ATE245447T1 - Inhibitor von gehirnödemen - Google Patents

Inhibitor von gehirnödemen

Info

Publication number: ATE245447T1
Authority: AT; Austria
Prior art keywords: endothelin antagonist; treating; brain edemas; edemas; preventing
Prior art date: 1995-06-02

Application number

AT96919984T

Other languages

English (en)

Inventor

Mitsuyoshi Ninomiya

Yoshiyuki Matsuo

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-02

Filing date

1996-05-29

Publication date

2003-08-15

1996-05-29 Application filed by Shionogi & Co filed Critical Shionogi & Co

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE245447T1 publication Critical patent/ATE245447T1/de

Links

206010048962 Brain oedema Diseases 0.000 title abstract 6
208000006752 brain edema Diseases 0.000 title abstract 6
239000003112 inhibitor Substances 0.000 title 1
239000002308 endothelin receptor antagonist Substances 0.000 abstract 4
239000004480 active ingredient Substances 0.000 abstract 1
229960003065 bosentan Drugs 0.000 abstract 1
SXTRWVVIEPWAKM-UHFFFAOYSA-N bosentan hydrate Chemical compound O.COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 SXTRWVVIEPWAKM-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT96919984T 1995-06-02 1996-05-29 Inhibitor von gehirnödemen ATE245447T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP16006095		1995-06-02
PCT/JP1996/001438 WO1996038173A1 (en)	1995-06-02	1996-05-29	Brain edema inhibitor

Publications (1)

Publication Number	Publication Date
ATE245447T1 true ATE245447T1 (de)	2003-08-15

Family

ID=15707042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96919984T ATE245447T1 (de)	1995-06-02	1996-05-29	Inhibitor von gehirnödemen

Country Status (16)

Country	Link
US (1)	US5945448A (de)
EP (1)	EP0838223B1 (de)
JP (1)	JP4011114B2 (de)
KR (1)	KR100399797B1 (de)
CN (1)	CN1083261C (de)
AT (1)	ATE245447T1 (de)
AU (1)	AU700182B2 (de)
BR (1)	BR9608413A (de)
CA (1)	CA2218028C (de)
DE (1)	DE69629195T2 (de)
DK (1)	DK0838223T3 (de)
ES (1)	ES2202449T3 (de)
PT (1)	PT838223E (de)
TR (1)	TR199701497T1 (de)
TW (1)	TW460286B (de)
WO (1)	WO1996038173A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6482857B1 (en)	1998-07-17	2002-11-19	The University Of Texas Southwestern Medical Center	Compositions which contain triterpenes for regulating hair growth
US6124362A (en)	1998-07-17	2000-09-26	The Procter & Gamble Company	Method for regulating hair growth
JP2007217438A (ja) *	2001-07-17	2007-08-30	Shionogi & Co Ltd	注射用医薬製剤
TWI232102B (en) *	2001-07-17	2005-05-11	Shionogi & Co	A pharmaceutical formulation for injection
EP2298315A1 (de)	2002-08-28	2011-03-23	Harbor BioSciences, Inc.	Therapeutische Behandlungsmethoden
WO2006098800A1 (en)	2005-01-14	2006-09-21	Airlite Plastics Co.	Insulated foam panel forms
JP2009530284A (ja) *	2006-03-13	2009-08-27	エンサイシブ・ファーマシューティカルズ・インコーポレイテッド	拡張期心不全を治療するための方法と組成物
US8080549B2 (en) *	2007-01-12	2011-12-20	Concert Pharmaceuticals, Inc.	Endothelin receptor antagonists
WO2008088727A2 (en)	2007-01-12	2008-07-24	Concert Pharmaceuticals, Inc.	Endothelin receptor antagonists
CA2793668A1 (en)	2011-10-31	2013-04-30	Bradley J. Crosby	An apparatus and method for construction of structures utilizing insulated concrete forms
CA2801735C (en)	2012-01-13	2019-08-06	Bradley J. Crosby	An apparatus and method for construction of structures utilizing insulated concrete forms
USD713975S1 (en)	2012-07-30	2014-09-23	Airlite Plastics Co.	Insulative insert for insulated concrete form
CA2985438A1 (en)	2016-11-14	2018-05-14	Airlite Plastics Co.	Concrete form with removable sidewall
US11155995B2 (en)	2018-11-19	2021-10-26	Airlite Plastics Co.	Concrete form with removable sidewall

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE164588T1 (de) *	1991-01-29	1998-04-15	Shionogi & Co	Triterpenderivat
ES2094622T3 (es) *	1993-06-11	1997-01-16	Shionogi & Co	Derivados triterpenos y antagonistas del receptor de endotelina que los contiene.
US5599811A (en) *	1995-02-21	1997-02-04	Warner-Lambert Company	Benzothiazine dioxides as endothelin antagonists

1996
- 1996-05-29 CA CA2218028A patent/CA2218028C/en not_active Expired - Fee Related
- 1996-05-29 DE DE69629195T patent/DE69629195T2/de not_active Expired - Lifetime
- 1996-05-29 ES ES96919984T patent/ES2202449T3/es not_active Expired - Lifetime
- 1996-05-29 BR BR9608413A patent/BR9608413A/pt not_active Application Discontinuation
- 1996-05-29 AU AU58440/96A patent/AU700182B2/en not_active Ceased
- 1996-05-29 EP EP96919984A patent/EP0838223B1/de not_active Expired - Lifetime
- 1996-05-29 WO PCT/JP1996/001438 patent/WO1996038173A1/ja not_active Ceased
- 1996-05-29 PT PT96919984T patent/PT838223E/pt unknown
- 1996-05-29 DK DK96919984T patent/DK0838223T3/da active
- 1996-05-29 KR KR1019970707867A patent/KR100399797B1/ko not_active Expired - Fee Related
- 1996-05-29 JP JP53636696A patent/JP4011114B2/ja not_active Expired - Fee Related
- 1996-05-29 CN CN96194363A patent/CN1083261C/zh not_active Expired - Fee Related
- 1996-05-29 TR TR97/01497T patent/TR199701497T1/xx unknown
- 1996-05-29 AT AT96919984T patent/ATE245447T1/de not_active IP Right Cessation
- 1996-05-29 US US08/930,827 patent/US5945448A/en not_active Expired - Lifetime
- 1996-06-01 TW TW085106558A patent/TW460286B/zh active

Also Published As

Publication number	Publication date
DK0838223T3 (da)	2003-11-17
CN1186441A (zh)	1998-07-01
WO1996038173A1 (en)	1996-12-05
KR100399797B1 (ko)	2004-04-13
AU5844096A (en)	1996-12-18
MX9708920A (es)	1998-03-31
KR19990008341A (ko)	1999-01-25
EP0838223A1 (de)	1998-04-29
EP0838223A4 (de)	2001-04-25
BR9608413A (pt)	1998-12-29
US5945448A (en)	1999-08-31
TW460286B (en)	2001-10-21
AU700182B2 (en)	1998-12-24
CN1083261C (zh)	2002-04-24
CA2218028A1 (en)	1996-12-05
TR199701497T1 (xx)	1998-06-22
DE69629195T2 (de)	2004-05-06
JP4011114B2 (ja)	2007-11-21
PT838223E (pt)	2003-12-31
DE69629195D1 (de)	2003-08-28
ES2202449T3 (es)	2004-04-01
EP0838223B1 (de)	2003-07-23
CA2218028C (en)	2010-07-06

Legal Events

Date

Code

Title

Description

2004-02-15

UEP

Publication of translation of european patent specification

Ref document number: 0838223

Country of ref document: EP

2012-02-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE195117T1 (de)	2000-08-15	1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
ATE245447T1 (de)	2003-08-15	Inhibitor von gehirnödemen
DK0778834T3 (da)	2000-04-17	Bicykliske, heterocykliske diarylforbindelser som inhibitorer af cyclooxygenase-2
RU94036772A (ru)	1996-08-27	Применение 2-фенил-3-ароилбензотиофенов для ингибирования эндометриоза
DK0715623T3 (da)	1999-02-22	Blodpladeaggregationsinhibitorer
ATE147981T1 (de)	1997-02-15	Verabreichung von lamotrigin zur behandlung von neuro-aids
WO1992019617A3 (en)	1992-12-10	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
RU94044454A (ru)	1996-10-10	Ингибитор аутоимунных заболеваний
PT752813E (pt)	2003-04-30	Inibidores de proteases de parasitas metazoarios
WO1992019211A3 (en)	1993-01-21	Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
RU94044356A (ru)	1996-10-10	Применение 2-фенил-3-ароилбензотиофенов для увеличения экспрессии тромбомодулина для ингибирования тромботического расстройства, для увеличения активации протеина с
ES2106531T3 (es)	1997-11-01	Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
NO923199D0 (no)	1992-08-14	Terapeutiske forbindelser
DE60225143D1 (de)	2008-04-03	Synergistische pharmazeutische zusammensetzungen zur behandlung bzw. prophylaxe von diabetes
DE69315699D1 (de)	1998-01-22	Inhibitoren gegen die aggregation von blutplättchen
DK0804418T3 (da)	2003-07-07	Platelataggregationshæmmere
DK0866711T3 (da)	2006-11-27	Anvendelse af 6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamid til fremstilling af et farmaceutisk præparat til modvirkning af sövnapnö
ATE160143T1 (de)	1997-11-15	2-substituierte morpholin- und thiomorpholinderivate als gaba-b antagonisten
ES2191763T3 (es)	2003-09-16	Inhibidor del desarrollo de dependencia/tolerancia a un agente analgesico narcotico.
KR950032194A (ko)	1995-12-20	신규푸린유도체 및 그 약학적으로 허용되는 염
DK0720598T3 (da)	1999-06-21	Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
NO923198L (no)	1993-02-16	Terapeutiske midler
AR015458A1 (es)	2001-05-02	Compuestos de tetrahidrofurano, y composicion farmaceutica que lo contiene.
FI941850A0 (fi)	1994-04-21	Uusi yhdiste, joka on leustroduksiini H, sen valmistus ja terapeuttinen käyttö