ATE264102T1 - Nicotin enthaltende pharmazeutische zusammensetzungen mit schneller transmukosaler absorption - Google Patents
Nicotin enthaltende pharmazeutische zusammensetzungen mit schneller transmukosaler absorptionInfo
- Publication number
- ATE264102T1 ATE264102T1 AT99972537T AT99972537T ATE264102T1 AT E264102 T1 ATE264102 T1 AT E264102T1 AT 99972537 T AT99972537 T AT 99972537T AT 99972537 T AT99972537 T AT 99972537T AT E264102 T1 ATE264102 T1 AT E264102T1
- Authority
- AT
- Austria
- Prior art keywords
- formulations
- nicotine
- pharmaceutical compositions
- compositions containing
- containing nicotine
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 4
- 229960002715 nicotine Drugs 0.000 title abstract 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 4
- 238000010521 absorption reaction Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- 210000005178 buccal mucosa Anatomy 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- 238000002670 nicotine replacement therapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9803986A SE9803986D0 (sv) | 1998-11-23 | 1998-11-23 | New compositions |
| PCT/SE1999/001983 WO2000030641A1 (en) | 1998-11-23 | 1999-11-04 | Nicotine-containing pharmaceutical compositions giving a rapid transmucosal absorption |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264102T1 true ATE264102T1 (de) | 2004-04-15 |
Family
ID=20413363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99972537T ATE264102T1 (de) | 1998-11-23 | 1999-11-04 | Nicotin enthaltende pharmazeutische zusammensetzungen mit schneller transmukosaler absorption |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6676959B1 (de) |
| EP (1) | EP1131071B1 (de) |
| JP (1) | JP2002530335A (de) |
| AT (1) | ATE264102T1 (de) |
| AU (1) | AU1434000A (de) |
| DE (1) | DE69916486T2 (de) |
| DK (1) | DK1131071T3 (de) |
| ES (1) | ES2220149T3 (de) |
| HK (1) | HK1040614B (de) |
| PT (1) | PT1131071E (de) |
| SE (1) | SE9803986D0 (de) |
| WO (1) | WO2000030641A1 (de) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0103210D0 (sv) * | 2001-09-27 | 2001-09-27 | Pharmacia Ab | New formulations and use thereof |
| SE0103211D0 (sv) * | 2001-09-27 | 2001-09-27 | Pharmacia Ab | New formulations and use thereof |
| US20030087937A1 (en) * | 2001-10-15 | 2003-05-08 | Nils-Olof Lindberg | Nicotine and cocoa powder compositions |
| SE0202365D0 (sv) | 2002-08-05 | 2002-08-05 | Pharmacia Ab | New formulation and use thereof |
| DE10251963A1 (de) * | 2002-11-08 | 2004-05-19 | Lts Lohmann Therapie-Systeme Ag | Transmucosale pharmazeutische Darreichungsform |
| US9358296B2 (en) * | 2003-02-24 | 2016-06-07 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
| SE0300831D0 (sv) * | 2003-03-26 | 2003-03-26 | Pharmacia Ab | New formulations and use therof |
| SE0300830D0 (sv) * | 2003-03-26 | 2003-03-26 | Pharmacia Ab | New formulations and use thereof |
| CN104397869B (zh) * | 2003-11-07 | 2016-06-08 | 美国无烟烟草有限责任公司 | 烟草组合物 |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| FR2882656B1 (fr) * | 2005-03-07 | 2007-06-22 | Schwartz Laboratoires Robert S | Composition antitabagique |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| US7946296B2 (en) * | 2006-05-26 | 2011-05-24 | Philip Morris Usa Inc. | Dissolvable tobacco film strips and method of making the same |
| WO2007072224A2 (en) * | 2006-09-13 | 2007-06-28 | Nara Institute Of Science And Technology | Increasing levels of nicotinic alkaloids |
| BRPI0719428A2 (pt) * | 2006-12-01 | 2014-02-25 | Cima Labs Inc | Forma de dosagem transmucosal oral sólida, método para tratar dependência de nicotina em um receptor que deseja tal tratamento, sistema de distribuição de nicotina transmucosal oral, e, método de substituíção de nicotina. |
| WO2008091588A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| ZA200905697B (en) * | 2007-02-15 | 2010-10-27 | Derma Young Ltd | Compositions and methods for enhancing transmucosal delivery |
| US8356606B2 (en) * | 2007-06-01 | 2013-01-22 | Philip Morris Usa Inc. | Production of micronized encapsulated tobacco particles for tobacco flavor delivery from an oral pouch |
| US9167835B2 (en) | 2008-12-30 | 2015-10-27 | Philip Morris Usa Inc. | Dissolvable films impregnated with encapsulated tobacco, tea, coffee, botanicals, and flavors for oral products |
| US9167847B2 (en) | 2009-03-16 | 2015-10-27 | Philip Morris Usa Inc. | Production of coated tobacco particles suitable for usage in a smokeless tobacoo product |
| EP2557947A1 (de) | 2010-04-14 | 2013-02-20 | Altria Client Services Inc. | Vorgeformtes rauchloses tabakprodukt |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| US20230255257A1 (en) * | 2010-08-11 | 2023-08-17 | R.J. Reynolds Tobacco Company | Meltable smokeless tobacco composition |
| US11116237B2 (en) * | 2010-08-11 | 2021-09-14 | R.J. Reynolds Tobacco Company | Meltable smokeless tobacco composition |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| US20140255452A1 (en) | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
| US10799548B2 (en) | 2013-03-15 | 2020-10-13 | Altria Client Services Llc | Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products |
| US11503853B2 (en) | 2013-09-09 | 2022-11-22 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition incorporating a botanical material |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| US9375033B2 (en) | 2014-02-14 | 2016-06-28 | R.J. Reynolds Tobacco Company | Tobacco-containing gel composition |
| EP3871515B1 (de) | 2014-05-27 | 2025-04-16 | R. J. Reynolds Tobacco Company | Nikotinsalze, co-kristalle und salz-co-kristallkomplexe |
| US10881133B2 (en) | 2015-04-16 | 2021-01-05 | R.J. Reynolds Tobacco Company | Tobacco-derived cellulosic sugar |
| US10869497B2 (en) | 2015-09-08 | 2020-12-22 | R.J. Reynolds Tobacco Company | High-pressure cold pasteurization of tobacco material |
| EP4338735B1 (de) | 2015-11-25 | 2026-02-04 | R. J. Reynolds Tobacco Company | Nikotinsalze, cokristalle und cokristall-salzkomplexe |
| US10532046B2 (en) | 2015-12-03 | 2020-01-14 | Niconovum Usa, Inc. | Multi-phase delivery compositions and products incorporating such compositions |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| US10499684B2 (en) | 2016-01-28 | 2019-12-10 | R.J. Reynolds Tobacco Company | Tobacco-derived flavorants |
| US11154087B2 (en) | 2016-02-02 | 2021-10-26 | R.J. Reynolds Tobacco Company | Method for preparing flavorful compounds isolated from black liquor and products incorporating the flavorful compounds |
| US11091446B2 (en) | 2017-03-24 | 2021-08-17 | R.J. Reynolds Tobacco Company | Methods of selectively forming substituted pyrazines |
| EP4635478A3 (de) | 2017-09-05 | 2026-01-07 | R. J. Reynolds Tobacco Company | Nikotinsalze, co-kristalle und salz-co-kristallkomplexe |
| US20190307082A1 (en) | 2018-04-05 | 2019-10-10 | R.J. Reynolds Tobacco Company | Oriental tobacco production methods |
| CN112384504A (zh) | 2018-06-15 | 2021-02-19 | R.J.雷诺兹烟草公司 | 烟碱的纯化 |
| WO2021116855A1 (en) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Oral compositions and methods of manufacture |
| WO2021116865A1 (en) | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Agents for oral composition |
| MX2023010620A (es) | 2021-03-09 | 2023-09-19 | Nicoventures Trading Ltd | Productos orales y metodos de fabricacion. |
| US20220354785A1 (en) | 2021-04-22 | 2022-11-10 | Nicoventures Trading Limited | Oral lozenge products |
| WO2022234522A1 (en) | 2021-05-06 | 2022-11-10 | Nicoventures Trading Limited | Oral compositions and related methods for reducing throat irritation |
| CA3233375A1 (en) | 2021-09-30 | 2023-04-06 | Michael Zawadzki | Oral product with a basic amine and an ion pairing agent |
| WO2023084499A1 (en) | 2021-11-15 | 2023-05-19 | Nicoventures Trading Limited | Products with enhanced sensory characteristics |
| WO2023248187A1 (en) | 2022-06-24 | 2023-12-28 | Nicoventures Trading Limited | Oral composition comprising a receptor modulator |
| GB202214771D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| US20260115133A1 (en) | 2022-10-07 | 2026-04-30 | Nicoventures Trading Limited | Oral product |
| GB202214775D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| AU2023357712A1 (en) | 2022-10-07 | 2025-04-17 | Nicoventures Trading Limited | Oral product |
| AU2023357713A1 (en) | 2022-10-07 | 2025-04-17 | Nicoventures Trading Limited | Oral product |
| GB202214803D0 (en) | 2022-10-07 | 2022-11-23 | Nicoventures Trading Ltd | Oral product |
| WO2024095163A1 (en) | 2022-11-01 | 2024-05-10 | Nicoventures Trading Limited | Oral composition comprising encapsulated ph adjusting agent |
| TW202434271A (zh) | 2022-11-04 | 2024-09-01 | 英商尼可創業貿易有限公司 | 口服產品 |
| GB202216465D0 (en) | 2022-11-04 | 2022-12-21 | Nicoventures Trading Ltd | Oral product |
| EP4672985A1 (de) | 2023-02-28 | 2026-01-07 | Nicoventures Trading Limited | Koffeinhaltiges orales produkt |
| GB202304445D0 (en) | 2023-03-27 | 2023-05-10 | Nicoventures Trading Ltd | Oral product |
| GB202307279D0 (en) | 2023-05-16 | 2023-06-28 | Nicoventures Trading Ltd | Oral product |
| GB202307278D0 (en) | 2023-05-16 | 2023-06-28 | Nicoventures Holdings Ltd | Oral product |
| EP4543417A1 (de) * | 2023-09-12 | 2025-04-30 | Fertin Pharma A/S | Im mund zerfallende nikotintablette zur verwendung unter der lippe |
| EP4585055A1 (de) | 2024-01-12 | 2025-07-16 | Nicoventures Trading Limited | Orales produkt mit probiotischer komponente |
| EP4599698A1 (de) | 2024-02-07 | 2025-08-13 | Nicoventures Trading Limited | Produkte mit sensorischen mitteln |
| EP4602929A1 (de) | 2024-02-19 | 2025-08-20 | Nicoventures Trading Limited | Orales produkt mit pulverbeschichtung |
| EP4623708A1 (de) | 2024-03-26 | 2025-10-01 | Nicoventures Trading Limited | Süssstoffzusammensetzung für in beutel verpackte orale produkte |
| EP4623702A1 (de) | 2024-03-27 | 2025-10-01 | Nicoventures Trading Limited | Orales produkt |
| EP4631502A1 (de) | 2024-04-12 | 2025-10-15 | Nicoventures Trading Limited | Verwendung von flavonen wie quercetin zur steigerung der kognitiven funktion und zur verringerung der nervosität |
| WO2026013602A1 (en) | 2024-07-10 | 2026-01-15 | Rai Strategic Holdings, Inc. | Oral products |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783207A (en) | 1985-05-01 | 1998-07-21 | University Of Utah Research Foundation | Selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine |
| JPS62175141A (ja) * | 1986-01-29 | 1987-07-31 | Kazuo Takatsu | 複合チヨコレ−ト |
| US5017400A (en) * | 1988-06-10 | 1991-05-21 | Suomen Xyrofin Oy | Non-cariogenic sweetener |
| US5004601A (en) * | 1988-10-14 | 1991-04-02 | Zetachron, Inc. | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith |
| US5098730A (en) * | 1988-11-14 | 1992-03-24 | Cultor Ltd. | Dietetic sweetening composition |
| US5512306A (en) * | 1992-06-19 | 1996-04-30 | Pharmica Ab | Smoking substitute |
| US5549906A (en) | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5362496A (en) * | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| JPH0940564A (ja) * | 1995-07-26 | 1997-02-10 | Taiyo Kagaku Co Ltd | 悪酔予防改善用組成物 |
| JPH0956333A (ja) * | 1995-08-21 | 1997-03-04 | Kozaburo Shiba | 機能性梅チョコレート |
| JP2001518520A (ja) * | 1997-10-03 | 2001-10-16 | キャリー メディカル コーポレイション | ニコチンレセプターアンタゴニストおよび抗抑うつ薬または抗不安薬を含有するニコチン嗜癖を治療する組成物 |
-
1998
- 1998-11-23 SE SE9803986A patent/SE9803986D0/xx unknown
-
1999
- 1999-11-04 AT AT99972537T patent/ATE264102T1/de not_active IP Right Cessation
- 1999-11-04 EP EP99972537A patent/EP1131071B1/de not_active Expired - Lifetime
- 1999-11-04 PT PT99972537T patent/PT1131071E/pt unknown
- 1999-11-04 HK HK02101182.4A patent/HK1040614B/en not_active IP Right Cessation
- 1999-11-04 DK DK99972537T patent/DK1131071T3/da active
- 1999-11-04 JP JP2000583524A patent/JP2002530335A/ja active Pending
- 1999-11-04 AU AU14340/00A patent/AU1434000A/en not_active Abandoned
- 1999-11-04 WO PCT/SE1999/001983 patent/WO2000030641A1/en not_active Ceased
- 1999-11-04 ES ES99972537T patent/ES2220149T3/es not_active Expired - Lifetime
- 1999-11-04 US US09/856,522 patent/US6676959B1/en not_active Expired - Fee Related
- 1999-11-04 DE DE69916486T patent/DE69916486T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2220149T3 (es) | 2004-12-01 |
| HK1040614B (en) | 2004-10-08 |
| PT1131071E (pt) | 2004-06-30 |
| WO2000030641A1 (en) | 2000-06-02 |
| DE69916486D1 (de) | 2004-05-19 |
| DE69916486T2 (de) | 2004-08-26 |
| HK1040614A1 (en) | 2002-06-21 |
| EP1131071B1 (de) | 2004-04-14 |
| AU1434000A (en) | 2000-06-13 |
| SE9803986D0 (sv) | 1998-11-23 |
| DK1131071T3 (da) | 2004-05-10 |
| US6676959B1 (en) | 2004-01-13 |
| JP2002530335A (ja) | 2002-09-17 |
| EP1131071A1 (de) | 2001-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1131071 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |