ATE256128T1 - Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung - Google Patents

Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung

Info

Publication number: ATE256128T1
Authority: AT; Austria
Prior art keywords: group; substituent; optionally; atom; hydrogen atom
Prior art date: 1998-10-21

Application number

AT99949322T

Other languages

English (en)

Inventor

Yasuhiko Kawano

Hideaki Nagaya

Michiyo Gyoten

Yukio Hara

Motoki Ikeuchi

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-21

Filing date

1999-10-20

Publication date

2003-12-15

1999-10-20 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE256128T1 publication Critical patent/ATE256128T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical class C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 12
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
125000001183 hydrocarbyl group Chemical group 0.000 abstract 6
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
125000002252 acyl group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 4
230000003266 anti-allergic effect Effects 0.000 abstract 3
230000001387 anti-histamine Effects 0.000 abstract 3
230000003110 anti-inflammatory effect Effects 0.000 abstract 3
239000000739 antihistaminic agent Substances 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
230000013764 eosinophil chemotaxis Effects 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
230000002401 inhibitory effect Effects 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
239000004215 Carbon black (E152) Substances 0.000 abstract 2
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 2
206010012438 Dermatitis atopic Diseases 0.000 abstract 2
206010039085 Rhinitis allergic Diseases 0.000 abstract 2
206010052568 Urticaria chronic Diseases 0.000 abstract 2
208000002205 allergic conjunctivitis Diseases 0.000 abstract 2
201000010105 allergic rhinitis Diseases 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
208000024998 atopic conjunctivitis Diseases 0.000 abstract 2
201000008937 atopic dermatitis Diseases 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
208000024376 chronic urticaria Diseases 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
150000002430 hydrocarbons Chemical class 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
201000004624 Dermatitis Diseases 0.000 abstract 1
206010012442 Dermatitis contact Diseases 0.000 abstract 1
206010037083 Prurigo Diseases 0.000 abstract 1
208000003251 Pruritus Diseases 0.000 abstract 1
208000024780 Urticaria Diseases 0.000 abstract 1
230000000172 allergic effect Effects 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
208000010247 contact dermatitis Diseases 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
230000001747 exhibiting effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical group [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

AT99949322T 1998-10-21 1999-10-20 Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung ATE256128T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP29942498		1998-10-21
JP29942598		1998-10-21
JP30731798		1998-10-28
PCT/JP1999/005786 WO2000023450A1 (en)	1998-10-21	1999-10-20	Fused pyridazine derivatives, process for the preparation of the same and uses thereof

Publications (1)

Publication Number	Publication Date
ATE256128T1 true ATE256128T1 (de)	2003-12-15

Family

ID=27338303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99949322T ATE256128T1 (de)	1998-10-21	1999-10-20	Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung

Country Status (9)

Country	Link
US (1)	US6627630B1 (de)
EP (1)	EP1123936B1 (de)
KR (1)	KR20010087738A (de)
CN (1)	CN1329614A (de)
AT (1)	ATE256128T1 (de)
AU (1)	AU6227399A (de)
CA (1)	CA2348022A1 (de)
DE (1)	DE69913558T2 (de)
WO (1)	WO2000023450A1 (de)

Families Citing this family (23)

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CA2458131A1 (en) *	2001-08-23	2003-03-06	Takeda Chemical Industries, Ltd.	Jnk activation inhibitor
US20050119251A1 (en) *	2001-12-21	2005-06-02	Jian-Min Fu	Nicotinamide derivatives and their use as therapeutic agents
US7390813B1 (en)	2001-12-21	2008-06-24	Xenon Pharmaceuticals Inc.	Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
AU2002357506A1 (en) *	2001-12-25	2003-07-15	Takeda Chemical Industries, Ltd.	Acid-containing preparations
JP4550353B2 (ja) *	2002-07-24	2010-09-22	株式会社医薬分子設計研究所	造血器型プロスタグランジンｄ２合成酵素阻害剤
KR101027360B1 (ko) *	2002-07-29	2011-04-11	스미또모 가가꾸 가부시끼가이샤	이미다조[1,2-ｂ]피리다진 유도체의 신규한 제조 방법
EP1541575B1 (de) *	2002-07-29	2010-03-03	Sumitomo Chemical Company, Limited	Neues verfahren zur herstellung eines imidazo(1,2-b)pyridazinderivats
US7235556B2 (en)	2003-04-16	2007-06-26	Alcon, Inc.	Methods of treating dry eye disorders
EP3042895A1 (de) *	2003-07-30	2016-07-13	Xenon Pharmaceuticals Inc.	Pyridazinderivate und deren verwendung als therapeutische wirkstoffe
EP2269610A3 (de) *	2004-09-20	2011-03-09	Xenon Pharmaceuticals Inc.	Heterozyklische Derivate und ihre Verwendung als Stearoyl-Coa-Desaturase-Inhibitoren
US7547698B2 (en) *	2004-09-20	2009-06-16	Xenon Pharmaceuticals Inc.	Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)
US20080167321A1 (en) *	2004-09-20	2008-07-10	Xenon Pharmaceuticals Inc.	Pyridine Derivatives For Inhibiting Human Stearoyl-Coa-Desaturase
EP1799667B1 (de)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe
MX2007003327A (es) *	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
EP2289510A1 (de)	2004-09-20	2011-03-02	Xenon Pharmaceuticals Inc.	Heterozyklische Derivate zur Behandlung von durch Stearoyl-Coa-Desaturase-Enzyme verursachten Krankheiten
MX2007003332A (es) *	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
MX2007003319A (es) *	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
JP4958786B2 (ja)	2004-09-20	2012-06-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体および治療薬としてのそれらの使用
JPWO2006088246A1 (ja) *	2005-02-18	2008-07-10	武田薬品工業株式会社	Ｇｐｒ３４受容体機能調節剤
BRPI0611187A2 (pt) *	2005-06-03	2010-08-24	Xenon Pharmaceuticals Inc	derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
EP1845098A1 (de) *	2006-03-29	2007-10-17	Ferrer Internacional, S.A.	Imidazo[1,2-b]pyridazinen, deren Herstellungverfahren und ihre Verwendung als GABA Rezeptor Liganden
PE20090506A1 (es) *	2007-07-26	2009-05-28	Novartis Ag	DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZIN COMO INHIBIDORES DE ALK5 Y/O ALK4
TW201512201A (zh) *	2013-03-14	2015-04-01	Forum Pharmaceuticals Inc	化合物的多晶型及鹽類

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US3957766A (en) *	1970-06-19	1976-05-18	Boehringer Mannheim G.M.B.H.	Novel nitrofuran compounds and pharmaceutical compositions
US3878217A (en)	1972-01-28	1975-04-15	Richardson Merrell Inc	Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4499088A (en)	1983-01-04	1985-02-12	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
FR2601366B1 (fr) *	1986-07-10	1988-11-25	Andre Buzas	Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
JPS6413090A (en)	1987-07-07	1989-01-17	Ube Industries	Xanthine derivative
GB8719368D0 (en) *	1987-08-15	1987-09-23	Wellcome Found	Heterocyclic compounds
PH27291A (en)	1989-01-31	1993-05-04	Takeda Chemical Industries Ltd	Imidazolpyrimidazines their production and use
EP0440119A1 (de)	1990-01-31	1991-08-07	Takeda Chemical Industries, Ltd.	Imidazopyridazinverbindungen, ihre Herstellung und Verwendung
ATE117690T1 (de)	1990-03-01	1995-02-15	Takeda Chemical Industries Ltd	Imidazopyridazine, ihre herstellung und verwendung.
TW211013B (de)	1991-12-27	1993-08-11	Takeda Pharm Industry Co Ltd
DE69322673T2 (de)	1992-03-18	1999-05-06	Takeda Chemical Industries, Ltd., Osaka	Imidazopyridazine als Antiasthmatika
LT3200B (en)	1992-03-18	1995-03-27	Takeda Chemical Industries Ltd	Triazolopyridazine methodfor production thereof and use
EP0620224B1 (de)	1993-04-12	1998-07-15	Takeda Chemical Industries, Ltd.	Triazolopyridazin-Derivate, ihre Herstellung und Verwendung
TW304878B (de) *	1993-09-21	1997-05-11	Takeda Pharm Industry Co Ltd
WO1996008496A1 (en) *	1994-09-16	1996-03-21	Takeda Chemical Industries, Ltd.	Triazolopyridazines process and intermediates for their preparation and their use as medicaments
JPH08337585A (ja) *	1995-01-30	1996-12-24	Takeda Chem Ind Ltd	セフェム化合物、その製造法および抗菌組成物
WO1996023798A1 (en)	1995-01-30	1996-08-08	Takeda Chemical Industries, Ltd.	Cephem compounds, their production and use
US20010007867A1 (en) *	1999-12-13	2001-07-12	Yuhpyng L. Chen	Substituted 6,5-hetero-bicyclic derivatives
EP0979231B1 (de) *	1997-04-25	2004-11-24	Takeda Chemical Industries, Ltd.	Condensierte pyridazine derivate,deren herstellung und verwendung
GB9718254D0 (en) *	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
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AU9002598A (en)	1997-09-16	1999-04-05	Takeda Chemical Industries Ltd.	Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs

1999
- 1999-10-20 KR KR1020017005039A patent/KR20010087738A/ko not_active Abandoned
- 1999-10-20 CA CA002348022A patent/CA2348022A1/en not_active Abandoned
- 1999-10-20 WO PCT/JP1999/005786 patent/WO2000023450A1/ja not_active Ceased
- 1999-10-20 AU AU62273/99A patent/AU6227399A/en not_active Abandoned
- 1999-10-20 AT AT99949322T patent/ATE256128T1/de not_active IP Right Cessation
- 1999-10-20 EP EP99949322A patent/EP1123936B1/de not_active Expired - Lifetime
- 1999-10-20 DE DE69913558T patent/DE69913558T2/de not_active Expired - Fee Related
- 1999-10-20 CN CN99814021A patent/CN1329614A/zh active Pending
- 1999-10-20 US US09/807,806 patent/US6627630B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6227399A (en)	2000-05-08
EP1123936A4 (de)	2002-02-27
US6627630B1 (en)	2003-09-30
KR20010087738A (ko)	2001-09-21
DE69913558D1 (de)	2004-01-22
WO2000023450A1 (en)	2000-04-27
EP1123936A1 (de)	2001-08-16
CA2348022A1 (en)	2000-04-27
DE69913558T2 (de)	2004-11-04
CN1329614A (zh)	2002-01-02
EP1123936B1 (de)	2003-12-10

Legal Events

Date	Code	Title	Description
2004-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69913558D1 (de)	2004-01-22	Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung
DE69827786D1 (de)	2004-12-30	Condensierte pyridazine derivate,deren herstellung und verwendung
ATE313535T1 (de)	2006-01-15	Pyrazinyl-piperazin-verbindungen, ihre anwendung und herstellung
ATE416176T1 (de)	2008-12-15	Kondensierte chinolinderivate und deren anwendung
WO2003080580A3 (en)	2004-02-05	Quinoline derivatives and their use as 5-ht6 ligands
DE68920773D1 (de)	1995-03-09	Chinoloncarbonsäure-Derivate.
DE69303191D1 (de)	1996-07-25	Naphthalinderivate, ihre Herstellungsverfahren und synthetische Zwischenprodukte dafür
ATE15182T1 (de)	1985-09-15	Benzochinon-derivate und deren herstellung.
NZ505968A (en)	2003-03-28	Sulfonylamino derivatives which inhibit matrix- degrading metallproteinases
ATE284860T1 (de)	2005-01-15	Neue verwendung von phenylheteroalkylamin- derivaten
DK0979821T3 (da)	2007-01-29	Tricykliske forbindelser
NO923528D0 (no)	1992-09-11	Benzyliden-karbamoyl-pyrrolidonanaloger
HUT45047A (en)	1988-05-30	Process for producing dihydropyridine derivatives with antiallergic and inflammation inhibiting effect and pharmaceuticals comprising the same
SG53130A1 (en)	1998-09-28	Pyridine derivatives process for preparing the same and intermediate therefor
NO160297C (no)	1989-04-05	Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oksoazetidinderivater
ID27509A (id)	2001-04-12	Turunan piridin tersubstitusi-2,3 proses pembuatannya, komposisi farmasi yang mengandung senyawa tersebut, dan senyawa-antaranya
ATE18196T1 (de)	1986-03-15	1,4-acyloxynaphthalenderivate, diese enthaltende kompositionen, verfahren fuer ihre herstellung und zwischenprodukte dafuer.
HUT56551A (en)	1991-09-30	Process for producing cinnoline carboxamide derivatives and pharmaceutical compositions comprising such compounds
DE3786109D1 (de)	1993-07-15	Pyrido(2,3-d)pyrimidin-derivate.
ATE207058T1 (de)	2001-11-15	Amine derivate, ihre herstellung und anwendung
FR2479219B1 (de)	1982-04-09
DE3785076D1 (de)	1993-05-06	Pyrido(4,3-d)pyrimidin-derivate.
MA20369A1 (fr)	1985-10-01	Compositions a base de derives de la piperidine ,nouveaux derives de la piperidine et leurs procedes de preparation
DE69923535D1 (de)	2005-03-10	Verfahren zur Herstellung von Dioxopenicillansäurederivaten
ATE265428T1 (de)	2004-05-15	Neue verwendung von phenylheteroalkylamin- derivaten