ATE256453T1 - Poröse hydroxyapatit-partikel als träger für medikamente - Google Patents

Poröse hydroxyapatit-partikel als träger für medikamente

Info

Publication number
ATE256453T1
ATE256453T1 AT98957268T AT98957268T ATE256453T1 AT E256453 T1 ATE256453 T1 AT E256453T1 AT 98957268 T AT98957268 T AT 98957268T AT 98957268 T AT98957268 T AT 98957268T AT E256453 T1 ATE256453 T1 AT E256453T1
Authority
AT
Austria
Prior art keywords
medications
carriers
hydroxyapatite particles
porous hydroxyapatite
porous
Prior art date
Application number
AT98957268T
Other languages
English (en)
Inventor
Christer Karlsson
Per Johan Lundberg
Adam Rosinski
Malin Soederbom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE256453T1 publication Critical patent/ATE256453T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98957268T 1997-11-28 1998-11-19 Poröse hydroxyapatit-partikel als träger für medikamente ATE256453T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704400A SE9704400D0 (sv) 1997-11-28 1997-11-28 Porous inorganic particles as carriers for drug substances
PCT/SE1998/002089 WO1999027912A1 (en) 1997-11-28 1998-11-19 Porous hydroxyapatite particles as carriers for drug substances

Publications (1)

Publication Number Publication Date
ATE256453T1 true ATE256453T1 (de) 2004-01-15

Family

ID=20409177

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98957268T ATE256453T1 (de) 1997-11-28 1998-11-19 Poröse hydroxyapatit-partikel als träger für medikamente

Country Status (26)

Country Link
US (1) US6558703B1 (de)
EP (1) EP1032370B1 (de)
JP (1) JP2001524513A (de)
KR (1) KR20010032557A (de)
CN (1) CN1280492A (de)
AR (1) AR016683A1 (de)
AT (1) ATE256453T1 (de)
AU (1) AU752044B2 (de)
BR (1) BR9814751A (de)
CA (1) CA2311780A1 (de)
DE (1) DE69820674T2 (de)
DK (1) DK1032370T3 (de)
ES (1) ES2210840T3 (de)
HU (1) HUP0100303A3 (de)
ID (1) ID24700A (de)
IL (1) IL136146A0 (de)
NO (1) NO20002719L (de)
NZ (1) NZ504353A (de)
PL (1) PL340927A1 (de)
PT (1) PT1032370E (de)
RU (1) RU2219907C2 (de)
SE (1) SE9704400D0 (de)
SK (1) SK6602000A3 (de)
TW (1) TW524694B (de)
WO (1) WO1999027912A1 (de)
ZA (1) ZA9810463B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924334D0 (en) * 1999-10-15 1999-12-15 Secr Defence Pharmaceutical products and methods of fabrication therefor
DE60128683T2 (de) * 2000-04-11 2008-01-24 Sankyo Co., Ltd. Stabilisierte pharmazeutische zusammenstellungen die den calziumkanalblocker azelnidipine enthalten
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
EP1569912B1 (de) 2002-12-03 2015-04-29 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidinderivate als faktor vii-a hemmer
KR101207553B1 (ko) 2005-06-02 2012-12-03 (주)씨앤팜 금속 이중층 수산화물을 포함하는 생체 주사제용 약물 담체
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
JP5027410B2 (ja) * 2005-12-13 2012-09-19 株式会社サンギ ユビキノン含有組成物
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
CA2644429C (en) * 2006-03-14 2014-07-29 Lidds Ab Bioresorbable controlled-release composition
GB0909460D0 (en) 2009-06-02 2009-07-15 Intrinsiq Materials Global Ltd Mesoporus material
PL2950923T3 (pl) 2013-02-01 2022-04-04 W.R. Grace & Co. - Conn. Porowaty żel krzemionkowy jako nośnik płynnych technologii
CN105555259A (zh) * 2013-09-20 2016-05-04 蒂洛特斯制药股份有限公司 延迟释放的药物制剂
CN104133014B (zh) * 2014-07-16 2015-09-16 广州法尔麦兰药物技术有限公司 一种考察布洛伪麻缓释制剂释放度的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413191D0 (en) 1984-05-23 1984-06-27 Beecham Group Plc Pharmaceutical composition
GB8713263D0 (en) 1987-06-05 1987-07-08 Unilever Plc Spheroidal silica
EP0376331A3 (de) 1988-12-29 1991-03-13 Asahi Kogaku Kogyo Kabushiki Kaisha Granula zur langsamen Wirkstoffabgabe sowie Verfahren zu deren Herstellung
US5149523A (en) * 1989-06-20 1992-09-22 Aktiebolaget Hassle Polystyrenesulfonate-drug complex and solid dosage forms thereof
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
US5443459A (en) * 1991-01-30 1995-08-22 Alza Corporation Osmotic device for delayed delivery of agent
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6096324A (en) * 1995-06-13 2000-08-01 Laboratory Skin Care Methods of delivering materials into the skin, and compositions used therein
JP3562878B2 (ja) * 1995-07-07 2004-09-08 丸尾カルシウム株式会社 花弁状多孔質ヒドロキシアパタイト微粒子及びその製造方法

Also Published As

Publication number Publication date
HUP0100303A3 (en) 2004-03-29
EP1032370A1 (de) 2000-09-06
SK6602000A3 (en) 2001-01-18
PL340927A1 (en) 2001-03-12
NO20002719L (no) 2000-07-28
KR20010032557A (ko) 2001-04-25
ES2210840T3 (es) 2004-07-01
US6558703B1 (en) 2003-05-06
BR9814751A (pt) 2000-10-03
AU752044B2 (en) 2002-09-05
ID24700A (id) 2000-08-03
NZ504353A (en) 2001-10-26
IL136146A0 (en) 2001-05-20
NO20002719D0 (no) 2000-05-26
RU2219907C2 (ru) 2003-12-27
CA2311780A1 (en) 1999-06-10
PT1032370E (pt) 2004-05-31
JP2001524513A (ja) 2001-12-04
DK1032370T3 (da) 2004-03-15
AR016683A1 (es) 2001-07-25
SE9704400D0 (sv) 1997-11-28
AU1356399A (en) 1999-06-16
CN1280492A (zh) 2001-01-17
WO1999027912A1 (en) 1999-06-10
DE69820674D1 (de) 2004-01-29
TW524694B (en) 2003-03-21
EP1032370B1 (de) 2003-12-17
ZA9810463B (en) 1999-05-21
HUP0100303A2 (hu) 2001-08-28
DE69820674T2 (de) 2004-09-30

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