ATE251668T1 - Reinigung von plasmafraktion - Google Patents

Reinigung von plasmafraktion

Info

Publication number
ATE251668T1
ATE251668T1 AT93917166T AT93917166T ATE251668T1 AT E251668 T1 ATE251668 T1 AT E251668T1 AT 93917166 T AT93917166 T AT 93917166T AT 93917166 T AT93917166 T AT 93917166T AT E251668 T1 ATE251668 T1 AT E251668T1
Authority
AT
Austria
Prior art keywords
factor
barium chloride
ligand
factors
recovered
Prior art date
Application number
AT93917166T
Other languages
English (en)
Inventor
Steven W Herring
Yahiro Uemura
Munehiro Noda
Kenneth T Shitanishi
Original Assignee
Alpha Therapeutic Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpha Therapeutic Corp filed Critical Alpha Therapeutic Corp
Application granted granted Critical
Publication of ATE251668T1 publication Critical patent/ATE251668T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT93917166T 1992-07-14 1993-07-13 Reinigung von plasmafraktion ATE251668T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/913,590 US5219995A (en) 1992-07-14 1992-07-14 Plasma fraction purification
PCT/US1993/006609 WO1994001466A1 (en) 1992-07-14 1993-07-13 Plasma fraction purification

Publications (1)

Publication Number Publication Date
ATE251668T1 true ATE251668T1 (de) 2003-10-15

Family

ID=25433423

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93917166T ATE251668T1 (de) 1992-07-14 1993-07-13 Reinigung von plasmafraktion

Country Status (8)

Country Link
US (1) US5219995A (de)
EP (1) EP0607392B1 (de)
JP (1) JP2716871B2 (de)
AT (1) ATE251668T1 (de)
AU (1) AU4677193A (de)
CA (1) CA2116691C (de)
DE (1) DE69333239T2 (de)
WO (1) WO1994001466A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270451A (en) * 1988-11-23 1993-12-14 Baxter Diagnostics Inc. Extraction method for preparing thromboplastin reagents
IT1260468B (it) * 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
US5219995A (en) * 1992-07-14 1993-06-15 Alpha Therapeutic Corporation Plasma fraction purification
EP0585504A1 (de) * 1992-09-04 1994-03-09 Pentapharm A.G. Phospholipidabhängiger Prothrombinaktivator und seine Anwendung in Lupusantikoagulanttesten
GB9503750D0 (en) * 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
US5677162A (en) * 1995-05-01 1997-10-14 New York Blood Center, Inc. Method for activating prothrombin to thrombin
CA2308610A1 (en) * 1997-11-05 1999-05-14 Welfide Corporation Heparin cofactor ii preparation and process therefor
AU2900599A (en) * 1998-03-10 1999-09-27 Baxter International Inc. Thrombin preparation and products and fibrin sealant methods employing same
RU2221578C1 (ru) * 2002-10-24 2004-01-20 Межрегиональная благотворительная общественная организация инвалидов "Общество больных гемофилией" Способ получения очищенного активированного фактора x свертывания крови
SE0203551D0 (sv) * 2002-12-02 2002-12-02 Biovitrum Ab Prothrombin purification
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
CN101198696B (zh) 2005-04-13 2014-02-26 阿斯利康(瑞典)有限公司 包含产生需要γ-羧化的蛋白质用的载体的宿主细胞
GB0710321D0 (en) 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
WO2010069946A1 (en) * 2008-12-16 2010-06-24 Crucell Holland B.V. Purification of factor v
ITFI20110084A1 (it) 2011-04-22 2012-10-23 Kedrion Spa Nuovo processo per la preparazione di un concentrato di fv virus inattivato a partire da plasma umano, scalabile a livello industriale.
EP3995141B1 (de) 2016-04-28 2024-01-03 Alkahest, Inc. Plasmafraktionen als therapie für thymuskrebs
LT3484502T (lt) 2016-08-18 2021-12-10 Alkahest, Inc. Kraujo plazmos frakcijos, kaip su senėjimu susijusio pažinimo sutrikimo gydymo priemonė
MX2019012795A (es) 2017-04-26 2020-02-13 Alkahest Inc Régimen de dosificación para el tratamiento de deterioros cognitivos y motores con plasma de sangre y productos de plasma de sangre.
SG11202100347QA (en) 2018-07-20 2021-02-25 Alkahest Inc Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
SG11202103696XA (en) 2018-10-26 2021-05-28 Alkahest Inc Use of plasma and plasma fractions for improvement of pain, wound healing, and postoperative recovery
AU2020378245A1 (en) 2019-11-04 2022-04-07 Alkahest, Inc. Blood plasma fractions for use in muscle regeneration
CN114746100B (zh) 2019-11-20 2024-10-25 万能溶剂有限公司 用于肝再生的血浆级分
WO2022218962A1 (en) 2021-04-13 2022-10-20 Grifols Worldwide Operations Limited Liquid composition comprising factor viii or factor viii/von willebrand factor complex
EP4689665A1 (de) 2023-03-29 2026-02-11 Grifols Worldwide Operations Limited Zusammensetzungen und verfahren zur herstellung von blutplasmaprodukten mit reduzierten konzentrationen an fzeriss-autoantikörpern
WO2025230830A1 (en) 2024-04-29 2025-11-06 Alkahest, Inc. Compositions of blood plasma fractions and their use in treatment of spinal muscular atrophy (sma)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725673A (en) * 1986-08-29 1988-02-16 Alpha Therapeutic Corporation Plasma fraction purification using silica resin bound to a ligand
CA1330302C (en) * 1988-01-18 1994-06-21 Miroslav Rybak Concentrates of coagulation factors ii, vii, ix and x, method of their preparation and use
US5219995A (en) * 1992-07-14 1993-06-15 Alpha Therapeutic Corporation Plasma fraction purification

Also Published As

Publication number Publication date
CA2116691A1 (en) 1994-01-20
EP0607392B1 (de) 2003-10-08
CA2116691C (en) 1998-04-14
WO1994001466A1 (en) 1994-01-20
EP0607392A1 (de) 1994-07-27
JP2716871B2 (ja) 1998-02-18
JPH06511018A (ja) 1994-12-08
AU4677193A (en) 1994-01-31
DE69333239D1 (de) 2003-11-13
DE69333239T2 (de) 2004-07-29
EP0607392A4 (en) 1996-03-27
US5219995A (en) 1993-06-15

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