ATE253074T1 - Festphasen-synthese - Google Patents

Festphasen-synthese

Info

Publication number: ATE253074T1
Authority: AT; Austria
Prior art keywords: support; solid phase; phase synthesis; synthesis; oligonucleotides
Prior art date: 1996-08-30

Application number

AT97936002T

Other languages

English (en)

Inventor

Marek Kwiatkowski

Mats Nilsson

Ulf Landegren

Original Assignee

Quiatech Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-30

Filing date

1997-08-27

Publication date

2003-11-15

1997-08-27 Application filed by Quiatech Ab filed Critical Quiatech Ab

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253074T1 publication Critical patent/ATE253074T1/de

Links

238000010532 solid phase synthesis reaction Methods 0.000 title abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
238000011068 loading method Methods 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Catalysts (AREA)

AT97936002T 1996-08-30 1997-08-27 Festphasen-synthese ATE253074T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9603171A SE9603171D0 (sv)	1996-08-30	1996-08-30	Solid phase synthesis
PCT/SE1997/001418 WO1998008857A1 (en)	1996-08-30	1997-08-27	Solid phase synthesis

Publications (1)

Publication Number	Publication Date
ATE253074T1 true ATE253074T1 (de)	2003-11-15

Family

ID=20403732

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97936002T ATE253074T1 (de)	1996-08-30	1997-08-27	Festphasen-synthese

Country Status (9)

Country	Link
US (4)	US6291669B1 (de)
EP (1)	EP0925306B1 (de)
JP (1)	JP2001505543A (de)
AT (1)	ATE253074T1 (de)
CA (1)	CA2264154A1 (de)
DE (1)	DE69725866T2 (de)
ES (1)	ES2210555T3 (de)
SE (1)	SE9603171D0 (de)
WO (1)	WO1998008857A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5854033A (en)	1995-11-21	1998-12-29	Yale University	Rolling circle replication reporter systems
SE9603171D0 (sv) *	1996-08-30	1996-08-30	Marek Kwiatkowski	Solid phase synthesis
US6309836B1 (en) *	1999-10-05	2001-10-30	Marek Kwiatkowski	Compounds for protecting hydroxyls and methods for their use
US7572642B2 (en) *	2001-04-18	2009-08-11	Ambrigen, Llc	Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US6977148B2 (en) *	2001-10-15	2005-12-20	Qiagen Gmbh	Multiple displacement amplification
US6617137B2 (en)	2001-10-15	2003-09-09	Molecular Staging Inc.	Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7297485B2 (en) *	2001-10-15	2007-11-20	Qiagen Gmbh	Method for nucleic acid amplification that results in low amplification bias
US7553619B2 (en)	2002-02-08	2009-06-30	Qiagen Gmbh	Detection method using dissociated rolling circle amplification
US20030153741A1 (en) *	2002-02-08	2003-08-14	Marek Kwiatkowski	Methods for separating oligonucleotides
US20040242897A1 (en) *	2002-07-31	2004-12-02	Guzaev Andrei P.	Universal support media for synthesis of oligomeric compounds
WO2004011474A1 (en) *	2002-07-31	2004-02-05	Isis Pharmaceuticals, Inc.	Universal support media for synthesis of oligomeric compounds
US6653468B1 (en) *	2002-07-31	2003-11-25	Isis Pharmaceuticals, Inc.	Universal support media for synthesis of oligomeric compounds
US7345163B2 (en)	2002-08-28	2008-03-18	Quiatech Ab	Process for separating and deprotecting oligonucleotides
US20040115643A1 (en) *	2002-12-12	2004-06-17	Lizardi Paul M.	Thermodynamic equilibrium extension of primers
CA2510587A1 (en)	2002-12-20	2004-07-15	Qiagen Gmbh	Nucleic acid amplification
US7955795B2 (en) *	2003-06-06	2011-06-07	Qiagen Gmbh	Method of whole genome amplification with reduced artifact production
US9487823B2 (en)	2002-12-20	2016-11-08	Qiagen Gmbh	Nucleic acid amplification
US6977153B2 (en)	2002-12-31	2005-12-20	Qiagen Gmbh	Rolling circle amplification of RNA
US7202264B2 (en) *	2003-01-31	2007-04-10	Isis Pharmaceuticals, Inc.	Supports for oligomer synthesis
US8043834B2 (en)	2003-03-31	2011-10-25	Qiagen Gmbh	Universal reagents for rolling circle amplification and methods of use
US20040248103A1 (en) *	2003-06-04	2004-12-09	Feaver William John	Proximity-mediated rolling circle amplification
US20050106589A1 (en) *	2003-11-17	2005-05-19	Hashem Akhavan-Tafti	Compositions and methods for releasing nucleic acids from solid phase binding materials
US20050130736A1 (en) *	2003-12-12	2005-06-16	Lottofone, Inc.	Prepaid wagering card
WO2005113804A1 (en) *	2004-05-20	2005-12-01	Trillion Genomics Limited	Use of mass labelled probes to detect target nucleic acids using mass spectrometry
US20060003651A1 (en) *	2004-07-01	2006-01-05	Building Materials Investment Corporation	Coating for granulated products to improve granule adhesion, staining, and tracking
JP2008533167A (ja) *	2005-03-15	2008-08-21	アプレラコーポレイション	分析物の検出のための、抗体の代替抗原系の使用
EP1863908B1 (de)	2005-04-01	2010-11-17	Qiagen GmbH	Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
EP1762627A1 (de)	2005-09-09	2007-03-14	Qiagen GmbH	Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US20080057499A1 (en) *	2006-02-06	2008-03-06	Affymetrix, Inc.	Methods for high specificity whole genome amplification and hybridization
CA2541567C (en) *	2006-03-31	2012-07-17	University Of Waterloo	Parallel soft spherical mimo receiver and decoding method
WO2010088273A1 (en)	2009-01-27	2010-08-05	Qiagen Gaithersburg	Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
US8628914B2 (en)	2010-05-26	2014-01-14	Qiagen Gaithersburg, Inc.	Quantitative helicase assay
US20140038182A1 (en)	2012-07-17	2014-02-06	Dna Logix, Inc.	Cooperative primers, probes, and applications thereof
CN117288934A (zh)	2013-03-13	2023-12-26	中尺度技术有限责任公司	改进的测定方法
US10114015B2 (en)	2013-03-13	2018-10-30	Meso Scale Technologies, Llc.	Assay methods
KR102757668B1 (ko)	2014-05-15	2025-01-21	메소 스케일 테크놀러지즈, 엘엘시	개선된 분석 방법
US11267846B2 (en)	2018-03-13	2022-03-08	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	High shear solid phase synthesis
WO2020068983A1 (en)	2018-09-25	2020-04-02	Co-Diagnostics, Inc.	Allele-specific design of cooperative primers for improved nucleic acid variant genotyping
CN120098057A (zh)	2019-03-01	2025-06-06	中尺度技术有限责任公司	用于免疫方法的被电化学发光标记的探针、使用这类探针的方法和包含这类探针的试剂盒
JP7727628B2 (ja)	2019-12-03	2025-08-21	アラマーバイオサイエンシーズ，インク．	核酸結合免疫サンドイッチアッセイ（ｎｕｌｉｓａ）
CN116096882A (zh) *	2020-04-06	2023-05-09	分子组装公司	用于合成核酸的可重复使用的起始子
US12704508B2 (en)	2021-06-02	2026-08-11	Alamar Biosciences, Inc.	Nucleic acid linked immune-sandwich assay (NULISA)
AU2022304570A1 (en)	2021-06-28	2024-01-18	Meso Scale Technologies, Llc.	Methods, compositions, and kits for assay signal amplification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5214134A (en) *	1990-09-12	1993-05-25	Sterling Winthrop Inc.	Process of linking nucleosides with a siloxane bridge
SE9003743D0 (sv) *	1990-11-26	1990-11-26	Pharmacia Ab	Method and means for oligonucleotide synthesis
CA2126748A1 (en)	1991-12-24	1993-06-25	Tepnel Medical Limited	Manipulating nucleic acid sequences
SE9603171D0 (sv) *	1996-08-30	1996-08-30	Marek Kwiatkowski	Solid phase synthesis

1996
- 1996-08-30 SE SE9603171A patent/SE9603171D0/xx unknown
1997
- 1997-08-27 ES ES97936002T patent/ES2210555T3/es not_active Expired - Lifetime
- 1997-08-27 JP JP51155998A patent/JP2001505543A/ja not_active Abandoned
- 1997-08-27 DE DE69725866T patent/DE69725866T2/de not_active Expired - Fee Related
- 1997-08-27 WO PCT/SE1997/001418 patent/WO1998008857A1/en not_active Ceased
- 1997-08-27 EP EP97936002A patent/EP0925306B1/de not_active Expired - Lifetime
- 1997-08-27 CA CA002264154A patent/CA2264154A1/en not_active Abandoned
- 1997-08-27 AT AT97936002T patent/ATE253074T1/de not_active IP Right Cessation
- 1997-08-27 US US09/254,048 patent/US6291669B1/en not_active Expired - Fee Related
2001
- 2001-08-02 US US09/921,203 patent/US6429309B1/en not_active Expired - Fee Related
2002
- 2002-03-25 US US10/106,832 patent/US6646118B2/en not_active Expired - Fee Related
2003
- 2003-10-14 US US10/685,331 patent/US20050027116A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US6429309B1 (en)	2002-08-06
EP0925306A1 (de)	1999-06-30
US6646118B2 (en)	2003-11-11
ES2210555T3 (es)	2004-07-01
CA2264154A1 (en)	1998-03-05
US20020177698A1 (en)	2002-11-28
US6291669B1 (en)	2001-09-18
JP2001505543A (ja)	2001-04-24
US20050027116A1 (en)	2005-02-03
EP0925306B1 (de)	2003-10-29
DE69725866T2 (de)	2004-09-09
WO1998008857A1 (en)	1998-03-05
DE69725866D1 (de)	2003-12-04
SE9603171D0 (sv)	1996-08-30
US20020035247A1 (en)	2002-03-21

Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69725866D1 (de)	2003-12-04	Festphasen-synthese
FI955530A7 (fi)	1996-01-12	Katalyyttikantaja, menetelmä katalyyttikantajan prekursorigeelin valmistamiseksi
MX9804732A (es)	1998-11-30	Uso de catalizadores de cedazo molecular de poro pequeño conteniendo metal de transicion en conversion de oxigenados.
AU1858597A (en)	1998-09-09	Olefin plant recovery system employing catalytic distillation
MX9101523A (es)	1992-06-05	Catalizador para la sintesis de 3,4-poliisopreno cristalino
PT1312609E (pt)	2006-05-31	Compostos de acido e ester boronico, sinteses e utilizacoes
DE69802909D1 (de)	2002-01-24	Heterogenes dampfphasencarbonylierunsverfahren
DE69611442D1 (de)	2001-02-08	Enzymatische synthese von glykosidischen verbindungen
AU7025891A (en)	1991-08-08	Catalyst system for distillation reactor
NO913570L (no)	1992-03-12	Katalysator til dampreforming av hydrokarboner.
IT1283232B1 (it)	1998-04-16	Procedimento per la sintesi di 2-buten-1, 4-diesteri
EP0830136A4 (de)	2001-01-24	Neue synthetische cryptophycine
ATE231507T1 (de)	2003-02-15	Synthese von azyklischen nukleosiden
WO1999051547A3 (en)	2000-07-06	Solid phase synthesis of organic compounds via phosphitylating reagents
NO995136D0 (no)	1999-10-21	Fremgangsmåte ved fremstilling av höy-aktive hydrokarbon syntesekatalysatorer, og katalysatorsammensetninger
NO994414D0 (no)	1999-09-10	Understöttet katalysatorsystem for polymerisering av alk-1-ener
ZA982860B (en)	1999-10-04	Catalyst system for high yield synthesis of polyolefins.
DK0906154T3 (da)	2001-10-08	Fremgangsmåde til præsulfidering af carbonhydridomdannelseskatalysatorer
ATE203753T1 (de)	2001-08-15	Kohlenhydratderivate und ihre synthese an fester phase
FI863502A7 (fi)	1987-03-03	Menetelmä synteesikaasun valmistamiseksi kiinteistä polttoaineista.
FR2661171B1 (fr)	1992-08-14	Procede de synthese de zircone stabilisee, zircone ainsi obtenue et catalyseur renfermant de la zircone stabilisee.
BR8504512A (pt)	1986-07-15	Processo para preparar catalisador para sintese de 1,2-dicloroetano
NO895017L (no)	1991-06-14	Understoettelse for katalysatorpakke.
NO913569D0 (no)	1991-09-10	Katalysator til dampreforming av hydrokarboner.
GR3005467T3 (de)	1993-05-24