ATE248147T1 - Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme - Google Patents

Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme

Info

Publication number: ATE248147T1
Authority: AT; Austria
Prior art keywords: alkynyl; cycloalkyl; alkenyl; alkyl; heteroaryl
Prior art date: 1997-05-14

Application number

AT98919091T

Other languages

English (en)

Inventor

Peter Moldt

Frank Waetjen

Jorgen Scheel-Krueger

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-14

Filing date

1998-05-12

Publication date

2003-09-15

1998-05-12 Application filed by Neurosearch As filed Critical Neurosearch As

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE248147T1 publication Critical patent/ATE248147T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
239000002858 neurotransmitter agent Substances 0.000 title abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 6
125000000304 alkynyl group Chemical group 0.000 abstract 6
125000000753 cycloalkyl group Chemical group 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 5
125000001072 heteroaryl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000000 cycloalkoxy group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
-1 3,4-methylenedioxyphenyl Chemical group 0.000 abstract 1
125000005356 cycloalkylalkenyl group Chemical group 0.000 abstract 1
125000005357 cycloalkylalkynyl group Chemical group 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229960002748 norepinephrine Drugs 0.000 abstract 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT98919091T 1997-05-14 1998-05-12 Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme ATE248147T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK55397		1997-05-14
PCT/DK1998/000185 WO1998051668A1 (en)	1997-05-14	1998-05-12	Piperidine derivatives as neurotransmitter re-uptake inhibitors

Publications (1)

Publication Number	Publication Date
ATE248147T1 true ATE248147T1 (de)	2003-09-15

Family

ID=8094843

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98919091T ATE248147T1 (de)	1997-05-14	1998-05-12	Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme

Country Status (7)

Country	Link
US (1)	US6376673B1 (de)
EP (1)	EP0981515B1 (de)
JP (1)	JP2001525812A (de)
AT (1)	ATE248147T1 (de)
AU (1)	AU7206398A (de)
DE (1)	DE69817557T2 (de)
WO (1)	WO1998051668A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6303627B1 (en) *	1998-06-19	2001-10-16	Eli Lilly And Company	Inhibitors of serotonin reuptake
AUPP627498A0 (en)	1998-10-02	1998-10-22	University Of Queensland, The	Novel peptides - i
US7215954B1 (en)	1999-03-18	2007-05-08	The Directv Group, Inc.	Resource allocation method for multi-platform communication system
EP1318988A2 (de)	2000-09-11	2003-06-18	Sepracor, Inc.	Liganden für monoamin rezeptoren und transporter, und verwendungsmethoden dafür (neurotransmission)
US7294637B2 (en)	2000-09-11	2007-11-13	Sepracor, Inc.	Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
WO2002053104A2 (en) *	2001-01-02	2002-07-11	Sention, Inc.	Use of catecholamine reuptake inhibitors to enhance memory
AR041879A1 (es) *	2002-11-01	2005-06-01	Neurosearch As	Derivados de piperidina y su utilizacion como inhibidores de la reabsocion de los neurotransmisores monoamina
DE60331762D1 (de) *	2002-11-01	2010-04-29	Neurosearch As	Neue piperidinderivate und deren verwendung als monoaminneurotransmitter-wiederaufnahmehemmer
ES2383358T3 (es)	2002-12-02	2012-06-20	Xenome Ltd	Péptidos de chi-conotoxina que tienen un ácido piroglutámico N-terminal
US7507717B2 (en)	2002-12-02	2009-03-24	Xenome Ltd.	Type II chi-conotoxin peptides (noradrenaline transporter inhibitors)
SE0401465D0 (sv)	2004-06-08	2004-06-08	Carlsson A Research Ab	New substituted piperdines as modulators of dopamine neurotransmission
WO2007065655A1 (en)	2005-12-07	2007-06-14	Neurosearch Sweden Ab	Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission
WO2010130672A1 (en) *	2009-05-12	2010-11-18	Glaxo Group Limited	Azabicyclo [4.1.0] heptane derivatives and their use as monoamine reuptake inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4048165A (en) *	1975-08-11	1977-09-13	Basf Aktiengesellschaft	Manufacture of 1-substituted oximino cyclo alkenes-(1)
IT1233446B (it)	1987-12-30	1992-04-01	Roussel Maestretti Spa	Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci
EP0367393A3 (de) *	1988-10-31	1991-03-27	Takeda Chemical Industries, Ltd.	Heterocyclische Verbindungen, deren Herstellung und Verwendung
PL193686B1 (pl) *	1995-09-07	2007-03-30	Hoffmann La Roche	Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych

1998
- 1998-05-12 AT AT98919091T patent/ATE248147T1/de not_active IP Right Cessation
- 1998-05-12 JP JP54871298A patent/JP2001525812A/ja not_active Ceased
- 1998-05-12 WO PCT/DK1998/000185 patent/WO1998051668A1/en not_active Ceased
- 1998-05-12 AU AU72063/98A patent/AU7206398A/en not_active Abandoned
- 1998-05-12 DE DE69817557T patent/DE69817557T2/de not_active Expired - Lifetime
- 1998-05-12 EP EP98919091A patent/EP0981515B1/de not_active Expired - Lifetime
1999
- 1999-10-12 US US09/415,227 patent/US6376673B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69817557T2 (de)	2004-06-17
AU7206398A (en)	1998-12-08
DE69817557D1 (de)	2003-10-02
EP0981515A1 (de)	2000-03-01
US6376673B1 (en)	2002-04-23
WO1998051668A1 (en)	1998-11-19
JP2001525812A (ja)	2001-12-11
EP0981515B1 (de)	2003-08-27

Legal Events

Date	Code	Title	Description
2004-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
UA49872C2 (uk)	2002-10-15	Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування
NO980919D0 (no)	1998-03-03	8-azabicyklo(3.2.1)okt-2-ene derivater, deres fremstilling og anvendelse
CA2187309A1 (en)	1995-10-26	Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors
DK0858461T3 (da)	2003-01-27	Kondenserede tropanderivater som neurotransmittergenoptagelsesinhibitorer
ATE383338T1 (de)	2008-01-15	N-(phenyl(piperidin-2-yl)methyl)benzamid-deriva e,verfahren zu deren herstellung und ihre therapeutische verwendung
DE69817557D1 (de)	2003-10-02	Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme
BR0211201A (pt)	2004-07-13	Composto, processo para a preparação desse composto, sua utilização, composição farmacêutica que compreende o mesmo e método para o tratamento de uma enfermidade em um mamìfero
DE60031577D1 (de)	2006-12-07	Hemmer der zelladhäsion
BR0013409B1 (pt)	2011-01-25	compostos fungicidas possuindo uma porção flúorvinil ou fluorpropenil-oxifeniloxima e processo para preparação dos mesmos.
DK0944618T3 (da)	2004-02-02	Nye N-benzensulfonyl-L-prolin-derivater, fremgangsmåde til deres fremstilling og deres anvendelse til terapeutiske formål
BR9812928A (pt)	2000-08-08	Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica