ATE261765T1 - Vorrichtung und verfahren zur synthese von polymeren mit anwendung von arrays - Google Patents

Vorrichtung und verfahren zur synthese von polymeren mit anwendung von arrays

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Publication number
ATE261765T1
ATE261765T1 AT00103594T AT00103594T ATE261765T1 AT E261765 T1 ATE261765 T1 AT E261765T1 AT 00103594 T AT00103594 T AT 00103594T AT 00103594 T AT00103594 T AT 00103594T AT E261765 T1 ATE261765 T1 AT E261765T1
Authority
AT
Austria
Prior art keywords
reaction well
synthesis
head assembly
base assembly
nozzle
Prior art date
Application number
AT00103594T
Other languages
English (en)
Inventor
Thomas M Brennan
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE261765T1 publication Critical patent/ATE261765T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1072—Multiple transfer devices with provision for selective pipetting of individual channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
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    • B01J2219/00279—Features relating to reactor vessels
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    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
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    • B01J2219/00279—Features relating to reactor vessels
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    • B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
    • B01J2219/00328—Movement by linear translation
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00414—Means for dispensing and evacuation of reagents using suction
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00414—Means for dispensing and evacuation of reagents using suction
    • B01J2219/00416—Vacuum
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    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
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    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polymerisation Methods In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT00103594T 1993-10-22 1994-10-19 Vorrichtung und verfahren zur synthese von polymeren mit anwendung von arrays ATE261765T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/142,593 US5472672A (en) 1993-10-22 1993-10-22 Apparatus and method for polymer synthesis using arrays

Publications (1)

Publication Number Publication Date
ATE261765T1 true ATE261765T1 (de) 2004-04-15

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ID=22500483

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00103594T ATE261765T1 (de) 1993-10-22 1994-10-19 Vorrichtung und verfahren zur synthese von polymeren mit anwendung von arrays
AT94931933T ATE195671T1 (de) 1993-10-22 1994-10-19 Gerät und verfahren zur polymersynthese mit gerüsten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT94931933T ATE195671T1 (de) 1993-10-22 1994-10-19 Gerät und verfahren zur polymersynthese mit gerüsten

Country Status (7)

Country Link
US (8) US5472672A (de)
EP (2) EP0734397B1 (de)
JP (3) JP3677041B2 (de)
AT (2) ATE261765T1 (de)
CA (1) CA2174648C (de)
DE (2) DE69433635T2 (de)
WO (1) WO1995011262A1 (de)

Families Citing this family (399)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6558633B1 (en) * 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
WO1996015768A1 (en) * 1994-11-18 1996-05-30 The Procter & Gamble Company Oral compositions
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6239273B1 (en) 1995-02-27 2001-05-29 Affymetrix, Inc. Printing molecular library arrays
US5599695A (en) * 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
WO1996030393A1 (en) * 1995-03-27 1996-10-03 Warner-Lambert Company A method for the synthesis of mixtures of compounds
US5759779A (en) * 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US5716584A (en) * 1995-09-07 1998-02-10 Pathogenesis Corporation Device for the synthesis of compounds in an array
US7026114B1 (en) * 1995-09-13 2006-04-11 Affymetrix, Inc. Methods and compositions for monitoring polymer array synthesis
KR19990063660A (ko) * 1995-09-22 1999-07-26 벌렉스 래보라토리즈, 인크. 다중 화학 반응을 위한 장치 및 방법
US5888830A (en) 1995-09-22 1999-03-30 Berlex Laboratories, Inc. Apparatus and process for multiple chemical reactions
GB9521775D0 (en) * 1995-10-24 1996-01-03 Pa Consulting Services Microwell plates
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
EP2332957B1 (de) * 1996-02-09 2015-04-08 Cornell Research Foundation, Inc. Detektion von Unterschieden in der Sequenz von Nukleinsäuren mittels der Ligasedetektionsreaktion und adressierbaren Arrays
US6063633A (en) * 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
US5840256A (en) * 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
US6033544A (en) * 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
EP0892672A4 (de) * 1996-04-09 2001-02-28 Sarnoff Corp Platte fur reaktionssystem
US5733509A (en) * 1996-04-17 1998-03-31 Motorola, Inc. Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars
US6706875B1 (en) * 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
US6048691A (en) * 1996-05-13 2000-04-11 Motorola, Inc. Method and system for performing a binding assay
US5731152A (en) * 1996-05-13 1998-03-24 Motorola, Inc. Methods and systems for biological reagent placement
US5792431A (en) * 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
DE19625397A1 (de) * 1996-06-25 1998-01-08 Deutsches Krebsforsch Verfahren zur Kombination von paralleler Oligonukleotidsynthese und Darstellung von Oligomer-Chips
US5798360A (en) * 1996-08-01 1998-08-25 Isis Pharmaceuticals, Inc. N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
US5922872A (en) * 1996-08-01 1999-07-13 Isis Pharmaceuticals, Inc. Meta-benzylic and alpha-amido compositions and methods for preparing same
US5817489A (en) 1996-08-01 1998-10-06 Isis Pharmaceuticals, Inc. Di-nitrogen heterocycle compositions
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
US5792430A (en) * 1996-08-12 1998-08-11 Monsanto Company Solid phase organic synthesis device with pressure-regulated manifold
US5981733A (en) * 1996-09-16 1999-11-09 Incyte Pharmaceuticals, Inc. Apparatus for the chemical synthesis of molecular arrays
US6149869A (en) * 1996-10-23 2000-11-21 Glaxo Wellcome Inc. Chemical synthesizers
US6042789A (en) * 1996-10-23 2000-03-28 Glaxo Group Limited System for parallel synthesis of organic compounds
US6875620B1 (en) * 1996-10-31 2005-04-05 Agilent Technologies, Inc. Tiling process for constructing a chemical array
US5780241A (en) 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6054325A (en) * 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
US5865224A (en) * 1996-12-20 1999-02-02 Life Technologies, Inc. Method and apparatus for automated dispensing
JP4663824B2 (ja) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド 多重化分子分析装置および方法
WO1998030904A1 (en) * 1997-01-09 1998-07-16 Mercury Diagnostics, Inc. Method for applying a reagent to an analytical test device
US6274094B1 (en) 1997-01-13 2001-08-14 Weller, Iii Harold Norris Nestable, modular apparatus for synthesis of multiple organic compounds
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US6001311A (en) * 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
WO1998035753A1 (de) * 1997-02-17 1998-08-20 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Vorrichtung für eine automatisierte chemische synthese
US6126904A (en) * 1997-03-07 2000-10-03 Argonaut Technologies, Inc. Apparatus and methods for the preparation of chemical compounds
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
US6224832B1 (en) 1997-05-30 2001-05-01 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
DE19828995B4 (de) * 1997-06-30 2006-01-12 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Anordnung von Mikroreaktionsgefäßen und Verfahren zur Abgabe einer Flüssigkeit aus einer Anordnung von Mikroreaktionsgefäßen
US7112449B1 (en) * 2000-04-05 2006-09-26 Nanogram Corporation Combinatorial chemical synthesis
US5961925A (en) 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
AU1107099A (en) * 1997-10-22 1999-05-10 Argonaut Technologies, Inc. Systems and methods for combinatorial organic synthesis of arrays of reaction
US6177558B1 (en) 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
CA2253164A1 (en) * 1997-11-14 1999-05-14 Edward Michael Sioma Apparatus and method used in multiple, simultaneous synthesis of general compounds
US6121054A (en) * 1997-11-19 2000-09-19 Trega Biosciences, Inc. Method for separation of liquid and solid phases for solid phase organic syntheses
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US5939024A (en) * 1997-12-23 1999-08-17 Packard Instrument Co. Microplate assembly
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
US7470547B2 (en) * 2003-07-31 2008-12-30 Biodot, Inc. Methods and systems for dispensing sub-microfluidic drops
US20020159919A1 (en) * 1998-01-09 2002-10-31 Carl Churchill Method and apparatus for high-speed microfluidic dispensing using text file control
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US20030215957A1 (en) * 1998-02-20 2003-11-20 Tony Lemmo Multi-channel dispensing system
US6027695A (en) * 1998-04-01 2000-02-22 Dupont Pharmaceuticals Company Apparatus for holding small volumes of liquids
US7321828B2 (en) * 1998-04-13 2008-01-22 Isis Pharmaceuticals, Inc. System of components for preparing oligonucleotides
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
WO1999054031A1 (en) * 1998-04-23 1999-10-28 Otter Coast Automation, Inc. Method and apparatus for synthesis of libraries of organic compounds
DE19819735A1 (de) * 1998-05-02 1999-11-04 Novartis Ag Vorrichtung und Verfahren zur Herstellung einer Anordnung von Kettenmolekülen auf einem Trägermaterial
US6253168B1 (en) 1998-05-12 2001-06-26 Isis Pharmaceuticals, Inc. Generation of virtual combinatorial libraries of compounds
US6872535B2 (en) 1998-05-20 2005-03-29 Aventis Pharmaceuticals Inc. Three-dimensional array of supports for solid-phase parallel synthesis and method of use
US6270730B1 (en) * 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
US6551557B1 (en) * 1998-07-07 2003-04-22 Cartesian Technologies, Inc. Tip design and random access array for microfluidic transfer
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6238627B1 (en) 1998-08-26 2001-05-29 Arqule, Inc. Reaction block and cover
US6271042B1 (en) 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6475440B1 (en) 1998-09-16 2002-11-05 Clontech Laboratories, Inc. Applicator for use in deposition of fluid samples onto a substrate surface
EP1000661A1 (de) * 1998-10-29 2000-05-17 Hans-Knöll-Institut für Naturstoff-Forschung e.v. Ultradünnwandige Mehrfachlochplatte für Heizblock-Thermozyklen
US6258323B1 (en) 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
US6264891B1 (en) * 1998-12-22 2001-07-24 Eos Biotechnology, Inc. Apparatus and method for concurrent chemical synthesis
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
EP1144106B1 (de) * 1998-12-30 2003-07-23 MWG -Biotech AG Vorrichtung zur durchführung von chemischen reaktionen
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US20030207464A1 (en) * 1999-02-19 2003-11-06 Tony Lemmo Methods for microfluidic aspirating and dispensing
WO2000056445A1 (en) * 1999-03-19 2000-09-28 Genomic Instrumentation Services, Inc. Polymer synthesizer
US6800250B1 (en) 1999-03-19 2004-10-05 Scott P. Hunicke-Smith Polymer synthesizer
US6511849B1 (en) 1999-04-23 2003-01-28 The Sir Mortimer B. Davis - Jewish General Hospital Microarrays of biological materials
US6143252A (en) * 1999-04-12 2000-11-07 The Perkin-Elmer Corporation Pipetting device with pipette tip for solid phase reactions
DE19919607A1 (de) * 1999-04-29 2000-11-16 Mets Ion Gmbh Ges Fuer Angewan Verfahren und Vorrichtung zur parallelen Herstellung von wenigstens 4n Oligonukleotiden
WO2000066360A1 (en) * 1999-05-04 2000-11-09 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
US6969763B1 (en) 1999-05-12 2005-11-29 Isis Pharmaceuticals, Inc. Molecular interaction sites of interleukin-2 RNA and methods of modulating the same
US20030083483A1 (en) * 1999-05-12 2003-05-01 Ecker David J. Molecular interaction sites of vimentin RNA and methods of modulating the same
US6589791B1 (en) 1999-05-20 2003-07-08 Cartesian Technologies, Inc. State-variable control system
US6593464B1 (en) 1999-05-24 2003-07-15 Invitrogen Corporation Method for deblocking of labeled oligonucleotides
WO2000076662A2 (en) * 1999-06-11 2000-12-21 Orchid Biosciences, Inc. Microenabled chemical reaction in microfluidic chips
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
WO2001016166A2 (en) * 1999-08-27 2001-03-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Polypeptides, comprising il-6 ligand-binding receptor domains, and related nucleic acids, antibodies, compositions, and methods of use
US6307004B1 (en) * 1999-09-20 2001-10-23 General Electric Company Method for parallel melt-polymerization
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US6329210B1 (en) * 1999-10-29 2001-12-11 Agilent Technologies, Inc. Method and apparatus for high volume polymer synthesis
AU2576601A (en) * 1999-12-08 2001-07-03 Glaxo Group Limited Novel supports for solid phase synthesis
US7390459B2 (en) * 1999-12-13 2008-06-24 Illumina, Inc. Oligonucleotide synthesizer
US6800439B1 (en) * 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
CA2401782A1 (en) * 2000-01-31 2001-08-02 John T. Mcdevitt Portable sensor array system
ATE487539T1 (de) * 2000-03-22 2010-11-15 Dewalch Technologies Inc Verfahren und gerät zur verarbeitung von substanzen in einem einzigen behälter
US20080260593A1 (en) * 2000-03-22 2008-10-23 Dewalch Norman Binz Method and apparatus for processing substances in a single container
WO2001072412A1 (de) * 2000-03-28 2001-10-04 Laser- Und Medizin-Technologie Gmbh Berlin Verfahren und vorrichtung zum aufbau und untersuchung von substanzbibliotheken
EP1274508B1 (de) * 2000-04-03 2007-12-05 Parabol Technologies S.A. Vorrichtung zur abgabe von genau kontrollierten kleinen flüssigkeitsmengen
US6432365B1 (en) * 2000-04-14 2002-08-13 Discovery Partners International, Inc. System and method for dispensing solution to a multi-well container
US6994827B2 (en) * 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
US7553644B2 (en) * 2000-07-13 2009-06-30 The Johns Hopkins University School Of Medicine Detection and treatment of polycystic kidney disease
US7018589B1 (en) * 2000-07-19 2006-03-28 Symyx Technologies, Inc. High pressure parallel reactor
EP1598432A3 (de) * 2000-07-31 2006-06-07 Agilent Technologies, Inc. Array-basierende Methoden zur Synthese von Nukleinsäuregemischen
WO2002016647A1 (en) * 2000-08-24 2002-02-28 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US6900013B1 (en) 2000-08-25 2005-05-31 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
EP1325323A2 (de) * 2000-10-13 2003-07-09 Avantium International B.V. Verfahren und vorrichtung zum screening von polykondensationskatalysatoren
US6849409B2 (en) * 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
US6656740B1 (en) * 2000-10-31 2003-12-02 Agilent Technologies, Inc. Pressure variation in array fabrication
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
US20080261220A1 (en) * 2000-11-30 2008-10-23 Third Wave Technologies, Inc. Nucleic Acid Detection Assays
NL1017374C2 (nl) * 2001-02-15 2002-08-16 Univ Delft Tech Inrichting voor het uitvoeren van een reactie, alsmede een werkwijze voor het uitvoeren van een reactie in de inrichting.
DE10108892B4 (de) * 2001-02-23 2005-08-18 Graffinity Pharmaceuticals Ag Synthesevorrichtung und Verfahren zu deren Herstellung
US7731905B2 (en) 2001-03-26 2010-06-08 Canon Kabushiki Kaisha Process for producing probe carrier and apparatus thereof
WO2002077194A2 (en) * 2001-03-26 2002-10-03 Linden Technologies, Inc. Polymer synthesis
US20020136772A1 (en) * 2001-03-26 2002-09-26 Tai-Nang Huang Polymer synthesis
US6692708B2 (en) * 2001-04-05 2004-02-17 Symyx Technologies, Inc. Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
US6867050B2 (en) * 2001-05-16 2005-03-15 Academia Sinica Apparatus and methods for chemical synthesis
WO2002094846A2 (en) * 2001-05-22 2002-11-28 Parallel Synthesis Technologies, Inc. Method for in situ, on-chip chemical synthesis
US6800491B2 (en) 2001-06-08 2004-10-05 Nalge Nunc International Corporation Robotic reservoir without liquid hangup
WO2003004596A1 (en) * 2001-07-06 2003-01-16 Precision System Science Co., Ltd. Reaction container and reaction device
US7708946B1 (en) * 2001-07-19 2010-05-04 Michael Sherman Device for protein detecting tests
US6969489B2 (en) * 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
US20030044798A1 (en) * 2001-08-31 2003-03-06 Lefkowitz Steven M. Methods for generating ligand arrays via deposition of ligands onto olefin displaying substrates, and arrays produced thereby
US7390463B2 (en) * 2001-09-07 2008-06-24 Corning Incorporated Microcolumn-based, high-throughput microfluidic device
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
US20030086829A1 (en) * 2001-10-24 2003-05-08 Livesay Eric A. High throughput chemical synthesizer
US6696298B2 (en) * 2001-12-07 2004-02-24 Biosearch Technologies, Inc. Multi-channel reagent dispensing apparatus
US20030113937A1 (en) * 2001-12-14 2003-06-19 3M Innovative Properties Company Desiccator system having modular elements
US6846454B2 (en) * 2001-12-24 2005-01-25 Agilent Technologies, Inc. Fluid exit in reaction chambers
US7282183B2 (en) * 2001-12-24 2007-10-16 Agilent Technologies, Inc. Atmospheric control in reaction chambers
US6783737B2 (en) * 2002-01-25 2004-08-31 Bristol-Myers Squibb Company High pressure chemistry reactor
JP2005515773A (ja) * 2002-01-28 2005-06-02 ナノスフェアー　インコーポレイテッド ハイブリダイゼーションの装置および方法
US7036653B2 (en) 2002-01-29 2006-05-02 Siemens Technology-To-Business Center Llc Load manipulation system
US6910569B2 (en) 2002-01-29 2005-06-28 Siemens Technology-To-Business Center, Llc Load singulation system and method
FR2837726B1 (fr) * 2002-03-26 2005-02-04 Centre Nat Rech Scient Dispositif et couvercle permettant l'acces aux echantillons d'une "plaque" d'echantillonage
US20030186302A1 (en) * 2002-03-29 2003-10-02 Yixin Wang Colorectal cancer diagnostics
US7122159B2 (en) * 2002-04-29 2006-10-17 Symyx Technologies, Inc. High pressure parallel reactor with individually sealable vessels
NZ536339A (en) 2002-05-08 2006-04-28 Northwest Biotherapeutics Inc Quality assays for antigen presenting cells
ATE444808T1 (de) * 2002-05-13 2009-10-15 Becton Dickinson Co Probenplatte mit verteileraufsatz
US20030232140A1 (en) * 2002-06-14 2003-12-18 Joseph Remick Methods for reagent removal in flow chambers
US20060045821A1 (en) * 2002-07-26 2006-03-02 Mckelvy Michael J Microreactor witii controllable pressure and temperature for in situ material investigations
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
DE10237704A1 (de) * 2002-08-09 2004-03-11 Chemogenix Gmbh Verfahren und Vorrichtung zum intermolekularen Transfer von Aktivierungsenergie zur Bindungsspaltung durch den Raum
DK1556297T3 (da) * 2002-10-29 2008-07-21 Siemens Ag Transportindretning med håndtering af fordelte genstande
DE20219127U1 (de) 2002-12-10 2003-03-06 MWG-BIOTECH AG, 85560 Ebersberg Abdeckvorrichtung für Mikrotiterplatten
US7541152B2 (en) * 2002-12-24 2009-06-02 Agilent Technologies, Inc. Integrated light source for diagnostic arrays
KR100537504B1 (ko) * 2003-01-20 2005-12-19 삼성전자주식회사 생물학적 시료 내에서의 단백질 검출을 위한 자동화된 유동 시스템
US6970240B2 (en) 2003-03-10 2005-11-29 Applera Corporation Combination reader
US20040191782A1 (en) * 2003-03-31 2004-09-30 Yixin Wang Colorectal cancer prognostics
US7025935B2 (en) * 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
EP1623010A4 (de) * 2003-04-25 2007-12-26 Janssen Pharmaceutica Nv Konservierung von rna in einer biologischen probe
DE10320871B3 (de) * 2003-05-09 2004-09-16 Evotec Technologies Gmbh Probenablageeinrichtung für einen Zellsortierer
US8409528B2 (en) 2003-06-19 2013-04-02 Abbott Laboratories Apparatus and method for handling fluids for analysis
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005003314A2 (en) * 2003-06-27 2005-01-13 Isis Pharmaceuticals, Inc. A method of selecting an active oligonucleotide predictive model
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US7417726B2 (en) 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
US7460223B2 (en) 2003-09-19 2008-12-02 Applied Biosystems Inc. Inverted orientation for a microplate
US20050226779A1 (en) 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US20050221357A1 (en) 2003-09-19 2005-10-06 Mark Shannon Normalization of gene expression data
US20050107909A1 (en) * 2003-11-14 2005-05-19 Siemens Technology-To-Business Center Llc Systems and methods for programming motion control
US20050107911A1 (en) * 2003-11-14 2005-05-19 Siemens Technology-To-Business Center Llc Systems and methods for controlling load motion actuators
US20050065633A1 (en) * 2003-11-14 2005-03-24 Michael Wynblatt Systems and methods for relative control of load motion actuators
US6991311B2 (en) * 2003-12-12 2006-01-31 Industrial Technology Research Institute Apparatus and method for introducing micro-volume liquid
WO2005058471A2 (en) * 2003-12-15 2005-06-30 Applera Corporation Automated oligomer synthesis
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
KR100597870B1 (ko) * 2004-04-01 2006-07-06 한국과학기술원 고속 스크리닝 또는 고속 분석을 위한 미소 유체 칩
US20050244984A1 (en) * 2004-04-28 2005-11-03 Parker Russell A Methods and compositions for calibrating chemical array readers
EP2290073A3 (de) 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
WO2006060653A2 (en) * 2004-11-30 2006-06-08 Veridex Llc Lung cancer prognostics
US7977119B2 (en) 2004-12-08 2011-07-12 Agilent Technologies, Inc. Chemical arrays and methods of using the same
KR100624458B1 (ko) * 2005-01-17 2006-09-19 삼성전자주식회사 휴대용 원심분리기
CA2603898A1 (en) * 2005-04-04 2006-10-12 Veridex, Llc Laser microdissection and microarray analysis of breast tumors reveal estrogen receptor related genes and pathways
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
AU2006259565B2 (en) 2005-06-15 2011-01-06 Complete Genomics, Inc. Single molecule arrays for genetic and chemical analysis
CN101277758A (zh) * 2005-09-14 2008-10-01 Illumina公司 连续聚合物合成器
ES2494843T3 (es) * 2005-09-19 2014-09-16 Janssen Diagnostics, Llc Métodos y materiales para identificar el origen de un carcinoma de origen primario desconocido
US20070202515A1 (en) * 2005-10-12 2007-08-30 Pathologica, Llc. Promac signature application
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US20070172837A1 (en) * 2006-01-23 2007-07-26 Kyle Schleifer Flow cell comprising ports and methods for using the same
US7995202B2 (en) * 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
JP2009529880A (ja) * 2006-03-13 2009-08-27 ベリデックス・エルエルシー 原発細胞の増殖
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
WO2007148337A2 (en) 2006-06-19 2007-12-27 Yeda Research And Development Co. Ltd. Programmable iterated elongation: a method for manufacturing synthetic genes and combinatorial dna and protein libraries
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
JP2010510964A (ja) 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路
DE102006035392A1 (de) 2006-11-02 2008-10-16 Signature Diagnostics Ag Prognostische Marker für die Vorhersage des fünfjährigen progressionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
DE102006035388A1 (de) * 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung von Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
DE102006035393A1 (de) 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
WO2008089449A2 (en) 2007-01-19 2008-07-24 Biodot, Inc. Systems and methods for high speed array printing and hybridization
US7807109B2 (en) 2007-05-14 2010-10-05 Freeslate, Inc. Parallel batch reactor with pressure monitoring
US20080286170A1 (en) * 2007-05-14 2008-11-20 Symyx Technologies, Inc. Parallel batch reactor
US7655191B2 (en) * 2007-05-14 2010-02-02 Symyx Solutions, Inc. Methods for chemical reactions in a parallel batch reactor
EP2195451A4 (de) * 2007-08-28 2011-01-19 Merck Sharp & Dohme Expressionsprofile von biomarkergenen bei notch-vermittelten krebserkrankungen
US8877141B2 (en) * 2007-09-06 2014-11-04 Qiagen Sciences Llc System for preparing arrays of biomolecules
EP2222851B1 (de) 2007-11-20 2017-06-28 Ionis Pharmaceuticals, Inc. Modulation der cd40-expression
US8602958B1 (en) * 2007-11-29 2013-12-10 Life Technologies Corporation Methods and assemblies for collecting liquid by centrifugation
US8211370B2 (en) 2007-12-07 2012-07-03 Thomas Downing Polymer synthesizer
WO2009078812A1 (en) * 2007-12-17 2009-06-25 Hai-Qing Gong Microfluidic device
EP2240401A1 (de) * 2008-01-04 2010-10-20 The Royal Institution for the Advancement of Learning/McGill University Mikrofluidisches mikroarraysystem und verfahren für die multiplex-analyse von biomolekülen
US20090192045A1 (en) * 2008-01-22 2009-07-30 Yuqiu Jiang Molecular staging of stage ii and iii colon cancer and prognosis
US7932036B1 (en) 2008-03-12 2011-04-26 Veridex, Llc Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase
CN101270332B (zh) * 2008-04-30 2012-05-30 广东省人民医院 用于细胞或组织培养和处理的装置和方法
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
JP5892791B2 (ja) 2008-05-14 2016-03-23 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 適応免疫における免疫調節物質の効果をモニターするための方法およびキット
CN102308004A (zh) 2008-10-30 2012-01-04 卡里斯生命科学卢森堡控股有限责任公司 评价rna图案的方法
CA2743211A1 (en) 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
US8741581B2 (en) 2009-04-27 2014-06-03 Technion Research And Development Foundation Ltd. Markers for cancer detection
US20110021749A1 (en) * 2009-07-27 2011-01-27 Demmitt Thomas J Chemical Plugs used with Automated Organic Polymer Synthesizers
US9771618B2 (en) * 2009-08-19 2017-09-26 Bioarray Genetics, Inc. Methods for treating breast cancer
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
WO2011069200A1 (en) * 2009-12-09 2011-06-16 Ezygene Pty Ltd Hyperprimers
AU2011205230A1 (en) 2010-01-13 2012-08-02 Caris Life Sciences Switzerland Holdings Gmbh Detection of gastrointestinal disorders
CN202823394U (zh) 2010-01-19 2013-03-27 伊鲁米那股份有限公司 用于处理化学反应的设备和系统
US8580201B2 (en) 2010-02-22 2013-11-12 Oligoco, Inc. Wicking-based reagent-solution draining in an automated system
WO2011102913A2 (en) * 2010-02-22 2011-08-25 Oligoco Wicking-based reagent-solution draining in an automated system
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
EP3214174B1 (de) 2010-03-04 2019-10-16 InteRNA Technologies B.V. Mirna-molekül, das über seine quelle definiert ist, und seine diagnostischen und therapeutischen verwendungen bei mit emt assoziierten krankheiten
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
EP2388336A1 (de) 2010-05-19 2011-11-23 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
WO2011146725A1 (en) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarkers for a multikinase inhibitor
US9353412B2 (en) 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
NZ605420A (en) 2010-07-06 2015-02-27 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
CA2817882C (en) 2010-11-17 2022-08-23 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
CN103429348B (zh) 2011-01-21 2016-03-09 拜奥－多特公司 具有纵向变换器和可替换毛细管的压电分配器
MX2013009863A (es) 2011-02-28 2013-12-06 Univ Iowa Res Found Cambios de la hormona anti-mulleriana en el embarazo y prediccion de sexo y de resultados adversos en el embarazo.
EP2527459A1 (de) 2011-05-02 2012-11-28 Rheinische Friedrich-Wilhelms-Universität Bonn Blutbasierte Gendetektion von nichtkleinzelligem Lungenkrebs
EP2520661A1 (de) 2011-05-02 2012-11-07 Rheinische Friedrich-Wilhelms-Universität Bonn Blutbasierte Genexpressionssignaturen bei Lungenkrebs
WO2012156515A1 (en) 2011-05-18 2012-11-22 Rheinische Friedrich-Wilhelms-Universität Bonn Molecular analysis of acute myeloid leukemia
EP2524968A1 (de) 2011-05-19 2012-11-21 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
EP2524967A1 (de) 2011-05-19 2012-11-21 Signature Diagnostics AG Verfahren und Kits zur Diagnostizierung eines kolorektalen Karzinoms
US8778848B2 (en) 2011-06-09 2014-07-15 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
CN103945931B (zh) 2011-09-26 2017-03-22 基因技术股份公司 高效的小体积核酸合成
US12595500B2 (en) 2011-09-26 2026-04-07 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (de) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas als diagnostische biomarker zur unterscheidung gutartiger von bösartigen tumoren in der schilddrüse
CA2862580A1 (en) 2011-10-28 2013-05-02 Millennium Pharmaceuticals, Inc. Biomarkers of response to nae inhibitors
CA3003082C (en) 2011-10-28 2020-12-15 Illumina, Inc. Microarray fabrication system and method
CA2855368A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
CA2855356A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
AU2012340192B2 (en) 2011-11-18 2016-04-07 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
CA2865170C (en) 2012-02-21 2020-12-22 Cytonics Corporation Systems, compositions, and methods for transplantation
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US20150152499A1 (en) 2012-07-03 2015-06-04 Interna Technologies B.V. Diagnostic portfolio and its uses
US10005594B2 (en) * 2012-08-31 2018-06-26 Universal Bio Research Co., Ltd. Deforming element-included dispensing tip, deforming element-included dispensing device, and deforming element-included dispensing processing method
JP6486826B2 (ja) 2012-10-01 2019-03-20 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
DK2925888T3 (en) 2012-11-28 2017-12-18 Merck Sharp & Dohme COMPOSITIONS AND METHODS OF CANCER TREATMENT
WO2014113204A1 (en) 2013-01-17 2014-07-24 Personalis, Inc. Methods and systems for genetic analysis
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
KR102230831B1 (ko) 2013-03-15 2021-03-22 일루미나 케임브리지 리미티드 변형된 뉴클레오사이드 또는 뉴클레오타이드
US9944992B2 (en) 2013-03-15 2018-04-17 The University Of Chicago Methods and compositions related to T-cell activity
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
US9758835B2 (en) 2013-03-15 2017-09-12 Baylor Research Institute Ulcerative colitis (UC)-associated colorectal neoplasia markers
US9771613B2 (en) 2013-04-02 2017-09-26 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acid
US8808989B1 (en) 2013-04-02 2014-08-19 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acids
US9279149B2 (en) 2013-04-02 2016-03-08 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acids
US11331643B2 (en) 2013-04-02 2022-05-17 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US11384377B2 (en) 2013-04-02 2022-07-12 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US10683536B2 (en) 2013-04-02 2020-06-16 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
MX363806B (es) 2013-07-01 2019-04-03 Illumina Inc Funcionalización de superficies sin catalizador e injerto de polímeros..
WO2015031654A2 (en) 2013-08-28 2015-03-05 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
EP3039161B1 (de) 2013-08-30 2021-10-06 Personalis, Inc. Verfahren und system zur genomanalyse
AU2014329535B2 (en) 2013-10-03 2017-09-07 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
US20160304969A1 (en) 2013-12-17 2016-10-20 Merck Sharp & Dohme Corp. Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists
WO2015095291A1 (en) 2013-12-19 2015-06-25 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
JP6666852B2 (ja) 2014-01-16 2020-03-18 イルミナ インコーポレイテッド 前立腺がん再発の予後に関する遺伝子発現パネル
US10261084B1 (en) 2014-02-19 2019-04-16 Stc.Unm Activated GTPase-based assays and kits for the diagnosis of sepsis and other infections
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
EP3183577B1 (de) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible oberflächenfunktionalisierung
US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
CN114805710B (zh) 2014-10-31 2023-11-17 伊鲁米纳剑桥有限公司 聚合物以及dna共聚物涂层
EP3230314B1 (de) 2014-12-08 2023-05-03 Berg LLC Verwendung von markern einschliesslich filamin a bei der diagnose und behandlung von prostatakrebs
CA3147259A1 (en) 2014-12-09 2016-06-16 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
EP3230498B1 (de) 2014-12-09 2023-01-18 Merck Sharp & Dohme LLC System und verfahren zur ableitung der gensignaturbiomarker der reaktion auf pd-1-antagonisten
EP3839510A3 (de) 2015-04-17 2021-08-25 Merck Sharp & Dohme Corp. Blutbasierte biomarker der tumorempfindlichkeit gegen pd-1-antagonisten
WO2017015018A1 (en) 2015-07-17 2017-01-26 Illumina, Inc. Polymer sheets for sequencing applications
SG11201809376WA (en) 2016-05-18 2018-12-28 Illumina Inc Self assembled patterning using patterned hydrophobic surfaces
EP3465501A4 (de) 2016-05-27 2020-02-26 Personalis, Inc. Personalisierte gentests
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
JP7042755B2 (ja) 2016-06-05 2022-03-28 バーグ エルエルシー 患者層別化及び潜在的バイオマーカー同定のためのシステム及び方法
AU2017393112B2 (en) * 2017-01-16 2022-09-08 Spi Bio Inc. Analytical device and method for assessing analyte within a sample
WO2018140606A1 (en) 2017-01-26 2018-08-02 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
MX2019012741A (es) 2017-04-28 2020-01-21 Merck Sharp & Dohme Biomarcadores para agentes terapeuticos contra el cancer.
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
US20190076814A1 (en) 2017-09-11 2019-03-14 Synthego Corporation Biopolymer synthesis system and method
WO2019051430A1 (en) * 2017-09-11 2019-03-14 Synthego Corporation METHOD AND SYSTEM FOR BIOPOLYMER SYNTHESIS
EP3704250A1 (de) 2017-11-03 2020-09-09 InteRNA Technologies B.V. Mirna-molekül, äquivalent, antagomir oder quelle davon zur behandlung und/oder diagnose eines zustands und/oder einer erkrankung im zusammenhang mit neuronaler defizienz oder neuronaler (re)generation
EP3714053B1 (de) 2017-11-22 2025-12-31 The University of Chicago Von chemischer sonde abhängige bewertung der proteinaktivität und verwendung davon
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
CN111989158B (zh) * 2018-04-15 2022-08-12 奥普图弗卢迪克生物鉴定有限责任公司 压差辅助排水系统
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
CA3106410A1 (en) 2018-07-23 2020-01-30 Dna Script Massively parallel enzymatic synthesis of nucleic acid strands
US20210349088A1 (en) 2018-10-18 2021-11-11 Oklahoma Medical Research Foundation Biomarkers For A Systemic Lupus Erythematosus (SLE) Disease Activity Immune Index That Characterizes Disease Activity
US12510539B2 (en) 2018-10-18 2025-12-30 Progentec Diagnostics, Inc. Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US12172154B2 (en) 2019-02-18 2024-12-24 Ctc Analytics Ag Fluid delivery device and method for carrying out chemical or biological assays
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
US20220205035A1 (en) 2019-04-05 2022-06-30 Board Of Regents, The University Of Texas System Methods and applications for cell barcoding
WO2020210521A2 (en) 2019-04-12 2020-10-15 The Regents Of The University Of California Compositions and methods for increasing muscle mass and oxidative metabolism
SG11202111824UA (en) 2019-04-30 2021-11-29 Larimar Therapeutics Inc Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
US11724261B1 (en) 2019-05-13 2023-08-15 Integrated Dna Technologies, Inc. Synthesizer system with inflatable seal and valve arrangement
WO2021092066A1 (en) 2019-11-05 2021-05-14 Personalis, Inc. Estimating tumor purity from single samples
JP2023510454A (ja) 2019-11-27 2023-03-14 イルミナ ケンブリッジ リミテッド シクロオクタテトラエンを含有する色素及び組成物
EP4164784B1 (de) * 2020-06-16 2025-06-25 DNA Script Verfahren zur enzymatischen polynukleotidsynthese
WO2021259881A1 (en) 2020-06-22 2021-12-30 Illumina Cambridge Limited Nucleosides and nucleotides with 3' acetal blocking group
US11473699B2 (en) 2020-06-26 2022-10-18 Biolytic Lab Performance, Inc Tubing support system
US11666882B2 (en) 2020-06-26 2023-06-06 Biolytic Lab Performance, Inc. Bidirectional flow reaction system for solid phase synthesis
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
WO2022197916A1 (en) * 2021-03-17 2022-09-22 Illumina, Inc. Non-contact dispenser assemblies and related systems and methods
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
EP4320441A1 (de) 2021-04-06 2024-02-14 BPGbio, Inc. Proteinmarker für östrogenrezeptor (er)-positiv- und östrogenrezeptor (er)-negativ-ähnlichen brustkrebs
CA3214819A1 (en) 2021-04-06 2022-10-13 Guisong WANG Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
JP2024516191A (ja) 2021-05-05 2024-04-12 イルミナ ケンブリッジ リミテッド ビス－ホウ素縮合複素環を含有する蛍光色素及び配列決定における使用
CN117916390A (zh) 2021-05-20 2024-04-19 伊鲁米纳公司 用于边合成边测序的组合物和方法
US12570831B2 (en) 2021-06-15 2026-03-10 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
WO2023004357A1 (en) 2021-07-23 2023-01-26 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
DE102021121265B4 (de) 2021-08-16 2024-03-07 Bluecatbio Gmbh Dispensiervorrichtung, Zentrifuge mit einer solchen Dispensiervorrichtung und Verfahren zum Reinigen von Dispensierdüsen
EP4413580A4 (de) 2021-10-05 2025-08-13 Personalis Inc Personalisierte tests zur personalisierten krebsüberwachung
CA3234961A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
US12611666B2 (en) 2022-03-22 2026-04-28 Illumina, Inc. Substrate with orthogonally functional nanodomains
EP4499862A1 (de) 2022-03-28 2025-02-05 Illumina, Inc. Markiertes avidin und sequenzierungsverfahren
AU2023246772A1 (en) 2022-03-29 2024-01-18 Illumina Inc. Chromenoquinoline dyes and uses in sequencing
CN119365780A (zh) 2022-04-06 2025-01-24 拉利玛生物医药公司 用于监测共济蛋白替代疗法的共济蛋白敏感性标志物
AU2023281871A1 (en) 2022-05-31 2024-11-14 Illumina, Inc Compositions and methods for nucleic acid sequencing
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
CA3259955A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. FLUORESCENT DYES CONTAINING A FUSIONED BIS-TETRACYCLIC BORON HETEROCYCLE AND THEIR USES IN SEQUENCED
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
US20250361558A1 (en) 2022-08-19 2025-11-27 Illumina, Inc. Third dna base pair site-specific dna detection
CN119213083A (zh) 2022-09-30 2024-12-27 伊路米纳有限公司 用于减少测序期间的光损伤的组合物和方法
US20240219835A1 (en) 2022-12-07 2024-07-04 Illumina, Inc. Etch-free photoresist patterning in multi-depth nanowells
CA3246536A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. TRANSITION METAL CATALYST COMPOSITIONS AND SYNTHETIC SEQUENCE PROCESSES
AU2023409219A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
CN119095984A (zh) 2022-12-27 2024-12-06 伊路米纳有限公司 使用3'烯丙基封端的核苷酸的测序方法
CN116159608B (zh) * 2022-12-29 2025-11-04 杭州联川生物技术股份有限公司 一种高通量基因合成仪的加液装置
AU2024247164A1 (en) 2023-03-29 2024-12-12 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
EP4689181A1 (de) 2023-03-30 2026-02-11 Illumina, Inc. Zusammensetzungen und verfahren zur nukleinsäuresequenzierung
WO2025006431A1 (en) 2023-06-28 2025-01-02 Illumina, Inc. Photoresist patterning in multi-depth nanowells
EP4735634A1 (de) 2023-06-30 2026-05-06 Illumina, Inc. Systeme und verfahren zur sequenzierung von polynukleotiden mit modifizierten basen
EP4735636A1 (de) 2023-06-30 2026-05-06 Illumina, Inc. Systeme und verfahren zur sequenzierung von polynukleotiden mit vier markierten nukleotiden
EP4735635A1 (de) 2023-06-30 2026-05-06 Illumina, Inc. Systeme und verfahren zur sequenzierung von polynukleotiden mit alternativen scatterplots
US20250075269A1 (en) 2023-08-31 2025-03-06 Illumina, Inc. Compositions and methods for nucleic acid sequencing
US12145121B1 (en) * 2023-10-18 2024-11-19 Sierra Biosystems, Inc. Flow control mechanism for high-throughput oligonucleotide synthesis
WO2025090596A1 (en) 2023-10-26 2025-05-01 Illumina, Inc. 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing
US20250163505A1 (en) 2023-11-17 2025-05-22 Illumina, Inc. Conjugated polymers or polymer dots as fluorescent labels
WO2025136890A1 (en) 2023-12-18 2025-06-26 Illumina, Inc. Hydrogel nanoparticles as labeling scaffold in sequencing
US20250215493A1 (en) 2023-12-28 2025-07-03 Illumina, Inc. Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing
WO2025144711A1 (en) 2023-12-29 2025-07-03 Illumina, Inc. Tricyclic polymethine dyes for nucleic acid sequencing
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer
WO2025184226A1 (en) 2024-02-28 2025-09-04 Illumina, Inc. Nucleotides with terminal phosphate capping
WO2025188906A1 (en) 2024-03-08 2025-09-12 Illumina, Inc. Modified adenosine nucleotides
WO2025221895A1 (en) 2024-04-19 2025-10-23 Illumina, Inc. Water soluble polymer scaffolds for dye labeling
WO2025230914A1 (en) 2024-04-29 2025-11-06 Illumina, Inc. Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis
WO2025248505A1 (en) 2024-05-31 2025-12-04 Wayne State University Methods for treating endometrial and ovarian hyperproliferative disorders
WO2026035914A1 (en) 2024-08-09 2026-02-12 Illumina, Inc. Nucleotides having 3'-hydroxy blocking groups
WO2026044153A1 (en) 2024-08-21 2026-02-26 Bpgbio, Inc. Use of biomarkers in the diagnosis of pancreatic cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US458066A (en) * 1891-08-18 John r
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4517338A (en) * 1983-06-20 1985-05-14 Chiron Corporation Multiple reactor system and method for polynucleotide synthesis
DK492788D0 (da) * 1988-09-02 1988-09-05 Morten Meldal Peptidsynteseapparat
US5047524A (en) * 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5106583A (en) * 1989-03-08 1992-04-21 Applied Biosystems, Inc. Automated protein hydrolysis system
DE4005518A1 (de) * 1990-02-22 1991-08-29 Boehringer Ingelheim Kg Verfahren und vorrichtung zur simultanen synthese mehrerer polypeptide
SE9002579D0 (sv) * 1990-08-07 1990-08-07 Pharmacia Ab Method and apparatus for carrying out biochemical reactions
JPH04308600A (ja) 1991-04-03 1992-10-30 Kokusan Kagaku Kk ペプチド合成用反応容器およびペプチド合　　　　　成用キット
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6589726B1 (en) * 1991-09-04 2003-07-08 Metrigen, Inc. Method and apparatus for in situ synthesis on a solid support
US6921636B1 (en) * 1991-09-04 2005-07-26 Metrigen, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5378776A (en) * 1991-12-26 1995-01-03 Nippon Petrochemicals Company, Limited Method for preparing optical polymer with radial transition in refractive index
DE4206488C2 (de) * 1992-03-02 1993-12-23 Deutsches Krebsforsch Vorrichtung zur Durchführung zeitgleich oder sequentiell ablaufender chemischer Reaktionen
US5368823A (en) * 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6001311A (en) * 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
JP4308600B2 (ja) 2003-07-10 2009-08-05 パイロットインキ株式会社 水性ボールペン

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JPH09507505A (ja) 1997-07-29
EP1025902A2 (de) 2000-08-09
CA2174648C (en) 2007-04-17
JP3677041B2 (ja) 2005-07-27
DE69425673T2 (de) 2001-04-19
WO1995011262A1 (en) 1995-04-27
US5472672A (en) 1995-12-05
EP0734397A1 (de) 1996-10-02
US7858364B2 (en) 2010-12-28
US20030069411A1 (en) 2003-04-10
US20090054605A1 (en) 2009-02-26
DE69425673D1 (de) 2000-09-28
JP2006206883A (ja) 2006-08-10
JP2005187821A (ja) 2005-07-14
US5529756A (en) 1996-06-25
DE69433635T2 (de) 2005-02-17
US5814700A (en) 1998-09-29
DE69433635D1 (de) 2004-04-22
US20110124529A1 (en) 2011-05-26
EP0734397A4 (de) 1997-04-02
US8084245B2 (en) 2011-12-27
EP0734397B1 (de) 2000-08-23
CA2174648A1 (en) 1995-04-27
US20050281719A1 (en) 2005-12-22
ATE195671T1 (de) 2000-09-15
JP4182104B2 (ja) 2008-11-19
US5837858A (en) 1998-11-17
EP1025902A3 (de) 2000-10-18
EP1025902B1 (de) 2004-03-17

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