ATE253567T1 - Benzofuranverbindungen, präparate und verfahren - Google Patents

Benzofuranverbindungen, präparate und verfahren

Info

Publication number: ATE253567T1
Authority: AT; Austria
Prior art keywords: alkyl; pyrrolidino; methods; formula; optionally substituted
Prior art date: 1994-09-20

Application number

AT95935147T

Other languages

English (en)

Inventor

Henry Uhlman Bryant

George Joseph Cullinan

Jeffrey Alan Dodge

Kennan Joseph Fahey

Charles David Jones

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-20

Filing date

1995-09-18

Publication date

2003-11-15

1995-09-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253567T1 publication Critical patent/ATE253567T1/de

Links

238000000034 method Methods 0.000 title abstract 2
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 1
201000009273 Endometriosis Diseases 0.000 abstract 1
206010027304 Menopausal symptoms Diseases 0.000 abstract 1
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 1
206010067269 Uterine fibrosis Diseases 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
239000000262 estrogen Substances 0.000 abstract 1
229940011871 estrogen Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
239000000583 progesterone congener Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT95935147T 1994-09-20 1995-09-18 Benzofuranverbindungen, präparate und verfahren ATE253567T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/309,271 US6703407B1 (en)	1994-09-20	1994-09-20	Benzofuran compounds, compositions, and methods
PCT/US1995/012348 WO1996009040A1 (en)	1994-09-20	1995-09-18	Benzofuran compounds, compositions, and methods

Publications (1)

Publication Number	Publication Date
ATE253567T1 true ATE253567T1 (de)	2003-11-15

Family

ID=23197477

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95935147T ATE253567T1 (de)	1994-09-20	1995-09-18	Benzofuranverbindungen, präparate und verfahren

Country Status (7)

Country	Link
US (2)	US6703407B1 (de)
EP (1)	EP0774966B1 (de)
AT (1)	ATE253567T1 (de)
AU (1)	AU3727795A (de)
DE (1)	DE69532079T2 (de)
ES (1)	ES2210316T3 (de)
WO (1)	WO1996009040A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10204082A (ja) *	1996-10-25	1998-08-04	Eli Lilly & Co	選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物
US7005428B1 (en)	1998-06-11	2006-02-28	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en)	1998-06-11	2002-10-15	Endorecherche, Inc.	Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU2512800A (en)	1999-02-03	2000-08-25	Eli Lilly And Company	Alpha1-adrenergic receptor antagonists
WO2001035946A2 (en) *	1999-11-15	2001-05-25	New Millennium Pharmaceutical Research, Inc.	Intranasal administration of raloxifene and tamoxifen
EP1113007A1 (de) *	1999-12-24	2001-07-04	Pfizer Inc.	Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten
ES2236536T3 (es) *	2001-05-22	2005-07-16	Eli Lilly And Company	Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos.
US6653346B1 (en) *	2002-02-07	2003-11-25	Galileo Pharmaceuticals, Inc.	Cytoprotective benzofuran derivatives
US7078541B2 (en) *	2002-02-07	2006-07-18	Galileo Pharmaceuticals, Inc.	Benzofuran derivatives
US6784205B2 (en) *	2002-03-01	2004-08-31	Sunesis Pharmaceuticals, Inc.	Compounds that modulate the activity of PTP-1B and TC-PTP
EP1601356A1 (de)	2003-02-25	2005-12-07	Eli Lilly and Company	Kristallines nicht solvatisiertes 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalenhydrochlorid
US6987194B2 (en) *	2003-04-30	2006-01-17	Fmc Corporation	Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives
US20040223912A1 (en) *	2003-05-07	2004-11-11	Montalto Michael Christopher	Compositions and methods for non-invasive imaging of soluble beta-amyloid
WO2004100998A2 (en)	2003-05-07	2004-11-25	General Electric Company	Compositions and methods for non-invasive imaging of soluble beta-amyloid
US20070066595A1 (en)	2004-01-22	2007-03-22	Dodge Jeffrey A	Selective estrogen receptor modulators
CN107693794A (zh)	2010-06-16	2018-02-16	恩多研究公司	治疗或预防雌激素相关疾病的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3396169A (en)	1966-10-26	1968-08-06	Upjohn Co	Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes
US3274213A (en)	1961-09-05	1966-09-20	Upjohn Co	Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
US3862232A (en)	1963-07-03	1975-01-21	Upjohn Co	1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof
US3313853A (en)	1963-10-16	1967-04-11	Upjohn Co	2-(tertiaryaminoalkoxyphenyl)-3, 4-dihydronaphthalenes and 2-(tertiaryaminoalkoxyphenyl) -3, 4- dihydro -1(2h)-naphthalenones
US3293263A (en)	1963-12-09	1966-12-20	Upjohn Co	Diphenylbenzocycloalkenes
US3320271A (en)	1964-06-01	1967-05-16	Upjohn Co	1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes
DE1300575B (de)	1965-05-21	1969-08-07	Bristol Myers Co	Benzo[b]thiophene
US3394125A (en) *	1965-10-23	1968-07-23	Bristol Myers Co	2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US3483293A (en)	1967-12-15	1969-12-09	Upjohn Co	Method for controlling birds and rodents
US3567737A (en)	1968-01-02	1971-03-02	Upjohn Co	Derivatives of (2-cycloalkyl-1-phenyl-3,4-dihydronaphthalenes and) 2 - cycloalkyl - 1 - phenyl - 1,2,3,4 - tetrahydro-naphthalenes
US3947470A (en) *	1974-06-20	1976-03-30	Smithkline Corporation	Substituted benzofurans and benzothiophenes
US3983245A (en) *	1975-02-06	1976-09-28	Smithkline Corporation	Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en)	1975-10-28	1979-01-09	Eli Lilly And Company	2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4230862A (en)	1975-10-28	1980-10-28	Eli Lilly And Company	Antifertility compounds
US4380635A (en)	1981-04-03	1983-04-19	Eli Lilly And Company	Synthesis of acylated benzothiophenes
US4418068A (en)	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
IL65404A0 (en) *	1981-04-03	1982-07-30	Lilly Co Eli	Benzothiophene compounds and process for preparing them
GB8311678D0 (en)	1983-04-28	1983-06-02	Ici Plc	Phenol derivatives
US4851554A (en) *	1987-04-06	1989-07-25	University Of Tennessee Research Corporation	Certain 3-substituted 2-alkyl benzofuran derivatives
US5254568A (en)	1990-08-09	1993-10-19	Council Of Scientific & Industrial Research	Benzopyrans as antiestrogenic agents
DE4122484A1 (de)	1991-07-06	1993-01-07	Teves Gmbh Alfred	Schaltungsanordnung zur erkennung von radsensordefekten
JP3157882B2 (ja) *	1991-11-15	2001-04-16	帝国臓器製薬株式会社	新規なベンゾチオフエン誘導体
US5354861A (en) *	1992-11-04	1994-10-11	National University Of Singapore	2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
US6756388B1 (en) *	1993-10-12	2004-06-29	Pfizer Inc.	Benzothiophenes and related compounds as estrogen agonists
US5492921A (en) *	1994-09-20	1996-02-20	Eli Lilly And Company	Benzothiophene compounds, compositions, and methods for inhibiting aortal smooth muscle proliferation
US5622974A (en) *	1995-03-10	1997-04-22	Eli Lilly And Company	α-substituted-3-benzyl-benzofurans
US5523309A (en) *	1995-03-10	1996-06-04	Eli Lilly And Company	Benzofuran pharmaceutical compounds
JP4111352B2 (ja)	1996-05-21	2008-07-02	新日鐵住金ステンレス株式会社	ステンレス鋼の高清浄化精錬法

1994
- 1994-09-20 US US08/309,271 patent/US6703407B1/en not_active Expired - Fee Related
1995
- 1995-05-10 US US08/435,437 patent/US6407243B1/en not_active Expired - Fee Related
- 1995-09-18 AT AT95935147T patent/ATE253567T1/de not_active IP Right Cessation
- 1995-09-18 DE DE69532079T patent/DE69532079T2/de not_active Expired - Fee Related
- 1995-09-18 EP EP95935147A patent/EP0774966B1/de not_active Expired - Lifetime
- 1995-09-18 ES ES95935147T patent/ES2210316T3/es not_active Expired - Lifetime
- 1995-09-18 AU AU37277/95A patent/AU3727795A/en not_active Abandoned
- 1995-09-18 WO PCT/US1995/012348 patent/WO1996009040A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1996009040A1 (en)	1996-03-28
DE69532079T2 (de)	2004-08-26
AU3727795A (en)	1996-04-09
EP0774966A4 (de)	1998-01-07
EP0774966A1 (de)	1997-05-28
DE69532079D1 (de)	2003-12-11
EP0774966B1 (de)	2003-11-05
ES2210316T3 (es)	2004-07-01
US6703407B1 (en)	2004-03-09
US6407243B1 (en)	2002-06-18

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE253567T1 (de)	2003-11-15	Benzofuranverbindungen, präparate und verfahren
NZ294177A (en)	1998-10-28	1-aralkyl-, 2-aryl-substituted naphthyl derivatives and pharmaceutical formulations
CA2228997A1 (en)	1997-02-27	Benzothiophene compounds
IL111995A (en)	2000-01-31	Use of raloxifene and related compounds in the preparation of medicaments useful for the treatment of menstrual symptoms
ATE255570T1 (de)	2003-12-15	1-aryloxy-2-arylnaphthylverbindungen, zwischenprodukte, zusammensetzungen und verfahren
MX9800800A (es)	1998-04-30	Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos.
TW372969B (en)	1999-11-01	Pharmaceutical composition for minimizing bone loss
ATE195519T1 (de)	2000-09-15	Benzothiophenderivat als pharmazeutika
YU34296A (en)	1999-11-22	Use a compounds for medicament obtaining and pharmaceutical composition thereof
MY113757A (en)	2002-05-31	Methods of inhibiting endometrial cancer
AU2003247589A8 (en)	2004-02-09	Pentacyclic oxepines and derivatives thereof, process for their preparation and pharmaceutical compositions containing them
MXPA05003166A (es)	2005-06-08	Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos.
CA2170479A1 (en)	1996-08-29	Benzothiophene compounds, intermediates, compositions, and methods
YU11896A (sh)	1998-12-23	Benzotiofenska jedinjenja, intermedijeri, kompozicije koje ih sadrže
MX9706741A (es)	1997-11-29	Compuestos farmaceuticos novedosos de naftilo.