ATE257701T1 - DIETARY COMPOSITION TO INCREASE METABOLISM AND RELIEF OXYDATIVE STRESS - Google Patents

DIETARY COMPOSITION TO INCREASE METABOLISM AND RELIEF OXYDATIVE STRESS

Info

Publication number
ATE257701T1
ATE257701T1 AT98930295T AT98930295T ATE257701T1 AT E257701 T1 ATE257701 T1 AT E257701T1 AT 98930295 T AT98930295 T AT 98930295T AT 98930295 T AT98930295 T AT 98930295T AT E257701 T1 ATE257701 T1 AT E257701T1
Authority
AT
Austria
Prior art keywords
relief
dietary composition
increase metabolism
oxydative stress
oxydative
Prior art date
Application number
AT98930295T
Other languages
German (de)
Inventor
Bruce N Ames
Tory M Hagen
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25363850&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE257701(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE257701T1 publication Critical patent/ATE257701T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Method for increasing the metabolic rate of aged mammalian cells in a patient without a corresponding increase in metabolic production of reactive oxygen species involves oral administration of 10 mg/kg/day of a carnitine (I) and at least 10 mg/kg/day of a mitochondrially active antioxidant (II).
AT98930295T 1997-06-16 1998-06-16 DIETARY COMPOSITION TO INCREASE METABOLISM AND RELIEF OXYDATIVE STRESS ATE257701T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/874,467 US5916912A (en) 1997-06-16 1997-06-16 Dietary composition for enhancing metabolism and alleviating oxidative stress
PCT/US1998/012545 WO1998057627A1 (en) 1997-06-16 1998-06-16 Dietary compositions for enhancing metabolism and alleviating oxidative stress

Publications (1)

Publication Number Publication Date
ATE257701T1 true ATE257701T1 (en) 2004-01-15

Family

ID=25363850

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98930295T ATE257701T1 (en) 1997-06-16 1998-06-16 DIETARY COMPOSITION TO INCREASE METABOLISM AND RELIEF OXYDATIVE STRESS

Country Status (8)

Country Link
US (1) US5916912A (en)
EP (2) EP1014965B1 (en)
JP (1) JP3537832B2 (en)
AT (1) ATE257701T1 (en)
AU (1) AU722302B2 (en)
DE (1) DE69821123T2 (en)
ES (1) ES2214714T3 (en)
WO (1) WO1998057627A1 (en)

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US6191162B1 (en) 1998-05-28 2001-02-20 Medical Research Institute Method of reducing serum glucose levels
US6905707B2 (en) 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US6197340B1 (en) 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
IT1302307B1 (en) 1998-09-01 2000-09-05 Sigma Tau Healthscience Spa COMPOSITION WITH ANTIOXIDANT ACTIVITY AND FOR IMPROVING THE METABOLIC USE OF GLUCOSE, INCLUDING ACETYL
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US6573299B1 (en) 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
WO2001021208A1 (en) 1999-09-23 2001-03-29 Juvenon Corporation Nutritional supplement for increased energy and stamina
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
CA2389623A1 (en) * 1999-11-03 2001-05-10 Juvenon, Inc. Method of treating benign forgetfulness
JP2003529347A (en) * 2000-01-25 2003-10-07 ジュヴェノン インコーポレイテッド Nutrition supplements for aged pets
US6996807B1 (en) * 2000-02-01 2006-02-07 Isogon Corporation Consolidation and reduction of usage data
US6476010B2 (en) 2000-03-10 2002-11-05 Hill's Pet Nutrition Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and lower animals
US20020115710A1 (en) * 2000-10-31 2002-08-22 Zicker Steven Curtis Composition and method
US20020076470A1 (en) * 2000-10-31 2002-06-20 Colgate-Palmolive Company Composition and method
US8669282B2 (en) 2000-10-31 2014-03-11 Hill's Pet Nutrition, Inc. Companion animal compositions including lipoic acid and methods of use thereof
US8592479B2 (en) * 2000-10-31 2013-11-26 Hill's Pet Nutrition, Inc. Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals
US20090156658A1 (en) * 2000-10-31 2009-06-18 Hill's Pet Nutrition, Inc. Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals
PL363426A1 (en) * 2001-03-09 2004-11-15 Societe Des Produits Nestle S.A. Composition improving age-related physiological deficits and increasing longevity
JP5028639B2 (en) * 2001-08-02 2012-09-19 成男 太田 Preventive or therapeutic agent for mitochondrial disease
US7030154B2 (en) 2002-06-07 2006-04-18 Juvenon, Inc. Stability of lipoic acid
US9955994B2 (en) 2002-08-02 2018-05-01 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
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ITMI20030831A1 (en) * 2003-04-22 2004-10-23 Laboratorio Chimico Int Spa BASIC SALT OF TIOTIC ACID WITH L-CARNITINE.
ES2479944T3 (en) * 2003-07-03 2014-07-25 Hill's Pet Nutrition, Inc. Compositions and methods to reduce age-related impairment in the mental activities of companion animals
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
EP1706146B1 (en) * 2003-12-31 2013-08-21 K-Pax Pharmaceuticals, Inc. Nutrient compositions and use thereof for enhanced effectiveness of the immune system
WO2006012267A1 (en) * 2004-06-29 2006-02-02 Elixirin Corporation Dietary compositions for enhancing metabolism and reducing reactive oxygen species
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
JP5138380B2 (en) * 2004-11-24 2013-02-06 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド Methods for increasing immune responses in animals
WO2006058278A2 (en) * 2004-11-24 2006-06-01 Hill's Pet Nutrition, Inc. Methods for improving liver clearance of xenobiotic substances in an animal
DK1830883T3 (en) * 2004-12-29 2013-11-25 Hills Pet Nutrition Inc PROCEDURE TO INFLUENCE A DEFINITION IN LEARNING AND / OR MEMORY OF ANIMALS
US8252742B2 (en) * 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8148325B2 (en) * 2004-12-30 2012-04-03 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8221343B2 (en) 2005-01-20 2012-07-17 Flowcardia, Inc. Vibrational catheter devices and methods for making same
US20060188866A1 (en) * 2005-02-18 2006-08-24 Children's Hospital Oakland Research Institute Diaminophenothiazine compositions and uses thereof
EP1906912B1 (en) * 2005-07-14 2012-08-15 Hill's Pet Nutrition, Inc. Method for prolonging the life of animals
US8492432B2 (en) * 2005-08-17 2013-07-23 Hill's Pet Nutrition, Inc. Methods for the treatment of kidney disease
US20100022629A1 (en) * 2006-01-13 2010-01-28 Elixirin Dietary Methods and Compositions for Enhancing Metabolism and Reducing Reactive Oxygen Species
US7282225B1 (en) 2006-09-27 2007-10-16 Occular Technologies, Inc. Composition and methods for improving retinal health
US8246643B2 (en) 2006-11-07 2012-08-21 Flowcardia, Inc. Ultrasound catheter having improved distal end
JP2008214338A (en) * 2007-02-08 2008-09-18 Shiseido Co Ltd Higher brain function lowering agent and delayed memory lowering agent
US20080226696A1 (en) * 2007-03-15 2008-09-18 Ben Treadwell Methods of improving learning abilities of aged companion animals
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
US20090191287A1 (en) * 2008-01-29 2009-07-30 Johnson W Dudley Mitigation of Inflammation-Related Injuries
ES2528758T3 (en) * 2008-12-30 2015-02-12 Hill's Pet Nutrition, Inc. Methods for increasing palatability of food compositions for pets
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US8226566B2 (en) 2009-06-12 2012-07-24 Flowcardia, Inc. Device and method for vascular re-entry
EP2311449A1 (en) 2009-10-14 2011-04-20 NÖM Aktiengesellschaft Orally administrated food supplement comprising carnitine
US20130224281A1 (en) * 2011-04-07 2013-08-29 United States Of America As Represented By The Administrator Of The National Aeronautics & Space Method and composition for ameliorating the effects for a subject exposed to radiation or other sources of oxidative stress
US9040082B2 (en) 2011-06-24 2015-05-26 K-Pax Pharmaceuticals, Inc. Compositions and methods for treatment of chronic fatigue
WO2013109269A1 (en) 2012-01-18 2013-07-25 Bard Peripheral Vascular, Inc. Vascular re-entry device
EP2879596A2 (en) 2012-08-02 2015-06-10 Flowcardia, Inc. Ultrasound catheter system
JP6288757B2 (en) * 2013-08-23 2018-03-07 京都府公立大学法人 Motor function improver
US20180140321A1 (en) 2016-11-23 2018-05-24 C. R. Bard, Inc. Catheter With Retractable Sheath And Methods Thereof
US11596726B2 (en) 2016-12-17 2023-03-07 C.R. Bard, Inc. Ultrasound devices for removing clots from catheters and related methods
US10758256B2 (en) 2016-12-22 2020-09-01 C. R. Bard, Inc. Ultrasonic endovascular catheter
US10582983B2 (en) 2017-02-06 2020-03-10 C. R. Bard, Inc. Ultrasonic endovascular catheter with a controllable sheath
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Also Published As

Publication number Publication date
ES2214714T3 (en) 2004-09-16
JP3537832B2 (en) 2004-06-14
DE69821123D1 (en) 2004-02-19
DE69821123T2 (en) 2004-10-14
CA2292497A1 (en) 1998-12-23
CA2292497C (en) 2003-11-11
EP1413304A1 (en) 2004-04-28
EP1014965B1 (en) 2004-01-14
EP1014965A1 (en) 2000-07-05
EP1014965A4 (en) 2001-12-19
US5916912A (en) 1999-06-29
WO1998057627A1 (en) 1998-12-23
AU7971598A (en) 1999-01-04
AU722302B2 (en) 2000-07-27
JP2001508804A (en) 2001-07-03

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