ATE249423T1 - Verfahren zur kristallisation von iopamidol - Google Patents

Verfahren zur kristallisation von iopamidol

Info

Publication number: ATE249423T1
Authority: AT; Austria
Prior art keywords: iopamidol; crystallization; alcohol; water; pentahydrates
Prior art date: 1998-11-09

Application number

AT99914791T

Other languages

English (en)

Inventor

Jin Kyu Park

Kyung Seok Choi

Dong Yub Lee

In Kyu Lee

Chang Hun Song

Dong Jun Lee

Original Assignee

Dong Kook Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-09

Filing date

1999-04-16

Publication date

2003-09-15

1999-04-16 Application filed by Dong Kook Pharm Co Ltd filed Critical Dong Kook Pharm Co Ltd

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249423T1 publication Critical patent/ATE249423T1/de

Links

XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title abstract 5
229960004647 iopamidol Drugs 0.000 title abstract 5
238000002425 crystallisation Methods 0.000 title abstract 3
230000008025 crystallization Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 1
150000004682 monohydrates Chemical class 0.000 abstract 1
150000004686 pentahydrates Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT99914791T 1998-11-09 1999-04-16 Verfahren zur kristallisation von iopamidol ATE249423T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1019980047785A KR20000031642A (ko)	1998-11-09	1998-11-09	이오파미돌의 결정화 방법
PCT/KR1999/000181 WO2000027804A1 (en)	1998-11-09	1999-04-16	Method for the crystallization of iopamidol

Publications (1)

Publication Number	Publication Date
ATE249423T1 true ATE249423T1 (de)	2003-09-15

Family

ID=19557566

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99914791T ATE249423T1 (de)	1998-11-09	1999-04-16	Verfahren zur kristallisation von iopamidol

Country Status (7)

Country	Link
US (1)	US20020022746A1 (de)
EP (1)	EP1129069B1 (de)
JP (1)	JP2002529445A (de)
KR (1)	KR20000031642A (de)
AT (1)	ATE249423T1 (de)
DE (1)	DE69911236T2 (de)
WO (1)	WO2000027804A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007073202A1 (en)	2005-12-19	2007-06-28	Ge Healthcare As	Purification process of iodixanol
CN117024303A (zh) *	2023-07-06	2023-11-10	江苏宇田医药有限公司	碘帕醇a型结晶及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110391A (en) *	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol
PT101720A (pt) *	1995-06-08	1997-01-31	Hovione Sociedade Quimica S A	Processo para a purificacao e cristalizacao de iopamidol
HU220965B1 (hu) *	1995-09-08	2002-07-29	Bracco International B.V.	Eljárás (S)-N,N'-bisz[2-hidroxi-1-(hidroxi-metil)-etil]-5-[(2-hidroxi-1-oxo-propil)-amino]-2,4,6-trijód-1,3-benzol-dikarboxamid vízből való kristályosítására
CZ299420B6 (cs) *	1997-02-11	2008-07-23	Bracco International B. V.	Zpusob krystalizace iopamidolu

1998
- 1998-11-09 KR KR1019980047785A patent/KR20000031642A/ko not_active Ceased
1999
- 1999-04-16 EP EP99914791A patent/EP1129069B1/de not_active Expired - Lifetime
- 1999-04-16 WO PCT/KR1999/000181 patent/WO2000027804A1/en not_active Ceased
- 1999-04-16 DE DE69911236T patent/DE69911236T2/de not_active Expired - Fee Related
- 1999-04-16 AT AT99914791T patent/ATE249423T1/de not_active IP Right Cessation
- 1999-04-16 JP JP2000580984A patent/JP2002529445A/ja not_active Ceased
2001
- 2001-05-09 US US09/852,140 patent/US20020022746A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69911236T2 (de)	2004-07-15
EP1129069A1 (de)	2001-09-05
KR20000031642A (ko)	2000-06-05
JP2002529445A (ja)	2002-09-10
DE69911236D1 (de)	2003-10-16
WO2000027804A1 (en)	2000-05-18
EP1129069B1 (de)	2003-09-10
US20020022746A1 (en)	2002-02-21

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Legal Events

Date

Code

Title

Description

2004-04-15

UEP

Publication of translation of european patent specification

Ref document number: 1129069

Country of ref document: EP

2007-01-15

REN

Ceased due to non-payment of the annual fee