ATE244262T1 - Verfahren zur herstellung von peptidzwischenprodukten - Google Patents

Verfahren zur herstellung von peptidzwischenprodukten

Info

Publication number: ATE244262T1
Authority: AT; Austria
Prior art keywords: intermediate products; peptide intermediate; producing peptide; synthesis; producing
Prior art date: 1999-10-19

Application number

AT00968148T

Other languages

English (en)

Inventor

Michael Stewart Ashwood

Christopher Brian Bishop

Ian Frank Cottrell

Khateeta Moneek Emerson

David Hands

Guo-Jie Ho

Joseph Edward Lynch

Yao-Jun Shi

Robert Darrin Wilson

Original Assignee

Merck Sharp & Dohme

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-19

Filing date

2000-10-18

Publication date

2003-07-15

2000-10-18 Application filed by Merck Sharp & Dohme, Merck & Co Inc filed Critical Merck Sharp & Dohme

2003-07-15 Application granted granted Critical

2003-07-15 Publication of ATE244262T1 publication Critical patent/ATE244262T1/de

Links

239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
- C07C69/42—Glutaric acid esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT00968148T 1999-10-19 2000-10-18 Verfahren zur herstellung von peptidzwischenprodukten ATE244262T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9924759.5A GB9924759D0 (en)	1999-10-19	1999-10-19	Process for preparing peptide intermediates
PCT/GB2000/004019 WO2001029065A1 (en)	1999-10-19	2000-10-18	Process for preparing peptide intermediates

Publications (1)

Publication Number	Publication Date
ATE244262T1 true ATE244262T1 (de)	2003-07-15

Family

ID=10863015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00968148T ATE244262T1 (de)	1999-10-19	2000-10-18	Verfahren zur herstellung von peptidzwischenprodukten

Country Status (10)

Country	Link
US (1)	US7262169B1 (de)
EP (1)	EP1226158B1 (de)
JP (1)	JP2003516319A (de)
AT (1)	ATE244262T1 (de)
AU (1)	AU7810000A (de)
CA (1)	CA2387995A1 (de)
DE (1)	DE60003711T2 (de)
ES (1)	ES2200951T3 (de)
GB (1)	GB9924759D0 (de)
WO (1)	WO2001029065A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1225918A2 (de) *	1999-10-19	2002-07-31	Merck & Co., Inc.	Konjugaten verwendbar bei prostata-krebs
CN107530395B (zh) *	2015-03-06	2021-10-22	康德生物医疗技术公司	制备药物相关肽的方法
EP4201951B1 (de) *	2021-12-21	2023-11-22	Bachem Holding AG	Verfahren zur peptidsynthese

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4376765A (en)	1980-03-31	1983-03-15	Institut International De Pathologie Cellulaire Et Moleculaire	Medicaments, their preparation and compositions containing same
FR2546163B1 (fr)	1983-05-16	1987-10-09	Centre Nat Rech Scient	Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
US6143864A (en)	1994-06-28	2000-11-07	Merck & Co., Inc.	Peptides
WO1996005863A1 (fr)	1994-08-19	1996-02-29	La Region Wallonne	Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation
WO1998010651A1 (en)	1996-09-12	1998-03-19	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
HRP970566A2 (en) *	1996-10-30	1998-08-31	Jones Deborah Defeo	Conjugates useful in the treatment of prostate canser
AU740597B2 (en)	1997-07-10	2001-11-08	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
TR200002260T2 (tr) *	1997-12-02	2000-12-21	Merck & Co., Inc.	Prostat kanserinin tedavisinde yararlı konjugatlar
WO1999044628A1 (en) *	1998-03-05	1999-09-10	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
EP1225918A2 (de) *	1999-10-19	2002-07-31	Merck & Co., Inc.	Konjugaten verwendbar bei prostata-krebs

1999
- 1999-10-19 GB GBGB9924759.5A patent/GB9924759D0/en not_active Ceased
2000
- 2000-10-18 AU AU78100/00A patent/AU7810000A/en not_active Abandoned
- 2000-10-18 US US10/111,154 patent/US7262169B1/en not_active Expired - Fee Related
- 2000-10-18 DE DE60003711T patent/DE60003711T2/de not_active Expired - Fee Related
- 2000-10-18 EP EP00968148A patent/EP1226158B1/de not_active Expired - Lifetime
- 2000-10-18 WO PCT/GB2000/004019 patent/WO2001029065A1/en not_active Ceased
- 2000-10-18 ES ES00968148T patent/ES2200951T3/es not_active Expired - Lifetime
- 2000-10-18 CA CA002387995A patent/CA2387995A1/en not_active Abandoned
- 2000-10-18 AT AT00968148T patent/ATE244262T1/de not_active IP Right Cessation
- 2000-10-18 JP JP2001531863A patent/JP2003516319A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DE60003711T2 (de)	2004-05-13
EP1226158B1 (de)	2003-07-02
ES2200951T3 (es)	2004-03-16
CA2387995A1 (en)	2001-04-26
US7262169B1 (en)	2007-08-28
DE60003711D1 (de)	2003-08-07
GB9924759D0 (en)	1999-12-22
JP2003516319A (ja)	2003-05-13
AU7810000A (en)	2001-04-30
EP1226158A1 (de)	2002-07-31
WO2001029065A1 (en)	2001-04-26

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Legal Events

Date	Code	Title	Description
2004-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties