ATE247971T1 - Liposomale oligonukleotidzusammensetzungen - Google Patents

Liposomale oligonukleotidzusammensetzungen

Info

Publication number
ATE247971T1
ATE247971T1 AT96925036T AT96925036T ATE247971T1 AT E247971 T1 ATE247971 T1 AT E247971T1 AT 96925036 T AT96925036 T AT 96925036T AT 96925036 T AT96925036 T AT 96925036T AT E247971 T1 ATE247971 T1 AT E247971T1
Authority
AT
Austria
Prior art keywords
pct
oligonucleotide compositions
sec
date
liposomal
Prior art date
Application number
AT96925036T
Other languages
English (en)
Inventor
William Guy Love
Judith Ann Phillips
Paul Leslie Nicklin
Karen Ophelia Hamilton
Original Assignee
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515743.4A external-priority patent/GB9515743D0/en
Priority claimed from GBGB9519130.0A external-priority patent/GB9519130D0/en
Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh
Application granted granted Critical
Publication of ATE247971T1 publication Critical patent/ATE247971T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96925036T 1995-08-01 1996-07-24 Liposomale oligonukleotidzusammensetzungen ATE247971T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515743.4A GB9515743D0 (en) 1995-08-01 1995-08-01 Compositions
GBGB9519130.0A GB9519130D0 (en) 1995-09-19 1995-09-19 Compositions
PCT/GB1996/001775 WO1997004787A1 (en) 1995-08-01 1996-07-24 Liposomal oligonucleotide compositions

Publications (1)

Publication Number Publication Date
ATE247971T1 true ATE247971T1 (de) 2003-09-15

Family

ID=26307496

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96925036T ATE247971T1 (de) 1995-08-01 1996-07-24 Liposomale oligonukleotidzusammensetzungen

Country Status (13)

Country Link
US (1) US6096720A (de)
EP (1) EP0843555B1 (de)
JP (1) JPH11511128A (de)
KR (1) KR19990036033A (de)
AT (1) ATE247971T1 (de)
AU (1) AU705644B2 (de)
BR (1) BR9609944A (de)
CA (1) CA2227989A1 (de)
DE (1) DE69629702T2 (de)
HU (1) HUP9802445A3 (de)
NO (1) NO980354D0 (de)
NZ (1) NZ313264A (de)
WO (1) WO1997004787A1 (de)

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US6096720A (en) 2000-08-01
WO1997004787A1 (en) 1997-02-13
DE69629702T2 (de) 2004-06-17
HUP9802445A2 (hu) 1999-02-01
EP0843555A1 (de) 1998-05-27
NZ313264A (en) 1999-11-29
HUP9802445A3 (en) 1999-03-29
EP0843555B1 (de) 2003-08-27
KR19990036033A (ko) 1999-05-25
DE69629702D1 (de) 2003-10-02
CA2227989A1 (en) 1997-02-13
NO980354L (no) 1998-01-27
JPH11511128A (ja) 1999-09-28
AU6590496A (en) 1997-02-26
BR9609944A (pt) 1999-05-18
NO980354D0 (no) 1998-01-27
AU705644B2 (en) 1999-05-27

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