ATE252919T1 - Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe - Google Patents

Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe

Info

Publication number
ATE252919T1
ATE252919T1 AT98942271T AT98942271T ATE252919T1 AT E252919 T1 ATE252919 T1 AT E252919T1 AT 98942271 T AT98942271 T AT 98942271T AT 98942271 T AT98942271 T AT 98942271T AT E252919 T1 ATE252919 T1 AT E252919T1
Authority
AT
Austria
Prior art keywords
polymer
body tissues
materials
compositions
pba
Prior art date
Application number
AT98942271T
Other languages
English (en)
Inventor
Jeffrey A Hubbell
Natalie D Winblade
Donald L Elbert
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE252919T1 publication Critical patent/ATE252919T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79—Polymers of vinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/931—Medical device coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Dental Preparations (AREA)
AT98942271T 1997-08-27 1998-08-27 Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe ATE252919T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5685497P 1997-08-27 1997-08-27
PCT/US1998/017754 WO1999010022A2 (en) 1997-08-27 1998-08-27 Methods and compositions to prevent formation of adhesions in biological tissues

Publications (1)

Publication Number Publication Date
ATE252919T1 true ATE252919T1 (de) 2003-11-15

Family

ID=22006976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942271T ATE252919T1 (de) 1997-08-27 1998-08-27 Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe

Country Status (8)

Country Link
US (2) US6596267B1 (de)
EP (1) EP1009451B1 (de)
JP (1) JP4503825B2 (de)
AT (1) ATE252919T1 (de)
AU (1) AU9036598A (de)
DE (1) DE69819343T2 (de)
ES (1) ES2210808T3 (de)
WO (1) WO1999010022A2 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
JP2001526935A (ja) * 1997-12-31 2001-12-25 デピュイ・オーソピーディックス・インコーポレイテッド 組織反応性接着剤組成物
US6350527B1 (en) 1998-08-27 2002-02-26 Eidgenossische Technische Hochschule Zurich Gels and multilayer surface structures from boronic acid containing polymers
GB9928956D0 (en) * 1999-12-07 2000-02-02 Malik Navid Internally supported biomimetic coating systems
US7592017B2 (en) 2000-03-10 2009-09-22 Mast Biosurgery Ag Resorbable thin membranes
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
US7244703B2 (en) * 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
US8425549B2 (en) 2002-07-23 2013-04-23 Reverse Medical Corporation Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US8048444B2 (en) * 2002-07-31 2011-11-01 Mast Biosurgery Ag Apparatus and method for preventing adhesions between an implant and surrounding tissues
KR101065155B1 (ko) * 2002-07-31 2011-09-16 마스트 바이오서저리 아게 이식체와 주위 조직 사이의 유착을 예방하기 위한 기구 및방법
US7704520B1 (en) * 2002-09-10 2010-04-27 Mast Biosurgery Ag Methods of promoting enhanced healing of tissues after cardiac surgery
US20060083767A1 (en) * 2003-02-27 2006-04-20 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
US20100266663A1 (en) * 2003-09-10 2010-10-21 Calhoun Christopher J Tissue-treating implantable compositions
CN101829319A (zh) 2003-12-08 2010-09-15 Cpex药品公司 用于胰岛素治疗的药用组合物及方法
WO2005072764A2 (en) * 2004-01-16 2005-08-11 Novocell, Inc. Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
EP1773900A4 (de) * 2004-07-30 2007-08-29 Basf Ag Polymerische boronsäurederivate und ihre verwendung be der papierherstellung
US20080091277A1 (en) * 2004-08-13 2008-04-17 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
ES2395154T3 (es) * 2004-08-13 2013-02-08 Mast Biosurgery Ag Prótesis quirúrgica con regiones biodegradables y no biodegradables
US9707252B2 (en) 2005-02-09 2017-07-18 Covidien Lp Synthetic sealants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US20080119877A1 (en) * 2005-08-12 2008-05-22 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
US7988988B2 (en) * 2005-11-21 2011-08-02 Bausch & Lomb Incorporated Contact lenses with mucin affinity
US8372126B2 (en) 2006-04-21 2013-02-12 Warsaw Orthopedic, Inc. Surgical fasteners with mechanical and osteogenic fixation means
US20080039362A1 (en) * 2006-08-09 2008-02-14 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US9675696B2 (en) 2006-11-14 2017-06-13 Warsaw Orthopedic, Inc. Method and use for increasing efficacy of anti-adhesive compositions in controlling inflammation and pain
EP2098256B1 (de) * 2006-11-17 2016-06-08 National Cerebral and Cardiovascular Center Bloodgerinnung verhinderndes material, beschichtungsmaterial und durch verwendung des materials hergestellte in-vivo-verweilelemente und behandlungsverfahren
US7832856B2 (en) 2006-12-20 2010-11-16 Bausch & Lomb Incorporated Coatings and solutions for contact lenses
US20080241270A1 (en) * 2007-03-30 2008-10-02 Neal Robert A Fluid composition for inhibiting surgical adhesion formation and related method of production
US20100034869A1 (en) * 2007-08-27 2010-02-11 Joerg Tessmar Block-polymer membranes for attenuation of scar tissue
JP2010540003A (ja) * 2007-08-27 2010-12-24 マスト バイオサージェリー アクチェンゲゼルシャフト 治癒中の瘢痕組織を減ずるための再吸収性障壁微小膜
US20100022951A1 (en) * 2008-05-19 2010-01-28 Luce, Forward, Hamilton 7 Scripps, Llp Detachable hub/luer device and processes
US9220522B2 (en) 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
US11337714B2 (en) 2007-10-17 2022-05-24 Covidien Lp Restoring blood flow and clot removal during acute ischemic stroke
US8585713B2 (en) 2007-10-17 2013-11-19 Covidien Lp Expandable tip assembly for thrombus management
US8066757B2 (en) 2007-10-17 2011-11-29 Mindframe, Inc. Blood flow restoration and thrombus management methods
US10123803B2 (en) 2007-10-17 2018-11-13 Covidien Lp Methods of managing neurovascular obstructions
US8926680B2 (en) 2007-11-12 2015-01-06 Covidien Lp Aneurysm neck bridging processes with revascularization systems methods and products thereby
US8088140B2 (en) 2008-05-19 2012-01-03 Mindframe, Inc. Blood flow restorative and embolus removal methods
US9198687B2 (en) 2007-10-17 2015-12-01 Covidien Lp Acute stroke revascularization/recanalization systems processes and products thereby
EP2226075A1 (de) * 2007-11-22 2010-09-08 The University of Tokyo Material zur prävention von gewebeadhäsion und material zur prävention von gelenkkontraktur
US20090169591A1 (en) * 2007-12-28 2009-07-02 Boston Scientific Scimed, Inc. Medical articles for the treatment of tumors
EP2254485B1 (de) 2008-02-22 2017-08-30 Covidien LP Vorrichtung zur flusswiederherstellung
EP2271390A4 (de) 2008-04-11 2016-07-20 Covidien Lp Monorail-neuro-mikrokatheter zur abgabe von medizinischen vorrichtungen zur behandlung von schlaganfall, verfahren und produkte
US20090304779A1 (en) * 2008-06-08 2009-12-10 Von Waldburg-Zeil Erich Graf Micro-membrane implant with cusped opening
US20100003306A1 (en) * 2008-06-08 2010-01-07 Mast Biosurgery Ag Pre-shaped user-formable micro-membrane implants
CA2730093A1 (en) * 2008-07-06 2010-01-14 Mast Biosurgery Ag Resorbable membrane implanting methods for reducing adhesions
US20100029545A1 (en) * 2008-08-04 2010-02-04 Sumerlin Brent S Boronic acid-containing block copolymers for controlled drug delivery
US8557292B2 (en) 2008-08-13 2013-10-15 California Institute Of Technology Carrier nanoparticles and related compositions, methods and systems
US8534031B2 (en) * 2008-12-30 2013-09-17 Bausch & Lomb Incorporated Packaging solutions
WO2010077708A1 (en) * 2008-12-30 2010-07-08 Bausch & Lomb Incorporated Packaging solutions
WO2010096558A1 (en) 2009-02-18 2010-08-26 Eyeon Particle Sciences Llc Bi-functional co-polymer use for ophthalmic and other topical and local applications
US20100310632A1 (en) * 2009-06-08 2010-12-09 Von Waldburg-Zeil Erich Graf Micro-membrane implant with cusped opening
US20100310628A1 (en) * 2009-06-08 2010-12-09 Mast Biosurgery Ag Pre-shaped user-formable micro-membrane implants
US9296988B2 (en) 2009-06-19 2016-03-29 The Regents Of The University Of California Three-dimensional cell adhesion matrix
US8660628B2 (en) 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
US9119605B2 (en) 2010-05-06 2015-09-01 Zimmer, Inc. Synthetic polymer adhesives and methods for making, using and delivering the same
US9234048B2 (en) * 2012-01-18 2016-01-12 Wisconsin Alumni Research Foundation Boronate-mediated delivery of molecules into cells
US9732101B2 (en) 2012-01-18 2017-08-15 Wisconsin Alumni Research Foundation Bioreversible boronates for delivery of molecules into cells
EP2727597A1 (de) * 2012-11-06 2014-05-07 Centre National de la Recherche Scientifique (CNRS) Auf Glukose reagierendes Hydrogel mit pba-geschröpfter Hyalonsäure (HA)
WO2014081425A1 (en) * 2012-11-21 2014-05-30 Empire Technology Development Llc Hydrophobic coatings that provide renewable hydrophilic surface
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
ES2882255T3 (es) 2015-07-01 2021-12-01 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
MX395496B (es) 2016-07-06 2025-03-25 Eyeon Particle Sciences Llc Uso de co-polímero bi-funcional para aplicaciones oftálmicas y otras aplicaciones tópicas y locales.
JP7485602B2 (ja) 2018-01-30 2024-05-16 アルコン インク． その上に潤滑性コーティングを有するコンタクトレンズ
WO2019241327A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
CN110639052B (zh) * 2019-09-30 2021-06-29 新乡医学院 一种促进创面愈合的复合凝胶体系及其制备方法和应用
CN110563974B (zh) * 2019-09-30 2021-09-28 新乡医学院 一种活性氧响应的自崩解水凝胶及其制备方法和应用
CN110522766B (zh) * 2019-09-30 2021-09-28 新乡医学院 一种负载肿瘤外泌体的凝胶体系及其制备方法和应用
CN113045759A (zh) * 2019-12-26 2021-06-29 财团法人工业技术研究院 接枝高分子与包含其的复合材料
CN113292671B (zh) * 2021-07-08 2023-09-05 南方科技大学 一种含有苯硼酸基团的高分子交联剂、其制备的生物粘合剂及制备方法和应用
CN116036375B (zh) * 2022-12-30 2024-07-23 四川大学 一种乙烯基双环噁唑烷交联生物瓣膜及其制备方法和用途
CN117982739B (zh) * 2024-02-05 2026-02-24 上海交通大学医学院附属仁济医院 一种用于子宫内膜修复的水凝胶及其制备方法
WO2025186703A1 (en) 2024-03-04 2025-09-12 Alcon Inc. Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4111863A (en) 1972-08-31 1978-09-05 Dynamit Nobel Aktiengesellschaft Method of preparing polymers analogous to enzymes
US4316985A (en) 1979-01-16 1982-02-23 Hoffmann-La Roche Inc. Cyclic compounds
US5240602A (en) 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
US4886924A (en) 1988-10-17 1989-12-12 The Dow Chemical Company Stereospecific synthesis of [E]-alkenes from enamines via hydroboration
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US5691292A (en) 1992-04-13 1997-11-25 The Procter & Gamble Company Thixotropic liquid automatic dishwashing composition with enzyme
JPH05310844A (ja) * 1992-05-08 1993-11-22 Nippon Oil & Fats Co Ltd フェニルボロン酸基含有重合体
US5594042A (en) 1993-05-18 1997-01-14 Dow Corning Corporation Radiation curable compositions containing vinyl ether functional polyorganosiloxanes
US5312959A (en) 1993-07-12 1994-05-17 E. I. Du Pont De Nemours And Company Purification of 2-methylglutaronitrile or adiponitrile
EP0745630A3 (de) 1995-06-01 1997-08-27 Enichem Spa Hochaktives Katalysatorsystem für die Herstellung von Polyethylenterephthalat
US5908624A (en) 1996-06-27 1999-06-01 Albany Medical College Antigenic modulation of cells
EP0901521B1 (de) 1996-02-01 2005-11-02 Biomedical Frontiers, Inc. Antigene modulation von zellen
CA2320156A1 (en) 1997-09-26 1999-04-08 Uab Research Foundation Reduced antigenic cells and uses therefor
US6312685B1 (en) 1998-03-13 2001-11-06 Timothy C. Fisher Red blood cells covalently bound with two different polyethylene glycol derivatives

Also Published As

Publication number Publication date
ES2210808T3 (es) 2004-07-01
US6596267B1 (en) 2003-07-22
EP1009451A2 (de) 2000-06-21
AU9036598A (en) 1999-03-16
JP4503825B2 (ja) 2010-07-14
WO1999010022A2 (en) 1999-03-04
DE69819343T2 (de) 2004-07-22
JP2003527874A (ja) 2003-09-24
US20030185787A1 (en) 2003-10-02
DE69819343D1 (de) 2003-12-04
US7029688B2 (en) 2006-04-18
WO1999010022A3 (en) 1999-06-10
EP1009451B1 (de) 2003-10-29

Similar Documents

Publication Publication Date Title
ATE252919T1 (de) Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe
BR9711241B8 (pt) processo para fabricar uma composição polimérica para prevenir ou inibir a formação de aderências de tecidos ou para inibir sangramento
WO2002039948A3 (en) Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
EP1795213A3 (de) Implantierbare mikrobielle Cellulosematerialien für verschiedene medizinische Anwendungen
WO2002041837A3 (en) Treatment of mucositis
EP1769795A3 (de) Arylharnstoffverbindungen in Kombination mit anderen zytostatischen oder zytotoxischen Substanzen zur Behandlung von Krebs beim Menschen
FI20001696A7 (fi) Biologisesti aktiivinen materiaali
DE69636989D1 (de) Bioaktive lasttragende zusammensetzungen zum knochenverbund
WO2004010854A3 (en) Apparatus and method for preventing adhesions between an implant and surrounding tissues
AU1387002A (en) New cross-linked derivatives of hyaluronic acid
ATE505551T1 (de) Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen
IL197686A0 (en) Pharmaceutical compositions containing alpha-4 integrin antagonists and uses thereof in the treatment of multiple myeloma and diseases associated therewith
ATE296116T1 (de) Ein kovalentes konjugat von clozapine und einer fettsäure und dessen verwendung zur behandlung von schizophrenie
BRPI0210282B8 (pt) composições compreendendo veículos de distribuição de fosfato de cálcio para proteínas osteoindutivas, e respectivo uso
ATE261316T1 (de) Injizierbare polymerzusammensetzung zur herstellung eines in-situ-implantats
WO2005103102A8 (fr) Copolymere sequence
DE60110801D1 (de) Verfahren zur herstellung von auf chitosan basierenden filmen mit verbessertem zellanhaftvermögen, daraus resultierendes produkt and anwendungen
DE69809284D1 (de) Immunomodulator mit anti-mikrobakteriellen und anti-mykobakteriellen eigenschaften, verfahren zu seiner herstellung und pharmazeutische zusammensetzungen zur behandlung von mykobakteriosen sowie von chronischen und nicht-spezifischen lungenzuständen, sexuell übertragbaren krankheiten und den daraus resultierenden immunschwächen
ATE250437T1 (de) Hämokompatible oberflächen und verfahren zu deren herstellung
ATE416794T1 (de) Kovalent gebundene, hydrophile beschichtungszusammensetzungen für chirurgische implantate
EP1080724A4 (de) Zusammenstellung die die mpt-aktivität mindert
EP1461056A4 (de) Verfahren zur herstellung und verwendung von polyoxyethyliertem rizinusöl in pharmazeutischen zusammensetzungen
CA2333379A1 (en) Lactide-containing polymer and medical material
DE60028671D1 (de) Verbesserte Polymerzusammensetzung und Verfahren zur Herstellung von Vulkanisaten damit
DE68921002D1 (de) Verfahren und mittel zur präventiven behandlung von chirurgischen adhäsionen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties