ATE258221T1 - Simuliertes biologisches auflösungs- und absorptionssystem - Google Patents
Simuliertes biologisches auflösungs- und absorptionssystemInfo
- Publication number
- ATE258221T1 ATE258221T1 AT98956732T AT98956732T ATE258221T1 AT E258221 T1 ATE258221 T1 AT E258221T1 AT 98956732 T AT98956732 T AT 98956732T AT 98956732 T AT98956732 T AT 98956732T AT E258221 T1 ATE258221 T1 AT E258221T1
- Authority
- AT
- Austria
- Prior art keywords
- chamber
- dissolution
- cell culture
- filter
- active compound
- Prior art date
Links
- 238000004090 dissolution Methods 0.000 title abstract 6
- 238000010521 absorption reaction Methods 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 239000013553 cell monolayer Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/006—Dissolution of tablets or the like
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/982,692 US6022733A (en) | 1997-12-02 | 1997-12-02 | Simulated biological dissolution and absorption system |
| PCT/CA1998/001090 WO1999028437A1 (en) | 1997-12-02 | 1998-11-30 | Simulated biological dissolution and absorption system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258221T1 true ATE258221T1 (de) | 2004-02-15 |
Family
ID=25529415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98956732T ATE258221T1 (de) | 1997-12-02 | 1998-11-30 | Simuliertes biologisches auflösungs- und absorptionssystem |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6022733A (de) |
| EP (1) | EP1034251B1 (de) |
| CN (1) | CN1179035C (de) |
| AT (1) | ATE258221T1 (de) |
| AU (1) | AU1328499A (de) |
| CA (1) | CA2312833A1 (de) |
| DE (1) | DE69821259T2 (de) |
| DK (1) | DK1034251T3 (de) |
| ES (1) | ES2214751T3 (de) |
| WO (1) | WO1999028437A1 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| CN1173776C (zh) | 1996-06-28 | 2004-11-03 | 卡钳技术有限公司 | 在微规模流体性设备里的高通过量的筛选分析系统 |
| US20060000722A1 (en) * | 1996-06-28 | 2006-01-05 | Caliper Life Sciences, Inc. | High throughput screening assay systems in microscale fluidic devices |
| GB9805519D0 (en) * | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Processes |
| US6485963B1 (en) * | 2000-06-02 | 2002-11-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof |
| US6667172B2 (en) * | 2001-09-19 | 2003-12-23 | The Cleveland Clinic Foundation | Cell and tissue culture modeling device and apparatus and method of using same |
| US7027970B2 (en) * | 2001-10-19 | 2006-04-11 | Globomax Llc | Tool for in vitro-in vivo correlation |
| US6799123B2 (en) * | 2001-11-05 | 2004-09-28 | Lyn Hughes | Dissolution test equipment and method |
| EP1490520A4 (de) * | 2002-03-12 | 2006-06-07 | Surface Logix Inc | Testvorrichtung, die die absorption, den stoffwechsel, die permeabiltät und/oder toxizität einer kandidatenverbindung analysiert |
| US6673598B1 (en) * | 2002-10-29 | 2004-01-06 | Synthecon, Inc. | Disposable culture bag |
| US7390653B2 (en) * | 2002-12-04 | 2008-06-24 | Synthecon, Inc. | Culture chamber for biologicals |
| US7144727B2 (en) * | 2003-04-14 | 2006-12-05 | Synthecon, Inc. | Interlinked culture chamber for biologicals |
| EP1730516A1 (de) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Verfahren und vorrichtung zur bewertung pharmazeutischer zusammensetzungen |
| GB0514702D0 (en) | 2005-07-18 | 2005-08-24 | Plant Bioscience Ltd | Apparatus, system and method |
| EP1777510A1 (de) * | 2005-10-21 | 2007-04-25 | Rohm and Haas Company | Verfahren und Vorrichtung zur Prüfung der Auflösung von Produkten |
| CA2672408C (en) * | 2007-03-30 | 2019-07-23 | 9898 Limited | Pharmacokinetic and pharmacodynamic modelling and methods for the development of phytocompositions or other multi-component compositions |
| FR2923065B1 (fr) * | 2007-10-30 | 2009-12-11 | Univ Dauvergne Clermont 1 | Dispositif de simulation d'un estomac d'un mammifere monogastrique ou d'un etre humain |
| FR2937455B1 (fr) | 2008-10-20 | 2010-12-03 | Gen Biscuit | Methode in vitro modelisant la consistance generee in vivo par un aliment au cours de sa digestion |
| EP2182342A1 (de) * | 2008-10-28 | 2010-05-05 | LEK Pharmaceuticals D.D. | Auflösungsvorrichtung mit zwei Fächern und Verfahren |
| DE102009022354B4 (de) * | 2009-05-15 | 2015-05-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Bioreaktorsystem |
| US10287539B2 (en) * | 2009-06-09 | 2019-05-14 | Jtec Corporation | Rotating culture vessel and automatic cell culture apparatus using same |
| US20100321028A1 (en) * | 2009-06-18 | 2010-12-23 | The Hong Kong Polytechnic University | System and method for determining the performance of a wearable electrode |
| EP2284821A1 (de) * | 2009-08-07 | 2011-02-16 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Verfahren, Vorrichtung und Computerprogrammprodukt zur Beurteilung der Desintegration einer Dosierform im Verdauungstrakt |
| EP2302353A1 (de) * | 2009-09-28 | 2011-03-30 | Sanofi-Aventis | Online-TEER-Messung in einem System zur Permeationsbestimmung mittels einer Durchfluss-Permeationszelle (FTPC) mit strukturell integrierten Elektroden |
| CN101968480B (zh) * | 2009-10-27 | 2013-09-11 | 闽南师范大学 | 药物中可被人体吸收的微量元素含量的模拟检测方法 |
| GB0921048D0 (en) * | 2009-12-01 | 2010-01-13 | Health Prot Agency | Assay method and apparatus |
| US8993042B2 (en) * | 2010-01-06 | 2015-03-31 | Toyota Motor Engineering & Manufacturing North America, Inc. | Method for determining the production parameters for a substrate coating process |
| US20110177179A1 (en) * | 2010-01-18 | 2011-07-21 | Sinoveda Canada, Inc. | Preparation of botanical extracts containing absorbable components using pharmaceutical platform technology |
| WO2011097566A1 (en) * | 2010-02-08 | 2011-08-11 | Renewable Process Technologies Llc | System and method for producing biomaterials |
| JP5576337B2 (ja) * | 2010-06-30 | 2014-08-20 | ローム アンド ハース カンパニー | 医薬剤形を溶出試験装置に分配するための送達装置 |
| US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
| EP2529770A1 (de) * | 2011-05-31 | 2012-12-05 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Verdauungssystem |
| US20130074587A1 (en) * | 2011-09-28 | 2013-03-28 | Mel Merciadez | System and method for dissolution analysis of drug-eluting medical devices |
| US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
| US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
| US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
| US9844757B2 (en) | 2014-03-12 | 2017-12-19 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
| US10376845B2 (en) | 2016-04-14 | 2019-08-13 | Lockheed Martin Corporation | Membranes with tunable selectivity |
| US9610546B2 (en) | 2014-03-12 | 2017-04-04 | Lockheed Martin Corporation | Separation membranes formed from perforated graphene and methods for use thereof |
| TW201504140A (zh) | 2013-03-12 | 2015-02-01 | Lockheed Corp | 形成具有均勻孔尺寸之多孔石墨烯之方法 |
| US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
| JP6087264B2 (ja) * | 2013-11-29 | 2017-03-01 | 株式会社日立ハイテクノロジーズ | 成分分析装置、薬効分析装置、及び分析方法 |
| CN105940479A (zh) | 2014-01-31 | 2016-09-14 | 洛克希德马丁公司 | 使用宽离子场穿孔二维材料 |
| CN106029596A (zh) | 2014-01-31 | 2016-10-12 | 洛克希德马丁公司 | 采用多孔非牺牲性支撑层的二维材料形成复合结构的方法 |
| JP2017534311A (ja) | 2014-09-02 | 2017-11-24 | ロッキード・マーチン・コーポレーション | 二次元膜材料をベースとする血液透析膜および血液濾過膜、ならびにそれを用いた方法 |
| US9546991B2 (en) | 2014-11-21 | 2017-01-17 | Absorption Systems Group, Llc | System for the concomitant assessment of drug dissolution, absorption and permeation and methods of using the same |
| US10228358B2 (en) | 2015-04-17 | 2019-03-12 | Pion Inc. | Apparatus and method for the assessment of concentration profiling and permeability rates |
| JP2018528144A (ja) | 2015-08-05 | 2018-09-27 | ロッキード・マーチン・コーポレーション | グラフェン系材料の穿孔可能なシート |
| WO2017023377A1 (en) | 2015-08-06 | 2017-02-09 | Lockheed Martin Corporation | Nanoparticle modification and perforation of graphene |
| WO2017180134A1 (en) * | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
| EP3442739A4 (de) | 2016-04-14 | 2020-03-04 | Lockheed Martin Corporation | Verfahren zur behandlung von graphenfolien für grossflächigen transfer mittels free-float-verfahren |
| EP3442697A4 (de) | 2016-04-14 | 2020-03-18 | Lockheed Martin Corporation | Selektive grenzflächenminderung von graphendefekten |
| EP3442786A4 (de) | 2016-04-14 | 2020-03-18 | Lockheed Martin Corporation | Zweidimensionale membranstrukturen mit strömungskanälen |
| KR20180133430A (ko) | 2016-04-14 | 2018-12-14 | 록히드 마틴 코포레이션 | 결함 형성 또는 힐링의 인 시츄 모니터링 및 제어를 위한 방법 |
| EP3412762A1 (de) * | 2017-06-06 | 2018-12-12 | ProDigest BVBA | Magen-darm-trakt-simulationssystem, kammern dafür und verfahren |
| CN108682252B (zh) * | 2018-06-11 | 2020-07-03 | 江南大学 | 一种基于连杆运动的食物吞咽模拟装置 |
| CN108735060B (zh) * | 2018-08-14 | 2024-08-02 | 晓东宜健(苏州)仪器设备有限公司 | 一种仿生人体食道和胃消化系统 |
| WO2020117855A1 (en) * | 2018-12-03 | 2020-06-11 | Lyndra, Inc. | Stomach simulating device |
| US11668723B2 (en) | 2019-07-09 | 2023-06-06 | Logan Instruments Corporation | Automated dissolution/permeation testing system |
| CN113174312A (zh) * | 2021-05-08 | 2021-07-27 | 苏州珀罗汀生物技术有限公司 | 一种蛋白生产装置及方法 |
| EP4366873A4 (de) * | 2021-07-08 | 2025-08-06 | Ourotech Inc | Systeme und verfahren zur vorhersage der behandlungswirksamkeit |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| CA1274159A (en) * | 1986-06-19 | 1990-09-18 | Joseph K.S. Lee | Dissolution cell and method for determining the in- vitro release of a drug |
| US4667504A (en) * | 1986-10-02 | 1987-05-26 | The United States Of America As Represented By The Secretary Of The Air Force | Flow through device for determination of the penetration rate of chemicals across biological membranes in vitro |
| US4988623A (en) * | 1988-06-30 | 1991-01-29 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Rotating bio-reactor cell culture apparatus |
| US5153131A (en) * | 1990-12-11 | 1992-10-06 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | High aspect reactor vessel and method of use |
| US5153132A (en) * | 1988-06-30 | 1992-10-06 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Three-dimensional co-culture process |
| US5026650A (en) * | 1988-06-30 | 1991-06-25 | The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration | Horizontally rotated cell culture system with a coaxial tubular oxygenator |
| US5181518A (en) * | 1991-02-04 | 1993-01-26 | Mcdonagh Paul F | Method of evaluating cardioprotective agents |
| NL9201907A (nl) * | 1992-11-02 | 1994-06-01 | Tno | Peristaltisch mengende reactor en peristaltische kleppenpomp. |
| US5698413A (en) * | 1993-05-05 | 1997-12-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of evaluating chemotherapeutic agents in vivo |
| CA2161224C (en) * | 1994-02-25 | 1999-02-02 | Gerald Brinker | Dissolution testing apparatus |
| US5527705A (en) * | 1994-09-12 | 1996-06-18 | Becton, Dickinson And Company | Roller bottle for trans-membrane co-culture of cells and method for its use |
| CA2201159A1 (en) * | 1994-09-27 | 1996-04-04 | Xenogenex, Inc. | Artificial liver apparatus and method |
-
1997
- 1997-12-02 US US08/982,692 patent/US6022733A/en not_active Expired - Fee Related
-
1998
- 1998-11-30 AT AT98956732T patent/ATE258221T1/de not_active IP Right Cessation
- 1998-11-30 EP EP98956732A patent/EP1034251B1/de not_active Expired - Lifetime
- 1998-11-30 CN CNB98813408XA patent/CN1179035C/zh not_active Expired - Fee Related
- 1998-11-30 CA CA002312833A patent/CA2312833A1/en not_active Abandoned
- 1998-11-30 WO PCT/CA1998/001090 patent/WO1999028437A1/en not_active Ceased
- 1998-11-30 ES ES98956732T patent/ES2214751T3/es not_active Expired - Lifetime
- 1998-11-30 DK DK98956732T patent/DK1034251T3/da active
- 1998-11-30 AU AU13284/99A patent/AU1328499A/en not_active Abandoned
- 1998-11-30 DE DE1998621259 patent/DE69821259T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69821259D1 (de) | 2004-02-26 |
| WO1999028437A1 (en) | 1999-06-10 |
| EP1034251A1 (de) | 2000-09-13 |
| CA2312833A1 (en) | 1999-06-10 |
| CN1179035C (zh) | 2004-12-08 |
| HK1034993A1 (en) | 2001-11-09 |
| DE69821259T2 (de) | 2004-11-18 |
| DK1034251T3 (da) | 2004-05-17 |
| ES2214751T3 (es) | 2004-09-16 |
| CN1284127A (zh) | 2001-02-14 |
| US6022733A (en) | 2000-02-08 |
| AU1328499A (en) | 1999-06-16 |
| EP1034251B1 (de) | 2004-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1034251 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |