ATE253356T1 - N-formyl hydroxylamin derivate als antibakterielle mittel - Google Patents

N-formyl hydroxylamin derivate als antibakterielle mittel

Info

Publication number: ATE253356T1
Authority: AT; Austria
Prior art keywords: alkyl; group; antibacterial agents; represents hydrogen; alk
Prior art date: 1998-12-16

Application number

AT99959596T

Other languages

English (en)

Inventor

Michael George Hunter

Raymond Paul Beckett

Martin John Clements

Mark Whittaker

Original Assignee

British Biotech Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-16

Filing date

1999-12-13

Publication date

2003-11-15

1999-12-13 Application filed by British Biotech Pharm filed Critical British Biotech Pharm

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253356T1 publication Critical patent/ATE253356T1/de

Links

239000003242 anti bacterial agent Substances 0.000 title abstract 2
KDGKTJGPFXIBEB-UHFFFAOYSA-N n-hydroxyformamide Chemical class ONC=O KDGKTJGPFXIBEB-UHFFFAOYSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000006728 (C1-C6) alkynyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
-1 hydroxy, mercapto Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000007970 thio esters Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Pyrane Compounds (AREA)

AT99959596T 1998-12-16 1999-12-13 N-formyl hydroxylamin derivate als antibakterielle mittel ATE253356T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9827805.4A GB9827805D0 (en)	1998-12-16	1998-12-16	Antibacterial agents
PCT/GB1999/004217 WO2000035440A1 (en)	1998-12-16	1999-12-13	N-formyl hydroxylamine derivatives as antibacterial agents

Publications (1)

Publication Number	Publication Date
ATE253356T1 true ATE253356T1 (de)	2003-11-15

Family

ID=10844420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99959596T ATE253356T1 (de)	1998-12-16	1999-12-13	N-formyl hydroxylamin derivate als antibakterielle mittel

Country Status (8)

Country	Link
US (1)	US6476067B1 (de)
EP (1)	EP1140058B1 (de)
JP (1)	JP2002532417A (de)
AT (1)	ATE253356T1 (de)
AU (1)	AU1672900A (de)
DE (1)	DE69912639T2 (de)
GB (1)	GB9827805D0 (de)
WO (1)	WO2000035440A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7323596B2 (en)	2000-12-21	2008-01-29	De Novo Pharmaceuticals Ltd.	Antimicrobial agents
UY27192A1 (es) *	2001-03-01	2002-09-30	Smithkline Beecham Corp	Inhibidores de peptido-deformilasa
UY27813A1 (es)	2002-05-31	2003-12-31	Smithkline Beecham Corp	Inhibidores de la peptido-desformilasa
US7442793B2 (en)	2002-12-11	2008-10-28	Smithkline Beecham Corporation	Peptide deformylase inhibitors
KR100774728B1 (ko)	2006-05-25	2007-11-08	일동제약주식회사	펩티드 데포르밀라제 저해제로서 신규의 엔-포르밀히드록실아민 유도체 및 그 제조방법
FR3098217B1 (fr) *	2019-07-05	2023-04-21	Pharmaleads	N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2518088B1 (fr) *	1981-12-16	1987-11-27	Roques Bernard	Nouveaux derives d'aminoacides, et leur application therapeutique
GB9514867D0 (en)	1995-07-20	1995-09-20	British Biotech Pharm	Metalloproteinase inhibitors
WO1997038705A1 (en) *	1996-04-12	1997-10-23	Bristol-Myers Squibb Company	N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors

1998
- 1998-12-16 GB GBGB9827805.4A patent/GB9827805D0/en not_active Ceased
1999
- 1999-12-13 DE DE69912639T patent/DE69912639T2/de not_active Expired - Fee Related
- 1999-12-13 US US09/868,076 patent/US6476067B1/en not_active Expired - Fee Related
- 1999-12-13 JP JP2000587760A patent/JP2002532417A/ja not_active Withdrawn
- 1999-12-13 WO PCT/GB1999/004217 patent/WO2000035440A1/en not_active Ceased
- 1999-12-13 EP EP99959596A patent/EP1140058B1/de not_active Expired - Lifetime
- 1999-12-13 AU AU16729/00A patent/AU1672900A/en not_active Abandoned
- 1999-12-13 AT AT99959596T patent/ATE253356T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2000035440A1 (en)	2000-06-22
EP1140058A1 (de)	2001-10-10
DE69912639T2 (de)	2004-09-16
DE69912639D1 (de)	2003-12-11
GB9827805D0 (en)	1999-02-10
AU1672900A (en)	2000-07-03
JP2002532417A (ja)	2002-10-02
US6476067B1 (en)	2002-11-05
EP1140058B1 (de)	2003-11-05

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
WO1999039704A8 (en)	2001-03-08	Antibacterial agents
NZ507560A (en)	2003-06-30	Hydroxamic acid derivatives as antibacterials
DK0641355T3 (da)	2000-10-09	Anvendelse af sulfamatderivater som steroid-sulfatase-inhibitorer
BR9908275A (pt)	2000-10-24	Inibidores de enzimas fosfolipase
BR0207025A (pt)	2004-02-17	Derivado de isoxazolina e herbicida contendo o mesmo como o ingrediente ativo
DE69920496D1 (de)	2004-10-28	Piperidin- und pyrrolidin-derivate enthaltend ein stickstoffoxid donor zur behandlung von stress
BR9910900A (pt)	2001-02-13	Derivados isotiazol úteis como agentes anticancerìgenos
DK0861228T3 (da)	2000-10-23	Lipopolyaminer som transfektionsmidler samt deres farmaceutiske anvendelser
BRPI0315188B8 (pt)	2021-05-25	composto e composição farmacêutica
DK0583485T3 (da)	1997-10-06	Ethanolaminderivater med sympathomimetiske og anti-pollakisuria-virkninger
DK0705257T3 (da)	1998-12-21	Aminosyrederivater som NO-syntaseinhibitorer
AP1555A (en)	2006-01-18	Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance
DE69912639D1 (de)	2003-12-11	N-formyl hydroxylamin derivate als antibakterielle mittel
ATE44748T1 (de)	1989-08-15	4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung.
DK1362844T3 (da)	2008-04-14	Benzylaminanalog
BR0006299A (pt)	2001-09-25	Derivados da 4-oxo-2-ureìdo-1,4,5,6-tetra-hidro-pirimidina
AU5879798A (en)	1998-09-08	Agents inhibiting progress of pterygium and postoperative recurrence of the same
WO2003022797A1 (en)	2003-03-20	Carba-sugar amine derivatives and treatments for disorder of glycolipid metabolism containing the same as the active ingredient
AU2118900A (en)	2000-08-18	Antibacterial hydroxamic acid derivatives
MX15635A (es)	1993-12-01	Amidas de acidos ciclometilen-1,2-dicarboxilicos y el procedimiento para su preparacion.
EP0712411A1 (de)	1996-05-22	Antiparasitiches mittel
DE60003671D1 (de)	2003-08-07	Halo-derivate von 9-deoxo-9a-aza-9a-homerythromycin a
AU4788896A (en)	1996-04-19	Imidazole derivative