253B1 (de)
JP (1)	JP4881524B2 (de)
KR (1)	KR100776105B1 (de)
CN (1)	CN1150200C (de)
AR (1)	AR029393A1 (de)
AT (1)	ATE242778T1 (de)
AU (1)	AU771628B2 (de)
BR (1)	BR0014057A (de)
CA (1)	CA2383829C (de)
CO (1)	CO5231228A1 (de)
DE (1)	DE60003323T2 (de)
DK (1)	DK1216253T3 (de)
ES (1)	ES2200921T3 (de)
HK (1)	HK1045696B (de)
IL (2)	IL148442A (de)
MY (1)	MY119965A (de)
NO (1)	NO331532B1 (de)
NZ (1)	NZ517552A (de)
PT (1)	PT1216253E (de)
SE (1)	SE9903345D0 (de)
TW (1)	TWI274057B (de)
WO (1)	WO2001021629A1 (de)
ZA (1)	ZA200201661B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9903345D0 (sv) *	1999-09-17	1999-09-17	Astra Pharma Prod	Novel process
AU2006298677A1 (en) *	2005-10-06	2007-04-12	Innate Pharma	Phosphoantigen salts of organic bases and methods for their crystallization
JP5363045B2 (ja) *	2008-07-24	2013-12-11	大八化学工業株式会社	ホスホン酸の製造方法
CN115990138A (zh)	2015-01-14	2023-04-21	奇斯药制品公司	包含高纯度坎格雷洛的药物制剂以及制备和使用它们的方法
CN111647016A (zh) *	2020-07-10	2020-09-11	成都纽瑞特医疗科技股份有限公司	羟基亚甲基二膦酸盐的制备方法
WO2024227846A2 (en)	2023-05-03	2024-11-07	Dna Script	Reagent used in deprotection of 3'-o-amino polynucleotides
WO2025093659A1 (en)	2023-11-04	2025-05-08	Dna Script	3'-o-aminooxymethyl blocked nucleotides and use thereof in enzymatic synthesis of polynucleotides

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3251907A (en) *	1962-08-23	1966-05-17	Procter & Gamble	Method for preparing tetra-secondary alkyl methylenediphosphonates
CA777769A (en) *	1963-03-18	1968-02-06	H. Roy Clarence	Substituted methylene diphosphonic acid compounds and detergent compositions
JPS54125777A (en)	1978-03-20	1979-09-29	Kao Corp	Bleaching composition
IT1201087B (it) *	1982-04-15	1989-01-27	Gentili Ist Spa	Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4478763A (en) *	1982-10-20	1984-10-23	Univ. Of Southern California	Process for preparing alpha-fluorinated alkanediphosphonates
JPS61123709A (ja) *	1984-11-19	1986-06-11	Nippon Soken Inc	排気ガス微粒子浄化機能を有する内燃機関の制御装置
US4689123A (en) *	1986-12-23	1987-08-25	The Dow Chemical Company	Novel tetraphosphonic acid compounds, intermediates and a process for their production
FI83421C (fi) *	1989-06-21	1991-07-10	Huhtamaeki Oy	Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
FI83657C (fi) *	1989-09-08	1991-08-12	Huhtamaeki Oy	Foerfarande foer framstaellning av metylenbisfosfonsyror.
FI89366C (fi)	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
KR100315612B1 (ko)	1993-02-10	2002-06-20	추후제출	N-알킬-2-치환아데노신트리포스페이트동족체
EP0742279A1 (de)	1995-05-10	1996-11-13	The Procter & Gamble Company	Saure wässrige flüssige Zusammensetzungen
SE9701219D0 (sv)	1997-04-04	1997-04-04	Astra Pharma Prod	New compounds
FI109088B (fi)	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
SE9903345D0 (sv) *	1999-09-17	1999-09-17	Astra Pharma Prod	Novel process

1999
- 1999-09-17 SE SE9903345A patent/SE9903345D0/xx unknown
2000
- 2000-09-11 WO PCT/GB2000/003473 patent/WO2001021629A1/en not_active Ceased
- 2000-09-11 NZ NZ517552A patent/NZ517552A/en not_active IP Right Cessation
- 2000-09-11 JP JP2001525004A patent/JP4881524B2/ja not_active Expired - Lifetime
- 2000-09-11 DE DE60003323T patent/DE60003323T2/de not_active Expired - Lifetime
- 2000-09-11 DK DK00958856T patent/DK1216253T3/da active
- 2000-09-11 HK HK02107336.6A patent/HK1045696B/en not_active IP Right Cessation
- 2000-09-11 CA CA002383829A patent/CA2383829C/en not_active Expired - Lifetime
- 2000-09-11 PT PT00958856T patent/PT1216253E/pt unknown
- 2000-09-11 EP EP00958856A patent/EP1216253B1/de not_active Expired - Lifetime
- 2000-09-11 ES ES00958856T patent/ES2200921T3/es not_active Expired - Lifetime
- 2000-09-11 IL IL14844200A patent/IL148442A/xx active IP Right Grant
- 2000-09-11 US US10/088,177 patent/US6657076B1/en not_active Expired - Lifetime
- 2000-09-11 AT AT00958856T patent/ATE242778T1/de active
- 2000-09-11 KR KR1020027003519A patent/KR100776105B1/ko not_active Expired - Lifetime
- 2000-09-11 CN CNB008121826A patent/CN1150200C/zh not_active Expired - Lifetime
- 2000-09-11 AU AU70270/00A patent/AU771628B2/en not_active Expired
- 2000-09-11 BR BR0014057-0A patent/BR0014057A/pt not_active Application Discontinuation
- 2000-09-14 TW TW089118778A patent/TWI274057B/zh not_active IP Right Cessation
- 2000-09-15 MY MYPI20004298A patent/MY119965A/en unknown
- 2000-09-15 AR ARP000104849A patent/AR029393A1/es active IP Right Grant
- 2000-09-18 CO CO00070530A patent/CO5231228A1/es active IP Right Grant
2002
- 2002-02-27 ZA ZA200201661A patent/ZA200201661B/en unknown
- 2002-03-14 NO NO20021269A patent/NO331532B1/no not_active IP Right Cessation
2003
- 2003-12-01 US US10/725,820 patent/US7288673B2/en not_active Expired - Lifetime
2005
- 2005-04-26 IL IL168246A patent/IL168246A/en active IP Right Grant

Also Published As

Publication number	Publication date
HK1045696A1 (en)	2002-12-06
MY119965A (en)	2005-08-30
KR20020029135A (ko)	2002-04-17
US7288673B2 (en)	2007-10-30
CN1150200C (zh)	2004-05-19
WO2001021629A1 (en)	2001-03-29
DE60003323T2 (de)	2004-04-29
AU771628B2 (en)	2004-04-01
ES2200921T3 (es)	2004-03-16
JP4881524B2 (ja)	2012-02-22
AU7027000A (en)	2001-04-24
CO5231228A1 (es)	2002-12-27
US6657076B1 (en)	2003-12-02
NZ517552A (en)	2003-09-26
NO20021269L (no)	2002-03-14
ZA200201661B (en)	2003-08-27
US20040171870A1 (en)	2004-09-02
PT1216253E (pt)	2003-10-31
DK1216253T3 (da)	2003-09-15
CA2383829A1 (en)	2001-03-29
NO331532B1 (no)	2012-01-23
IL168246A (en)	2010-05-17
DE60003323D1 (de)	2003-07-17
IL148442A (en)	2005-08-31
HK1045696B (en)	2003-11-21
CA2383829C (en)	2009-01-20
AR029393A1 (es)	2003-06-25
SE9903345D0 (sv)	1999-09-17
TWI274057B (en)	2007-02-21
BR0014057A (pt)	2002-05-21
IL148442A0 (en)	2002-09-12
JP2003509517A (ja)	2003-03-11
KR100776105B1 (ko)	2007-11-15
CN1371383A (zh)	2002-09-25
EP1216253B1 (de)	2003-06-11
NO20021269D0 (no)	2002-03-14
EP1216253A1 (de)	2002-06-26

Legal Events

Date

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Title

Description

2004-01-15

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