ATE255123T1 - Dinucleotid-kristalle - Google Patents

Dinucleotid-kristalle

Info

Publication number: ATE255123T1
Authority: AT; Austria
Prior art keywords: dcp4u; present; crystals; monophosphate; raw material
Prior art date: 1999-06-30

Application number

AT00942412T

Other languages

English (en)

Inventor

Kenya Mori

Takanori Miyashita

Hideaki Maeda

Hiroshi Sato

Yutaka Noda

Original Assignee

Yamasa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-30

Filing date

2000-06-30

Publication date

2003-12-15

2000-06-30 Application filed by Yamasa Corp filed Critical Yamasa Corp

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE255123T1 publication Critical patent/ATE255123T1/de

Links

239000013078 crystal Substances 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 4
DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 abstract 3
DJJCXFVJDGTHFX-ZAKLUEHWSA-N uridine-5'-monophosphate Chemical compound O[C@@H]1[C@@H](O)[C@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-ZAKLUEHWSA-N 0.000 abstract 3
NCMVOABPESMRCP-SHYZEUOFSA-N 2'-deoxycytosine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 NCMVOABPESMRCP-SHYZEUOFSA-N 0.000 abstract 2
BHIIGRBMZRSDRI-UHFFFAOYSA-N [chloro(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(Cl)OC1=CC=CC=C1 BHIIGRBMZRSDRI-UHFFFAOYSA-N 0.000 abstract 2
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 2
239000002994 raw material Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
235000011180 diphosphates Nutrition 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT00942412T 1999-06-30 2000-06-30 Dinucleotid-kristalle ATE255123T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18495099		1999-06-30
PCT/JP2000/004336 WO2001002416A1 (en)	1999-06-30	2000-06-30	Dinucleotide crystals

Publications (1)

Publication Number	Publication Date
ATE255123T1 true ATE255123T1 (de)	2003-12-15

Family

ID=16162200

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT00942412T ATE255123T1 (de)	1999-06-30	2000-06-30	Dinucleotid-kristalle
AT03018399T ATE300551T1 (de)	1999-06-30	2000-06-30	Dinukleotid-kristalle

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT03018399T ATE300551T1 (de)	1999-06-30	2000-06-30	Dinukleotid-kristalle

Country Status (22)

Country	Link
US (1)	US6617444B1 (de)
EP (2)	EP1191032B1 (de)
JP (1)	JP3421666B2 (de)
KR (1)	KR100593723B1 (de)
CN (1)	CN1144811C (de)
AT (2)	ATE255123T1 (de)
AU (1)	AU767136B2 (de)
BR (1)	BR0012205A (de)
CA (1)	CA2376860C (de)
CZ (1)	CZ303172B6 (de)
DE (2)	DE60021629T2 (de)
EA (1)	EA004707B1 (de)
ES (2)	ES2245431T3 (de)
HU (1)	HU229225B1 (de)
IL (1)	IL147163A (de)
MX (1)	MXPA02000035A (de)
NO (1)	NO321169B1 (de)
NZ (1)	NZ516301A (de)
PL (2)	PL202176B1 (de)
SK (1)	SK284178B6 (de)
WO (1)	WO2001002416A1 (de)
ZA (1)	ZA200110468B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7078391B2 (en)	1997-02-10	2006-07-18	Inspire Pharmaceuticals, Inc.	Method of treating edematous retinal disorders
US6818629B2 (en)	1997-02-10	2004-11-16	Inspire Pharmaceuticals, Inc.	Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7223744B2 (en)	1997-02-10	2007-05-29	Inspire Pharmaceuticals, Inc.	Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6872710B2 (en)	1997-07-25	2005-03-29	Inspire Pharmaceuticals, Inc.	Di(uridine 5′)-tetraphosphate and salts thereof
US6548658B2 (en) *	1997-07-25	2003-04-15	Inspire Pharmaceuticals, Inc.	Di-(uridine 5′)-tetraphosphate and salts thereof
NZ516301A (en) *	1999-06-30	2003-07-25	Yamasa Corp	Dinucleotide crystals
US6867199B2 (en)	2000-08-21	2005-03-15	Inspire Pharmaceuticals, Inc.	Dinucleoside polyphosphate compositions and their therapeutic use
US7161029B2 (en) *	2003-12-17	2007-01-09	Ajinomoto Co., Inc.	DiL-lysine monosulfate trihydrate crystal and method of making
CN100363376C (zh) *	2006-06-12	2008-01-23	南京工业大学	一种5’-核苷三磷酸钠盐的结晶方法
CN114478660B (zh) *	2015-06-29	2025-03-18	雅玛山酱油株式会社	P1，p4-二(尿苷5′)-四磷酸晶体的保存方法
KR102259309B1 (ko) *	2016-10-25	2021-06-01	야마사 쇼유 가부시키가이샤	P1, p4-디(우리딘 5'-)테트라포스페이트의 정제 방법
CN111253456B (zh) *	2020-03-13	2021-05-11	广东先强药业有限公司	一种地纽福索钠的制备方法
CN111704637A (zh) *	2020-06-28	2020-09-25	南京工业大学	一种采用膜蒸馏结晶精制核苷酸的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07242685A (ja) *	1994-01-12	1995-09-19	Unitika Ltd	ジアデノシン四リン酸水和物の製造方法
US5900407A (en) *	1997-02-06	1999-05-04	Inspire Pharmaceuticals, Inc.	Method of treating dry eye disease with uridine triphosphates and related compounds
US5837861A (en) *	1997-02-10	1998-11-17	Inspire Pharmaceuticals, Inc.	Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency
EP0981534B1 (de)	1997-02-06	2006-05-03	Inspire Pharmaceuticals, Inc.	Dinukleotide und ihre verwendungen
US6596725B2 (en) *	1997-02-10	2003-07-22	Inspire Pharmaceuticals, Inc.	Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
CA2295515C (en)	1997-07-25	2006-03-14	Inspire Pharmaceuticals, Inc.	Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof
TW593331B (en) *	1997-07-25	2004-06-21	Inspire Pharmaceuticals Inc	Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
DE69905464T2 (de) *	1998-05-22	2004-01-15	Inspire Pharmaceuticals Inc	Therapeutische dinucleotide und deren derivate
EP1043329B1 (de) *	1998-10-02	2002-08-28	Yamasa Corporation	Ein kristall von diuridine tetraphosphat oder ein solches salz und verfahren zu seiner herstellung, verfahren und herstellung der vorgenannten zusammensetzung
EP1140967A1 (de) *	1998-12-23	2001-10-10	University Of North Carolina At Chapel Hill	Gezielter gentransfer unter verwendung von an g-protein gekoppelten rezeptoren
NZ516301A (en) *	1999-06-30	2003-07-25	Yamasa Corp	Dinucleotide crystals

2000
- 2000-06-30 NZ NZ516301A patent/NZ516301A/en not_active IP Right Cessation
- 2000-06-30 US US09/700,728 patent/US6617444B1/en not_active Expired - Lifetime
- 2000-06-30 EP EP00942412A patent/EP1191032B1/de not_active Expired - Lifetime
- 2000-06-30 AT AT00942412T patent/ATE255123T1/de not_active IP Right Cessation
- 2000-06-30 WO PCT/JP2000/004336 patent/WO2001002416A1/ja not_active Ceased
- 2000-06-30 BR BR0012205-0A patent/BR0012205A/pt not_active Application Discontinuation
- 2000-06-30 AU AU57067/00A patent/AU767136B2/en not_active Ceased
- 2000-06-30 HU HU0201531A patent/HU229225B1/hu not_active IP Right Cessation
- 2000-06-30 MX MXPA02000035A patent/MXPA02000035A/es active IP Right Grant
- 2000-06-30 CN CNB008097356A patent/CN1144811C/zh not_active Expired - Fee Related
- 2000-06-30 DE DE60021629T patent/DE60021629T2/de not_active Expired - Lifetime
- 2000-06-30 ES ES03018399T patent/ES2245431T3/es not_active Expired - Lifetime
- 2000-06-30 AT AT03018399T patent/ATE300551T1/de not_active IP Right Cessation
- 2000-06-30 SK SK1870-2001A patent/SK284178B6/sk not_active IP Right Cessation
- 2000-06-30 DE DE60006814T patent/DE60006814T2/de not_active Expired - Lifetime
- 2000-06-30 PL PL384307A patent/PL202176B1/pl unknown
- 2000-06-30 IL IL14716300A patent/IL147163A/xx not_active IP Right Cessation
- 2000-06-30 KR KR1020017016184A patent/KR100593723B1/ko not_active Expired - Fee Related
- 2000-06-30 CZ CZ20014502A patent/CZ303172B6/cs not_active IP Right Cessation
- 2000-06-30 EA EA200200109A patent/EA004707B1/ru not_active IP Right Cessation
- 2000-06-30 EP EP03018399A patent/EP1362862B1/de not_active Expired - Lifetime
- 2000-06-30 ES ES00942412T patent/ES2211566T3/es not_active Expired - Lifetime
- 2000-06-30 PL PL352363A patent/PL202200B1/pl unknown
- 2000-06-30 JP JP2001507852A patent/JP3421666B2/ja not_active Expired - Fee Related
- 2000-06-30 CA CA002376860A patent/CA2376860C/en not_active Expired - Fee Related
2001
- 2001-12-20 ZA ZA200110468A patent/ZA200110468B/en unknown
- 2001-12-27 NO NO20016381A patent/NO321169B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
MXPA02000035A (es)	2003-07-21
NZ516301A (en)	2003-07-25
DE60021629D1 (de)	2005-09-01
CA2376860C (en)	2006-11-07
PL202176B1 (pl)	2009-06-30
EA200200109A1 (ru)	2002-06-27
CZ20014502A3 (cs)	2002-05-15
SK284178B6 (sk)	2004-10-05
ES2245431T3 (es)	2006-01-01
HUP0201531A2 (en)	2002-08-28
CZ303172B6 (cs)	2012-05-09
NO20016381D0 (no)	2001-12-27
PL202200B1 (pl)	2009-06-30
AU767136B2 (en)	2003-10-30
CN1359387A (zh)	2002-07-17
ZA200110468B (en)	2003-04-04
EA004707B1 (ru)	2004-06-24
AU5706700A (en)	2001-01-22
NO20016381L (no)	2002-02-28
SK18702001A3 (sk)	2002-06-04
EP1191032A1 (de)	2002-03-27
CA2376860A1 (en)	2001-01-11
DE60006814D1 (de)	2004-01-08
PL352363A1 (en)	2003-08-25
EP1362862B1 (de)	2005-07-27
ATE300551T1 (de)	2005-08-15
BR0012205A (pt)	2002-05-28
ES2211566T3 (es)	2004-07-16
EP1362862A1 (de)	2003-11-19
DE60021629T2 (de)	2006-01-05
JP3421666B2 (ja)	2003-06-30
EP1191032B1 (de)	2003-11-26
HUP0201531A3 (en)	2005-02-28
IL147163A0 (en)	2002-08-14
US6617444B1 (en)	2003-09-09
KR20020028903A (ko)	2002-04-17
CN1144811C (zh)	2004-04-07
IL147163A (en)	2005-11-20
HU229225B1 (en)	2013-09-30
DE60006814T2 (de)	2004-05-19
NO321169B1 (no)	2006-03-27
WO2001002416A1 (en)	2001-01-11
EP1191032A4 (de)	2002-07-17
KR100593723B1 (ko)	2006-06-30

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE300551T1 (de)	2005-08-15	Dinukleotid-kristalle
FI104176B (fi)	1999-11-30	Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi
CA2028151A1 (en)	1990-10-14	Antiviral compounds
CA2051239A1 (en)	1992-03-15	Prodrugs of phosphonates
CA2295515A1 (en)	1999-02-04	Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof
FR2374334A1 (fr)	1978-07-13	Nouveaux nucleosides utiles comme medicaments et procede pour leur preparation
AU747096C (en)	2003-01-23	Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same, and method for producing said compound
ES2019685B3 (es)	1991-07-01	Procedimiento para la fabricacion de productos firmes o en forma de pasta
RU95108553A (ru)	1996-11-20	Способ получения нуклеозидных аналогов с использованием бициклических промежуточных продуктов
CA2135853A1 (en)	1995-05-16	Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
EA199900291A1 (ru)	1999-08-26	Натриевая соль поли-(2,5-дигидрокси-фенилен)-4-тиосульфокислоты линейного строения как регулятор метаболизма клетки и способ ее получения
KR100243440B1 (ko)	2000-03-02	세코-누클레오시드의 리포누클레오티드, 이들의 제조방법 및 항바이러스제로서 이들을 사용하는 방법
RU95103392A (ru)	1996-12-20	Способ получения 1-гидроксиадамантана
EP0590539A3 (de)	1994-04-13	Tetrathiafulvalene Derivate Vorlaüfer, Terathiafulvalene Derivate und Verfahren zu deren Herstellung
JPS565458A (en)	1981-01-20	Preparation of 1-ethyl-2- 2-methoxy-5- sulfamoylbenzamidemethyl pyrrolidine
KR100325682B1 (ko)	2002-02-25	2',3'-디디하이드로-2',3'-디데옥시시티딘 유도체의 제조방법
JPS6490161A (en)	1989-04-06	Production of optically active cyanohydrin or its enantiomer
RO113859B1 (ro)	1998-11-30	Procedeu pentru prepararea diclorurii bis(2-cloretil) amidofosforice
JPH0667940B2 (ja)	1994-08-31	２’，３’‐ジデオキシプリンヌクレオシド類の製造方法
JPS6414199A (en)	1989-01-18	Production of high purity beta-form silicon nitride whisker
CA2024796A1 (en)	1992-03-07	Process for producing chlorosulfonyl isocyanate
KR960014130A (ko)	1996-05-22	세펨 유도체의 제조방법
TH38735A3 (th)	2000-06-21	กระบวนการสำหรับการผลิตตะแกรงโมเลกุล
LV12664A (lv)	2001-05-20	Synthesis of 4-substituted 2-oxobutenic acid sodium salts