ATE261932T1 - Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion - Google Patents

Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion

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Publication number
ATE261932T1
ATE261932T1 AT99966584T AT99966584T ATE261932T1 AT E261932 T1 ATE261932 T1 AT E261932T1 AT 99966584 T AT99966584 T AT 99966584T AT 99966584 T AT99966584 T AT 99966584T AT E261932 T1 ATE261932 T1 AT E261932T1
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Austria
Prior art keywords
beta
alpha
inhibitors
cell adhesion
mediated cell
Prior art date
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AT99966584T
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English (en)
Inventor
Bradley R Teegarden
Honnappa Jayakumar
Kenji Matsuki
Robert A Chrusciel
Jed F Fisher
Steven P Tanis
Edward W Thomas
James R Blinn
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Tanabe Seiyaku Co
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Publication of ATE261932T1 publication Critical patent/ATE261932T1/de

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
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    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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AT99966584T 1998-12-22 1999-12-20 Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion ATE261932T1 (de)

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Application Number Priority Date Filing Date Title
US11350198P 1998-12-22 1998-12-22
PCT/US1999/030665 WO2000037429A2 (en) 1998-12-22 1999-12-20 INHIBITORS OF α4β1 MEDIATED CELL ADHESION

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MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
DK1265606T3 (da) * 1999-08-13 2007-02-12 Biogen Idec Inc Celleadhæsionsinhibitorer
US6388084B1 (en) 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
HRP20020467A2 (en) * 1999-12-06 2004-04-30 Hoffmann La Roche 4-pyridinyl-n-acyl-l-phenylalanines
WO2001047868A1 (en) * 1999-12-28 2001-07-05 Ajinomoto Co., Inc. Novel phenylalanine derivatives
WO2001070670A1 (en) * 2000-03-23 2001-09-27 Ajinomoto Co., Inc. Novel phenylalanine derivative
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
JPWO2002022563A1 (ja) * 2000-09-14 2004-01-22 東レ株式会社 ウレア誘導体及びそれを有効成分とする接着分子阻害剤
DE10124041A1 (de) * 2001-05-16 2002-11-21 Graffinity Pharm Design Gmbh Protease Inhibitoren
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
EP1546089A2 (de) 2002-08-09 2005-06-29 TransTech Pharma Inc. Aryl- und heteroarylverbindungen und verfahren zur modulierung der koagulation
WO2005014534A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
US7544699B2 (en) 2003-08-08 2009-06-09 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
ATE509941T1 (de) 2006-01-11 2011-06-15 Seikagaku Kogyo Co Ltd Cycloalkylcarbonylaminosäureester-derivat und herstellungsverfahren dafür
JP3975226B2 (ja) * 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
WO2008103310A1 (en) 2007-02-16 2008-08-28 Synta Pharmaceuticals Corp. Substituted fused-ring compounds for inflammation and immune-related uses
WO2011094890A1 (en) * 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
CN106588690B (zh) * 2016-12-19 2019-06-04 广西中医药大学 毛鸡骨草甲素Abrusamide的制备方法

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US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
PT991619E (pt) * 1997-06-23 2004-02-27 Upjohn Co Inibidores da adesao celular mediada pela alfa4beta1

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WO2000037429A2 (en) 2000-06-29
ES2220140T3 (es) 2004-12-01
PT1144365E (pt) 2004-06-30
EP1144365A2 (de) 2001-10-17
EP1144365A3 (de) 2003-07-09
EP1144365B1 (de) 2004-03-17
AU2209500A (en) 2000-07-12
DE69915692T2 (de) 2005-02-10
WO2000037429A3 (en) 2003-05-22

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