ATE262590T1 - Fermentative herstellung von carotenoiden - Google Patents

Fermentative herstellung von carotenoiden

Info

Publication number
ATE262590T1
ATE262590T1 AT96108556T AT96108556T ATE262590T1 AT E262590 T1 ATE262590 T1 AT E262590T1 AT 96108556 T AT96108556 T AT 96108556T AT 96108556 T AT96108556 T AT 96108556T AT E262590 T1 ATE262590 T1 AT E262590T1
Authority
AT
Austria
Prior art keywords
dna sequence
encodes
flavobacterium
dna
beta
Prior art date
Application number
AT96108556T
Other languages
English (en)
Inventor
Hans-Peter Hohmann
Luis Pasamontes
Michel Tessier
Adolphus Van Loon
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE262590T1 publication Critical patent/ATE262590T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
AT96108556T 1995-06-09 1996-05-29 Fermentative herstellung von carotenoiden ATE262590T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95108888 1995-06-09

Publications (1)

Publication Number Publication Date
ATE262590T1 true ATE262590T1 (de) 2004-04-15

Family

ID=8219341

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96108556T ATE262590T1 (de) 1995-06-09 1996-05-29 Fermentative herstellung von carotenoiden

Country Status (8)

Country Link
US (4) US6087152A (de)
EP (1) EP0747483B1 (de)
JP (1) JP4252632B2 (de)
CN (2) CN100554427C (de)
AT (1) ATE262590T1 (de)
DE (1) DE69631924T2 (de)
DK (1) DK0747483T3 (de)
ES (1) ES2216027T3 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358722B1 (en) 1994-04-25 2002-03-19 Roche Vitamins, Inc. Heat tolerant phytases
US6699704B1 (en) 1994-04-25 2004-03-02 Roche Vitamins Inc. Heat tolerant phytases
US5827652A (en) 1995-10-31 1998-10-27 Applied Food Biotechnology, Inc. Zeaxanthin formulations for human ingestion
DE69722852T2 (de) 1996-05-06 2004-05-06 F. Hoffmann-La Roche Ag Fermentative Herstellung von Biotin
DE69738611T2 (de) 1996-09-19 2009-04-30 Dsm Ip Assets B.V. Alkohol-Aldehyd-Dehydrogenasen
EP0853127B1 (de) 1996-09-27 2004-11-03 DSM IP Assets B.V. Biotin-Biosynthese-Gene II
EP0872554B1 (de) 1996-12-02 2003-06-11 F. Hoffmann-La Roche Ag Verbesserte fermentative Herstellung von Carotenoide
CA2231948C (en) 1997-03-25 2010-05-18 F. Hoffmann-La Roche Ag Modified phytases
NZ330940A (en) * 1997-07-24 2000-02-28 F Production of consensus phytases from fungal origin using computer programmes
CA2239802A1 (en) * 1997-08-21 1999-02-21 F. Hoffmann-La Roche Ag D-sorbitol dehydrogenase gene
JP3032841B2 (ja) 1997-12-02 2000-04-17 農林水産省果樹試験場長 β−カロテンハイドロキシラーゼ遺伝子
AU3169999A (en) * 1998-04-14 1999-11-01 Kyowa Hakko Kogyo Co. Ltd. Process for producing isoprenoid compounds by using microorganisms and method for detecting compounds having antibacterial or herbicidal activity
DE19818665A1 (de) * 1998-04-27 1999-10-28 Basf Ag Verfahren zur biotechnologischen Oxidation von substituierten Trimethylcyclohexenylverbindungen
US6720174B1 (en) 1999-01-28 2004-04-13 Novozymes A/S Phytases
DE19916140A1 (de) 1999-04-09 2000-10-12 Basf Ag Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten
JP4463347B2 (ja) 1999-09-30 2010-05-19 新日本石油株式会社 飼料添加用色素含有物
US7468275B2 (en) * 2000-01-28 2008-12-23 The Scripps Research Institute Synthetic internal ribosome entry sites and methods of identifying same
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) * 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US7691406B2 (en) 2000-10-27 2010-04-06 ZeaVision LLC. Zeaxanthin formulations for human ingestion
US20050260699A1 (en) * 2000-11-22 2005-11-24 Desouza Mervyn L Carotenoid biosynthesis
KR100704072B1 (ko) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. 개선된 이소프레노이드 제조 방법
ES2195758B1 (es) 2001-12-31 2005-03-01 Antibioticos, S.A.U. Procedimiento mejorado de produccion de licopeno mediante la fermentacion de cepas seleccionadas de blakeslea trispora, formulaciones y usos del licopeno obtenido.
US7105634B2 (en) * 2002-02-11 2006-09-12 E. I. Du Pont De Nemours And Company Genetic constructs encoding carotenoid biosynthetic enzymes
US20040048657A1 (en) * 2002-09-05 2004-03-11 Michael Gauselmann Gaming machine with selectable features
EP1546314A1 (de) * 2002-09-27 2005-06-29 DSM IP Assets B.V. Bhyd gen
JP2006500055A (ja) * 2002-09-27 2006-01-05 ディーエスエム アイピー アセッツ ビー．ブイ． ファフィア属によるゼアキサンチンの製造方法
US8088363B2 (en) 2002-10-28 2012-01-03 Zeavision Llc Protection against sunburn and skin problems with orally-ingested high-dosage zeaxanthin
US9192586B2 (en) 2003-03-10 2015-11-24 Zeavision Llc Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders
US7098000B2 (en) * 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
DE102004007624A1 (de) * 2004-02-17 2005-09-15 Sungene Gmbh & Co. Kgaa Neue Ketolasen und Verfahren zur Herstellung von Ketocarotinoiden
US7941211B2 (en) 2003-11-17 2011-05-10 Zeavision, Llc. Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders
US7091031B2 (en) * 2004-08-16 2006-08-15 E. I. Du Pont De Nemours And Company Carotenoid hydroxylase enzymes
US7074604B1 (en) * 2004-12-29 2006-07-11 E. I. Du Pont De Nemours And Company Bioproduction of astaxanthin using mutant carotenoid ketolase and carotenoid hydroxylase genes
CN101218352B (zh) 2005-03-18 2013-09-04 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
CN100387726C (zh) * 2005-03-28 2008-05-14 浙江省农业科学院 一种β-胡萝卜素的生产方法
JP2006280297A (ja) * 2005-04-01 2006-10-19 Tosoh Corp ゲラニルゲラニル２リン酸合成酵素及びその遺伝子等
US7217537B2 (en) * 2005-09-15 2007-05-15 E. I. Du Pont De Nemours And Company Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
KR100832584B1 (ko) * 2007-04-05 2008-05-27 에스케이에너지 주식회사 라이코펜의 생합성에 관여하는 유전자, 그 유전자를포함하는 재조합 벡터, 및 그 재조합 벡터로 형질전환된미생물
KR101441613B1 (ko) 2007-05-04 2014-09-26 아미코젠주식회사 재조합 대장균을 이용한 라이코펜 생산 방법
CN101671683B (zh) * 2009-09-27 2012-03-07 上海大学 与胡萝卜素合成有关的合成酶基因、其编码蛋白及其应用
EP2554675B1 (de) 2010-03-30 2019-05-01 JXTG Nippon Oil & Energy Corporation Verfahren zur herstellung von zeaxanthin durch fermentierung
CA2843549A1 (en) * 2011-08-08 2013-02-14 Shriram RAGHAVAN Methods and materials for recombinant production of saffron compounds
KR102113368B1 (ko) 2012-12-20 2020-05-22 디에스엠 아이피 어셋츠 비.브이. 카로틴 수산화효소 및 이의 카로티노이드 생산에 있어서의 용도
CN105452444A (zh) 2013-08-08 2016-03-30 尼普拜耳公司 用于水产养殖和动物饲料的甲基营养生物
KR102299236B1 (ko) * 2013-10-25 2021-09-06 사운드 애그리컬쳐 컴퍼니 스트리고락톤 제제 및 그의 용도
CN103805623B (zh) * 2014-01-17 2016-02-03 河北大学 一种虾青素合成基因重组质粒及其制备方法和用途
CA3109156C (en) * 2014-05-16 2023-08-15 Academia Sinica Recombinant polynucleotide sequence for producing astaxanthin and uses thereof
AU2016253008B2 (en) 2015-04-24 2020-10-22 Sound Agriculture Company Methods for hydraulic enhancement of crops
CN104962530B (zh) * 2015-06-05 2017-12-12 南京理工大学 一种酶融合表达蛋白及其在虾青素生产方面的应用
JP2019165635A (ja) * 2016-08-10 2019-10-03 味の素株式会社 Ｌ−アミノ酸の製造法
CN106801028B (zh) * 2017-01-17 2019-12-31 中山大学 产高含量玉米黄素或虾青素工程菌及其应用
US11560583B2 (en) 2017-06-01 2023-01-24 Knipbio, Inc. Heterologous carotenoid production in microorganisms
US12447202B2 (en) 2018-05-17 2025-10-21 Lumen Bioscience, Inc. Arthrospira platensis oral vaccine delivery platform
WO2020018586A1 (en) 2018-07-16 2020-01-23 Lumen Bioscience, Inc. Thermostable phycobiliproteins produced in spirulina
WO2021003456A1 (en) 2019-07-03 2021-01-07 Lumen Bioscience, Inc. Arthrospira platensis non-parenteral therapeutic delivery platform
CN112831427B (zh) * 2021-01-20 2022-08-23 山东大学 一株高产β-胡萝卜素的解脂耶氏酵母及其应用
CN117264865B (zh) * 2023-11-21 2024-03-12 清华大学 重组红色红球菌及其在化合物合成中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891504A (en) * 1970-07-31 1975-06-24 Hoffmann La Roche Process for the manufacture of zeaxanthin
CH595444A5 (en) * 1975-02-14 1978-02-15 Nestle Sa Biosynthesis of lycopene for use as food colourant
EP0393690B1 (de) * 1989-04-21 1995-03-29 Kirin Beer Kabushiki Kaisha Zur Synthese von Karotinoiden verwendbare DNA-Sequenzen
EP0534955B1 (de) * 1989-08-30 1997-05-28 Applied Food Biotechnology, Inc. Verfahren zur Herstellung einer Zeaxanthin enthaltenden Zusammensetzung mittels eines Mikroorganismus der Spezies Flavobacterium multivorum
GB8928179D0 (en) * 1989-12-13 1990-02-14 Ici Plc Dna,constructs,cells and plants derived therefrom
WO1991013078A1 (en) * 1990-03-02 1991-09-05 Amoco Corporation Biosynthesis of carotenoids in genetically engineered hosts
JP3383342B2 (ja) * 1992-10-01 2003-03-04 株式会社海洋バイオテクノロジー研究所 アスタキサンチンの製造法
US5935808A (en) 1997-07-29 1999-08-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Carotenoid-producing bacterial species and process for production of carotenoids using same

Also Published As

Publication number Publication date
DE69631924D1 (de) 2004-04-29
EP0747483A3 (de) 1997-05-07
ES2216027T3 (es) 2004-10-16
DK0747483T3 (da) 2004-06-28
JP4252632B2 (ja) 2009-04-08
US20020147371A1 (en) 2002-10-10
CN1607253A (zh) 2005-04-20
EP0747483A2 (de) 1996-12-11
JPH0923888A (ja) 1997-01-28
CN1141952A (zh) 1997-02-05
CN1168828C (zh) 2004-09-29
DE69631924T2 (de) 2004-08-12
US6087152A (en) 2000-07-11
US6124113A (en) 2000-09-26
US6613543B2 (en) 2003-09-02
EP0747483B1 (de) 2004-03-24
CN100554427C (zh) 2009-10-28
US6207409B1 (en) 2001-03-27

Similar Documents

Publication Publication Date Title
ATE262590T1 (de) Fermentative herstellung von carotenoiden
EP0872554B1 (de) Verbesserte fermentative Herstellung von Carotenoide
Cunningham Jr et al. A study in scarlet: enzymes of ketocarotenoid biosynthesis in the flowers of Adonis aestivalis
DK1005565T3 (da) Nye carotenoidproducerende bakteriearter og fremgangsmåde til fremstilling af carotenoider ved anvendelse heraf
EP0735137A4 (de) DNA - Kette zur Synthese von Xanthophyll und Prozess zur Herstellung von Xanthophyll
NO20060177L (no) Gener som koder for karotenoidforbindelser
US20050003474A1 (en) Carotenoid biosynthesis
US9963731B2 (en) Method for producing carotenoids each having 50 carbon atoms
WO2005001024A3 (en) Genes encoding carotenoid compounds
WO2004104180A3 (en) Genes encoding carotenoid biosynthetic enzymes
CA2381822A1 (en) Process of producing carotenoid pigments
WO2003016503A3 (en) Genes encoding carotenoid compounds
CN106801028B (zh) 产高含量玉米黄素或虾青素工程菌及其应用
CA2539069A1 (en) Process for producing carotenoid compound
WO1999061652A1 (en) Carotenoid ketolase genes and gene products, production of ketocarotenoids and methods of modifying carotenoids using the genes
US20070026484A1 (en) Method to increase hydrophobic compound titer in a recombinant microorganism
KR100814941B1 (ko) 대장균에 의한 라이코펜의 대량 제조방법
KR101299567B1 (ko) 아젤라잔틴ａ 대사회로의 구축 및 대장균을 통한 아젤라잔틴ａ의 합성
AU2005206350A1 (en) Method for producing carotenoids and bacteria used therefor
WO2004056972A2 (en) Parallel chromosomal stacking of traits in bacteria
WO2005010156A3 (en) Genes encoding carotenoid compounds
Hirschberg et al. Carotenoid-producing bacterial species and process for production of carotenoids using same
Cheng Recent patents on carotenoid production in microbes
NO20060783L (no) Gener kodende for karotenoid forbindelser

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties