ATE261432T1 - Verfahren zur herstellung von 4-phenyl-1,2,3,6- tetrahydropyridin-derivaten und die dafür verwendeten zwischenprodukte - Google Patents
Verfahren zur herstellung von 4-phenyl-1,2,3,6- tetrahydropyridin-derivaten und die dafür verwendeten zwischenprodukteInfo
- Publication number
- ATE261432T1 ATE261432T1 AT99401497T AT99401497T ATE261432T1 AT E261432 T1 ATE261432 T1 AT E261432T1 AT 99401497 T AT99401497 T AT 99401497T AT 99401497 T AT99401497 T AT 99401497T AT E261432 T1 ATE261432 T1 AT E261432T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- reacting
- compound
- formula
- agent
- Prior art date
Links
- OMPXTQYWYRWWPH-UHFFFAOYSA-N 4-phenyl-1,2,3,6-tetrahydropyridine Chemical class C1NCCC(C=2C=CC=CC=2)=C1 OMPXTQYWYRWWPH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- WXYOOZZZTKTPRH-UHFFFAOYSA-N 4-phenyl-1,2,3,6-tetrahydropyridin-5-ol Chemical class C1CNCC(O)=C1C1=CC=CC=C1 WXYOOZZZTKTPRH-UHFFFAOYSA-N 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000011917 diastereoselective reduction Methods 0.000 abstract 1
- 238000003683 electrophilic halogenation reaction Methods 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9807677A FR2780056B1 (fr) | 1998-06-18 | 1998-06-18 | Nouveau procede de preparation de derives de la 4-phenyl-1-2 3,6-tetrahydropyridine et les produits imtermediaires mis en oeuvre |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261432T1 true ATE261432T1 (de) | 2004-03-15 |
Family
ID=9527532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99401497T ATE261432T1 (de) | 1998-06-18 | 1999-06-17 | Verfahren zur herstellung von 4-phenyl-1,2,3,6- tetrahydropyridin-derivaten und die dafür verwendeten zwischenprodukte |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6136981A (de) |
| EP (1) | EP0965588B1 (de) |
| JP (1) | JP4538114B2 (de) |
| AT (1) | ATE261432T1 (de) |
| CA (1) | CA2275192C (de) |
| DE (1) | DE69915413T2 (de) |
| DK (1) | DK0965588T3 (de) |
| ES (1) | ES2213991T3 (de) |
| FR (1) | FR2780056B1 (de) |
| HU (1) | HU225621B1 (de) |
| PT (1) | PT965588E (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5981747B2 (ja) * | 2012-03-28 | 2016-08-31 | 東ソー・ファインケム株式会社 | アザディールス−アルダー反応用触媒、それを用いたテトラヒドロピリジン化合物の製造方法 |
| BR112017022666A8 (pt) | 2015-04-20 | 2022-10-18 | Tolero Pharmaceuticals Inc | Preparando resposta à alvocidib por perfilamento mitocondrial |
| CN111349118B (zh) | 2015-05-18 | 2023-08-22 | 住友制药肿瘤公司 | 具有增加的生物利用度的阿伏西地前药 |
| RU2759963C2 (ru) | 2015-08-03 | 2021-11-19 | Сумитомо Даиниппон Фарма Онколоджи, Инк. | Комбинированные терапии для лечения рака |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| JP6619519B2 (ja) | 2016-12-19 | 2019-12-11 | トレロ ファーマシューティカルズ， インコーポレイテッド | プロファイリングペプチドおよび感受性プロファイリングのための方法 |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| MX2021006544A (es) | 2018-12-04 | 2021-07-07 | Sumitomo Pharma Oncology Inc | Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer. |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2338043A1 (fr) * | 1976-01-13 | 1977-08-12 | Delmar Chem | Derives de 4-arylpiperidine et procedes de production |
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| US5849733A (en) * | 1996-05-10 | 1998-12-15 | Bristol-Myers Squibb Co. | 2-thio or 2-oxo flavopiridol analogs |
| US6268499B1 (en) * | 1998-08-10 | 2001-07-31 | Hoffman-La Roche Inc. | Process and intermediates for preparation of substituted piperidine-epoxides |
-
1998
- 1998-06-18 FR FR9807677A patent/FR2780056B1/fr not_active Expired - Lifetime
-
1999
- 1999-06-15 CA CA002275192A patent/CA2275192C/fr not_active Expired - Lifetime
- 1999-06-16 JP JP16964099A patent/JP4538114B2/ja not_active Expired - Lifetime
- 1999-06-16 US US09/334,776 patent/US6136981A/en not_active Expired - Lifetime
- 1999-06-17 DE DE69915413T patent/DE69915413T2/de not_active Expired - Lifetime
- 1999-06-17 HU HU9902040A patent/HU225621B1/hu unknown
- 1999-06-17 AT AT99401497T patent/ATE261432T1/de active
- 1999-06-17 ES ES99401497T patent/ES2213991T3/es not_active Expired - Lifetime
- 1999-06-17 EP EP99401497A patent/EP0965588B1/de not_active Expired - Lifetime
- 1999-06-17 PT PT99401497T patent/PT965588E/pt unknown
- 1999-06-17 DK DK99401497T patent/DK0965588T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000026418A (ja) | 2000-01-25 |
| EP0965588B1 (de) | 2004-03-10 |
| US6136981A (en) | 2000-10-24 |
| DE69915413T2 (de) | 2004-08-19 |
| PT965588E (pt) | 2004-07-30 |
| HUP9902040A2 (hu) | 2001-11-28 |
| FR2780056A1 (fr) | 1999-12-24 |
| ES2213991T3 (es) | 2004-09-01 |
| HU225621B1 (en) | 2007-05-02 |
| CA2275192C (fr) | 2008-12-30 |
| HU9902040D0 (en) | 1999-08-30 |
| JP4538114B2 (ja) | 2010-09-08 |
| EP0965588A1 (de) | 1999-12-22 |
| CA2275192A1 (fr) | 1999-12-18 |
| FR2780056B1 (fr) | 2000-08-04 |
| DE69915413D1 (de) | 2004-04-15 |
| DK0965588T3 (da) | 2004-06-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE254612T1 (de) | Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen | |
| DE69638035D1 (de) | Verfahren zur Herstellung substituierter 1,1,1-Trifluoro-3-buten-2-one | |
| AU2381695A (en) | Intermediates in pharmaceutical camptothecin preparation | |
| HU9203761D0 (en) | Method for producing substituted pyridine derivatives | |
| ATE261432T1 (de) | Verfahren zur herstellung von 4-phenyl-1,2,3,6- tetrahydropyridin-derivaten und die dafür verwendeten zwischenprodukte | |
| ATE241594T1 (de) | N-phenylacetoacetamide und verfahren zu ihrer herstellung | |
| ATE138376T1 (de) | Verfahren zur herstellung von benzylphthalazinonderivaten und von deren salzen | |
| DE69839732D1 (de) | Verfahren zur herstellung von 3,4-dihydroxy-3cyclobuten-1,2-dion | |
| PL349933A1 (en) | Novel compounds beta-hydroxyalylamides, method of obtaining them and their application | |
| ATE270287T1 (de) | 2,3-dihydro-1h-isoindolderivate, verfahren zu ihrer herstellung und ihre verwendung als hemmer der serotoninwiederaufnahme | |
| ATE127449T1 (de) | Anilinderivate und verfahren zu ihrer herstellung. | |
| ATE554094T1 (de) | Verfahren zur herstellung von 3-cephem- verbindungen | |
| DE69007203D1 (de) | Imidazolderivate, Verfahren zu deren Herstellung und diese enthaltende Antiulkusmittel. | |
| ATE103598T1 (de) | Verfahren zur herstellung von zwischenprodukten in der synthese von diltiazem. | |
| ATE172964T1 (de) | Verfahren zur herstellung von (-)-n-methyl-n-(4- (4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4- dichlorophenyl)butyl>-benzamid und ihr pharmazeutisch annehmbares salz | |
| ATE205178T1 (de) | Verfahren zur herstellung von 3,4-dihydroxy-3- cyclobuten-1,2-dion | |
| DK0521766T3 (da) | Hidtil ukendt fremgangsmåde til syntese af enantiomerer af 3-aminochromanderivater | |
| ATE223377T1 (de) | Verfahren zur herstellung von difluoracetophenon- derivaten | |
| ATE407118T1 (de) | Verfahren zur herstellung von n-alkoxycarbonyl- piperidin derivaten sowie zwischenverbindungen dafür | |
| ATE225350T1 (de) | Verfahren zur herstellung von folsäure | |
| DE69615570D1 (de) | Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten | |
| ATE256096T1 (de) | Verfahren zur herstellung von 2- arylvinylalkylethern und 1,4-diaryl-2-fluor-2- butenen | |
| ATE253048T1 (de) | Verfahren zur herstellung von piperidincarbonsäureamiden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0965588 Country of ref document: EP |