ATE254129T1 - Fluoreszierende chelate als gewebespezifische bildgebende mittel - Google Patents

Fluoreszierende chelate als gewebespezifische bildgebende mittel

Info

Publication number
ATE254129T1
ATE254129T1 AT97918519T AT97918519T ATE254129T1 AT E254129 T1 ATE254129 T1 AT E254129T1 AT 97918519 T AT97918519 T AT 97918519T AT 97918519 T AT97918519 T AT 97918519T AT E254129 T1 ATE254129 T1 AT E254129T1
Authority
AT
Austria
Prior art keywords
tissue
imaging agents
specific imaging
chelates
fluorescent
Prior art date
Application number
AT97918519T
Other languages
English (en)
Inventor
Garry E Kiefer
Darryl J Bornhop
Original Assignee
Dow Global Technologies Inc
Univ Texas Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc, Univ Texas Tech filed Critical Dow Global Technologies Inc
Application granted granted Critical
Publication of ATE254129T1 publication Critical patent/ATE254129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97918519T 1996-04-19 1997-04-08 Fluoreszierende chelate als gewebespezifische bildgebende mittel ATE254129T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63514296A 1996-04-19 1996-04-19
US72833996A 1996-10-09 1996-10-09
PCT/US1997/005692 WO1997040055A1 (en) 1996-04-19 1997-04-08 Fluorescent chelates as visual tissue specific imaging agents

Publications (1)

Publication Number Publication Date
ATE254129T1 true ATE254129T1 (de) 2003-11-15

Family

ID=27092308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97918519T ATE254129T1 (de) 1996-04-19 1997-04-08 Fluoreszierende chelate als gewebespezifische bildgebende mittel

Country Status (11)

Country Link
US (1) US5928627A (de)
EP (1) EP0898574B1 (de)
KR (1) KR20000010533A (de)
AT (1) ATE254129T1 (de)
AU (1) AU719002B2 (de)
CA (1) CA2251924C (de)
DE (1) DE69726135T2 (de)
IL (1) IL126659A (de)
NO (1) NO984840L (de)
TW (1) TW422841B (de)
WO (1) WO1997040055A1 (de)

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US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
AU4847100A (en) * 1999-05-14 2000-12-05 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
WO2001027699A1 (en) * 1999-10-14 2001-04-19 Meridian Chemical Technologies, Inc. Method for authentication of an item
US6748259B1 (en) 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US6686203B2 (en) * 2000-09-11 2004-02-03 William J. Calvo Histologic visualization of cyanoacrylate embolization
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
AU2002323528C1 (en) * 2001-09-04 2009-11-12 Texas Tech University Multi-use multimodal imaging chelates
US6962690B2 (en) 2001-10-22 2005-11-08 Dow Global Technologies Inc. Tissue specific fluorescent chelates possessing long wavelength UV excitation
WO2003035114A1 (en) * 2001-10-22 2003-05-01 Dow Global Technologies Inc. Radiopharmaceutical agent for the treatment of early stage cancer
US20030185870A1 (en) 2001-11-20 2003-10-02 Grinstaff Mark W. Interfacial biomaterials
US20020106811A1 (en) * 2002-04-14 2002-08-08 Jefferson Trent D. Method for authentication of an item
US7754884B2 (en) 2005-01-03 2010-07-13 Vanderbilt University Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
US8188116B2 (en) 2002-09-04 2012-05-29 Vanderbilt University Agents for therapy efficacy monitoring and deep tissue imaging
CA2533621C (en) * 2003-06-20 2013-12-10 The Texas A & M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
EP1646926A2 (de) 2003-07-18 2006-04-19 Cytokinetics, Inc. Charakterisierung biologischer stimuli durch ansprechkurven
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
CN1871233B (zh) * 2003-08-29 2011-07-13 沃拉克有限公司 新型螯合剂和螯合物及其应用
US8071626B2 (en) 2003-12-18 2011-12-06 Wallac Oy Chelating agents and highly luminescent and stable chelates and their use
EP1694672B1 (de) * 2003-12-18 2012-06-20 Wallac Oy Neue chelatisierungsmittel und hochlumineszente und stabile chelate sowie deren anwendung
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
WO2006020779A2 (en) * 2004-08-10 2006-02-23 Dow Global Technologies Inc. Targeting chelants and chelates
US20060033752A1 (en) * 2004-08-13 2006-02-16 Gering David T Method and apparatus for displaying pixel data
WO2007104135A1 (en) 2006-03-10 2007-09-20 Mds (Canada) Inc. Bifunctional polyazamacrocyclic chelating agents
US8140141B2 (en) * 2006-05-17 2012-03-20 University Of Utah Research Foundation Devices and methods for fluorescent inspection and/or removal of material in a sample
US7570986B2 (en) * 2006-05-17 2009-08-04 The United States Of America As Represented By The Secretary Of Health And Human Services Teniae coli guided navigation and registration for virtual colonoscopy
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US7595699B1 (en) * 2008-03-04 2009-09-29 Freescale Semiconductor, Inc. Look loop circuit and method having improved lock time
GB0804190D0 (en) * 2008-03-06 2008-04-16 Ge Healthcare Ltd Ester imaging agents
WO2010075003A1 (en) * 2008-12-16 2010-07-01 The University Of Akron Lanthanide ion complexes and imaging method
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
RU2435642C1 (ru) * 2010-05-18 2011-12-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ГОУ ВПО КубГУ) Способ получения материала на основе целлюлозы и его применение для определения тяжелых металлов
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
ES2830392T3 (es) 2014-07-23 2021-06-03 Ohio State Innovation Foundation Métodos y composiciones relacionados con fragmentos de anticuerpo que se unen a la glicoproteína 72 asociada a tumores (TAG-72)
WO2016118812A1 (en) 2015-01-23 2016-07-28 Vanderbilt University A robust interferometer and methods of using same
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
EP3483592B1 (de) * 2016-07-05 2020-07-22 Konica Minolta, Inc. Verfahren zur quantifizierung von biologischem material, bildverarbeitungsvorrichtung, system zur unterstützung von pathologischen diagnosen und programm
ES2867895T3 (es) 2018-11-30 2021-10-21 Phytobiotics Futterzusatzstoffe Gmbh Sistema para el análisis de imágenes de excrementos de animales

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SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
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FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
DK0570575T3 (da) * 1991-12-10 1998-08-24 Dow Chemical Co Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf
US5312922A (en) * 1992-04-06 1994-05-17 Nordion International Inc. Europium and terbium chelators for time-resolved fluorometric assays
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
JPH08509976A (ja) * 1993-05-06 1996-10-22 ザ・ダウ・ケミカル・カンパニー コントラスト剤として使用するためのビシクロポリアザマクロシクロホスホン酸、それらの錯体および複合体ならびにそれらの製造方法
US5462725A (en) * 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1994026755A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes, a process for their preparation, and their conjugates, for use as radiopharmaceuticals
US5457186A (en) * 1993-10-13 1995-10-10 Wallac Oy Luminescent lanthanide chelates with decreased non-radiative energy loss
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence

Also Published As

Publication number Publication date
KR20000010533A (ko) 2000-02-15
EP0898574B1 (de) 2003-11-12
WO1997040055A1 (en) 1997-10-30
US5928627A (en) 1999-07-27
DE69726135D1 (de) 2003-12-18
NO984840D0 (no) 1998-10-16
CA2251924C (en) 2006-05-30
CA2251924A1 (en) 1997-10-30
AU719002B2 (en) 2000-05-04
IL126659A (en) 2003-05-29
AU2660697A (en) 1997-11-12
DE69726135T2 (de) 2004-08-26
NO984840L (no) 1998-12-16
IL126659A0 (en) 1999-08-17
EP0898574A1 (de) 1999-03-03
TW422841B (en) 2001-02-21

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Legal Events

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