ATE24721T1 - Amino und amidoderivate von chloro-nitro-amino und alkylamino-pyrazinen als adjunkten fuer therapeutischen strahl verwendbar. - Google Patents

Amino und amidoderivate von chloro-nitro-amino und alkylamino-pyrazinen als adjunkten fuer therapeutischen strahl verwendbar.

Info

Publication number: ATE24721T1
Authority: AT; Austria
Prior art keywords: amino; chloro; alkylamino; produce; nitro
Prior art date: 1982-06-09

Application number

AT82302976T

Other languages

English (en)

Inventor

George D Hartman

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-09

Filing date

1982-06-09

Publication date

1987-01-15

1982-06-09 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1987-01-15 Application granted granted Critical

1987-01-15 Publication of ATE24721T1 publication Critical patent/ATE24721T1/de

Links

-1 AMINO Chemical class 0.000 title abstract 5
230000001225 therapeutic effect Effects 0.000 title 1
YPKQEGJKVUTYPH-UHFFFAOYSA-N 5,6-dichloro-3-nitropyrazin-2-amine Chemical compound NC1=NC(Cl)=C(Cl)N=C1[N+]([O-])=O YPKQEGJKVUTYPH-UHFFFAOYSA-N 0.000 abstract 3
150000001412 amines Chemical class 0.000 abstract 3
150000003973 alkyl amines Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 abstract 1
MNURQUMUZCBVPI-UHFFFAOYSA-N 2-nitropyrazine Chemical compound [O-][N+](=O)C1=CN=CC=N1 MNURQUMUZCBVPI-UHFFFAOYSA-N 0.000 abstract 1
UFOUSHWZVOIJKK-UHFFFAOYSA-N 3-amino-5,6-dichloropyrazine-2-carboxylic acid Chemical compound NC1=NC(Cl)=C(Cl)N=C1C(O)=O UFOUSHWZVOIJKK-UHFFFAOYSA-N 0.000 abstract 1
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Natural products C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000006193 diazotization reaction Methods 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical class NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT82302976T 1982-06-09 1982-06-09 Amino und amidoderivate von chloro-nitro-amino und alkylamino-pyrazinen als adjunkten fuer therapeutischen strahl verwendbar. ATE24721T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP82302976A EP0096125B1 (de)	1982-06-09	1982-06-09	Amino und Amidoderivate von Chloro-Nitro-Amino und Alkylamino-Pyrazinen als Adjunkten für therapeutischen Strahl verwendbar

Publications (1)

Publication Number	Publication Date
ATE24721T1 true ATE24721T1 (de)	1987-01-15

Family

ID=8189695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT82302976T ATE24721T1 (de)	1982-06-09	1982-06-09	Amino und amidoderivate von chloro-nitro-amino und alkylamino-pyrazinen als adjunkten fuer therapeutischen strahl verwendbar.

Country Status (3)

Country	Link
EP (1)	EP0096125B1 (de)
AT (1)	ATE24721T1 (de)
DE (1)	DE3274980D1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN109485916A (zh) *	2018-11-20	2019-03-19	武汉工程大学	一种氨基吡嗪类阻燃剂的合成及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3541093A (en) *	1968-08-22	1970-11-17	Merck & Co Inc	Process for the preparation of 1h-imidazo(4,5-b)pyrazine-2-ones
NL6911867A (de) *	1968-08-31	1970-03-03
US3660397A (en) *	1970-04-17	1972-05-02	Merck & Co Inc	Imidazo(4 5-b)pyrazines

1982
- 1982-06-09 AT AT82302976T patent/ATE24721T1/de not_active IP Right Cessation
- 1982-06-09 DE DE8282302976T patent/DE3274980D1/de not_active Expired
- 1982-06-09 EP EP82302976A patent/EP0096125B1/de not_active Expired

Also Published As

Publication number	Publication date
DE3274980D1 (en)	1987-02-12
EP0096125B1 (de)	1987-01-07
EP0096125A1 (de)	1983-12-21

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Legal Events

Date	Code	Title	Description
1987-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties