ATE258551T1 - (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung - Google Patents

(2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung

Info

Publication number
ATE258551T1
ATE258551T1 AT98921668T AT98921668T ATE258551T1 AT E258551 T1 ATE258551 T1 AT E258551T1 AT 98921668 T AT98921668 T AT 98921668T AT 98921668 T AT98921668 T AT 98921668T AT E258551 T1 ATE258551 T1 AT E258551T1
Authority
AT
Austria
Prior art keywords
thienyl
acetonitriles
ethylamino
halophenyl
production
Prior art date
Application number
AT98921668T
Other languages
English (en)
Inventor
Alain Heymes
Bertrand Castro
Maria Bakonyi
Nagy Marianna Csatarine
Leventene Molnar
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of ATE258551T1 publication Critical patent/ATE258551T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT98921668T 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung ATE258551T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9700886A HU225504B1 (en) 1997-05-13 1997-05-13 Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
PCT/HU1998/000046 WO1998051682A1 (en) 1997-05-13 1998-05-11 New intermediates and process for the preparation thereof

Publications (1)

Publication Number Publication Date
ATE258551T1 true ATE258551T1 (de) 2004-02-15

Family

ID=89995121

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98921668T ATE258551T1 (de) 1997-05-13 1998-05-11 (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung

Country Status (14)

Country Link
US (1) US6215005B1 (de)
EP (1) EP0981525B1 (de)
JP (1) JP4279903B2 (de)
AT (1) ATE258551T1 (de)
AU (1) AU7444698A (de)
BR (1) BR9809113B1 (de)
CA (1) CA2288637C (de)
DE (1) DE69821347T2 (de)
DK (1) DK0981525T3 (de)
ES (1) ES2213900T3 (de)
HU (1) HU225504B1 (de)
NO (1) NO325305B1 (de)
PT (1) PT981525E (de)
WO (1) WO1998051682A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226421B1 (en) 1998-11-09 2008-12-29 Sanofi Aventis Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
WO2004081016A1 (en) 2003-03-12 2004-09-23 Cadila Healthcare Limited Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate
US20040250673A1 (en) * 2003-06-10 2004-12-16 Salerno Paul Michael Ergonomic pedal board
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
PT1680430E (pt) 2003-11-03 2010-04-26 Cadila Healthcare Ltd Processos para a preparação da forma i de bissulfato de (s)-(+)-clopidogrel
EP1704152A2 (de) * 2004-09-21 2006-09-27 Teva Pharmaceutical Industries Ltd Kristallines clopidogrelhydrobromid und verfahren zu dessen herstellung
CA2594763A1 (en) * 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
US8063217B2 (en) 2005-07-12 2011-11-22 Rpg Life Sciences Limited Process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl)-6, 7-dihydrothieno[3,2-C]pyridine-5(4H) -acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
CN102014899A (zh) * 2006-04-27 2011-04-13 因-斯韦特实验室有限公司 硫酸氢氯吡格雷多晶型物的制备方法
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
EP1980563A1 (de) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Verfahren zur Herstellung von Methyl (+)-(S)-Alpha-(O-Chlorophenyl)-6,7-Dihydrothieno-[3,2-C]pyridine-5(4H) Acetat
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel
KR102860417B1 (ko) * 2023-08-21 2025-09-17 ㈜분자와물질 다성분, 단일반응에 의한 질소-치환된 아미노산을 포함하는 테트라하이드로티에노피리딘 유도체의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508455A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives des (thienyl-2)- et (thienyl-3)-2 ethylamines
FR2530247B1 (fr) 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2608607B1 (fr) 1986-12-23 1989-04-28 Sanofi Sa Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2614619B1 (fr) * 1987-04-29 1989-09-15 Sanofi Sa Procede de preparation de n-((chloro-2)-benzyl) (thienyl-2)-2 ethylamine
FR2652575B1 (fr) * 1989-09-29 1992-01-24 Sanofi Sa Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
JP2001501922A (ja) * 1996-09-12 2001-02-13 ローヌ―プーラン ローラー ファーマシューティカルズ インコーポレイテッド キラルな１―アリール―及び１―ヘテロアリール―２―置換エチル―２―アミンの立体特異的な製造

Also Published As

Publication number Publication date
HU225504B1 (en) 2007-01-29
NO995531D0 (no) 1999-11-12
JP2001525817A (ja) 2001-12-11
CA2288637C (en) 2005-11-15
DK0981525T3 (da) 2004-05-10
EP0981525A1 (de) 2000-03-01
BR9809113B1 (pt) 2010-03-09
NO325305B1 (no) 2008-03-25
ES2213900T3 (es) 2004-09-01
NO995531L (no) 1999-12-13
HU9700886D0 (en) 1997-07-28
JP4279903B2 (ja) 2009-06-17
DE69821347T2 (de) 2004-12-02
AU7444698A (en) 1998-12-08
BR9809113A (pt) 2000-08-01
HUP9700886A3 (en) 2000-06-28
WO1998051682A1 (en) 1998-11-19
HUP9700886A2 (hu) 1999-09-28
PT981525E (pt) 2004-05-31
US6215005B1 (en) 2001-04-10
DE69821347D1 (de) 2004-03-04
EP0981525B1 (de) 2004-01-28
CA2288637A1 (en) 1998-11-19

Similar Documents

Publication Publication Date Title
ATE258551T1 (de) (2-(2-thienyl)-ethylamino)-(2-halophenyl)- acetonitrile als zwischenprodukte und verfahren zu ihrer herstellung
ATE238294T1 (de) Zwischenprodukte und verfahren zu ihrer herstellung
NO982850L (no) Ny syntese
MX9605206A (es) 1alfa,26-dihidroxi-d-homo-vitamina d3.
PT923554E (pt) N-benzilpiperidina e derivados tetrahidropiridina
DE59606920D1 (de) Chirale methylphenyloxazolidinone
ATE266030T1 (de) 1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen
NO20016151L (no) Fremstilling av substituerte piperidin-4-oner
DK0891341T3 (da) 1,3,4-Oxadiazinderivater samt deres anvendelse som pesticider
DE60235365D1 (de) Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
YU12000A (sh) Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
PT1206452E (pt) Processo de preparacao de compostos benzoper-hidroisoindole
DE60003807D1 (de) Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung
ATE196292T1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
IL158356A0 (en) Benzoheterocycles
YU22797A (sh) Postupak i intermedijarna jedinjenja za dobijanje pesticidnih fluoroolefinskih jedinjenja
BR9807785A (pt) Processo para a preparação do composto, e, composto
BR9909151A (pt) processos para preparação de intermediários
DE60006125D1 (de) Herstellung von 2-(2-arylmorpholin-2-yl)ethanolderivaten und zwischenprodukte
BR9807913A (pt) 7-acilamino-3-(metilhidrazono)metil cefalosporinas substituìdas antibacterianas e intermediários
DE60000790D1 (de) [(2-substituierte-5-[3-thienyl)-benzyl]-[2-([2-isopropoxy-5-fluoro]-phenoxy)-ethyl]-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente
ATE244217T1 (de) Herstellung von beta-mehtylcarbapenem- zwischenprodukten
AU1392600A (en) Alkyl esters of 3-(3,4-dihalogenophenyl)-2,6-dioxopiperidine-3-propionic acid useful as intermediates
NO993650L (no) Nye forbindelser med hemoregulerende effekt
NO20006377L (no) Syntese av benzo[F]kinolinoner

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0981525

Country of ref document: EP