ATE251129T1 - Derivatives of aminoalkane sulphonic, phosphonic and phosphinic acids, their preparation and their use as medicaments - Google Patents

Derivatives of aminoalkane sulphonic, phosphonic and phosphinic acids, their preparation and their use as medicaments

Info

Publication number
ATE251129T1
ATE251129T1 AT98904231T AT98904231T ATE251129T1 AT E251129 T1 ATE251129 T1 AT E251129T1 AT 98904231 T AT98904231 T AT 98904231T AT 98904231 T AT98904231 T AT 98904231T AT E251129 T1 ATE251129 T1 AT E251129T1
Authority
AT
Austria
Prior art keywords
radical
derivatives
phosphonic
medicaments
preparation
Prior art date
Application number
AT98904231T
Other languages
English (en)
Inventor
Jean-Jacques Berthelon
Philippe Durbin
Original Assignee
Merck Sante Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sante Sas filed Critical Merck Sante Sas
Application granted granted Critical
Publication of ATE251129T1 publication Critical patent/ATE251129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT98904231T 1998-01-27 1998-01-27 Derivatives of aminoalkane sulphonic, phosphonic and phosphinic acids, their preparation and their use as medicaments ATE251129T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/FR1998/000147 WO1999037606A1 (fr) 1998-01-27 1998-01-27 Nouveaux derives d'acides aminoalkane sulfoniques, phosphoniques et phosphiniques, leur preparation et leur utilisation comme medicaments

Publications (1)

Publication Number Publication Date
ATE251129T1 true ATE251129T1 (de) 2003-10-15

Family

ID=9521619

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98904231T ATE251129T1 (de) 1998-01-27 1998-01-27 Derivatives of aminoalkane sulphonic, phosphonic and phosphinic acids, their preparation and their use as medicaments

Country Status (12)

Country Link
US (1) US6265437B1 (de)
EP (1) EP1051393B1 (de)
JP (1) JP4156795B2 (de)
AT (1) ATE251129T1 (de)
AU (1) AU762988B2 (de)
CA (1) CA2319272C (de)
DE (1) DE69818709T2 (de)
DK (1) DK1051393T3 (de)
ES (1) ES2209110T3 (de)
PT (1) PT1051393E (de)
SI (1) SI1051393T1 (de)
WO (1) WO1999037606A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
AR049199A1 (es) * 2004-06-04 2006-07-05 Aventis Pharma Inc Derivados de acido propano-fosfinico sustituido
US8044100B2 (en) * 2004-12-22 2011-10-25 Bellus Health Inc. Methods and compositions for treating amyloid-related diseases
FR2899895B1 (fr) * 2006-04-12 2010-09-17 Servier Lab Nouveaux sels de strontium d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2830727C (en) 2006-10-12 2016-11-29 Bhi Limited Partnership Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
KR100877134B1 (ko) * 2007-05-03 2009-01-09 주식회사 엔지켐 아캄프로세이트 칼슘의 제조방법
US20090069419A1 (en) * 2007-09-07 2009-03-12 Bernd Jandeleit Masked carboxylate neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US20090082464A1 (en) * 2007-09-07 2009-03-26 Bernd Jandeleit Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
WO2009052191A1 (en) * 2007-10-15 2009-04-23 Xenoport, Inc. Internally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
DE102008048791A1 (de) * 2008-09-24 2010-03-25 Merck Patent Gmbh Neue Kristallform von Calcium-3-Acetylaminopropan-1-sulfonat
IT1392327B1 (it) * 2008-09-26 2012-02-28 Laboratorio Chimico Int Spa Nuova forma polimorfa del calcio acamprosato

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2384751A1 (fr) * 1977-03-23 1978-10-20 Francaise Coop Pharma Nouveaux derives de la taurine a activite neuro-musculaire renforcee
FR2457281A1 (fr) * 1979-05-23 1980-12-19 Meram Lab Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee

Also Published As

Publication number Publication date
SI1051393T1 (en) 2004-02-29
CA2319272A1 (en) 1999-07-29
PT1051393E (pt) 2004-02-27
EP1051393A1 (de) 2000-11-15
CA2319272C (en) 2005-11-08
EP1051393B1 (de) 2003-10-01
ES2209110T3 (es) 2004-06-16
US6265437B1 (en) 2001-07-24
JP4156795B2 (ja) 2008-09-24
DE69818709D1 (en) 2003-11-06
DK1051393T3 (da) 2004-02-02
DE69818709T2 (de) 2004-08-19
JP2002501040A (ja) 2002-01-15
AU6219098A (en) 1999-08-09
AU762988B2 (en) 2003-07-10
WO1999037606A1 (fr) 1999-07-29

Similar Documents

Publication Publication Date Title
ES2099436T3 (es) Compuestos biologicamente activos de tipo fosfotriesteres.
CA2079486A1 (en) Chelator compositions comprising alpha- diamine compounds
ATE251129T1 (de) Derivatives of aminoalkane sulphonic, phosphonic and phosphinic acids, their preparation and their use as medicaments
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
DK0544812T3 (da) Bisphosphonsyrederivater som anti-arthritiske midler
CA2065104A1 (en) Erucyl, brassidyl and nervonyl derivatives
IE39824B1 (en) Cyclic amino phosphonic acids
DK392788D0 (da) Arylderivater
ES8308570A1 (es) Un procedimiento para producir 5'-fosfato de 1, beta d-arabino-furanosil-(e)-5-(2-halogenovinil) uracilo.
IE45090L (en) N-phosphonomethylene - aminoalkane phosphonic acids.
CA2019704A1 (en) N,n-disubstituted phthalamic acids and their ammonium salts, and their uses thereof as surfactants, emulsifiers, and conditioning agents in shampoos
DE3372364D1 (en) 1-carboxyalkanoylperhydroindole-2-carboxylic acids and derivatives
YU79892A (sh) Herbicidni sastavi
AU3429784A (en) Use of quinoline derivatives for the protection of cultivated plants
SE8205867L (sv) Nya 4-fenyl-4-oxo-2-butensyraderivat, deras salter, framstellning derav, anvendning derav som lekemedel och kompositioner innehallande dem
AU4953997A (en) New histidine derivatives, preparation process, and their use as free antiradical agents
ATE35994T1 (de) Dihydroxyalkandiphosphonsaeuren.
FI925875A0 (fi) Foerfarande foer framstaellning av nya som inhibitorer av proteolytiska enzymer anvaendbara 2-sackarinylmetyl- och 4,5,6,7-tetrahydro-2-sackarinylmetylfosfater, -fosfonater och -fosfinater
GR3032519T3 (en) Cyclohexane derivatives, processes for their preparation and their use as glucose-6-phosphatase inhibitors.
ES2114790A1 (es) Mezcla reguladora del crecimiento de las plantas.
SE8701887L (sv) Nya 4-fenyl-4-oxo-2-butensyraderivat, deras framstellningsforfarande, derasanvendning som lekemedel och kompositioner innehallande dem
IL106080A (en) Pharmaceutical compositions containing amidinoalkane-1, 1-bisphosphonic acids and some such novel compounds
MY101628A (en) Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
ES8103110A1 (es) Un procedimiento para preparar arilalquil- y ariloxi-alquil-fosfonatos
DE3576649D1 (de) Prostaglandine zur behandlung von gehirnanoxie.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1051393

Country of ref document: EP