ATE264323T1 - Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten - Google Patents

Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten

Info

Publication number: ATE264323T1
Authority: AT; Austria
Prior art keywords: angiotensin; action; antagonists; heterocyclic compounds; diseases
Prior art date: 1992-09-14

Application number

AT97120618T

Other languages

English (en)

Inventor

Keiji Kubo

Yoshiyuki Inada

Takehiko Naka

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-14

Filing date

1993-09-14

Publication date

2004-04-15

1993-09-14 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE264323T1 publication Critical patent/ATE264323T1/de

Links

229940123413 Angiotensin II antagonist Drugs 0.000 title 1
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
150000002391 heterocyclic compounds Chemical class 0.000 title 1
208000024827 Alzheimer disease Diseases 0.000 abstract 2
230000002490 cerebral effect Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010008190 Cerebrovascular accident Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
230000009471 action Effects 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
201000008383 nephritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97120618T 1992-09-14 1993-09-14 Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten ATE264323T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP24530892		1992-09-14
JP34385592		1992-12-24

Publications (1)

Publication Number	Publication Date
ATE264323T1 true ATE264323T1 (de)	2004-04-15

Family

ID=26537163

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT97120618T ATE264323T1 (de)	1992-09-14	1993-09-14	Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten
AT93114754T ATE167861T1 (de)	1992-09-14	1993-09-14	1,2,4-oxadiazolyl oder 1,2,4-thiadiazolyl- derivate als angiotensin ii antagonisten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT93114754T ATE167861T1 (de)	1992-09-14	1993-09-14	1,2,4-oxadiazolyl oder 1,2,4-thiadiazolyl- derivate als angiotensin ii antagonisten

Country Status (5)

Country	Link
US (1)	US5500427A (de)
EP (2)	EP0588299B1 (de)
AT (2)	ATE264323T1 (de)
CA (1)	CA2106135A1 (de)
DE (2)	DE69333489T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2115985A1 (en) *	1993-02-25	1994-08-26	Kohei Nishikawa	Vascular hypertrophy suppressor
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
CZ154994A3 (en) *	1993-07-02	1995-09-13	Senju Pharma Co	Visual hypotensive agent
GB9514160D0 (en) *	1994-07-25	1995-09-13	Zeneca Ltd	Aromatic compounds
JPH10203981A (ja) *	1997-01-21	1998-08-04	Kureha Chem Ind Co Ltd	心疾患改善剤
US7812044B2 (en)	2001-11-13	2010-10-12	Takeda Pharmaceutical Company Limited	Anticancer agents
US7232828B2 (en)	2002-08-10	2007-06-19	Bethesda Pharmaceuticals, Inc.	PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
KR100896380B1 (ko) *	2005-01-07	2009-05-08	화이자 프로덕츠 인코포레이티드	헤테로방향족 퀴놀린 화합물 및 ｐｄｅ10 저해제로서의그의 용도
RU2007131400A (ru)	2005-03-01	2009-04-10	Вайет (Us)	Соединения циннолина и их применение в качестве модуляторов х-рецепторов печени
WO2008021849A2 (en)	2006-08-09	2008-02-21	Smithkline Beecham Corporation	Novel compounds as antagonists or inverse agonists at opioid receptors
TW200823204A (en) *	2006-10-17	2008-06-01	Arena Pharm Inc	Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
US7803940B2 (en) *	2006-11-24	2010-09-28	Takeda Pharmaceutical Company Limited	Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases
KR20090085117A (ko) *	2006-11-24	2009-08-06	다케다 야쿠힌 고교 가부시키가이샤	헤테로모노시클릭 화합물 및 이의 용도
DE102017115778A1 (de)	2017-07-13	2019-01-17	Karl Storz Se & Co. Kg	Medizinisches Instrument zum Abtragen von Gewebe
CN110143955B (zh) *	2018-02-11	2023-01-20	中国科学院上海药物研究所	含杂环侧链的噁二唑衍生物、合成方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5104891A (en) *	1989-12-11	1992-04-14	G. D. Searle & Co.	Cycloheptimidazolone compounds as angiotensin ii antagonists for control of hypertension
EP0434038A1 (de) *	1989-12-22	1991-06-26	Takeda Chemical Industries, Ltd.	Kondensierte Imidazolderivate, ihre Herstellung und Verwendung
IL99246A0 (en) *	1990-09-10	1992-07-15	Abbott Lab	Angiotensin ii receptor antagonists and pharmaceutical compositions containing them
FR2673427B1 (fr) *	1991-03-01	1993-06-18	Sanofi Elf	Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
TW274551B (de) *	1991-04-16	1996-04-21	Takeda Pharm Industry Co Ltd
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them

1993
- 1993-09-14 AT AT97120618T patent/ATE264323T1/de not_active IP Right Cessation
- 1993-09-14 DE DE69333489T patent/DE69333489T2/de not_active Expired - Fee Related
- 1993-09-14 DE DE69319391T patent/DE69319391T2/de not_active Expired - Fee Related
- 1993-09-14 EP EP93114754A patent/EP0588299B1/de not_active Expired - Lifetime
- 1993-09-14 EP EP97120618A patent/EP0829479B1/de not_active Expired - Lifetime
- 1993-09-14 AT AT93114754T patent/ATE167861T1/de not_active IP Right Cessation
- 1993-09-14 US US08/120,450 patent/US5500427A/en not_active Expired - Fee Related
- 1993-09-14 CA CA002106135A patent/CA2106135A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US5500427A (en)	1996-03-19
EP0829479A1 (de)	1998-03-18
ATE167861T1 (de)	1998-07-15
EP0829479B1 (de)	2004-04-14
DE69333489D1 (de)	2004-05-19
EP0588299B1 (de)	1998-07-01
DE69333489T2 (de)	2005-04-14
DE69319391D1 (de)	1998-08-06
EP0588299A3 (en)	1994-06-01
EP0588299A2 (de)	1994-03-23
DE69319391T2 (de)	1998-10-29
CA2106135A1 (en)	1994-03-15

Legal Events

Date	Code	Title	Description
2004-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69233057D1 (de)	2003-06-18	Heterozyklische Verbindungen, Verfahren zu deren Herstellung und deren Anwendung als Angiotensin-II-Antagonist
ATE264323T1 (de)	2004-04-15	Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten
ATE244240T1 (de)	2003-07-15	Kondensierte heterocyclische verbindungen, ihre herstellung und verwendung
DE69328975D1 (de)	2000-08-10	Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
CA2142610A1 (en)	1994-03-17	Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
ATE161537T1 (de)	1998-01-15	Kondensierte pyrimidinderivate und deren verwendung als angiotensin-ii-antagonisten
NO920298D0 (no)	1992-01-22	2,3,6-substituerte kinazolinoner
MA21896A1 (fr)	1991-04-01	Procede de prepatration d'acides imidazolyl - alcenoiques .
DE60023318D1 (de)	2006-03-02	Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
DE60041710D1 (de)	2009-04-16	Polycycloalkylpurine als adenosinrezeptorantagonisten
DK260588A (da)	1988-11-12	Heterocykliske ketoner
DE60012751D1 (de)	2004-09-09	Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
DE69418789D1 (de)	1999-07-08	2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
DE69117431D1 (de)	1996-04-04	Thienoimidazolderivate, ihre Herstellung und Verwendung
AU5629590A (en)	1990-12-06	Triazine or triazole condensed system having serotonin 2-receptor antagonistic activity
ATE201406T1 (de)	2001-06-15	Bizyklische verbindungen als eaa rezeptor antagonisten
DK0755393T3 (da)	2001-12-17	Nye krystalformer af 1-[5-methansulfonamidoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazin