ATE251608T1 - Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten - Google Patents

Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten

Info

Publication number
ATE251608T1
ATE251608T1 AT96942564T AT96942564T ATE251608T1 AT E251608 T1 ATE251608 T1 AT E251608T1 AT 96942564 T AT96942564 T AT 96942564T AT 96942564 T AT96942564 T AT 96942564T AT E251608 T1 ATE251608 T1 AT E251608T1
Authority
AT
Austria
Prior art keywords
represents hydrogen
compositions containing
amino
containing same
medicinal compositions
Prior art date
Application number
AT96942564T
Other languages
English (en)
Inventor
Shiro Miyoshi
Kohei Ogawa
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Application granted granted Critical
Publication of ATE251608T1 publication Critical patent/ATE251608T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91Dibenzofurans; Hydrogenated dibenzofurans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04Diamides of sulfuric acids
    • C07C307/10Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76Dibenzothiophenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
AT96942564T 1996-01-10 1996-12-18 Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten ATE251608T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP257696 1996-01-10
PCT/JP1996/003689 WO1997025311A1 (en) 1996-01-10 1996-12-18 Novel tricyclic compounds and drug compositions containing the same

Publications (1)

Publication Number Publication Date
ATE251608T1 true ATE251608T1 (de) 2003-10-15

Family

ID=11533209

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942564T ATE251608T1 (de) 1996-01-10 1996-12-18 Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten

Country Status (13)

Country Link
US (4) US6037362A (de)
EP (1) EP0882707B1 (de)
JP (1) JP2000239255A (de)
KR (1) KR100395280B1 (de)
CN (2) CN1083831C (de)
AT (1) ATE251608T1 (de)
AU (1) AU715233B2 (de)
CA (1) CA2242351C (de)
DE (1) DE69630319T2 (de)
ES (1) ES2208772T3 (de)
NO (2) NO312159B1 (de)
PT (1) PT882707E (de)
WO (1) WO1997025311A1 (de)

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EP1070046A1 (de) * 1998-04-06 2001-01-24 Fujisawa Pharmaceutical Co., Ltd. Propanolaminderivate
US20030073644A1 (en) * 1998-11-11 2003-04-17 Smithkline Beecham P.L.C. Combinations comprising a beta-agonist and a further antidiabetic agent
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CA2355079A1 (en) * 1998-12-15 2000-06-22 Shiro Miyoshi Novel heterocyclic compounds and drug compositions containing the same
TW519537B (en) * 1999-03-26 2003-02-01 Asahi Chemical Ind Process for the preparation of tricylic amino-alcohol derivatives
WO2000059885A1 (en) * 1999-04-01 2000-10-12 Asahi Kasei Kabushiki Kaisha Method for the preparation of tricyclic amino alcohol derivatives through azides
CA2377760A1 (en) * 1999-07-09 2001-01-18 Asahi Kasei Kabushiki Kaisha Process for the preparation of tricyclic amino alcohol derivatives
AU6596800A (en) * 1999-09-03 2001-04-10 Asahi Kasei Kabushiki Kaisha Processes for the preparation of tricyclic amino alcohol derivatives
US20030220329A1 (en) * 1999-09-17 2003-11-27 Duke University Method of improving beta-adrenergic receptor function
MXPA02003423A (es) * 1999-10-04 2002-08-20 Ashai Kasei Kabushiki Kaisha Metodo para mejorar la solubilidad de los derivados de aminoalcoholes triciclicos.
CA2394778A1 (en) * 1999-12-16 2002-06-14 Shiro Miyoshi Novel substituted tricyclic compounds
US20030018061A1 (en) * 2000-01-28 2003-01-23 Kohei Ogawa Novel remedies with the use of beta 3 agonist
WO2001083453A1 (en) * 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Novel substituted tricyclic compounds
WO2001083452A1 (en) * 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Novel tricyclic compounds
PT1277736E (pt) * 2000-04-28 2007-10-12 Asahi Kasei Pharma Corp Novos compostos bicíclicos
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
WO2002051806A1 (en) * 2000-12-22 2002-07-04 Astrazeneca Ab Carbazole derivatives and their use as neuropeptide y5 receptor ligands
JPWO2002074306A1 (ja) * 2001-03-19 2004-07-08 旭化成ファーマ株式会社 脂肪肝治療薬
GB0121941D0 (en) * 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
KR100816527B1 (ko) * 2001-09-12 2008-04-10 한국화학연구원 페닐테트라졸 유도체로 치환된 β-아미노알코올 화합물
EP1447400B1 (de) * 2001-10-25 2008-09-17 Asahi Kasei Pharma Corporation Bicyclische verbindung
AU2003209527A1 (en) 2002-02-27 2003-09-09 Pfizer Products Inc. Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
MXPA04008298A (es) 2002-02-27 2004-11-26 Pfizer Prod Inc Procesos e intermedios utiles en la preparacion de agonistas de receptor beta-3 adrenergico.
US6864268B2 (en) 2002-02-27 2005-03-08 Pfizer Inc. β3 adrenergic receptor agonists
EP1424079A1 (de) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Kombination eines beta-3-Rezeptoragonisten und eines Serotonin und/oder Norepinephrin-Wiederaufnahmeinhibitors
MXPA05008587A (es) * 2003-02-14 2005-11-04 Kissei Pharmaceutical Derivados de alcohol amino, composiciones farmaceuticas que contienen los mismos, y usos de los mismos.
JP4644601B2 (ja) * 2003-10-24 2011-03-02 キッセイ薬品工業株式会社 アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途
US8501994B2 (en) 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US7718822B2 (en) 2007-08-28 2010-05-18 Sepracor Inc. Carbamate Stereoisomer
JPWO2010041569A1 (ja) 2008-10-09 2012-03-08 旭化成ファーマ株式会社 インダゾール化合物
EP2351742A4 (de) 2008-10-09 2012-03-28 Asahi Kasei Pharma Corp Indazolderivate
US20100222404A1 (en) * 2008-11-04 2010-09-02 Asahi Kasei Pharma Corporation Indazole derivative dihydrochloride
US20120225909A1 (en) * 2009-09-30 2012-09-06 Asahi Kasei Pharma Corporation Indazole analog
WO2012032546A2 (en) * 2010-09-08 2012-03-15 Cadila Healthcare Limited Process for the preparation of salmeterol and its intermediates
ES2394349B1 (es) 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
US10478445B2 (en) 2013-07-03 2019-11-19 Georgetown University Boronic acid derivatives of resveratrol for activating deacetylase enzymes
US11053255B2 (en) 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
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GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses
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Also Published As

Publication number Publication date
PT882707E (pt) 2004-02-27
US6037362A (en) 2000-03-14
EP0882707A1 (de) 1998-12-09
EP0882707A4 (de) 2001-04-11
AU715233B2 (en) 2000-01-20
NO20012876D0 (no) 2001-06-11
NO20012876L (no) 1998-09-10
NO983197L (no) 1998-09-10
EP0882707B1 (de) 2003-10-08
DE69630319D1 (de) 2003-11-13
HK1017669A1 (en) 1999-11-26
CA2242351C (en) 2003-03-11
KR100395280B1 (ko) 2004-06-04
AU1170897A (en) 1997-08-01
CN1209119A (zh) 1999-02-24
NO312159B1 (no) 2002-04-02
DE69630319T2 (de) 2004-07-29
ES2208772T3 (es) 2004-06-16
CA2242351A1 (en) 1997-07-17
US20030139475A1 (en) 2003-07-24
JP2000239255A (ja) 2000-09-05
US6545053B1 (en) 2003-04-08
WO1997025311A1 (en) 1997-07-17
US6187809B1 (en) 2001-02-13
CN1295064A (zh) 2001-05-16
KR19990077162A (ko) 1999-10-25
CN1083831C (zh) 2002-05-01

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