ATE260336T1 - Verfahren zur aktivierung von prothrombin zu thrombin - Google Patents

Verfahren zur aktivierung von prothrombin zu thrombin

Info

Publication number: ATE260336T1
Authority: AT; Austria
Prior art keywords: thrombin; prothrombin; absence; activating; activating prothrombin
Prior art date: 1996-08-09

Application number

AT97113588T

Other languages

English (en)

Inventor

Hiroshi Kaetsu

Jun Mizuguchi

Takayoshi Hamamoto

Original Assignee

Chemo Sero Therapeut Res Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-09

Filing date

1997-08-06

Publication date

2004-03-15

1997-08-06 Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE260336T1 publication Critical patent/ATE260336T1/de

Links

108010094028 Prothrombin Proteins 0.000 title abstract 4
102100027378 Prothrombin Human genes 0.000 title abstract 4
108090000190 Thrombin Proteins 0.000 title abstract 4
229940039716 prothrombin Drugs 0.000 title abstract 4
229960004072 thrombin Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
230000003213 activating effect Effects 0.000 title abstract 2
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
108010000499 Thromboplastin Proteins 0.000 abstract 1
102000002262 Thromboplastin Human genes 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
159000000007 calcium salts Chemical class 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

AT97113588T 1996-08-09 1997-08-06 Verfahren zur aktivierung von prothrombin zu thrombin ATE260336T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP22769596A JP3944267B2 (ja)	1996-08-09	1996-08-09	プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法

Publications (1)

Publication Number	Publication Date
ATE260336T1 true ATE260336T1 (de)	2004-03-15

Family

ID=16864906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97113588T ATE260336T1 (de)	1996-08-09	1997-08-06	Verfahren zur aktivierung von prothrombin zu thrombin

Country Status (6)

Country	Link
US (1)	US5811279A (de)
EP (1)	EP0823476B1 (de)
JP (1)	JP3944267B2 (de)
AT (1)	ATE260336T1 (de)
DE (1)	DE69727736T2 (de)
DK (1)	DK0823476T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6274090B1 (en) *	1998-08-05	2001-08-14	Thermogenesis Corp.	Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) *	1999-06-04	2002-10-29	Thermogenesis Corp.	Method for preparing thrombin for use in a biological glue
AU6214200A (en) *	1999-07-14	2001-02-05	Research Foundation Of The State University Of New York, The	Assay of the activation state of platelets
EP1585386A4 (de) *	2002-02-20	2009-09-02	American Integrated Biolog Inc	Rekombinante produktion im speichel
US20070011752A1 (en) *	2005-05-06	2007-01-11	American Integrated Biologics, Inc.	Production of human proteins in transgenic animal saliva
RU2457248C2 (ru) *	2010-06-09	2012-07-27	Общество с ограниченной ответственностью фирма "Технология-Стандарт"	Способ промышленного получения тромбина
EA028016B1 (ru) *	2013-06-06	2017-09-29	Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор")	Набор для измерения параметров системы гемостаза в образце крови или ее компонентов
RU2698206C1 (ru) *	2018-07-02	2019-08-23	Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор")	Набор реагентов для диагностики степени нейровоспаления
GB2579630A (en)	2018-12-07	2020-07-01	Biotherapy Services Ltd	Methods and compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3560475A (en) *	1969-06-19	1971-02-02	Baxter Laboratories Inc	Prothrombin complex prepared by precipitation with polyethylene glycol
US3682881A (en) *	1970-10-02	1972-08-08	Baxter Laboratories Inc	Fractionation of plasma using glycine and polyethylene glycol
US5138034A (en) *	1989-07-12	1992-08-11	The Green Cross Corporation	Method of fractionating plasma proteins
US5281528A (en) *	1989-12-18	1994-01-25	Warner-Lambert Company	Process for purified thromboplastin for ultra-pure thrombin preparation
JPH04365481A (ja) *	1991-06-11	1992-12-17	Green Cross Corp:The	トロンビンの製造法
FR2679251B1 (fr) *	1991-07-18	1993-11-12	Nord Assoc Essor Transfusion San	Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) *	1991-11-04	1994-09-26	Immuno Ag	Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) *	1991-11-19	1993-05-27	Behringwerke Ag	Verfahren zur herstellung eines virussicheren thrombinkonzentrates
JPH0733799A (ja) *	1993-07-20	1995-02-03	Green Cross Corp:The	高比活性トロンビンおよびその製造方法
JPH07308190A (ja) *	1994-05-18	1995-11-28	Green Cross Corp:The	トロンビンの製造方法
US5677162A (en) *	1995-05-01	1997-10-14	New York Blood Center, Inc.	Method for activating prothrombin to thrombin

1996
- 1996-08-09 JP JP22769596A patent/JP3944267B2/ja not_active Expired - Lifetime
1997
- 1997-08-01 US US08/905,041 patent/US5811279A/en not_active Expired - Lifetime
- 1997-08-06 EP EP97113588A patent/EP0823476B1/de not_active Expired - Lifetime
- 1997-08-06 DK DK97113588T patent/DK0823476T3/da active
- 1997-08-06 AT AT97113588T patent/ATE260336T1/de active
- 1997-08-06 DE DE69727736T patent/DE69727736T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5811279A (en)	1998-09-22
EP0823476A2 (de)	1998-02-11
JP3944267B2 (ja)	2007-07-11
DE69727736T2 (de)	2004-11-25
DE69727736D1 (de)	2004-04-01
DK0823476T3 (da)	2004-06-14
EP0823476B1 (de)	2004-02-25
JPH1052267A (ja)	1998-02-24
EP0823476A3 (de)	1999-09-01

Legal Events

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2004-11-15

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Publication of translation of european patent specification

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