ATE256476T1 - Unterdrückung von tnfalpha und il-12 in der therapie - Google Patents

Unterdrückung von tnfalpha und il-12 in der therapie

Info

Publication number
ATE256476T1
ATE256476T1 AT97912367T AT97912367T ATE256476T1 AT E256476 T1 ATE256476 T1 AT E256476T1 AT 97912367 T AT97912367 T AT 97912367T AT 97912367 T AT97912367 T AT 97912367T AT E256476 T1 ATE256476 T1 AT E256476T1
Authority
AT
Austria
Prior art keywords
tnf
tnfalpha
suppression
therapy
disclosed
Prior art date
Application number
AT97912367T
Other languages
English (en)
Inventor
Marc Feldmann
Anne-Marie Aline Miche Malfait
Debra Maree Butler
Fionula Mary Brennan
Ravinder Nath Maini
Original Assignee
Kennedy Inst Of Rheumatology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kennedy Inst Of Rheumatology filed Critical Kennedy Inst Of Rheumatology
Application granted granted Critical
Publication of ATE256476T1 publication Critical patent/ATE256476T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97912367T 1996-11-15 1997-11-17 Unterdrückung von tnfalpha und il-12 in der therapie ATE256476T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74997996A 1996-11-15 1996-11-15
PCT/GB1997/003151 WO1998022137A1 (en) 1996-11-15 1997-11-17 SUPPRESSION OF TNF α AND IL-12 IN THERAPY

Publications (1)

Publication Number Publication Date
ATE256476T1 true ATE256476T1 (de) 2004-01-15

Family

ID=25016019

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97912367T ATE256476T1 (de) 1996-11-15 1997-11-17 Unterdrückung von tnfalpha und il-12 in der therapie

Country Status (9)

Country Link
US (1) US20070178099A1 (de)
EP (1) EP0936923B1 (de)
AT (1) ATE256476T1 (de)
AU (1) AU4959997A (de)
DE (1) DE69726878T2 (de)
DK (1) DK0936923T3 (de)
ES (1) ES2213209T3 (de)
PT (1) PT936923E (de)
WO (1) WO1998022137A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706264B1 (en) 1994-03-14 2004-03-16 Genetics Institute, Llc Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y
US7220717B2 (en) 1997-08-14 2007-05-22 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use
US7704944B2 (en) 1997-08-14 2010-04-27 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
AU2612100A (en) * 1999-01-13 2000-08-01 Rockefeller University, The Methods of promoting or enhancing interleukin-12 production through administration of thalidomide
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
US7883704B2 (en) 1999-03-25 2011-02-08 Abbott Gmbh & Co. Kg Methods for inhibiting the activity of the P40 subunit of human IL-12
HUP0200575A3 (en) * 1999-03-25 2004-11-29 Abbott Gmbh & Co Kg Human antibodies that bind human il-12 and methods for producing
PT1237575E (pt) * 1999-12-14 2008-11-17 Genentech Inc Antagonista de tnf-alfa e antagonista de lfa-1 para tratar a artrite reumatóide
ME00546B (me) * 2000-02-21 2011-10-10 Serono Lab Korišćenje inhibitora il-18
EP2316531A1 (de) 2000-08-10 2011-05-04 Cold Spring Harbor Laboratory Gesteigertes kognitives Training
US20040224316A1 (en) 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
US7868015B2 (en) 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US6881407B2 (en) * 2000-08-11 2005-04-19 Ashok Amin Method for treating hepatitis
EP1188438A1 (de) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
EP1199074A1 (de) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen
GB0128138D0 (en) * 2001-11-23 2002-01-16 King S College London Pharmaceutical use
US20030161828A1 (en) * 2002-02-19 2003-08-28 Abbott Gmbh & Co. Kg Use of TNF antagonists as drugs for the treatment of patients with an inflammatory reaction and without suffering from total organ failure
US9028822B2 (en) 2002-06-28 2015-05-12 Domantis Limited Antagonists against TNFR1 and methods of use therefor
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
EP1651266B1 (de) * 2003-07-25 2010-03-03 Laboratorios Silanes, S.A. de C.V. Verabreichung von anti-tnf-alpha f(ab')2 antikörper-fragmenten
US7435799B2 (en) 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
KR20090100461A (ko) 2007-01-16 2009-09-23 아보트 러보러터리즈 건선의 치료방법
RU2476442C2 (ru) 2007-03-29 2013-02-27 Эббот Лэборетриз Кристаллические антитела против il-12 человека
WO2009117289A2 (en) 2008-03-18 2009-09-24 Abbott Laboratories Methods for treating psoriasis
MX2011004199A (es) * 2008-10-20 2011-05-24 Abbott Lab Anticuerpos que unen a il-18 y metodos para purificar los mismos.
NZ592095A (en) 2008-10-20 2013-01-25 Abbott Lab Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography
BRPI0920572A8 (pt) * 2008-10-20 2015-10-27 Abbott Lab Inativação viral durante a purificação dos anticorpos
MX2011004198A (es) * 2008-10-20 2011-05-24 Abbott Lab Anticerpos que unen a il-12 y metodos para purificar los mismos.
SG179135A1 (en) 2009-09-14 2012-05-30 Abbott Lab Methods for treating psoriasis
GB201013975D0 (en) 2010-08-20 2010-10-06 Imp Innovations Ltd Method of treating desease
US8394593B2 (en) * 2010-02-12 2013-03-12 Trudeau Institute Use of an IL-12 receptor splice variant and molecular assay to quantify expression thereof
US8877212B2 (en) 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US5698195A (en) * 1991-03-18 1997-12-16 New York University Medical Center Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
EP1857553A1 (de) * 1991-03-18 2007-11-21 New York University Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor
CA2146647C (en) * 1992-10-08 2009-05-05 Marc Feldmann Treatment of autoimmune and inflammatory disorders
US5536657A (en) * 1993-07-19 1996-07-16 Hoffmann-La Roche Inc. Recombinant DNA encoding human receptor for interleukin-12
ZA95960B (en) * 1994-03-14 1995-10-10 Genetics Inst Use of interleukin-12 antagonists in the treatment of autoimmune diseases
EP0759466B1 (de) * 1995-08-01 2005-12-28 F. Hoffmann-La Roche Ag Interleukin-12-beta-Rezeptoren mit niedriger Bindungsaffinität

Also Published As

Publication number Publication date
DE69726878D1 (de) 2004-01-29
WO1998022137A1 (en) 1998-05-28
ES2213209T3 (es) 2004-08-16
DE69726878T2 (de) 2004-10-21
EP0936923A1 (de) 1999-08-25
AU4959997A (en) 1998-06-10
PT936923E (pt) 2004-04-30
DK0936923T3 (da) 2004-04-26
EP0936923B1 (de) 2003-12-17
US20070178099A1 (en) 2007-08-02

Similar Documents

Publication Publication Date Title
DE69726878D1 (de) UNTERDRÜCKUNG VON TNFalpha UND IL-12 IN DER THERAPIE
DE68920529D1 (de) Blockcopolymere und Zusammensetzungen davon.
ATE330973T1 (de) Antagonisten von g protein-gekoppelten rezeptoren
ATE281840T1 (de) Behandlung von diarrhoe
ATE414517T1 (de) Verabreichung von injizierbarem antibiotikum in das ohr eines tieres
DE69119688D1 (de) Pfropfcopolymere und Pfropfcopolymer-/Protein- Zusammensetzungen
DE68918943D1 (de) Gewebeentzusammensetzung und verfahren.
EP0205579A4 (de) Verfahren und zusammensetzungen zur verwendung in der diagnose und behandlung autoimmuner krankheiten.
FR2658536B1 (fr) Compositions et procedes d'electrodeposition.
DE69719754D1 (de) Therapeutische verwendungen von bpi-protein produkten bei menschen mit durch trauma verursachter blutung
DE3852389D1 (de) Rissformungsverhütung in implantierten Prothesen.
EP0656791A4 (de) Therapeutische zusammensetzungen und verfahren unter verwendung von pqq.
CA2094275A1 (en) Methods and compositions for the treatment of cell proliferation disorders
ATE76579T1 (de) Interferon-zusammensetzungen.
IT8921128A0 (it) Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
EP0642333A4 (de) Verfahren und zusammensetzungen zur behandlung von krankheiten verbunden mit mangelhaften immunfunktion.
ITRM920305A1 (it) Composizione farmaceutica per il trattamento dello shock, particolarmente dello shock cardiogeno e dello shock settico.
MA19965A1 (fr) 3',5'-diarabinosides, leur preparation et leur application en therapeutique
IT8125518A0 (it) Procedimento per la polimerizzazione e copolimerizzazione in sospensione di cloruro di vinile.
IT9003692A0 (it) Dispositivo per l' assemblaggio di pannelli di mobili in genere.
IT1206319B (it) Dispositivo per lo scorrimento e l'ancoraggio di cassetti, cestelli corpi estraibili in genere, da mobili ed altro.
IT9021051A0 (it) "procedimento di estrzione e purificazione del gamma interferone umano ricombite"
Mason The effect of externally administered propionate on lactate efflux from frog sartorius muscles.
CA2133995A1 (en) Method and composition for the treatment of disorders involving immunological dysfunction
DE69619522D1 (de) Therapie unter verwendung von lymphotoxin und thrombopoietin

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0936923

Country of ref document: EP