ATE256118T1 - Verfahren zur herstellung von benzofuranen oder benzothiophenen - Google Patents

Verfahren zur herstellung von benzofuranen oder benzothiophenen

Info

Publication number: ATE256118T1
Authority: AT; Austria
Prior art keywords: cyclizing; chain; carbon atoms; benzofuranes; benzothiophenes
Prior art date: 1999-10-21

Application number

AT00971484T

Other languages

English (en)

Inventor

Thierry Schlama

Original Assignee

Rhodia Chimie Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2000-10-23

Publication date

2003-12-15

1999-10-21 Priority claimed from FR9913251A external-priority patent/FR2800064B1/fr

2000-05-24 Priority claimed from FR0006629A external-priority patent/FR2809397B1/fr

2000-10-23 Application filed by Rhodia Chimie Sa filed Critical Rhodia Chimie Sa

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256118T1 publication Critical patent/ATE256118T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
150000001491 aromatic compounds Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
-1 benzothiophene compound Chemical class 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
FCEHBMOGCRZNNI-UHFFFAOYSA-N thianaphthalene Natural products C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
- C07B37/10—Cyclisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT00971484T 1999-10-21 2000-10-23 Verfahren zur herstellung von benzofuranen oder benzothiophenen ATE256118T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9913251A FR2800064B1 (fr)	1999-10-21	1999-10-21	Procede de preparation d'un compose de type benzofurane ou benzothiophene
FR0006629A FR2809397B1 (fr)	2000-05-24	2000-05-24	Procede de preparation d'un compose de type benzofuranne ou benzothiophene
PCT/FR2000/002947 WO2001029019A1 (fr)	1999-10-21	2000-10-23	Procede de preparation d'un compose de type benzofurane ou benzothiophene

Publications (1)

Publication Number	Publication Date
ATE256118T1 true ATE256118T1 (de)	2003-12-15

Family

ID=26212419

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00971484T ATE256118T1 (de)	1999-10-21	2000-10-23	Verfahren zur herstellung von benzofuranen oder benzothiophenen

Country Status (13)

Country	Link
US (1)	US6555697B1 (de)
EP (1)	EP1222181B1 (de)
JP (1)	JP2003512365A (de)
CN (1)	CN1200935C (de)
AT (1)	ATE256118T1 (de)
AU (1)	AU1033101A (de)
BR (1)	BR0014810A (de)
CA (1)	CA2387724C (de)
DE (1)	DE60007164T2 (de)
ES (1)	ES2213050T3 (de)
HU (1)	HUP0203205A3 (de)
PT (1)	PT1222181E (de)
WO (1)	WO2001029019A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002230409A1 (en) *	2000-11-27	2002-06-03	Eli Lilly And Company	Process for preparing 3-aryl-benzo(b)thiophenes
IL146389A0 (en)	2001-11-08	2002-07-25	Isp Finetech Ltd	Process for the preparation of dronedarone
DE10237819A1 (de) *	2002-08-19	2004-03-04	Bayer Ag	5-Nitrobenzofurane
US6960669B2 (en) *	2003-09-10	2005-11-01	Crompton Co./Cie	Utilization of phosphorus pentasulfide in thionylations using phase transfer catalysis
FR2914643B1 (fr) *	2007-04-06	2009-06-05	Finorga Soc Par Actions Simpli	Procede de preparation du 2-(n-butyl)-5-nitrobenzofurane
FR2915482B1 (fr) *	2007-04-27	2009-11-27	Finorga	Procede de preparation du 2-(n-butyl)-5-nitrobenzofurane.
TW201107303A (en)	2009-05-27	2011-03-01	Sanofi Aventis	Process for the production of benzofurans
UY32657A (es) *	2009-05-27	2010-12-31	Sanofi Aventis	Procedimiento para la fabricación de productos intermedios de dronedarona
FR2958290B1 (fr)	2010-03-30	2012-10-19	Sanofi Aventis	Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en)	2010-06-18	2011-12-28	Sanofi Sa	Process for the preparation of dronedarone and the novel intermediates
WO2012032545A1 (en)	2010-09-08	2012-03-15	Cadila Healthcare Limited	Processes for preparing dronedarone and its intermediates
WO2012120544A2 (en)	2011-03-10	2012-09-13	Sun Pharmaceutical Industries Ltd.	PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
HUP1100167A2 (en)	2011-03-29	2012-11-28	Sanofi Sa	Process for preparation of dronedarone by mesylation
HUP1100165A2 (en)	2011-03-29	2012-12-28	Sanofi Sa	Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr)	2011-11-29	2013-11-15	Sanofi Sa	Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (de)	2012-01-20	2013-07-24	Sanofi	Verfahren zur Herstellung von Dronedaron unter Verwendung von Dibutylaminopropanolreagenz
WO2013121235A2 (en)	2012-02-13	2013-08-22	Sanofi	Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en)	2012-02-14	2016-02-02	Sanofi	Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en)	2012-02-22	2013-08-29	Sanofi	Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en)	2012-05-31	2016-01-19	Sanofi	Process for preparation of dronedarone by Grignard reaction
CN108675972B (zh) *	2018-08-01	2020-09-11	北京嘉林药业股份有限公司	一种盐酸胺碘酮中间体2-丁基苯并呋喃的制备方法
CN110483871A (zh) *	2019-08-15	2019-11-22	陈全明	一种抗压耐磨的hdpe双壁波纹管
CN114539193B (zh) *	2022-01-20	2024-08-06	安徽普利药业有限公司	一种盐酸胺碘酮中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3577441A (en)	1967-03-07	1971-05-04	Warner Lambert Pharmaceutical	Nitro substituted benzofurans
DE3031738A1 (de) *	1980-08-22	1982-04-01	Troponwerke GmbH & Co KG, 5000 Köln	Verfahren zur herstellung von benzo (b) thiophen-derivaten und ihre verwendung als zwischenprodukte
FR2665444B1 (fr) *	1990-08-06	1992-11-27	Sanofi Sa	Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2800067B1 (fr) *	1999-10-21	2004-12-17	Rhodia Chimie Sa	Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations

2000
- 2000-10-23 CN CNB008145709A patent/CN1200935C/zh not_active Expired - Fee Related
- 2000-10-23 AU AU10331/01A patent/AU1033101A/en not_active Abandoned
- 2000-10-23 AT AT00971484T patent/ATE256118T1/de not_active IP Right Cessation
- 2000-10-23 CA CA2387724A patent/CA2387724C/fr not_active Expired - Fee Related
- 2000-10-23 PT PT00971484T patent/PT1222181E/pt unknown
- 2000-10-23 WO PCT/FR2000/002947 patent/WO2001029019A1/fr not_active Ceased
- 2000-10-23 HU HU0203205A patent/HUP0203205A3/hu unknown
- 2000-10-23 US US10/110,443 patent/US6555697B1/en not_active Expired - Fee Related
- 2000-10-23 ES ES00971484T patent/ES2213050T3/es not_active Expired - Lifetime
- 2000-10-23 DE DE60007164T patent/DE60007164T2/de not_active Expired - Lifetime
- 2000-10-23 JP JP2001531819A patent/JP2003512365A/ja active Pending
- 2000-10-23 EP EP00971484A patent/EP1222181B1/de not_active Expired - Lifetime
- 2000-10-23 BR BR0014810-5A patent/BR0014810A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR0014810A (pt)	2002-06-11
WO2001029019A1 (fr)	2001-04-26
CA2387724A1 (fr)	2001-04-26
US6555697B1 (en)	2003-04-29
CA2387724C (fr)	2011-09-20
EP1222181A1 (de)	2002-07-17
PT1222181E (pt)	2004-04-30
CN1200935C (zh)	2005-05-11
ES2213050T3 (es)	2004-08-16
EP1222181B1 (de)	2003-12-10
DE60007164T2 (de)	2004-09-16
JP2003512365A (ja)	2003-04-02
CN1382133A (zh)	2002-11-27
HUP0203205A2 (hu)	2003-03-28
HUP0203205A3 (en)	2003-04-28
AU1033101A (en)	2001-04-30
DE60007164D1 (de)	2004-01-22

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2004-09-15

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