ATE252387T1 - Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungen - Google Patents
Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungenInfo
- Publication number
- ATE252387T1 ATE252387T1 AT99957321T AT99957321T ATE252387T1 AT E252387 T1 ATE252387 T1 AT E252387T1 AT 99957321 T AT99957321 T AT 99957321T AT 99957321 T AT99957321 T AT 99957321T AT E252387 T1 ATE252387 T1 AT E252387T1
- Authority
- AT
- Austria
- Prior art keywords
- occular
- treatment
- neovascular diseases
- staurosporine derivatives
- staurosporine
- Prior art date
Links
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 abstract 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 abstract 1
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- 208000007135 Retinal Neovascularization Diseases 0.000 abstract 1
- 230000002207 retinal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19867798A | 1998-11-23 | 1998-11-23 | |
| PCT/EP1999/008987 WO2000030651A1 (en) | 1998-11-23 | 1999-11-22 | Use of staurosporine derivatives for treating ocular neovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252387T1 true ATE252387T1 (de) | 2003-11-15 |
Family
ID=22734344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99957321T ATE252387T1 (de) | 1998-11-23 | 1999-11-22 | Verwendung von staurosporine derivaten zur behandlung von okularen neovaskularen erkrankungen |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1131073B1 (de) |
| JP (2) | JP2002530342A (de) |
| KR (1) | KR100698449B1 (de) |
| CN (1) | CN1172673C (de) |
| AT (1) | ATE252387T1 (de) |
| AU (1) | AU761092B2 (de) |
| BR (1) | BR9915569A (de) |
| CA (1) | CA2348890C (de) |
| DE (1) | DE69912304T2 (de) |
| DK (1) | DK1131073T3 (de) |
| ES (1) | ES2211197T3 (de) |
| ID (1) | ID29970A (de) |
| IL (2) | IL142757A0 (de) |
| NO (1) | NO328085B1 (de) |
| NZ (1) | NZ511559A (de) |
| PT (1) | PT1131073E (de) |
| WO (1) | WO2000030651A1 (de) |
| ZA (1) | ZA200103925B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0122318D0 (en) * | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
| US20030119812A1 (en) * | 2001-11-08 | 2003-06-26 | Brazzell Romulus Kimbro | Method for decreasing capillary permeability in the retina |
| EP1531793A1 (de) * | 2002-07-23 | 2005-05-25 | Novartis AG | Augensalbenzusammensetzung mit einem arzneimittel, einer salbengrundlage und einem l slichmachenden/dispergierenden mittel |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| CN101580515B (zh) * | 2008-05-16 | 2011-06-08 | 上海医药工业研究院 | 一种星形孢菌素提取纯化的方法 |
| WO2010104933A1 (en) | 2009-03-11 | 2010-09-16 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| CN102924479A (zh) * | 2011-08-09 | 2013-02-13 | 山东鲁北药业有限公司 | 一种星孢菌素类衍生物的半合成方法 |
| EP2755482B1 (de) | 2011-09-15 | 2016-06-01 | Merck Sharp & Dohme Corp. | Kombination von mk-1775 und mk-8776 zur behandlung von krebs |
| ME02925B (de) | 2012-11-28 | 2018-04-20 | Merck Sharp & Dohme | Zusammensetzungen und verfahren zur behandlung von krebs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| EP0651650A4 (de) * | 1992-07-08 | 1996-04-17 | Celtrix Pharma | METHODE ZUR BEHANDLUNG VON AUGENKRANKHEITEN MITTELS TGF--g(b). |
| US6410322B1 (en) * | 1993-07-27 | 2002-06-25 | Hybridon Inc | Antisense oligonucleotide inhibition of vascular endothelial growth factor expression |
| WO1997034920A1 (en) * | 1996-03-21 | 1997-09-25 | Sugen, Inc. | Assays for kdr/flk-1 receptor tyrosine kinase inhibitors |
| UA54427C2 (uk) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
| ATE365550T1 (de) * | 1998-03-13 | 2007-07-15 | Univ Johns Hopkins Med | Verwendung von einem protein kinase hemmer wie z.b. genistein bei der behandlung von diabetischer retinopathie |
-
1999
- 1999-11-22 BR BR9915569-9A patent/BR9915569A/pt not_active Application Discontinuation
- 1999-11-22 CA CA002348890A patent/CA2348890C/en not_active Expired - Fee Related
- 1999-11-22 WO PCT/EP1999/008987 patent/WO2000030651A1/en not_active Ceased
- 1999-11-22 DE DE69912304T patent/DE69912304T2/de not_active Expired - Lifetime
- 1999-11-22 KR KR1020017006415A patent/KR100698449B1/ko not_active Expired - Fee Related
- 1999-11-22 EP EP99957321A patent/EP1131073B1/de not_active Expired - Lifetime
- 1999-11-22 AT AT99957321T patent/ATE252387T1/de active
- 1999-11-22 JP JP2000583534A patent/JP2002530342A/ja not_active Ceased
- 1999-11-22 IL IL14275799A patent/IL142757A0/xx active IP Right Grant
- 1999-11-22 NZ NZ511559A patent/NZ511559A/xx not_active IP Right Cessation
- 1999-11-22 CN CNB99813600XA patent/CN1172673C/zh not_active Expired - Fee Related
- 1999-11-22 ID IDW00200101090A patent/ID29970A/id unknown
- 1999-11-22 DK DK99957321T patent/DK1131073T3/da active
- 1999-11-22 ES ES99957321T patent/ES2211197T3/es not_active Expired - Lifetime
- 1999-11-22 AU AU15066/00A patent/AU761092B2/en not_active Ceased
- 1999-11-22 PT PT99957321T patent/PT1131073E/pt unknown
-
2001
- 2001-04-23 IL IL142757A patent/IL142757A/en not_active IP Right Cessation
- 2001-05-15 ZA ZA200103925A patent/ZA200103925B/en unknown
- 2001-05-21 NO NO20012490A patent/NO328085B1/no not_active IP Right Cessation
-
2011
- 2011-02-07 JP JP2011023933A patent/JP2011088938A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2348890C (en) | 2009-05-12 |
| DE69912304D1 (de) | 2003-11-27 |
| HK1040182A1 (en) | 2002-05-31 |
| EP1131073B1 (de) | 2003-10-22 |
| PT1131073E (pt) | 2004-03-31 |
| JP2002530342A (ja) | 2002-09-17 |
| NZ511559A (en) | 2004-01-30 |
| KR20010078398A (ko) | 2001-08-20 |
| JP2011088938A (ja) | 2011-05-06 |
| EP1131073A1 (de) | 2001-09-12 |
| WO2000030651A1 (en) | 2000-06-02 |
| DK1131073T3 (da) | 2004-02-02 |
| CA2348890A1 (en) | 2000-06-02 |
| CN1172673C (zh) | 2004-10-27 |
| AU1506600A (en) | 2000-06-13 |
| ID29970A (id) | 2001-10-25 |
| BR9915569A (pt) | 2001-08-14 |
| ES2211197T3 (es) | 2004-07-01 |
| NO20012490L (no) | 2001-06-25 |
| DE69912304T2 (de) | 2004-07-22 |
| CN1328462A (zh) | 2001-12-26 |
| KR100698449B1 (ko) | 2007-03-23 |
| IL142757A0 (en) | 2002-03-10 |
| AU761092B2 (en) | 2003-05-29 |
| ZA200103925B (en) | 2002-07-25 |
| NO20012490D0 (no) | 2001-05-21 |
| IL142757A (en) | 2007-07-04 |
| NO328085B1 (no) | 2009-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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