ATE263767T1 - Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion - Google Patents
Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektionInfo
- Publication number
- ATE263767T1 ATE263767T1 AT00935544T AT00935544T ATE263767T1 AT E263767 T1 ATE263767 T1 AT E263767T1 AT 00935544 T AT00935544 T AT 00935544T AT 00935544 T AT00935544 T AT 00935544T AT E263767 T1 ATE263767 T1 AT E263767T1
- Authority
- AT
- Austria
- Prior art keywords
- injection
- powdery
- cabapenem
- crystalline
- derivatives
- Prior art date
Links
- 238000002347 injection Methods 0.000 title abstract 3
- 239000007924 injection Substances 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 3
- 238000002441 X-ray diffraction Methods 0.000 abstract 2
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- CUGZEDSDRBMZMY-UHFFFAOYSA-N trihydrate;hydrochloride Chemical compound O.O.O.Cl CUGZEDSDRBMZMY-UHFFFAOYSA-N 0.000 abstract 2
- 239000004599 antimicrobial Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15681099 | 1999-06-03 | ||
| JP2000153891 | 2000-05-25 | ||
| PCT/JP2000/003642 WO2000075143A1 (en) | 1999-06-03 | 2000-06-05 | Crystals of carbapenem derivatives and pharmaceutical preparations for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE263767T1 true ATE263767T1 (de) | 2004-04-15 |
Family
ID=26484468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935544T ATE263767T1 (de) | 1999-06-03 | 2000-06-05 | Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7084268B1 (de) |
| EP (1) | EP1182204B1 (de) |
| JP (1) | JP4130078B2 (de) |
| AT (1) | ATE263767T1 (de) |
| AU (1) | AU5105100A (de) |
| CA (1) | CA2375601C (de) |
| DE (1) | DE60009695T2 (de) |
| WO (1) | WO2000075143A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE277930T1 (de) * | 1999-07-30 | 2004-10-15 | Eisai Co Ltd | Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte |
| US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| EP1790634A3 (de) * | 2003-06-18 | 2007-06-13 | Teva Pharmaceutical Industries Ltd. | Fluvastatin-natrium im Kristallform und Verfahren zu dessen Herstellung |
| CN101400663A (zh) * | 2006-01-10 | 2009-04-01 | 史密丝克莱恩比彻姆公司 | {2-甲基-4-[4-甲基-2-(4-三氟甲基苯基)噻唑-5-基甲硫基]苯氧基}-乙酸的多晶型 |
| JP4954345B1 (ja) * | 2011-07-06 | 2012-06-13 | アピ株式会社 | 医薬品原薬の無菌化精製装置 |
| CN102964348A (zh) * | 2012-12-21 | 2013-03-13 | 卫宏远 | 新美罗培南晶型及其制备方法 |
| RU2696582C2 (ru) * | 2013-03-15 | 2019-08-05 | Перл Терапьютикс, Инк. | Способы и системы кондиционирования дисперсных кристаллических материалов |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE60588B1 (en) | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
| JP2654077B2 (ja) | 1988-04-20 | 1997-09-17 | 日本レダリー株式会社 | 結晶形態の１−メチル−カルバペネム化合物 |
| JP3848693B2 (ja) | 1994-07-06 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規カルバペネム誘導体 |
| JPH10212241A (ja) * | 1996-05-27 | 1998-08-11 | Sumitomo Pharmaceut Co Ltd | Ｂｄｎｆを安定に含有する製剤 |
| JPH10152491A (ja) | 1996-11-21 | 1998-06-09 | Dai Ichi Seiyaku Co Ltd | 結晶性カルバペネム化合物 |
| JP3317649B2 (ja) * | 1997-01-13 | 2002-08-26 | 日本ワイスレダリー株式会社 | 結晶形態のカルバペネム化合物 |
| EP0875253B1 (de) * | 1997-05-02 | 2005-04-06 | Seikagaku Corporation | Chondroitinase enthaltende Zusammensetzungen |
| WO1998052918A1 (en) | 1997-05-23 | 1998-11-26 | Eisai Co., Ltd. | Intermediates useful in producing carbapenem and process for the stereoselective production of the same |
| CA2298682A1 (en) * | 1997-07-31 | 1999-02-11 | Smithkline Beecham P.L.C. | Mercaptoacylamino acids as metallo-beta-lactamase inhibitors |
| US6100047A (en) * | 1999-04-07 | 2000-08-08 | Zen Bio, Inc. | Modulation of the sulfonylurea receptor and calcium in adipocytes for treatment of obesity/diabetes |
-
2000
- 2000-06-05 DE DE60009695T patent/DE60009695T2/de not_active Expired - Lifetime
- 2000-06-05 JP JP2001502425A patent/JP4130078B2/ja not_active Expired - Fee Related
- 2000-06-05 EP EP00935544A patent/EP1182204B1/de not_active Expired - Lifetime
- 2000-06-05 AT AT00935544T patent/ATE263767T1/de not_active IP Right Cessation
- 2000-06-05 US US09/979,679 patent/US7084268B1/en not_active Expired - Fee Related
- 2000-06-05 CA CA002375601A patent/CA2375601C/en not_active Expired - Fee Related
- 2000-06-05 AU AU51051/00A patent/AU5105100A/en not_active Abandoned
- 2000-06-05 WO PCT/JP2000/003642 patent/WO2000075143A1/ja not_active Ceased
-
2005
- 2005-10-26 US US11/259,509 patent/US20060040916A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7084268B1 (en) | 2006-08-01 |
| EP1182204A4 (de) | 2002-10-30 |
| EP1182204B1 (de) | 2004-04-07 |
| WO2000075143A1 (en) | 2000-12-14 |
| JP4130078B2 (ja) | 2008-08-06 |
| AU5105100A (en) | 2000-12-28 |
| EP1182204A1 (de) | 2002-02-27 |
| CA2375601C (en) | 2008-07-29 |
| DE60009695D1 (de) | 2004-05-13 |
| CA2375601A1 (en) | 2000-12-14 |
| US20060040916A1 (en) | 2006-02-23 |
| DE60009695T2 (de) | 2004-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1182204 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |