ATE254129T1 - Fluoreszierende chelate als gewebespezifische bildgebende mittel - Google Patents

Fluoreszierende chelate als gewebespezifische bildgebende mittel

Info

Publication number
ATE254129T1
ATE254129T1 AT97918519T AT97918519T ATE254129T1 AT E254129 T1 ATE254129 T1 AT E254129T1 AT 97918519 T AT97918519 T AT 97918519T AT 97918519 T AT97918519 T AT 97918519T AT E254129 T1 ATE254129 T1 AT E254129T1
Authority
AT
Austria
Prior art keywords
tissue
imaging agents
specific imaging
chelates
fluorescent
Prior art date
Application number
AT97918519T
Other languages
English (en)
Inventor
Garry E Kiefer
Darryl J Bornhop
Original Assignee
Dow Global Technologies Inc
Univ Texas Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc, Univ Texas Tech filed Critical Dow Global Technologies Inc
Application granted granted Critical
Publication of ATE254129T1 publication Critical patent/ATE254129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97918519T 1996-04-19 1997-04-08 Fluoreszierende chelate als gewebespezifische bildgebende mittel ATE254129T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63514296A 1996-04-19 1996-04-19
US72833996A 1996-10-09 1996-10-09
PCT/US1997/005692 WO1997040055A1 (en) 1996-04-19 1997-04-08 Fluorescent chelates as visual tissue specific imaging agents

Publications (1)

Publication Number Publication Date
ATE254129T1 true ATE254129T1 (de) 2003-11-15

Family

ID=27092308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97918519T ATE254129T1 (de) 1996-04-19 1997-04-08 Fluoreszierende chelate als gewebespezifische bildgebende mittel

Country Status (11)

Country Link
US (1) US5928627A (de)
EP (1) EP0898574B1 (de)
KR (1) KR20000010533A (de)
AT (1) ATE254129T1 (de)
AU (1) AU719002B2 (de)
CA (1) CA2251924C (de)
DE (1) DE69726135T2 (de)
IL (1) IL126659A (de)
NO (1) NO984840L (de)
TW (1) TW422841B (de)
WO (1) WO1997040055A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7328059B2 (en) * 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
WO2000070528A2 (en) * 1999-05-14 2000-11-23 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
WO2001027699A1 (en) * 1999-10-14 2001-04-19 Meridian Chemical Technologies, Inc. Method for authentication of an item
US6748259B1 (en) 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US6686203B2 (en) * 2000-09-11 2004-02-03 William J. Calvo Histologic visualization of cyanoacrylate embolization
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
EP1429783A4 (de) * 2001-09-04 2006-08-09 Univ Texas Tech Vielseitig einsetzbare chelate für die multimodale bildeinstellung
DE60212424T2 (de) * 2001-10-22 2006-10-12 Dow Global Technologies, Inc., Midland Radiopharmazeutisches mittel zur behandlung von krebs im frühstadium
DE60207288T2 (de) * 2001-10-22 2006-05-18 Dow Global Technologies, Inc., Midland Gewebespezifische fluoreszierende chelate
AU2002367566B2 (en) 2001-11-20 2008-10-16 Duke University Interfacial biomaterials
US20020106811A1 (en) * 2002-04-14 2002-08-08 Jefferson Trent D. Method for authentication of an item
US8188116B2 (en) 2002-09-04 2012-05-29 Vanderbilt University Agents for therapy efficacy monitoring and deep tissue imaging
US7754884B2 (en) * 2005-01-03 2010-07-13 Vanderbilt University Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
EP1654531A1 (de) * 2003-06-20 2006-05-10 The Texas A & M University System Verfahren und system zum fluoreszenz-kontrastverstärkten abbilden im nahinfrarotbereich mit flächiger beleuchtung und flächiger detektion
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
GB2423988A (en) 2003-07-18 2006-09-13 Cytokinetics Inc Characterizing biological stimuli by response curves
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
EP1658282B1 (de) * 2003-08-29 2010-10-27 Wallac Oy Neue chelatbildner und chelate und deren verwendung
US8071626B2 (en) 2003-12-18 2011-12-06 Wallac Oy Chelating agents and highly luminescent and stable chelates and their use
CA2550074A1 (en) * 2003-12-18 2005-06-30 Wallac Oy Novel chelating agents and highly luminescent and stable chelates and their use
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
US20060033752A1 (en) * 2004-08-13 2006-02-16 Gering David T Method and apparatus for displaying pixel data
JP5503149B2 (ja) 2006-03-10 2014-05-28 ノルディオン・（カナダ）・インコーポレイテッド 二官能性ポリアザ大環状キレート剤
US7570986B2 (en) * 2006-05-17 2009-08-04 The United States Of America As Represented By The Secretary Of Health And Human Services Teniae coli guided navigation and registration for virtual colonoscopy
US8140141B2 (en) * 2006-05-17 2012-03-20 University Of Utah Research Foundation Devices and methods for fluorescent inspection and/or removal of material in a sample
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US7595699B1 (en) * 2008-03-04 2009-09-29 Freescale Semiconductor, Inc. Look loop circuit and method having improved lock time
GB0804190D0 (en) * 2008-03-06 2008-04-16 Ge Healthcare Ltd Ester imaging agents
WO2010075003A1 (en) * 2008-12-16 2010-07-01 The University Of Akron Lanthanide ion complexes and imaging method
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
RU2435642C1 (ru) * 2010-05-18 2011-12-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ГОУ ВПО КубГУ) Способ получения материала на основе целлюлозы и его применение для определения тяжелых металлов
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
CA2956161A1 (en) 2014-07-23 2016-01-28 Ohio State Innovation Foundation Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)
EP3247988A4 (de) 2015-01-23 2018-12-19 Vanderbilt University Robustes interferometer und verfahren zur verwendung davon
EP3408649B1 (de) 2016-01-29 2023-06-14 Vanderbilt University Interferometrie mit antwortfunktion in freier lösung
JP6911855B2 (ja) * 2016-07-05 2021-07-28 コニカミノルタ株式会社 生体物質定量方法、画像処理装置、病理診断支援システム及びプログラム
ES2867895T3 (es) 2018-11-30 2021-10-21 Phytobiotics Futterzusatzstoffe Gmbh Sistema para el análisis de imágenes de excrementos de animales

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
US5645818A (en) * 1989-03-24 1997-07-08 Guerbet S.A. Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
CA2042075C (en) * 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
WO1994026754A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
EP0570575B1 (de) * 1991-12-10 1997-12-10 The Dow Chemical Company Bicycloazamakrocyclophosphon-Säure, Komplexe, Konjugate, Kontrastmittel und Herstellung
US5312922A (en) * 1992-04-06 1994-05-17 Nordion International Inc. Europium and terbium chelators for time-resolved fluorometric assays
US5462725A (en) * 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1994026755A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes, a process for their preparation, and their conjugates, for use as radiopharmaceuticals
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5457186A (en) * 1993-10-13 1995-10-10 Wallac Oy Luminescent lanthanide chelates with decreased non-radiative energy loss
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence

Also Published As

Publication number Publication date
DE69726135D1 (de) 2003-12-18
NO984840D0 (no) 1998-10-16
EP0898574A1 (de) 1999-03-03
US5928627A (en) 1999-07-27
KR20000010533A (ko) 2000-02-15
IL126659A (en) 2003-05-29
CA2251924A1 (en) 1997-10-30
NO984840L (no) 1998-12-16
TW422841B (en) 2001-02-21
AU719002B2 (en) 2000-05-04
WO1997040055A1 (en) 1997-10-30
AU2660697A (en) 1997-11-12
EP0898574B1 (de) 2003-11-12
DE69726135T2 (de) 2004-08-26
IL126659A0 (en) 1999-08-17
CA2251924C (en) 2006-05-30

Similar Documents

Publication Publication Date Title
DE69726135D1 (de) Fluoreszierende chelate als gewebespezifische bildgebende mittel
DK1021712T3 (da) Phosphorescerende dendritiske makromolekylære forbindelser til billeddannelse af oxygen i væv
ATE316377T1 (de) Tricyclopolyazamacrocyclophosphonsäuren, ihre komplexe und derivate, für eine verwendung als kontrastmittel
DE69819309D1 (de) Verabreichbare formulierugen und ihre anwendung in mri
DE69431660D1 (de) 2-pyridylmethylen-polyazamacrocyclophosphonsäuren, ihre komplexe und derivate zur verwendung als kontrastmittel
DE60131257D1 (de) Diffusionsbildgebung von gewebe
NO923821D0 (no) Diagnostiske midler
FR2753897B1 (fr) Dispositif pour le diagnostic endoscopique photodynamique de tissu tumoral
EP1409549A4 (de) Zusammensetzungen und verfahren für die diagnose und behandlung von tumoren
EE200200321A (et) Lähi-infrapunafluorestsentskontrastaine ja fluorestsentskuvamine
DE60207288D1 (de) Gewebespezifische fluoreszierende chelate
DE69827633D1 (de) Oxidationszusammensetzung und verwendungen derselben für die behandlung von keratinischen fasern
DE69838509D1 (de) Verwendung von rekombinanten menschlichen uteroglobin zur behandlung von fibrotischen krankheitszuständen
HU0101295D0 (en) Composition for the oxidation dyeing of keratin fibres and dyeing process using it
HU0000670D0 (en) Composition for the oxidation dyeing of keratin fibres and dyeing process using this composition
FR2807653B1 (fr) Composition de teinture d'oxydation des fibres keratiniques comprenant une 1-(4-aminophenyl)-pyrrolidine et un systeme enzymatique
AU2001294165A1 (en) Apparatus for prostate cancer diagnose
TR200001715T2 (tr) Potasyum kanalı açıcıları.
FI972285L (fi) Kelaattiyhdisteiden käyttö röntgendiagnostisina aineina maksa- ja sappitutkimuksissa
AU2002232433A1 (en) Methods and compositions for diagnosis and treatment of cancer using arginine m ethyltransferase 3
ATE265840T1 (de) Oxidationsfärbemittel für keratinfasern, das eine laccase enthält, und verfahren zur färbung mit diesem mittel
IL145589A0 (en) In vivo stain compounds and methods of use to identify dysplastic tissue
UA28113C2 (uk) Спосіб експрес-тестування ефективності реабілітації здоров'я людини
UA29506C2 (uk) Лікувально-косметичний засіб "фіто-пелоїд"
GB0018989D0 (en) The novel use of medium/long chain fatty acids (carbon chain length 4-16) to preserve and protect human organ function during transplantation,transportation &

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties