ATE247984T1 - Bioreduktive konjugate zur gezielten wirkstoffzufuhr - Google Patents
Bioreduktive konjugate zur gezielten wirkstoffzufuhrInfo
- Publication number
- ATE247984T1 ATE247984T1 AT98904282T AT98904282T ATE247984T1 AT E247984 T1 ATE247984 T1 AT E247984T1 AT 98904282 T AT98904282 T AT 98904282T AT 98904282 T AT98904282 T AT 98904282T AT E247984 T1 ATE247984 T1 AT E247984T1
- Authority
- AT
- Austria
- Prior art keywords
- bioreductive
- active ingredients
- targeted delivery
- disease
- linked
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- 231100000065 noncytotoxic Toxicity 0.000 abstract 2
- 230000002020 noncytotoxic effect Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000001277 chronic periodontitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 230000001146 hypoxic effect Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/559—Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9703002.7A GB9703002D0 (en) | 1997-02-11 | 1997-02-11 | Bioreductively activated drug targeting |
| GBGB9712090.1A GB9712090D0 (en) | 1997-06-10 | 1997-06-10 | Bioreductively activated drug targeting |
| PCT/GB1998/000461 WO1998035701A1 (en) | 1997-02-11 | 1998-02-13 | Drug targeting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE247984T1 true ATE247984T1 (de) | 2003-09-15 |
Family
ID=26310992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98904282T ATE247984T1 (de) | 1997-02-11 | 1998-02-13 | Bioreduktive konjugate zur gezielten wirkstoffzufuhr |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7829555B1 (de) |
| EP (1) | EP0988057B1 (de) |
| JP (1) | JP2001512425A (de) |
| AT (1) | ATE247984T1 (de) |
| CA (1) | CA2280874A1 (de) |
| DE (1) | DE69817565T2 (de) |
| ES (1) | ES2206891T3 (de) |
| WO (1) | WO1998035701A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9808562D0 (en) * | 1998-04-22 | 1998-06-24 | Univ Cardiff | Treatment of stroke and other ischaemic conditions |
| AU5429699A (en) * | 1998-08-19 | 2000-03-14 | Theramark Limited | Drug targeting |
| DE602004020187D1 (de) * | 2003-02-20 | 2009-05-07 | Constant Res & Dev Ltd | Prozess zur Herstellung einer Dexamethason enthaltenden Formulierung zur oralen Anwendung |
| GB0517957D0 (en) | 2005-09-03 | 2005-10-12 | Morvus Technology Ltd | Method of combating infection |
| GB0526552D0 (en) | 2005-12-29 | 2006-02-08 | Morvus Technology Ltd | New use |
| GB2442202A (en) | 2006-09-30 | 2008-04-02 | Morvus Technology Ltd | Vermin poison |
| CN109758587B (zh) * | 2019-02-25 | 2022-04-05 | 华东师范大学 | 一种具有乏氧靶向性的多价配体药物偶联物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2131020B (en) | 1982-11-25 | 1986-10-01 | Gerald Edward Adams | Improvements relating to compounds useful in radiotherapy or chemotherapy |
| US5086068A (en) * | 1988-02-26 | 1992-02-04 | Alberta Cancer Board | Immunochemical detection of hypoxia in normal and tumor tissue |
| GB9113487D0 (en) | 1991-06-21 | 1991-08-07 | Amersham Int Plc | Agents for hypoxic cells |
| GB9114336D0 (en) | 1991-07-03 | 1991-08-21 | Nat Res Dev | Anti-tumour compounds ii |
| GB9114426D0 (en) | 1991-07-03 | 1991-08-21 | Nat Res Dev | Compounds useful for treating tumours ii |
| IT1251472B (it) | 1991-09-12 | 1995-05-15 | Boehringer Mannheim Italia | Ossaazafosforine utili come agenti antitumorali, un processo per la loro preparazione e composizioni farmaceutiche che le contengono |
| GB9219566D0 (en) | 1992-09-16 | 1992-10-28 | Adams Gerald E | Novel bioreductive agents |
| GB9219565D0 (en) | 1992-09-16 | 1992-10-28 | Adams Gerald E | Novel bioreductive compounds |
| IL105244A (en) | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
| CA2136803A1 (en) * | 1993-12-22 | 1995-06-23 | Kazumi Ogata | Steroid derivatives |
| GB9404400D0 (en) | 1994-03-07 | 1994-04-20 | Wood Pauline J | Potentiation of bioreductive agents |
| AU4981896A (en) * | 1995-02-14 | 1996-09-04 | Sequus Pharmaceuticals, Inc. | Liposome composition and method for administering liposome-loadable drugs |
| WO1997023456A1 (en) | 1995-12-21 | 1997-07-03 | British Technology Group Ltd. | Indoloquinone derivatives as bioreductive agents |
-
1998
- 1998-02-13 AT AT98904282T patent/ATE247984T1/de not_active IP Right Cessation
- 1998-02-13 JP JP53331898A patent/JP2001512425A/ja not_active Ceased
- 1998-02-13 WO PCT/GB1998/000461 patent/WO1998035701A1/en not_active Ceased
- 1998-02-13 EP EP98904282A patent/EP0988057B1/de not_active Expired - Lifetime
- 1998-02-13 US US09/367,261 patent/US7829555B1/en not_active Expired - Fee Related
- 1998-02-13 ES ES98904282T patent/ES2206891T3/es not_active Expired - Lifetime
- 1998-02-13 DE DE69817565T patent/DE69817565T2/de not_active Expired - Lifetime
- 1998-02-13 CA CA002280874A patent/CA2280874A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7829555B1 (en) | 2010-11-09 |
| EP0988057A1 (de) | 2000-03-29 |
| WO1998035701A1 (en) | 1998-08-20 |
| CA2280874A1 (en) | 1998-08-20 |
| JP2001512425A (ja) | 2001-08-21 |
| DE69817565T2 (de) | 2004-06-24 |
| EP0988057B1 (de) | 2003-08-27 |
| DE69817565D1 (de) | 2003-10-02 |
| ES2206891T3 (es) | 2004-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |