ATE258177T1 - Verfahren für die herstellung und zwischenprodukte von tetrahydro-(1,8)- naphthyridin - Google Patents
Verfahren für die herstellung und zwischenprodukte von tetrahydro-(1,8)- naphthyridinInfo
- Publication number
- ATE258177T1 ATE258177T1 AT00986221T AT00986221T ATE258177T1 AT E258177 T1 ATE258177 T1 AT E258177T1 AT 00986221 T AT00986221 T AT 00986221T AT 00986221 T AT00986221 T AT 00986221T AT E258177 T1 ATE258177 T1 AT E258177T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydro
- naphthyridine
- production
- intermediate products
- useful
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZCZVGQCBSJLDDS-UHFFFAOYSA-N 1,2,3,4-tetrahydro-1,8-naphthyridine Chemical compound C1=CC=C2CCCNC2=N1 ZCZVGQCBSJLDDS-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- BWMYVZPZPGAOPC-UHFFFAOYSA-N 3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine Chemical compound C1CCNC2=NC(CCCN)=CC=C21 BWMYVZPZPGAOPC-UHFFFAOYSA-N 0.000 abstract 1
- 229940127449 Integrin Receptor Antagonists Drugs 0.000 abstract 1
- 108010040765 Integrin alphaV Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16726099P | 1999-11-23 | 1999-11-23 | |
| PCT/US2000/031790 WO2001038328A1 (en) | 1999-11-23 | 2000-11-20 | Process and intermediates to a tetrahydro-[1,8]-naphthyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258177T1 true ATE258177T1 (de) | 2004-02-15 |
Family
ID=22606628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00986221T ATE258177T1 (de) | 1999-11-23 | 2000-11-20 | Verfahren für die herstellung und zwischenprodukte von tetrahydro-(1,8)- naphthyridin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6423845B1 (de) |
| EP (1) | EP1235828B1 (de) |
| JP (1) | JP2003514908A (de) |
| AT (1) | ATE258177T1 (de) |
| AU (1) | AU768875B2 (de) |
| CA (1) | CA2391013C (de) |
| DE (1) | DE60007894T2 (de) |
| ES (1) | ES2213063T3 (de) |
| WO (1) | WO2001038328A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002022615A1 (en) | 2000-09-14 | 2002-03-21 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
| CN101415676A (zh) | 2006-04-17 | 2009-04-22 | 住友化学株式会社 | N-叔丁氧基羰基-2-吡咯烷酮类及其制造方法 |
| JP5272324B2 (ja) * | 2006-04-17 | 2013-08-28 | 住友化学株式会社 | Ｎ−ｔｅｒｔ−ブトキシカルボニル−２−ピロリジノン類およびその製造方法 |
| DK3929196T3 (da) | 2013-09-24 | 2023-09-25 | Fujifilm Corp | Farmaceutisk sammensætning af en nitrogenholdig forbindelse eller salt deraf, eller metalkompleks deraf |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952341A (en) * | 1996-10-30 | 1999-09-14 | Merck & Co., Inc. | Integrin antagonists |
| CA2268940A1 (en) | 1996-10-30 | 1998-05-07 | Merck & Co., Inc. | Integrin antagonists |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| SK9192000A3 (en) | 1997-12-17 | 2001-03-12 | Merck & Co Inc | Integrin receptor antagonists |
| US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
| ES2243016T3 (es) | 1997-12-17 | 2005-11-16 | MERCK & CO., INC. | Antagonistas de receptores de integrinas. |
| GB2356630A (en) * | 1999-11-10 | 2001-05-30 | Merck & Co Inc | Intermediates used in the preparation of tetrahydronaphthyridine |
-
2000
- 2000-11-20 AT AT00986221T patent/ATE258177T1/de not_active IP Right Cessation
- 2000-11-20 WO PCT/US2000/031790 patent/WO2001038328A1/en not_active Ceased
- 2000-11-20 EP EP00986221A patent/EP1235828B1/de not_active Expired - Lifetime
- 2000-11-20 ES ES00986221T patent/ES2213063T3/es not_active Expired - Lifetime
- 2000-11-20 AU AU22500/01A patent/AU768875B2/en not_active Ceased
- 2000-11-20 JP JP2001540091A patent/JP2003514908A/ja not_active Withdrawn
- 2000-11-20 DE DE60007894T patent/DE60007894T2/de not_active Expired - Lifetime
- 2000-11-20 CA CA2391013A patent/CA2391013C/en not_active Expired - Fee Related
- 2000-11-21 US US09/718,139 patent/US6423845B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2213063T3 (es) | 2004-08-16 |
| CA2391013A1 (en) | 2001-05-31 |
| WO2001038328A1 (en) | 2001-05-31 |
| AU2250001A (en) | 2001-06-04 |
| US6423845B1 (en) | 2002-07-23 |
| EP1235828B1 (de) | 2004-01-21 |
| CA2391013C (en) | 2010-09-21 |
| AU768875B2 (en) | 2004-01-08 |
| DE60007894T2 (de) | 2004-10-28 |
| EP1235828A4 (de) | 2003-01-22 |
| DE60007894D1 (de) | 2004-02-26 |
| EP1235828A1 (de) | 2002-09-04 |
| JP2003514908A (ja) | 2003-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |