ATE248924T1 - Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung - Google Patents
Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendungInfo
- Publication number
- ATE248924T1 ATE248924T1 AT92913153T AT92913153T ATE248924T1 AT E248924 T1 ATE248924 T1 AT E248924T1 AT 92913153 T AT92913153 T AT 92913153T AT 92913153 T AT92913153 T AT 92913153T AT E248924 T1 ATE248924 T1 AT E248924T1
- Authority
- AT
- Austria
- Prior art keywords
- cea
- methods
- application
- recombinant viruses
- expressing recombinant
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title 1
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 abstract 7
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 abstract 7
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700618 Vaccinia virus Species 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69502491A | 1991-05-06 | 1991-05-06 | |
| US87964992A | 1992-05-06 | 1992-05-06 | |
| PCT/US1992/003843 WO1992019266A1 (en) | 1991-05-06 | 1992-05-06 | Recombinant virus expressing carcinoembryonic antigen and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE248924T1 true ATE248924T1 (de) | 2003-09-15 |
Family
ID=27105497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92913153T ATE248924T1 (de) | 1991-05-06 | 1992-05-06 | Karcinoembryonale antigen expremierende rekombinante viren und methoden ihrer anwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5698530A (de) |
| EP (1) | EP0584266B1 (de) |
| JP (1) | JP3399943B2 (de) |
| AT (1) | ATE248924T1 (de) |
| AU (1) | AU674492B2 (de) |
| CA (1) | CA2102623C (de) |
| DE (1) | DE69233186T2 (de) |
| DK (1) | DK0584266T3 (de) |
| ES (1) | ES2206446T3 (de) |
| WO (1) | WO1992019266A1 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| AT399656B (de) * | 1993-03-19 | 1995-06-26 | Boehringer Ingelheim Int | Verfahren zur herstellung von krebsvakzinen |
| US6093700A (en) * | 1995-05-11 | 2000-07-25 | Thomas Jefferson University | Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF |
| JP3907698B2 (ja) * | 1994-10-03 | 2007-04-18 | アメリカ合衆国 | 抗原を発現する組み換えウイルスと免疫刺激分子を発現する組み換えウイルスとを含む組成物 |
| US6045802A (en) | 1994-10-03 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule |
| US5612030A (en) | 1995-01-17 | 1997-03-18 | University Of Kentucky Research Foundation | Anti-idiotype monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| US5977316A (en) * | 1995-01-17 | 1999-11-02 | The Board Of Trustees Of The University Of Kentucky | Monoclonal antibody 1A7 and related polypeptides |
| US5935821A (en) | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| US6001349A (en) | 1995-02-22 | 1999-12-14 | Therion Biologics Corporation | Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof |
| US6372208B1 (en) | 1999-09-28 | 2002-04-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
| US5872154A (en) * | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
| US6251957B1 (en) | 1995-02-24 | 2001-06-26 | Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant virus |
| DK0811073T3 (da) * | 1995-02-24 | 2007-05-21 | Univ Pennsylvania | Avendelse af immunmodulatorer til fremstilling af medikamenter til inhibering af immunresponser mod co-administrerede rekombinanter |
| US5480640A (en) * | 1995-05-02 | 1996-01-02 | Schering Corporation | Alpha interferon for treating prostate cancer |
| US6165460A (en) * | 1995-07-10 | 2000-12-26 | Therion Biologics Corporation | Generation of immune responses to prostate-specific antigen (PSA) |
| CA2261989C (en) | 1996-07-25 | 2008-09-30 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| AU5805798A (en) * | 1996-12-31 | 1998-07-31 | Wistar Institute, The | Recombinant adenoviral vector expressing antigens associated with colorectal tumors |
| DE19716892C1 (de) * | 1997-04-22 | 1998-09-03 | Gsf Forschungszentrum Umwelt | Expression von Immunglobulin-Zytokin-Fusionsproteinen in malignen B-Zellen |
| US6120806A (en) * | 1997-06-25 | 2000-09-19 | Whitmire; David R. | Oral formulations for controlled release of alcohol deterrents |
| EP1015035B1 (de) * | 1997-08-13 | 2009-01-28 | The Uab Research Foundation | Impfung durch topische verwendung genetischer vektoren |
| PT1447414E (pt) * | 1997-10-10 | 2007-07-18 | Us Gov Health & Human Serv | Péptidos antagonistas do antigénio carcinoembrionário ( cea ). |
| US6756038B1 (en) | 1997-10-10 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Agonist and antagonist peptides of carcinoembryonic antigen (CEA) |
| US6355244B1 (en) | 1997-11-17 | 2002-03-12 | University Of Kentucky Research Foundation | Methods and compositions for the treatment of psoriasis |
| US6506385B1 (en) | 1998-04-17 | 2003-01-14 | Embrex, Inc. | Live vaccines and methods of treatment therewith |
| US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
| US6896881B1 (en) * | 1999-09-24 | 2005-05-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| ATE395930T1 (de) | 1999-10-22 | 2008-06-15 | Aventis Pasteur | Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene |
| DK1282702T3 (da) | 2000-05-10 | 2007-04-02 | Sanofi Pasteur Ltd | Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf |
| WO2003050268A2 (en) * | 2001-12-12 | 2003-06-19 | Aventis Pasteur Limited | Enhancement of the immune response using cd36-binding domain |
| AU2003203140A1 (en) * | 2002-01-17 | 2003-07-30 | Pharmexa A/S | Immunogenic carcinoembryonic antigen (cea) |
| US6949629B2 (en) * | 2002-03-13 | 2005-09-27 | Aspenbio, Inc. | Methods for purifying selected CEA family member proteins |
| EP1864691B1 (de) * | 2002-04-09 | 2011-07-20 | Sanofi Pasteur Limited | Modifizierte CEA-Nukleinsäure und entsprechende Expressionsvektoren |
| AU2004280608B2 (en) * | 2002-04-09 | 2012-04-05 | Sanofi Pasteur, Inc. | Modified CEA/B7 vector |
| WO2004037284A1 (en) * | 2002-10-22 | 2004-05-06 | Sanofi Pasteur Limited | Anti-cancer vaccines and high-dose cytokines as adjuvants |
| WO2004072287A1 (en) * | 2003-02-13 | 2004-08-26 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Rhesus carcino embryonic antigen, nucleotides encoding same, and uses thereof |
| WO2005019455A1 (en) * | 2003-08-22 | 2005-03-03 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Synthetic gene encoding rhesus monkey carcinoembryonic antigen and uses thereof |
| AU2005212479B2 (en) * | 2004-02-11 | 2009-09-10 | Msd Italia S.R.L. | Carcinoembryonic antigen fusion proteins and uses thereof |
| AU2009223727B2 (en) | 2008-03-14 | 2014-09-11 | Sanofi Pasteur Biologics, Llc | Replication-defective flavivirus vaccines and vaccine vectors |
| US20120263754A1 (en) | 2011-02-15 | 2012-10-18 | Immune Design Corp. | Methods for Enhancing Immunogen Specific Immune Responses by Vectored Vaccines |
| WO2012141984A1 (en) | 2011-04-08 | 2012-10-18 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| KR102136433B1 (ko) | 2012-05-16 | 2020-07-22 | 이뮨 디자인 코포레이션 | Hsv-2 백신 |
| WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
| US9725494B2 (en) * | 2013-05-17 | 2017-08-08 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Soluble CD27 (sCD27) and the use thereof |
| CA2939093A1 (en) | 2014-02-14 | 2015-08-20 | Immune Design Corp. | Immunotherapy of cancer through combination of local and systemic immune stimulation |
| EP3169352A1 (de) | 2014-07-15 | 2017-05-24 | Immune Design Corp. | Prime-boost-therapieschemata mit einem tlr4-agonist-adjuvans und einem lentivirusvektor |
| US20190183870A1 (en) | 2016-01-05 | 2019-06-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Combination of histone deacetylase inhibitor and immunotherapy |
| WO2017136342A1 (en) | 2016-02-02 | 2017-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells |
| EP4706777A2 (de) | 2016-04-15 | 2026-03-11 | Alpine Immune Sciences, Inc. | Immunmodulatorische proteine mit cd80-variante und verwendungen davon |
| IL262365B2 (en) | 2016-04-15 | 2024-11-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins ICOS ligand variants and uses thereof |
| US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
| CN110088127A (zh) | 2016-07-28 | 2019-08-02 | 高山免疫科学股份有限公司 | Cd155变体免疫调节蛋白及其用途 |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| PT3596116T (pt) | 2017-03-16 | 2023-12-04 | Alpine Immune Sciences Inc | Proteínas imunomoduladoras de pd-l1 variante e suas utilizações |
| EP3596114A2 (de) | 2017-03-16 | 2020-01-22 | Alpine Immune Sciences, Inc. | Cd80-variante immunmodulatorische proteine und verwendungen davon |
| JP2020511144A (ja) | 2017-03-16 | 2020-04-16 | アルパイン イミューン サイエンシズ インコーポレイテッド | Pd−l2バリアント免疫調節タンパク質及びその使用 |
| KR20190125481A (ko) * | 2017-03-17 | 2019-11-06 | 백심 아게 | 암의 면역요법을 위한 신규 pd-l1 표적화 dna 백신 |
| MX2019011599A (es) | 2017-03-30 | 2019-12-19 | Univ Queensland | Moleculas quimericas y usos de las mismas. |
| WO2019040994A1 (en) | 2017-09-01 | 2019-03-07 | The Australian National University | IMMUNOREGULATOR MOLECULES AND USES THEREOF |
| KR102813968B1 (ko) | 2017-10-10 | 2025-05-29 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| SMT202600062T1 (it) | 2017-10-18 | 2026-03-09 | Alpine Immune Sciences Inc | Proteine immunomodulatrici del ligando di icos variante e composizioni e metodi correlati |
| SG11202006148UA (en) | 2018-01-03 | 2020-07-29 | Alpine Immune Sciences Inc | Multi-domain immunomodulatory proteins and methods of use thereof |
| US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
| AU2019345151B2 (en) | 2018-09-19 | 2025-04-17 | Alpine Immune Sciences, Inc. | Methods and uses of variant CD80 fusion proteins and related constructs |
| WO2020113141A2 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| EP4438054A3 (de) | 2019-04-17 | 2025-01-08 | Alpine Immune Sciences, Inc. | Verfahren und verwendungen von icos-ligandenvarianten (icosl)-fusionsproteinen |
| JP7748393B2 (ja) | 2020-05-08 | 2025-10-02 | アルパイン イミューン サイエンシズ インコーポレイテッド | Aprilおよびbaff阻害免疫調節タンパク質、ならびにその使用方法 |
| KR20240019124A (ko) | 2021-05-07 | 2024-02-14 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Taci-fc 융합 면역조절 단백질의 투여 및 치료 방법 |
| WO2023172883A1 (en) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins of variant cd80 polypeptides, cell therapies thereof and related methods and uses |
| WO2024077018A2 (en) | 2022-10-04 | 2024-04-11 | Alpine Immune Sciences, Inc. | Methods and uses of taci-fc fusion immunomodulatory protein |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| GB8508845D0 (en) * | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| EP0263933B1 (de) * | 1986-08-13 | 1993-10-20 | Miles Inc. | Karzinoembryonisches Antigen kodierende cDNS |
| WO1989001973A2 (en) * | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
-
1992
- 1992-05-06 DK DK92913153T patent/DK0584266T3/da active
- 1992-05-06 DE DE69233186T patent/DE69233186T2/de not_active Expired - Lifetime
- 1992-05-06 WO PCT/US1992/003843 patent/WO1992019266A1/en not_active Ceased
- 1992-05-06 EP EP92913153A patent/EP0584266B1/de not_active Expired - Lifetime
- 1992-05-06 AT AT92913153T patent/ATE248924T1/de active
- 1992-05-06 JP JP51202592A patent/JP3399943B2/ja not_active Expired - Lifetime
- 1992-05-06 CA CA002102623A patent/CA2102623C/en not_active Expired - Lifetime
- 1992-05-06 AU AU20060/92A patent/AU674492B2/en not_active Expired
- 1992-05-06 ES ES92913153T patent/ES2206446T3/es not_active Expired - Lifetime
-
1994
- 1994-07-01 US US08/270,106 patent/US5698530A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0584266B1 (de) | 2003-09-03 |
| CA2102623A1 (en) | 1992-11-07 |
| ES2206446T3 (es) | 2004-05-16 |
| AU674492B2 (en) | 1997-01-02 |
| CA2102623C (en) | 2003-04-22 |
| DE69233186T2 (de) | 2004-06-03 |
| DK0584266T3 (da) | 2003-12-29 |
| EP0584266A1 (de) | 1994-03-02 |
| AU2006092A (en) | 1992-12-21 |
| JPH06508025A (ja) | 1994-09-14 |
| JP3399943B2 (ja) | 2003-04-28 |
| EP0584266A4 (de) | 1995-04-05 |
| WO1992019266A1 (en) | 1992-11-12 |
| US5698530A (en) | 1997-12-16 |
| DE69233186D1 (de) | 2003-10-09 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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