ATE262532T1 - Substituierte camptothecinderivate und verfahren zur ihrer herstellung - Google Patents
Substituierte camptothecinderivate und verfahren zur ihrer herstellungInfo
- Publication number
- ATE262532T1 ATE262532T1 AT96919763T AT96919763T ATE262532T1 AT E262532 T1 ATE262532 T1 AT E262532T1 AT 96919763 T AT96919763 T AT 96919763T AT 96919763 T AT96919763 T AT 96919763T AT E262532 T1 ATE262532 T1 AT E262532T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- production
- camptothecine
- derivatives
- camptothecine derivatives
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9510716.5A GB9510716D0 (en) | 1995-05-26 | 1995-05-26 | Substituted camptothecin derivatives and process for their preparation |
| PCT/EP1996/002008 WO1996037496A1 (en) | 1995-05-26 | 1996-05-10 | Substituted camptothecin derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262532T1 true ATE262532T1 (de) | 2004-04-15 |
Family
ID=10775098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96919763T ATE262532T1 (de) | 1995-05-26 | 1996-05-10 | Substituierte camptothecinderivate und verfahren zur ihrer herstellung |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5856333A (de) |
| EP (1) | EP0777670B1 (de) |
| JP (1) | JPH10503220A (de) |
| CN (1) | CN1159192A (de) |
| AR (1) | AR003126A1 (de) |
| AT (1) | ATE262532T1 (de) |
| AU (1) | AU5817996A (de) |
| BR (1) | BR9606396A (de) |
| CA (1) | CA2194700A1 (de) |
| DE (1) | DE69631943D1 (de) |
| GB (1) | GB9510716D0 (de) |
| HU (1) | HUP9702400A3 (de) |
| IL (1) | IL118410A0 (de) |
| NO (1) | NO970293L (de) |
| NZ (1) | NZ308514A (de) |
| PL (1) | PL318279A1 (de) |
| WO (1) | WO1996037496A1 (de) |
| ZA (1) | ZA964138B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| GB9702807D0 (en) | 1997-02-12 | 1997-04-02 | Pharmacia & Upjohn Spa | Alkynyl-substituted camptothecins and process for their preparation |
| AU6272598A (en) * | 1997-02-14 | 1998-09-08 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
| JP2001525823A (ja) | 1997-05-15 | 2001-12-11 | イーライ・リリー・アンド・カンパニー | 抗血栓化合物 |
| HUP9701554D0 (en) * | 1997-09-18 | 1997-11-28 | Human Oltoanyagtermeloe Gyogys | Pharmaceutical composition containing plazma proteins |
| US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6288072B1 (en) | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| KR100717916B1 (ko) | 2000-02-28 | 2007-05-11 | 아방티 파르마 소시에테 아노님 | 캄프토테신 및 피리미딘 유도체를 포함하는 암 치료용 조성물 |
| US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
| US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| IL155509A0 (en) | 2000-10-27 | 2003-11-23 | Aventis Pharma Sa | A combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
| AR039391A1 (es) | 2002-04-08 | 2005-02-16 | Glaxo Group Ltd | Compuesto de ciclopenteno, composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| CN100406460C (zh) * | 2003-11-10 | 2008-07-30 | 中国科学院上海药物研究所 | 喜树碱的新衍生物、制备方法和用途 |
| US20090104254A1 (en) | 2004-12-22 | 2009-04-23 | Rutgers, The State University Of New Jersey | Controlled Release Hydrogels |
| WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
| US8410045B2 (en) | 2006-03-30 | 2013-04-02 | Drais Pharmaceuticals, Inc. | Camptothecin-peptide conjugates and pharmaceutical compositions containing the same |
| CN101880285B (zh) * | 2010-06-24 | 2012-07-04 | 华东师范大学 | 一种烯丙基取代喜树碱化合物的合成方法 |
| CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
| TWI895608B (zh) | 2021-04-29 | 2025-09-01 | 愛爾蘭商艾伯維製造管理無限公司 | 抗c-Met抗體藥物結合物 |
| CN118829449A (zh) * | 2022-01-12 | 2024-10-22 | 瑞泽恩制药公司 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
| US5340817A (en) * | 1987-04-14 | 1994-08-23 | Research Triangle Institute | Method of treating tumors with anti-tumor effective camptothecin compounds |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| WO1991004260A2 (en) * | 1989-09-15 | 1991-04-04 | Research Triangle Institute | 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs |
| GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
-
1995
- 1995-05-26 GB GBGB9510716.5A patent/GB9510716D0/en active Pending
-
1996
- 1996-05-10 EP EP96919763A patent/EP0777670B1/de not_active Expired - Lifetime
- 1996-05-10 JP JP8535320A patent/JPH10503220A/ja not_active Withdrawn
- 1996-05-10 HU HU9702400A patent/HUP9702400A3/hu unknown
- 1996-05-10 AU AU58179/96A patent/AU5817996A/en not_active Abandoned
- 1996-05-10 NZ NZ308514A patent/NZ308514A/en unknown
- 1996-05-10 US US08/776,192 patent/US5856333A/en not_active Expired - Fee Related
- 1996-05-10 WO PCT/EP1996/002008 patent/WO1996037496A1/en not_active Ceased
- 1996-05-10 PL PL96318279A patent/PL318279A1/xx unknown
- 1996-05-10 BR BR9606396A patent/BR9606396A/pt not_active Application Discontinuation
- 1996-05-10 CA CA002194700A patent/CA2194700A1/en not_active Abandoned
- 1996-05-10 CN CN96190541A patent/CN1159192A/zh active Pending
- 1996-05-10 AT AT96919763T patent/ATE262532T1/de not_active IP Right Cessation
- 1996-05-10 DE DE69631943T patent/DE69631943D1/de not_active Expired - Lifetime
- 1996-05-23 ZA ZA964138A patent/ZA964138B/xx unknown
- 1996-05-23 IL IL11841096A patent/IL118410A0/xx unknown
- 1996-05-24 AR ARP960102705A patent/AR003126A1/es unknown
-
1997
- 1997-01-23 NO NO970293A patent/NO970293L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9510716D0 (en) | 1995-07-19 |
| JPH10503220A (ja) | 1998-03-24 |
| EP0777670A1 (de) | 1997-06-11 |
| IL118410A0 (en) | 1996-09-12 |
| DE69631943D1 (de) | 2004-04-29 |
| HUP9702400A3 (en) | 1998-07-28 |
| ZA964138B (en) | 1996-11-27 |
| NO970293D0 (no) | 1997-01-23 |
| BR9606396A (pt) | 1997-10-14 |
| EP0777670B1 (de) | 2004-03-24 |
| WO1996037496A1 (en) | 1996-11-28 |
| AU5817996A (en) | 1996-12-11 |
| CA2194700A1 (en) | 1996-11-28 |
| AR003126A1 (es) | 1998-07-08 |
| US5856333A (en) | 1999-01-05 |
| NO970293L (no) | 1997-03-06 |
| CN1159192A (zh) | 1997-09-10 |
| PL318279A1 (en) | 1997-06-09 |
| HUP9702400A2 (hu) | 1998-06-29 |
| NZ308514A (en) | 1998-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69631943D1 (de) | Substituierte camptothecinderivate und verfahren zur ihrer herstellung | |
| DE69527054D1 (de) | Retroreflektierender gegenstand und verfahren zur herstellung | |
| DE69322094D1 (de) | Heterogene membrane und verfahren zur herstellung | |
| DE69632570D1 (de) | Wasserabsorbierendes pulver und verfahren zur herstellung | |
| DE69626833D1 (de) | Ernährungsergänzungsgetränk und verfahren zur herstellung desselben | |
| ATE216704T1 (de) | Propiophenonderivate und verfahren zu ihrer herstellung | |
| DE69623926D1 (de) | Kugelgelenk und verfahren zur herstellung | |
| DE69819015D1 (de) | Norbonenpolymer und verfahren zur herstellung | |
| DE59404480D1 (de) | Fullerenderivate, verfahren zur herstellung und deren verwendung | |
| DE69611599D1 (de) | Halbaromatische polyamidzusamensetzung und verfahren zu ihrer herstellung | |
| DE69620405D1 (de) | Verbesserte polyarylenetherzusammensetzungen und verfahren zu ihrer herstellung | |
| DE69524977D1 (de) | Lösliche, elektroleitfähige polypyrrole und verfahren zur herstellung | |
| DE69625176D1 (de) | Camptothecin-derivate und verfahren zu ihrer herstellung | |
| ATE195937T1 (de) | Pyridazinone-derivate und verfahren zur deren herstellung | |
| ATE209208T1 (de) | Zwischenprodukte und verfahren zur herstellung olanzapin | |
| ATE290003T1 (de) | Verfahren zur herstellung von pyrazolo-(4,3- d)pyrimidin-7-ones und zwischenprodukte davon | |
| DE69626009D1 (de) | Pyrrolidinylhydroxamsäuren und verfahren zu ihrer herstellung | |
| DE69425748D1 (de) | Transistoren und verfahren zur herstellung | |
| DE69724801D1 (de) | Verfahren und zwischenprodukte zur herstellung substituierter chromanolderivate | |
| DE69515697D1 (de) | Blockcopolymere und verfahren zur herstellung | |
| DE69536010D1 (de) | Nassreibungsmaterial und verfahren zu ihrer herstellung | |
| DE59707046D1 (de) | Kontinuierliches Verfahren zur Herstellung von 4-Aminopiperidinen | |
| DE69801795D1 (de) | Indolyl-pyrrolylidenmethylpyrrol-derivate und verfahren zu ihrer herstellung | |
| DE69907895D1 (de) | Mastixzusammensetzung und verfahren zur ihrer herstellung | |
| DE69523571D1 (de) | Pyridylimidazol-derivate und verfahren zu ihrer herstellung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |