ATE246174T1 - Tosylprolin-derivate als thymidylat-synthase inhibitoren - Google Patents

Tosylprolin-derivate als thymidylat-synthase inhibitoren

Info

Publication number: ATE246174T1
Authority: AT; Austria
Prior art keywords: tosylproline; synthase inhibitors; derivatives; thymidylate synthase; methods
Prior art date: 2000-02-02

Application number

AT01905352T

Other languages

English (en)

Inventor

Daniel A Erlanson

Original Assignee

Sunesis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-02

Filing date

2001-02-02

Publication date

2003-08-15

2001-02-02 Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc

2003-08-15 Application granted granted Critical

2003-08-15 Publication of ATE246174T1 publication Critical patent/ATE246174T1/de

Links

CGPHGPCHVUSFFA-UHFFFAOYSA-N 1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxylic acid Chemical class C1=CC(C)=CC=C1S(=O)(=O)N1C(C(O)=O)CCC1 CGPHGPCHVUSFFA-UHFFFAOYSA-N 0.000 title abstract 2
239000003734 thymidylate synthase inhibitor Substances 0.000 title abstract 2
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000000843 anti-fungal effect Effects 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
229940125687 antiparasitic agent Drugs 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229940121357 antivirals Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)
Cosmetics (AREA)

AT01905352T 2000-02-02 2001-02-02 Tosylprolin-derivate als thymidylat-synthase inhibitoren ATE246174T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/496,378 US6143776A (en)	2000-02-02	2000-02-02	Tosylproline analogs as thymidylate synthase inhibitors
PCT/US2001/003391 WO2001056987A1 (en)	2000-02-02	2001-02-02	Tosylproline analogs as thymidylate synthase inhibitors

Publications (1)

Publication Number	Publication Date
ATE246174T1 true ATE246174T1 (de)	2003-08-15

Family

ID=23972366

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01905352T ATE246174T1 (de)	2000-02-02	2001-02-02	Tosylprolin-derivate als thymidylat-synthase inhibitoren

Country Status (8)

Country	Link
US (1)	US6143776A (de)
EP (1)	EP1252141B1 (de)
JP (1)	JP2003521535A (de)
AT (1)	ATE246174T1 (de)
AU (2)	AU3324201A (de)
CA (1)	CA2398752A1 (de)
DE (1)	DE60100539T2 (de)
WO (1)	WO2001056987A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6589978B2 (en) *	2000-06-30	2003-07-08	Hoffman-La Roche Inc.	1-sulfonyl pyrrolidine derivatives
CN100350036C (zh) *	2001-04-27	2007-11-21	宝洁公司	用于控制生物膜的装置和方法
BRPI0215858B1 (pt) *	2002-07-24	2020-11-10	Keddem Bio-Science Ltd	método para obter informações a respeito de uma área quimicamente ativa de uma molécula-alvo
WO2010138955A2 (en) *	2009-05-29	2010-12-02	University Of Florida Research Foundation, Inc.	Methods and compositions for treating neoplasia
ITMI20130085A1 (it) *	2013-01-22	2014-07-23	Gabriele Cruciani	Nuove molecole per uso come agenti antitumorali
EP3793990B1 (de)	2018-05-16	2023-07-19	Infex Therapeutics Limited	Antibakterielle verbindungen
BR112021021454A2 (pt)	2019-05-06	2021-12-21	Janssen Sciences Ireland Unlimited Co	Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv
WO2021242753A1 (en) *	2020-05-26	2021-12-02	The Regents Of The University Of Michigan	Mitochondrial targeting compounds for the treatment of associated diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0031237B1 (de) *	1979-12-19	1984-10-17	National Research Development Corporation	Chinazolinderivate, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung als Anti-Krebs-Mittel
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
US4925939A (en) *	1989-01-05	1990-05-15	Sloan-Kettering Institute For Cancer Research	6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives
US5958930A (en) *	1991-04-08	1999-09-28	Duquesne University Of The Holy Ghost	Pyrrolo pyrimidine and furo pyrimidine derivatives
GB9205320D0 (en) *	1992-03-11	1992-04-22	Ici Plc	Anti-tumour compounds
GB9205907D0 (en) *	1992-03-18	1992-04-29	Cancer Res Inst Royal	Anti-cancer compounds
DE69716449T2 (de) *	1996-08-28	2003-08-07	The Procter & Gamble Company, Cincinnati	Substituierte zyklische amine als metalloproteaseinhibitoren
JP4024309B2 (ja) *	1996-10-22	2007-12-19	第一三共株式会社	新規な感染症治療薬
AR016133A1 (es) *	1997-07-31	2001-06-20	Wyeth Corp	Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria

2000
- 2000-02-02 US US09/496,378 patent/US6143776A/en not_active Expired - Fee Related
2001
- 2001-02-02 AU AU3324201A patent/AU3324201A/xx active Pending
- 2001-02-02 EP EP01905352A patent/EP1252141B1/de not_active Expired - Lifetime
- 2001-02-02 CA CA002398752A patent/CA2398752A1/en not_active Abandoned
- 2001-02-02 AU AU2001233242A patent/AU2001233242B2/en not_active Ceased
- 2001-02-02 WO PCT/US2001/003391 patent/WO2001056987A1/en not_active Ceased
- 2001-02-02 JP JP2001556837A patent/JP2003521535A/ja not_active Withdrawn
- 2001-02-02 AT AT01905352T patent/ATE246174T1/de not_active IP Right Cessation
- 2001-02-02 DE DE60100539T patent/DE60100539T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1252141B1 (de)	2003-07-30
CA2398752A1 (en)	2001-08-09
DE60100539D1 (en)	2003-09-04
AU3324201A (en)	2001-08-14
EP1252141A1 (de)	2002-10-30
WO2001056987A1 (en)	2001-08-09
JP2003521535A (ja)	2003-07-15
AU2001233242B2 (en)	2004-11-18
DE60100539T2 (de)	2004-06-09
US6143776A (en)	2000-11-07

Legal Events

Date	Code	Title	Description
2004-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
SE0202463D0 (sv)	2002-08-14	Novel compounds
DE60309848D1 (de)	2007-01-04	Purinderivate als kinaseinhibitoren
TW200608977A (en)	2006-03-16	Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
EA200501928A1 (ru)	2006-12-29	Пирролодигидроизохинолины как ингибиторы pde10
UA88012C2 (uk)	2009-09-10	Похідні хіназоліндіону як інгібітори parp
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
SG154433A1 (en)	2009-08-28	Phthalazine derivatives as parp inhibitors
DE60314623D1 (de)	2007-08-09	Substituierte pyrazolopyrimidine
ATE389635T1 (de)	2008-04-15	Pharmazeutisch wirksame piperidinderivate
ATE302775T1 (de)	2005-09-15	Carbolinderivate
NO20044995L (no)	2005-01-18	Heterosykliske forbindelser
ATE430747T1 (de)	2009-05-15	2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren
MXPA05012247A (es)	2006-02-10	Derivados de bencimidazol nuevos.
ATE346067T1 (de)	2006-12-15	Carbolinderivate
GB0308201D0 (en)	2003-05-14	Novel compounds
DE602006011752D1 (de)	2010-03-04	Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate
DK1643984T3 (da)	2011-10-24	Anvendelse af parthenolidderivater som antileukæmiske og cytotoksske midler
DE60313350D1 (de)	2007-05-31	Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmer
ECSP055912A (es)	2005-11-22	Compuestos de 2-aminocarbonil-quinolina como antagonistas del receptor de difosfato de adenosina en plaquetas
UY27980A1 (es)	2004-03-31	Indoles 2,7-sustituidos
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
ATE419242T1 (de)	2009-01-15	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
ATE246174T1 (de)	2003-08-15	Tosylprolin-derivate als thymidylat-synthase inhibitoren
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate
SE0202461D0 (sv)	2002-08-14	Novel compounds