ATE257822T1 - Aminoiminochinon und aminochinon alkaloid verbindungen als caspase inhibitoren - Google Patents

Aminoiminochinon und aminochinon alkaloid verbindungen als caspase inhibitoren

Info

Publication number: ATE257822T1
Authority: AT; Austria
Prior art keywords: aminoiminochinone; aminoquinone; compounds; caspase inhibitors; alkaloid compounds
Prior art date: 1998-07-08

Application number

AT99933942T

Other languages

English (en)

Inventor

Sarath P Gunasekera

Peter J Mccarthy

Ross E Longley

Shirley A Pomponi

Amy E Wright

Original Assignee

Harbor Branch Oceanographic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-08

Filing date

1999-07-08

Publication date

2004-01-15

1999-07-08 Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic

2004-01-15 Application granted granted Critical

2004-01-15 Publication of ATE257822T1 publication Critical patent/ATE257822T1/de

Links

-1 AMINOQUINONE ALKALOID COMPOUNDS Chemical class 0.000 title 1
102000011727 Caspases Human genes 0.000 title 1
108010076667 Caspases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
HGURXOJCPLDAEO-UHFFFAOYSA-N 6-amino-5-chloro-3-(1,2-dihydroxyethyl)-1h-indole-4,7-dione Chemical compound O=C1C(N)=C(Cl)C(=O)C2=C1NC=C2C(O)CO HGURXOJCPLDAEO-UHFFFAOYSA-N 0.000 abstract 2
HKOYUVBHEPHPMA-UHFFFAOYSA-N chembl523545 Chemical compound O=C1C(N)=C(Cl)C(=N)C2=C1NC=C2C(O)CO HKOYUVBHEPHPMA-UHFFFAOYSA-N 0.000 abstract 2
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
239000004090 neuroprotective agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Fats And Perfumes (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)

AT99933942T 1998-07-08 1999-07-08 Aminoiminochinon und aminochinon alkaloid verbindungen als caspase inhibitoren ATE257822T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9202098P	1998-07-08	1998-07-08
PCT/US1999/015763 WO2000002858A1 (en)	1998-07-08	1999-07-08	Aminoiminoquinone and aminoquinine alkaloid compounds as capase inhibitors

Publications (1)

Publication Number	Publication Date
ATE257822T1 true ATE257822T1 (de)	2004-01-15

Family

ID=22230890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99933942T ATE257822T1 (de)	1998-07-08	1999-07-08	Aminoiminochinon und aminochinon alkaloid verbindungen als caspase inhibitoren

Country Status (8)

Country	Link
US (1)	US6218419B1 (de)
EP (1)	EP1095018B1 (de)
JP (1)	JP2003520186A (de)
AT (1)	ATE257822T1 (de)
CA (1)	CA2335623C (de)
DE (1)	DE69914200T2 (de)
ES (1)	ES2214037T3 (de)
WO (1)	WO2000002858A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6492170B1 (en)	2000-09-11	2002-12-10	Isis Pharmaceuticals, Inc.	Antisense modulation of caspase 9 expression
US6566135B1 (en)	2000-10-04	2003-05-20	Isis Pharmaceuticals, Inc.	Antisense modulation of caspase 6 expression
JP2006503852A (ja) *	2002-09-25	2006-02-02	ユニバーシティーオブロチェスター	抗癌薬としてのカスパーゼインヒビター
ES2599319T3 (es) *	2006-06-26	2017-02-01	Macrogenics, Inc.	Anticuerpos específicos de Fc RIIB y métodos de uso de éstos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3265698A (en) *	1964-08-07	1966-08-09	American Cyanamid Co	Novel substituted 3-(alpha-carbamoyloxy-lower alkyl)-4, 7-indoloquinones
US5028613A (en)	1990-02-16	1991-07-02	Repligen Corporation	Novel pyrroloquinoline alkaloids and methods of use
WO1997023456A1 (en) *	1995-12-21	1997-07-03	British Technology Group Ltd.	Indoloquinone derivatives as bioreductive agents
AU738341B2 (en) *	1996-10-11	2001-09-13	Abbott Gmbh & Co. Kg	Asparate ester inhibitors of interleukin-1beta converting enzyme

1999
- 1999-07-08 JP JP2000559089A patent/JP2003520186A/ja active Pending
- 1999-07-08 US US09/349,070 patent/US6218419B1/en not_active Expired - Lifetime
- 1999-07-08 EP EP99933942A patent/EP1095018B1/de not_active Expired - Lifetime
- 1999-07-08 AT AT99933942T patent/ATE257822T1/de not_active IP Right Cessation
- 1999-07-08 DE DE69914200T patent/DE69914200T2/de not_active Expired - Lifetime
- 1999-07-08 ES ES99933942T patent/ES2214037T3/es not_active Expired - Lifetime
- 1999-07-08 WO PCT/US1999/015763 patent/WO2000002858A1/en not_active Ceased
- 1999-07-08 CA CA002335623A patent/CA2335623C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2335623C (en)	2009-09-08
CA2335623A1 (en)	2000-01-20
DE69914200T2 (de)	2004-10-14
DE69914200D1 (de)	2004-02-19
EP1095018B1 (de)	2004-01-14
US6218419B1 (en)	2001-04-17
JP2003520186A (ja)	2003-07-02
ES2214037T3 (es)	2004-09-01
EP1095018A1 (de)	2001-05-02
WO2000002858A1 (en)	2000-01-20

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Legal Events

Date	Code	Title	Description
2004-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties