ATE250414T1 - Pharmazeutische zubereitungen enthaltend eine kombination aus isosorbid-nitrat und acetylsalicylsaeure - Google Patents
Pharmazeutische zubereitungen enthaltend eine kombination aus isosorbid-nitrat und acetylsalicylsaeureInfo
- Publication number
- ATE250414T1 ATE250414T1 AT97945018T AT97945018T ATE250414T1 AT E250414 T1 ATE250414 T1 AT E250414T1 AT 97945018 T AT97945018 T AT 97945018T AT 97945018 T AT97945018 T AT 97945018T AT E250414 T1 ATE250414 T1 AT E250414T1
- Authority
- AT
- Austria
- Prior art keywords
- isosorbide nitrate
- phase
- combination
- pharmaceutical preparations
- isosorbide
- Prior art date
Links
- YWXYYJSYQOXTPL-JGWLITMVSA-N [(3r,3ar,6s,6as)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-JGWLITMVSA-N 0.000 title abstract 3
- -1 ACETYL SALICYL Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 229960003827 isosorbide mononitrate Drugs 0.000 abstract 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9621749.2A GB9621749D0 (en) | 1996-10-18 | 1996-10-18 | Pharmaceutical combination formulation |
| GBGB9713549.5A GB9713549D0 (en) | 1996-10-18 | 1997-06-26 | Pharmaceutical combination formulation |
| PCT/GB1997/002849 WO1998017271A1 (en) | 1996-10-18 | 1997-10-15 | Pharmaceutical composition comprising a combination of isosorbide nitrate with acetylsalicylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250414T1 true ATE250414T1 (de) | 2003-10-15 |
Family
ID=26310251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97945018T ATE250414T1 (de) | 1996-10-18 | 1997-10-15 | Pharmazeutische zubereitungen enthaltend eine kombination aus isosorbid-nitrat und acetylsalicylsaeure |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0930880B1 (de) |
| AT (1) | ATE250414T1 (de) |
| AU (1) | AU4633197A (de) |
| DE (1) | DE69725155D1 (de) |
| GB (1) | GB9713549D0 (de) |
| WO (1) | WO1998017271A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9905261A (pt) * | 1999-09-30 | 2001-07-24 | Libbs Farmaceutica Ltda | Uma nova associação medicamentosa de liberação programada |
| CN105902509B (zh) * | 2015-09-28 | 2018-08-17 | 天方药业有限公司 | 一种复方单硝酸异山梨酯缓释片及其制备方法 |
| CN110478328A (zh) * | 2019-08-15 | 2019-11-22 | 仁和堂药业有限公司 | 单硝酸异山梨酯片的制备工艺 |
| CN110559269A (zh) * | 2019-08-15 | 2019-12-13 | 仁和堂药业有限公司 | 一种单硝酸异山梨酯片剂及其质量检测方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61148115A (ja) * | 1984-12-21 | 1986-07-05 | Tooa Eiyoo Kk | 難溶性薬物の徐放性製剤及びその製造法 |
| WO1994003421A2 (en) * | 1992-07-30 | 1994-02-17 | Cal International Limited | Esters and combinations of an organic nitrate and a salicylate |
| PT654263E (pt) * | 1993-11-23 | 2002-06-28 | Euro Celtique Sa | Metodo para a preparacao de uma composicao de libertyacao prolongada |
-
1997
- 1997-06-26 GB GBGB9713549.5A patent/GB9713549D0/en active Pending
- 1997-10-15 DE DE69725155T patent/DE69725155D1/de not_active Expired - Lifetime
- 1997-10-15 EP EP97945018A patent/EP0930880B1/de not_active Expired - Lifetime
- 1997-10-15 WO PCT/GB1997/002849 patent/WO1998017271A1/en not_active Ceased
- 1997-10-15 AT AT97945018T patent/ATE250414T1/de not_active IP Right Cessation
- 1997-10-15 AU AU46331/97A patent/AU4633197A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0930880A1 (de) | 1999-07-28 |
| WO1998017271A1 (en) | 1998-04-30 |
| EP0930880B1 (de) | 2003-09-24 |
| GB9713549D0 (en) | 1997-09-03 |
| AU4633197A (en) | 1998-05-15 |
| DE69725155D1 (de) | 2003-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |