ATE248592T1 - Verwendung von naaladase hemmern zur herstellung eines medikaments zur behandlung von bestimmten krankheiten - Google Patents

Verwendung von naaladase hemmern zur herstellung eines medikaments zur behandlung von bestimmten krankheiten

Info

Publication number: ATE248592T1
Authority: AT; Austria
Prior art keywords: medication; produce; treatment; certain diseases; naaladase inhibitors
Prior art date: 1998-12-31

Application number

AT99967675T

Other languages

English (en)

Inventor

Barbara S Slusher

Xi-Chun May Lu

Krystyna Wozniak

Original Assignee

Guilford Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-31

Filing date

1999-12-29

Publication date

2003-09-15

1999-12-29 Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE248592T1 publication Critical patent/ATE248592T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
102000003958 Glutamate Carboxypeptidase II Human genes 0.000 abstract 1
108090000369 Glutamate Carboxypeptidase II Proteins 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
210000002744 extracellular matrix Anatomy 0.000 abstract 1
230000036737 immune function Effects 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000003908 liver function Effects 0.000 abstract 1
230000023105 myelination Effects 0.000 abstract 1
230000035771 neuroregeneration Effects 0.000 abstract 1
230000004203 pancreatic function Effects 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
230000029663 wound healing Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Gynecology & Obstetrics (AREA)
Rheumatology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99967675T 1998-12-31 1999-12-29 Verwendung von naaladase hemmern zur herstellung eines medikaments zur behandlung von bestimmten krankheiten ATE248592T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22429198A	1998-12-31	1998-12-31
US09/425,197 US6444657B1 (en)	1998-12-31	1999-10-22	Methods for treating certain diseases using naaladase inhibitors
PCT/US1999/031039 WO2000038785A2 (en)	1998-12-31	1999-12-29	Methods for treating certain diseases using naaladase inhibitors

Publications (1)

Publication Number	Publication Date
ATE248592T1 true ATE248592T1 (de)	2003-09-15

Family

ID=26918579

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99967675T ATE248592T1 (de)	1998-12-31	1999-12-29	Verwendung von naaladase hemmern zur herstellung eines medikaments zur behandlung von bestimmten krankheiten

Country Status (8)

Country	Link
US (2)	US6444657B1 (de)
EP (2)	EP1371367A1 (de)
JP (1)	JP2002533421A (de)
AT (1)	ATE248592T1 (de)
AU (1)	AU2392100A (de)
CA (1)	CA2354052A1 (de)
DE (1)	DE69911057D1 (de)
WO (1)	WO2000038785A2 (de)

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1999
- 1999-10-22 US US09/425,197 patent/US6444657B1/en not_active Expired - Fee Related
- 1999-12-29 AU AU23921/00A patent/AU2392100A/en not_active Abandoned
- 1999-12-29 WO PCT/US1999/031039 patent/WO2000038785A2/en not_active Ceased
- 1999-12-29 EP EP03019536A patent/EP1371367A1/de not_active Withdrawn
- 1999-12-29 EP EP99967675A patent/EP1140048B1/de not_active Expired - Lifetime
- 1999-12-29 DE DE69911057T patent/DE69911057D1/de not_active Expired - Lifetime
- 1999-12-29 AT AT99967675T patent/ATE248592T1/de not_active IP Right Cessation
- 1999-12-29 JP JP2000590733A patent/JP2002533421A/ja active Pending
- 1999-12-29 CA CA002354052A patent/CA2354052A1/en not_active Abandoned
2002
- 2002-08-01 US US10/209,011 patent/US6806261B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1140048B1 (de)	2003-09-03
US6444657B1 (en)	2002-09-03
WO2000038785A3 (en)	2000-09-21
EP1371367A1 (de)	2003-12-17
AU2392100A (en)	2000-07-31
US6806261B2 (en)	2004-10-19
JP2002533421A (ja)	2002-10-08
WO2000038785A2 (en)	2000-07-06
EP1140048A2 (de)	2001-10-10
US20030017965A1 (en)	2003-01-23
CA2354052A1 (en)	2000-07-06
DE69911057D1 (de)	2003-10-09

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2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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