ATE253037T1 - Verfahren zur racematspaltung von tramadol - Google Patents
Verfahren zur racematspaltung von tramadolInfo
- Publication number
- ATE253037T1 ATE253037T1 AT99973014T AT99973014T ATE253037T1 AT E253037 T1 ATE253037 T1 AT E253037T1 AT 99973014 T AT99973014 T AT 99973014T AT 99973014 T AT99973014 T AT 99973014T AT E253037 T1 ATE253037 T1 AT E253037T1
- Authority
- AT
- Austria
- Prior art keywords
- tramadol
- racemat
- cleaving
- single enantiomer
- substantially single
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title abstract 2
- 229960004380 tramadol Drugs 0.000 title abstract 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Glass Compositions (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9826540.8A GB9826540D0 (en) | 1998-12-02 | 1998-12-02 | Process |
| PCT/GB1999/003843 WO2000032554A1 (en) | 1998-12-02 | 1999-11-18 | Process for the resolution of tramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253037T1 true ATE253037T1 (de) | 2003-11-15 |
Family
ID=10843543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99973014T ATE253037T1 (de) | 1998-12-02 | 1999-11-18 | Verfahren zur racematspaltung von tramadol |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6323368B1 (de) |
| EP (1) | EP1135357B1 (de) |
| JP (1) | JP2002531429A (de) |
| KR (1) | KR20010112223A (de) |
| CN (1) | CN1329587A (de) |
| AT (1) | ATE253037T1 (de) |
| AU (1) | AU747431B2 (de) |
| BR (1) | BR9915868A (de) |
| CA (1) | CA2353549A1 (de) |
| DE (1) | DE69912474D1 (de) |
| GB (1) | GB9826540D0 (de) |
| WO (1) | WO2000032554A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0010437D0 (en) * | 2000-04-28 | 2000-06-14 | Darwin Discovery Ltd | Process |
| AU2002364517A1 (en) | 2001-11-30 | 2003-06-17 | Sepracor Inc. | Tramadol analogs and uses thereof |
| JP4357848B2 (ja) | 2003-02-12 | 2009-11-04 | 株式会社リコー | スクアリリウム金属キレート化合物および光記録媒体 |
| GB0325051D0 (en) * | 2003-10-27 | 2003-12-03 | Smithkline Beecham Corp | New process |
| JP2007509856A (ja) * | 2003-10-27 | 2007-04-19 | スミスクライン ビーチャム コーポレーション | （＋）−（２ｓ，３ｓ）−２−（３−クロロフェニル）−３，５，５−トリメチル−２−モルホリノール、その塩および溶媒和物を調製するための酵素触媒動的速度論分割方法 |
| WO2006006071A1 (en) * | 2004-07-07 | 2006-01-19 | Pfizer Products Inc. | Resolution of an aryl-fused azapolycyclic compound |
| BRPI0516132A (pt) * | 2004-10-07 | 2007-12-04 | Vitae Pharmaceuticals Inc | compostos, composição destes, método de antagonização de uma ou mais proteases aspárticas e método para tratar ou melhorar um distúrbio mediado por protease aspártica |
| TWI411607B (zh) * | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | 天門冬胺酸蛋白酶抑制劑 |
| EP1785412A1 (de) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Verfahren zur Rückgewinnung von Tramadol |
| JP2010503682A (ja) * | 2006-09-18 | 2010-02-04 | ビテ ファーマシューティカルズ， インコーポレイテッド | レニン阻害剤としてのピペリジン誘導体 |
| CL2007002689A1 (es) * | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
| WO2009096996A1 (en) * | 2007-06-20 | 2009-08-06 | Smithkline Beecham Corporation | Renin inhibitors |
| CN101434552B (zh) * | 2007-11-16 | 2012-05-23 | 江苏恒瑞医药股份有限公司 | 4,5-二甲氧基-1-(甲基氨基甲基)-苯并环丁烷的拆分 |
| AR077692A1 (es) * | 2009-08-06 | 2011-09-14 | Vitae Pharmaceuticals Inc | Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3830934A (en) | 1967-07-27 | 1974-08-20 | Gruenenthal Chemie | Analgesic and antitussive compositions and methods |
| DE19601745C1 (de) | 1996-01-19 | 1997-10-09 | Gruenenthal Gmbh | Verfahren zur Racematspaltung von Tramadol |
-
1998
- 1998-12-02 GB GBGB9826540.8A patent/GB9826540D0/en not_active Ceased
-
1999
- 1999-11-18 EP EP99973014A patent/EP1135357B1/de not_active Expired - Lifetime
- 1999-11-18 DE DE69912474T patent/DE69912474D1/de not_active Expired - Lifetime
- 1999-11-18 JP JP2000585196A patent/JP2002531429A/ja active Pending
- 1999-11-18 CA CA002353549A patent/CA2353549A1/en not_active Abandoned
- 1999-11-18 AU AU11708/00A patent/AU747431B2/en not_active Ceased
- 1999-11-18 BR BR9915868-0A patent/BR9915868A/pt not_active IP Right Cessation
- 1999-11-18 CN CN99813993A patent/CN1329587A/zh active Pending
- 1999-11-18 WO PCT/GB1999/003843 patent/WO2000032554A1/en not_active Ceased
- 1999-11-18 AT AT99973014T patent/ATE253037T1/de not_active IP Right Cessation
- 1999-11-18 KR KR1020017006815A patent/KR20010112223A/ko not_active Withdrawn
- 1999-11-30 US US09/452,012 patent/US6323368B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1135357B1 (de) | 2003-10-29 |
| AU747431B2 (en) | 2002-05-16 |
| AU1170800A (en) | 2000-06-19 |
| EP1135357A1 (de) | 2001-09-26 |
| JP2002531429A (ja) | 2002-09-24 |
| WO2000032554A1 (en) | 2000-06-08 |
| CN1329587A (zh) | 2002-01-02 |
| DE69912474D1 (de) | 2003-12-04 |
| GB9826540D0 (en) | 1999-01-27 |
| BR9915868A (pt) | 2001-08-21 |
| US6323368B1 (en) | 2001-11-27 |
| KR20010112223A (ko) | 2001-12-20 |
| CA2353549A1 (en) | 2000-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |