ATE252575T1 - Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung - Google Patents
Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendungInfo
- Publication number
- ATE252575T1 ATE252575T1 AT98936270T AT98936270T ATE252575T1 AT E252575 T1 ATE252575 T1 AT E252575T1 AT 98936270 T AT98936270 T AT 98936270T AT 98936270 T AT98936270 T AT 98936270T AT E252575 T1 ATE252575 T1 AT E252575T1
- Authority
- AT
- Austria
- Prior art keywords
- indoles
- production
- dihydroindole derivatives
- dihydroindole
- derivatives
- Prior art date
Links
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5371397P | 1997-07-25 | 1997-07-25 | |
| DK89297 | 1997-07-25 | ||
| PCT/DK1998/000336 WO1999005140A1 (en) | 1997-07-25 | 1998-07-20 | Indole and 2,3-dihydroindole derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252575T1 true ATE252575T1 (de) | 2003-11-15 |
Family
ID=26064857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98936270T ATE252575T1 (de) | 1997-07-25 | 1998-07-20 | Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6476035B1 (de) |
| EP (1) | EP1007523B9 (de) |
| JP (1) | JP2003524571A (de) |
| KR (1) | KR100545329B1 (de) |
| AT (1) | ATE252575T1 (de) |
| AU (1) | AU736596B2 (de) |
| BG (1) | BG64904B1 (de) |
| CA (1) | CA2297825C (de) |
| CZ (1) | CZ295937B6 (de) |
| DE (1) | DE69819173T2 (de) |
| ES (1) | ES2206963T3 (de) |
| HU (1) | HU225101B1 (de) |
| NZ (1) | NZ502252A (de) |
| PT (1) | PT1007523E (de) |
| WO (1) | WO1999005140A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19730989A1 (de) * | 1997-07-18 | 1999-01-21 | Merck Patent Gmbh | Piperazin-Derivate |
| EP0982304B1 (de) * | 1998-06-30 | 2002-10-02 | Eli Lilly And Company | Auf serotonin-verwandte Systeme wirkende Piperidin-Derivate |
| EP1146045A1 (de) * | 1998-06-30 | 2001-10-17 | Eli Lilly And Company | Auf Serotonin-verwandte Systeme wirkende Piperidin-Derivate |
| ATE299142T1 (de) * | 1999-08-23 | 2005-07-15 | Solvay Pharm Bv | Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme |
| CN1149212C (zh) * | 1999-09-29 | 2004-05-12 | 伊莱利利公司 | 用作再摄入抑制剂的哌啶衍生物 |
| JP2003510321A (ja) * | 1999-09-29 | 2003-03-18 | イーライ・リリー・アンド・カンパニー | セロトニン再取込み抑制薬としてのピペリジン誘導体 |
| AU2002243394A1 (en) | 2000-11-16 | 2002-06-24 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
| EP1353913A2 (de) | 2001-01-16 | 2003-10-22 | AstraZeneca AB | Therapeutische heterocyclische verbindungen |
| AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| US6656950B2 (en) * | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
| US7208495B2 (en) | 2001-07-05 | 2007-04-24 | Takeda Pharmaceutical Company Limited | Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof |
| DK1408976T5 (da) * | 2001-07-20 | 2011-01-10 | Psychogenics Inc | Behandling af ADHD (Attention deficit hyperactivity disorder) |
| KR100636475B1 (ko) * | 2002-05-13 | 2006-10-18 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 조절제로서 벤족사진 유도체 및 이의 용도 |
| DE10326940A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| DE10326939A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
| EP1824486B1 (de) * | 2004-12-07 | 2009-03-18 | Solvay Pharmaceuticals B.V. | Bezdioxan-piperazin-derivate mit einer kombination aus affinität für dopamin-d2-rezeptoren und serotonin-wiederaufnahme-stellen |
| US20070072870A2 (en) | 2004-12-08 | 2007-03-29 | Solvay Pharmeceuticals B.V. | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition |
| DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
| US20070026441A1 (en) * | 2005-07-22 | 2007-02-01 | Olson William C | Methods for reducing viral load in HIV-1-infected patients |
| GT200600414A (es) * | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| CL2008000119A1 (es) * | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| US8288390B2 (en) | 2009-03-10 | 2012-10-16 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
| US8367676B2 (en) * | 2009-06-30 | 2013-02-05 | Astrazeneca Ab | 2-carboxamide-7-piperazinyl-benzofuran derivatives 774 |
| CA2821480A1 (en) | 2010-12-20 | 2012-06-28 | Astrazeneca Ab | 2-carboxamide-4-piperazinyl-benzofuran derivative |
| PL395469A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
| EP2953792B1 (de) * | 2013-02-05 | 2019-03-20 | 3M Innovative Properties Company | Grafikartikel |
| WO2015014256A1 (en) | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| CN106243088B (zh) | 2015-06-03 | 2019-01-04 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| WO2023201423A1 (en) * | 2022-04-19 | 2023-10-26 | Mindset Pharma Inc. | Indoline derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412097A (en) * | 1964-09-07 | 1968-11-19 | Koninklijke Pharma Fab Nv | Indole derivatives |
| US5200948A (en) * | 1988-02-05 | 1993-04-06 | Tandy Corporation | Recording method and apparatus |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| DE4127849A1 (de) | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| CA2134038C (en) * | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
| EP0714663A3 (de) * | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potenzierung von Wirkstoffresponz durch Serotonin 1A Rezeptor Antagonisten |
| WO1998028290A1 (en) * | 1996-12-20 | 1998-07-02 | H. Lundbeck A/S | Indane or dihydroindole derivatives |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
-
1998
- 1998-07-20 AT AT98936270T patent/ATE252575T1/de not_active IP Right Cessation
- 1998-07-20 WO PCT/DK1998/000336 patent/WO1999005140A1/en not_active Ceased
- 1998-07-20 KR KR1020007000802A patent/KR100545329B1/ko not_active Expired - Fee Related
- 1998-07-20 EP EP98936270A patent/EP1007523B9/de not_active Expired - Lifetime
- 1998-07-20 HU HU0002830A patent/HU225101B1/hu not_active IP Right Cessation
- 1998-07-20 DE DE69819173T patent/DE69819173T2/de not_active Expired - Fee Related
- 1998-07-20 CA CA002297825A patent/CA2297825C/en not_active Expired - Fee Related
- 1998-07-20 JP JP2000504136A patent/JP2003524571A/ja active Pending
- 1998-07-20 PT PT98936270T patent/PT1007523E/pt unknown
- 1998-07-20 NZ NZ502252A patent/NZ502252A/en unknown
- 1998-07-20 ES ES98936270T patent/ES2206963T3/es not_active Expired - Lifetime
- 1998-07-20 AU AU85340/98A patent/AU736596B2/en not_active Ceased
- 1998-07-20 CZ CZ2000285A patent/CZ295937B6/cs not_active IP Right Cessation
-
2000
- 2000-01-25 US US09/491,204 patent/US6476035B1/en not_active Expired - Fee Related
- 2000-02-10 BG BG104148A patent/BG64904B1/bg unknown
-
2002
- 2002-08-16 US US10/223,046 patent/US6727263B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU736596B2 (en) | 2001-08-02 |
| HUP0002830A3 (en) | 2001-10-29 |
| DE69819173T2 (de) | 2004-04-15 |
| KR20010022229A (ko) | 2001-03-15 |
| HUP0002830A2 (hu) | 2001-09-28 |
| PT1007523E (pt) | 2004-02-27 |
| WO1999005140A1 (en) | 1999-02-04 |
| AU8534098A (en) | 1999-02-16 |
| CZ2000285A3 (cs) | 2000-06-14 |
| NZ502252A (en) | 2001-09-28 |
| US6727263B2 (en) | 2004-04-27 |
| BG64904B1 (bg) | 2006-08-31 |
| EP1007523B9 (de) | 2004-09-08 |
| CA2297825C (en) | 2006-03-14 |
| CA2297825A1 (en) | 1999-02-04 |
| KR100545329B1 (ko) | 2006-01-24 |
| US20030018050A1 (en) | 2003-01-23 |
| HU225101B1 (en) | 2006-06-28 |
| ES2206963T3 (es) | 2004-05-16 |
| JP2003524571A (ja) | 2003-08-19 |
| EP1007523A1 (de) | 2000-06-14 |
| CZ295937B6 (cs) | 2005-12-14 |
| BG104148A (en) | 2001-05-31 |
| DE69819173D1 (de) | 2003-11-27 |
| EP1007523B1 (de) | 2003-10-22 |
| US6476035B1 (en) | 2002-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1007523 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |