ATE255561T1 - Verfahren und zusammensetzungen zur behandlung von leukämie - Google Patents

Verfahren und zusammensetzungen zur behandlung von leukämie

Info

Publication number: ATE255561T1
Authority: AT; Austria
Prior art keywords: methods; compositions; treating leukemia; aryl; thiazole
Prior art date: 1999-03-12

Application number

AT00908883T

Other languages

English (en)

Inventor

Chaim M Roifman

Aviv Gazit

Alexander Levitzki

Original Assignee

Hsc Res Dev Lp

Yissum Res Dev Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-12

Filing date

2000-03-13

Publication date

2003-12-15

2000-03-13 Application filed by Hsc Res Dev Lp, Yissum Res Dev Co filed Critical Hsc Res Dev Lp

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE255561T1 publication Critical patent/ATE255561T1/de

Links

208000032839 leukemia Diseases 0.000 title 1
239000000203 mixture Substances 0.000 title 1
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
230000001613 neoplastic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Hematology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT00908883T 1999-03-12 2000-03-13 Verfahren und zusammensetzungen zur behandlung von leukämie ATE255561T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002265396A CA2265396A1 (en)	1999-03-12	1999-03-12	Methods and compositions for treating leukemia
PCT/CA2000/000266 WO2000055128A1 (en)	1999-03-12	2000-03-13	Methods and compositions for treating leukemia

Publications (1)

Publication Number	Publication Date
ATE255561T1 true ATE255561T1 (de)	2003-12-15

Family

ID=4163382

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00908883T ATE255561T1 (de)	1999-03-12	2000-03-13	Verfahren und zusammensetzungen zur behandlung von leukämie

Country Status (7)

Country	Link
EP (1)	EP1161417B1 (de)
AT (1)	ATE255561T1 (de)
AU (1)	AU3140300A (de)
CA (1)	CA2265396A1 (de)
DE (1)	DE60006944T2 (de)
IL (1)	IL145385A0 (de)
WO (1)	WO2000055128A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0122914D0 (en) *	2001-09-22	2001-11-14	Univ Nottingham	Modulation of stat activity
WO2003068157A2 (en) *	2002-02-11	2003-08-21	The Brigham And Women's Hospital, Inc.	Kinase inhibitors and methods of use thereof
EP2061768A2 (de)	2006-09-28	2009-05-27	Exelixis, Inc.	Imidazol-4,5-dicarboxamide derivaten als jak-modulatoren
US8173688B2 (en) *	2008-06-13	2012-05-08	Nexmed Holdings, Inc.	Thiazole compounds, and compositions and methods using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6910994A (en) *	1993-05-14	1994-12-12	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Methods and compounds for inhibiting cell proliferative disorders characterized by abnormal (abl) activity
AU2096895A (en) *	1994-03-07	1995-09-25	Sugen, Incorporated	Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof

1999
- 1999-03-12 CA CA002265396A patent/CA2265396A1/en not_active Abandoned
2000
- 2000-03-13 AT AT00908883T patent/ATE255561T1/de not_active IP Right Cessation
- 2000-03-13 EP EP00908883A patent/EP1161417B1/de not_active Expired - Lifetime
- 2000-03-13 DE DE60006944T patent/DE60006944T2/de not_active Expired - Fee Related
- 2000-03-13 IL IL14538500A patent/IL145385A0/xx unknown
- 2000-03-13 WO PCT/CA2000/000266 patent/WO2000055128A1/en not_active Ceased
- 2000-03-13 AU AU31403/00A patent/AU3140300A/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2265396A1 (en)	2000-09-12
DE60006944D1 (de)	2004-01-15
EP1161417A1 (de)	2001-12-12
EP1161417B1 (de)	2003-12-03
IL145385A0 (en)	2002-06-30
DE60006944T2 (de)	2004-11-11
WO2000055128A1 (en)	2000-09-21
AU3140300A (en)	2000-10-04

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Legal Events

Date	Code	Title	Description
2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties