ATE254122T1 - Indolderivate als 5-ht1b und 5-ht1d agonisten - Google Patents
Indolderivate als 5-ht1b und 5-ht1d agonistenInfo
- Publication number
- ATE254122T1 ATE254122T1 AT98942759T AT98942759T ATE254122T1 AT E254122 T1 ATE254122 T1 AT E254122T1 AT 98942759 T AT98942759 T AT 98942759T AT 98942759 T AT98942759 T AT 98942759T AT E254122 T1 ATE254122 T1 AT E254122T1
- Authority
- AT
- Austria
- Prior art keywords
- ht1b
- indole derivatives
- ht1d agonists
- ht1d
- agonists
- Prior art date
Links
- 101710138639 5-hydroxytryptamine receptor 1B Proteins 0.000 title 1
- 102100027499 5-hydroxytryptamine receptor 1B Human genes 0.000 title 1
- 101710138068 5-hydroxytryptamine receptor 1D Proteins 0.000 title 1
- 102100027493 5-hydroxytryptamine receptor 1D Human genes 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- ZFKIEMWXMVCZHP-UHFFFAOYSA-N 1h-indole;piperazine Chemical class C1CNCCN1.C1=CC=C2NC=CC2=C1 ZFKIEMWXMVCZHP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9710606A FR2767527B1 (fr) | 1997-08-25 | 1997-08-25 | Derives de piperazines indoliques, utiles comme medicaments et procede de preparation |
| PCT/FR1998/001826 WO1999010344A1 (fr) | 1997-08-25 | 1998-08-20 | Derives d'indole comme agonistes de 5-ht1b et 5-ht1d |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE254122T1 true ATE254122T1 (de) | 2003-11-15 |
Family
ID=9510463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98942759T ATE254122T1 (de) | 1997-08-25 | 1998-08-20 | Indolderivate als 5-ht1b und 5-ht1d agonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6277853B1 (de) |
| EP (1) | EP1007524B1 (de) |
| JP (1) | JP2001514180A (de) |
| CN (1) | CN1272108A (de) |
| AT (1) | ATE254122T1 (de) |
| AU (1) | AU736074B2 (de) |
| BR (1) | BR9811348A (de) |
| CA (1) | CA2301750A1 (de) |
| DE (1) | DE69819742D1 (de) |
| FR (1) | FR2767527B1 (de) |
| WO (1) | WO1999010344A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1482931B1 (de) * | 2002-03-05 | 2011-10-19 | TransTech Pharma, Inc. | Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen |
| DK1587821T6 (da) * | 2002-12-19 | 2025-05-26 | Scripps Research Inst | Sammensætninger og fremgangsmåder til stabilisering af trans-thyretin og inhibering af transthyretin-fejlfoldning |
| AU2004210711B2 (en) * | 2003-02-12 | 2010-07-08 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
| CN1805743A (zh) * | 2003-05-20 | 2006-07-19 | 特兰斯泰克制药公司 | 用作逆转淀粉样变性及其他与之相关疾病的rage拮抗剂 |
| WO2005080346A1 (en) * | 2004-02-12 | 2005-09-01 | Transtech Pharma, Inc. | Substituted azole derivatives, compositions, and methods of use |
| WO2005112913A1 (en) * | 2004-05-20 | 2005-12-01 | The Scripps Research Institute | Transthyretin stabilization |
| CA2636929A1 (en) | 2005-12-21 | 2007-07-12 | Decode Genetics, Ehf | Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation |
| EP1991544B1 (de) * | 2006-01-30 | 2018-08-15 | vTv Therapeutics LLC | Substituierte imidazol- derivate und ihre verwendung als ptpase inhibitoren |
| WO2008034016A2 (en) * | 2006-09-15 | 2008-03-20 | Foldrx Pharmaceuticals, Inc. | Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins |
| WO2011002067A1 (ja) * | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| CA2772797C (en) | 2009-09-30 | 2018-09-25 | Transtech Pharma, Inc. | Substituted imidazole derivatives |
| WO2013038351A1 (en) | 2011-09-16 | 2013-03-21 | Pfizer Inc. | Solid forms of a transthyretin dissociation inhibitor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2699918B1 (fr) * | 1992-12-30 | 1995-03-17 | Pf Medicament | Ligands sélectifs des récepteurs 5HY1D-5HT1B dérivés d'indole-pipérazine utiles comme médicaments. |
| FR2712591B1 (fr) * | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
-
1997
- 1997-08-25 FR FR9710606A patent/FR2767527B1/fr not_active Expired - Fee Related
-
1998
- 1998-08-20 JP JP2000507673A patent/JP2001514180A/ja active Pending
- 1998-08-20 CA CA002301750A patent/CA2301750A1/fr not_active Abandoned
- 1998-08-20 AU AU90774/98A patent/AU736074B2/en not_active Ceased
- 1998-08-20 EP EP98942759A patent/EP1007524B1/de not_active Expired - Lifetime
- 1998-08-20 DE DE69819742T patent/DE69819742D1/de not_active Expired - Lifetime
- 1998-08-20 US US09/486,258 patent/US6277853B1/en not_active Expired - Fee Related
- 1998-08-20 CN CN98809585A patent/CN1272108A/zh active Pending
- 1998-08-20 AT AT98942759T patent/ATE254122T1/de not_active IP Right Cessation
- 1998-08-20 WO PCT/FR1998/001826 patent/WO1999010344A1/fr not_active Ceased
- 1998-08-20 BR BR9811348-8A patent/BR9811348A/pt not_active IP Right Cessation
-
2001
- 2001-07-11 US US09/903,469 patent/US6589953B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007524B1 (de) | 2003-11-12 |
| FR2767527B1 (fr) | 1999-11-12 |
| EP1007524A1 (de) | 2000-06-14 |
| AU9077498A (en) | 1999-03-16 |
| JP2001514180A (ja) | 2001-09-11 |
| DE69819742D1 (de) | 2003-12-18 |
| WO1999010344A1 (fr) | 1999-03-04 |
| AU736074B2 (en) | 2001-07-26 |
| US6277853B1 (en) | 2001-08-21 |
| CN1272108A (zh) | 2000-11-01 |
| FR2767527A1 (fr) | 1999-02-26 |
| US20020061891A1 (en) | 2002-05-23 |
| CA2301750A1 (fr) | 1999-03-04 |
| US6589953B2 (en) | 2003-07-08 |
| BR9811348A (pt) | 2000-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |