ATE262909T1 - Intravenöse alendronatformulierungen - Google Patents

Intravenöse alendronatformulierungen

Info

Publication number: ATE262909T1
Authority: AT; Austria
Prior art keywords: intravenous; bone disease; alendronate formulations; formulations; intravenous alendronate
Prior art date: 1994-08-24

Application number

AT95929625T

Other languages

English (en)

Inventor

Gerald S Brenner

Musa M Ghannam

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-24

Filing date

1995-08-21

Publication date

2004-04-15

1995-08-21 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE262909T1 publication Critical patent/ATE262909T1/de

Links

OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title abstract 2
229940062527 alendronate Drugs 0.000 title abstract 2
238000001990 intravenous administration Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
206010020584 Hypercalcaemia of malignancy Diseases 0.000 abstract 1
208000030136 Marchiafava-Bignami Disease Diseases 0.000 abstract 1
208000029725 Metabolic bone disease Diseases 0.000 abstract 1
208000037848 Metastatic bone disease Diseases 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
208000008750 humoral hypercalcemia of malignancy Diseases 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Physical Education & Sports Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT95929625T 1994-08-24 1995-08-21 Intravenöse alendronatformulierungen ATE262909T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/296,192 US5780455A (en)	1994-08-24	1994-08-24	Intravenous alendronate formulations
PCT/US1995/010583 WO1996005842A1 (en)	1994-08-24	1995-08-21	Intravenous alendronate formulations

Publications (1)

Publication Number	Publication Date
ATE262909T1 true ATE262909T1 (de)	2004-04-15

Family

ID=23140992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95929625T ATE262909T1 (de)	1994-08-24	1995-08-21	Intravenöse alendronatformulierungen

Country Status (10)

Country	Link
US (3)	US5780455A (de)
EP (1)	EP0777484B1 (de)
JP (2)	JP3962429B2 (de)
AT (1)	ATE262909T1 (de)
AU (1)	AU698411B2 (de)
CA (1)	CA2197210C (de)
DE (1)	DE69532810T2 (de)
ES (1)	ES2216017T3 (de)
PT (1)	PT777484E (de)
WO (1)	WO1996005842A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1148050A1 (de) *	1992-05-21	2001-10-24	Monsanto Company	Retrovirale Proteaseinhibitoren
US5780455A (en) *	1994-08-24	1998-07-14	Merck & Co., Inc.	Intravenous alendronate formulations
US5616571A (en) *	1995-06-06	1997-04-01	Merck & Co., Inc.	Bisphosphonates prevent bone loss associated with immunosuppressive therapy
CN1238691A (zh) *	1996-10-04	1999-12-15	麦克公司	液体阿仑膦酸盐制剂
US20010031244A1 (en) *	1997-06-13	2001-10-18	Chiesi Farmaceutici S.P.A.	Pharmaceutical aerosol composition
US5994329A (en)	1997-07-22	1999-11-30	Merck & Co., Inc.	Method for inhibiting bone resorption
US6432932B1 (en)	1997-07-22	2002-08-13	Merck & Co., Inc.	Method for inhibiting bone resorption
US6331533B1 (en)	1998-11-16	2001-12-18	Merck & Co., Inc.	Method for inhibiting dental resorptive lesions
US6794536B1 (en) *	1998-12-10	2004-09-21	Aesqen, Inc.	Method for preparation of disodium pamidronate
US6677320B2 (en) *	2000-01-20	2004-01-13	Hoffmann-La Roches Inc.	Parenteral bisphosphonate composition with improved local tolerance
CA2399136A1 (en) *	2000-02-09	2001-08-16	Hideo Kato	1h-imidazopyridine derivatives
ATE314862T1 (de) *	2000-05-05	2006-02-15	Hoffmann La Roche	Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze
WO2002022615A1 (en) *	2000-09-14	2002-03-21	Merck & Co., Inc.	Alpha v integrin receptor antagonists
CN1441674A (zh) *	2000-09-18	2003-09-10	福荷福尔丁和考有限公司	二磷酸盐溶液
US8721625B2 (en) *	2001-01-26	2014-05-13	Cook Medical Technologies Llc	Endovascular medical device with plurality of wires
CA2372450A1 (en) *	2001-05-10	2001-09-19	Pharmaceutical Partners Of Canada Inc.	Liquid injectable formulation of disodium pamidronate
AT502590A1 (de) *	2001-09-27	2007-04-15	Oekopharm Forschungs Und Entwi	Basenhältige mikronährstoffmischung
CA2480814A1 (en) *	2002-04-05	2003-10-23	Merck & Co., Inc.	Method for inhibiting bone resorption with an alendronate and vitamin d formulation
US20050261250A1 (en) *	2004-05-19	2005-11-24	Merck & Co., Inc.,	Compositions and methods for inhibiting bone resorption
EP1796683A1 (de) *	2004-07-15	2007-06-20	Nanobac Life Sciences	Verfahren und zusammensetzungen zur verwaltung von kalziumchelatoren, biphosphonaten und/oder citratverbindungen sowie deren pharmazeutische verwendungen
US20060134190A1 (en) *	2004-12-16	2006-06-22	Banner Pharmacaps Inc.	Formulations of bisphosphonate drugs with improved bioavailability
US20060204567A1 (en) *	2005-03-08	2006-09-14	Jiang Hu	Potato proteinase inhibitor II exhibits activity in elevating fasting plasma cholecystokinin concentrations
US7605148B2 (en) *	2007-04-16	2009-10-20	Aurobindo Pharma Ltd.	Aqueous oral solution of bisphosphonic acid
US20100286038A1 (en) *	2007-09-21	2010-11-11	Valentyn Antochshuk	Formulation containing cyclin-dependent kinase inhibiting compound and method of treating tumors using the same
US20110065672A1 (en) *	2009-09-16	2011-03-17	Mount Sinai School Of Medicine Of New York University	Bisphosphonate-prostatic acid phosphatase inhibitor conjugates to treat prostate cancer bone metastasis
EP2363111A1 (de) *	2010-03-01	2011-09-07	Combino Pharm, S.L.	Stabile pharmazeutische Zusammensetzung mit Bisphosphonat
US9682090B2 (en)	2014-11-14	2017-06-20	University Of Washington	Methods for treating and preventing prostate cancer bone metastases
EP4271370A4 (de) *	2020-12-29	2024-12-04	Next Science IP Holdings Pty Ltd	Zusammensetzung und verfahren zur krebsbehandlung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06700B2 (ja) *	1986-03-27	1994-01-05	旭化成工業株式会社	安定な水性液剤
DE3623397A1 (de) *	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
JP2617508B2 (ja) *	1988-02-05	1997-06-04	エーザイ株式会社	安定なジフェンヒドラミン含有水溶液
US4922007A (en) *	1989-06-09	1990-05-01	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
JP2974722B2 (ja) *	1990-04-03	1999-11-10	帝国臓器製薬株式会社	カルシトニン注射液
US5019651A (en) *	1990-06-20	1991-05-28	Merck & Co., Inc.	Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5270365A (en) *	1991-12-17	1993-12-14	Merck & Co., Inc.	Prevention and treatment of periodontal disease with alendronate
EP0675723A4 (de) *	1992-12-23	1998-08-05	Merck & Co Inc	Biphosphonat/östrogen-therapie zur behandlung und prävention von knochenverlust.
US5462932A (en) *	1994-05-17	1995-10-31	Merck & Co., Inc.	Oral liquid alendronate formulations
US5780455A (en) *	1994-08-24	1998-07-14	Merck & Co., Inc.	Intravenous alendronate formulations

1994
- 1994-08-24 US US08/296,192 patent/US5780455A/en not_active Expired - Fee Related
1995
- 1995-08-21 PT PT95929625T patent/PT777484E/pt unknown
- 1995-08-21 DE DE69532810T patent/DE69532810T2/de not_active Expired - Lifetime
- 1995-08-21 AT AT95929625T patent/ATE262909T1/de not_active IP Right Cessation
- 1995-08-21 ES ES95929625T patent/ES2216017T3/es not_active Expired - Lifetime
- 1995-08-21 EP EP95929625A patent/EP0777484B1/de not_active Expired - Lifetime
- 1995-08-21 AU AU33320/95A patent/AU698411B2/en not_active Ceased
- 1995-08-21 WO PCT/US1995/010583 patent/WO1996005842A1/en not_active Ceased
- 1995-08-21 CA CA002197210A patent/CA2197210C/en not_active Expired - Fee Related
- 1995-08-21 JP JP50823396A patent/JP3962429B2/ja not_active Expired - Fee Related
1998
- 1998-03-02 US US09/033,015 patent/US5843924A/en not_active Expired - Fee Related
- 1998-05-05 US US09/072,602 patent/US5914323A/en not_active Expired - Fee Related
2003
- 2003-09-03 JP JP2003311481A patent/JP4177208B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU3332095A (en)	1996-03-14
US5914323A (en)	1999-06-22
CA2197210A1 (en)	1996-02-29
JP4177208B2 (ja)	2008-11-05
DE69532810D1 (de)	2004-05-06
AU698411B2 (en)	1998-10-29
JPH10504574A (ja)	1998-05-06
US5843924A (en)	1998-12-01
DE69532810T2 (de)	2005-02-17
ES2216017T3 (es)	2004-10-16
EP0777484B1 (de)	2004-03-31
JP3962429B2 (ja)	2007-08-22
JP2004075690A (ja)	2004-03-11
US5780455A (en)	1998-07-14
WO1996005842A1 (en)	1996-02-29
CA2197210C (en)	2008-02-19
EP0777484A4 (de)	1998-08-05
EP0777484A1 (de)	1997-06-11
PT777484E (pt)	2004-06-30

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 0777484

Country of ref document: EP

2011-05-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE262909T1 (de)	2004-04-15	Intravenöse alendronatformulierungen
Nishimura et al.	1995	Auricular prostheses and osseointegrated implants: UCLA experience
DK0527835T3 (da)	1995-04-18	Doseringsform til afgivelse af et anti-Parkinsonmiddel
DK1123094T3 (da)	2007-08-20	Terapeutiske præparater (II)
BR9813524A (pt)	2002-02-19	Processos para tratamento de toxicidades associadas com a administração de um agente terapêutico a um mamìfero, para tratamento de toxicidades associadas com a exposição de um mamìfero à terapia de radiação, para tratamento de neuro- ou nefrodistúrbios em um humano, e, para tratamento de distúrbios e sintomas clìnicos associados com diabetes do tipo i ou do tipo ii em um humano
DK0759757T3 (da)	2002-10-07	Orale, væskeformige alendronatformuleringer
EP1365769A4 (de)	2005-08-10	Arzneimittel zur behandlung von osteonekrose und zur versorgung von patienten mit risiko für die entstehung von osteonekrose
RU94046316A (ru)	1996-10-20	Применение высокоэффективных фосфонатов при изготовлении лекарственных средств для лечения остеопороза
DK0833643T3 (da)	2005-05-30	Formuleringer af vandfrit mononatriumsalt af alendronat og deres anvendelse til behandling af knoglesygdomme
HUP0100437A2 (hu)	2002-05-29	Szabályzott felszabadulású gyógyszerkészítmény tolterodin adagolására
TR200001891T2 (tr)	2000-11-21	ASPB28- İnsan ensülini ve kullanımı.
SE8704248D0 (sv)	1987-10-30	Medical use
BG104797A (en)	2001-07-31	Use of dexmedetomi dine for sedative effect in patients in an intensive care unit
DK0629400T3 (da)	2000-02-14	Idebenon-holdige præparater til behandling af Alzheimer's syge
BR0009380A (pt)	2001-12-26	Tratamento de câncer melhorado comtemozolomida
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SE9101341D0 (sv)	1991-05-03	New medicinal use
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FI20010233A0 (fi)	2001-02-08	Menetelmä sydämen vajaatoiminnan hoitoon
SANADA et al.	1986	Clinical histories before hospitalization in gastric cancer cases