ATE264329T1 - Verfahren zur herstellung von antipsychotischem 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- - Google Patents

Verfahren zur herstellung von antipsychotischem 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-

Info

Publication number
ATE264329T1
ATE264329T1 AT00940737T AT00940737T ATE264329T1 AT E264329 T1 ATE264329 T1 AT E264329T1 AT 00940737 T AT00940737 T AT 00940737T AT 00940737 T AT00940737 T AT 00940737T AT E264329 T1 ATE264329 T1 AT E264329T1
Authority
AT
Austria
Prior art keywords
benzisoxazole
fluoro
pyrido
pyrimidin
methyl
Prior art date
Application number
AT00940737T
Other languages
English (en)
Inventor
Tarur V Radhakrishnan
Dhananjay Govind Sathe
Chandrakant V Suryavanshi
Original Assignee
Rpg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rpg Life Sciences Ltd filed Critical Rpg Life Sciences Ltd
Application granted granted Critical
Publication of ATE264329T1 publication Critical patent/ATE264329T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00940737T 2000-05-05 2000-05-05 Verfahren zur herstellung von antipsychotischem 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- ATE264329T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2000/000053 WO2001085731A1 (en) 2000-05-05 2000-05-05 A PROCESS FOR THE PREPARATION OF ANTI-PSCHOTIC 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2,-a]pyrimidin-4-one

Publications (1)

Publication Number Publication Date
ATE264329T1 true ATE264329T1 (de) 2004-04-15

Family

ID=11076248

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00940737T ATE264329T1 (de) 2000-05-05 2000-05-05 Verfahren zur herstellung von antipsychotischem 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-

Country Status (7)

Country Link
US (1) US6897308B1 (de)
EP (1) EP1280804B1 (de)
AT (1) ATE264329T1 (de)
AU (1) AU2000255635A1 (de)
CZ (1) CZ295402B6 (de)
DE (1) DE60009959T2 (de)
WO (1) WO2001085731A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE401313T1 (de) 2000-08-14 2008-08-15 Teva Pharma Herstellung von risperidon
HU227118B1 (en) * 2001-11-13 2010-07-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
KR20040034996A (ko) * 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
EP1560814A1 (de) 2002-11-13 2005-08-10 Synthon B.V. Verfahren zur herstellung von risperidon und zwischenprodukte
US20070179163A1 (en) * 2003-09-26 2007-08-02 Rao Guntu S Process for the preparation of risperidone
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
WO2007093870A2 (en) * 2006-02-15 2007-08-23 Orchid Chemicals & Pharmaceuticals Limited A process for the preparation of risperidone
US7915412B2 (en) 2006-08-14 2011-03-29 Teva Pharmaceutical Industries, Ltd. Process for the synthesis of 9-hydroxy risperidone (paliperidone)
US7820816B2 (en) * 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
EP2152315B1 (de) 2007-05-25 2016-01-06 Indivior UK Limited Formulierungen von risperidon-verbindungen mit verzögerter freisetzung
CN101353347B (zh) * 2007-07-26 2011-06-01 齐鲁制药有限公司 一种利培酮的制备方法
EP2285804A4 (de) * 2008-04-21 2011-09-14 Glenmark Generics Ltd Verfahren zur herstellung von paliperidonzwischenprodukten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US5015740A (en) 1988-08-05 1991-05-14 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
US4957916A (en) * 1988-08-05 1990-09-18 Janssen Pharmaceutica N.V. Antipsychotic 3-piperazinylbenzazole derivatives
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
ES2074966B1 (es) * 1994-02-11 1996-06-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.

Also Published As

Publication number Publication date
US6897308B1 (en) 2005-05-24
EP1280804A1 (de) 2003-02-05
CZ20023666A3 (cs) 2003-02-12
WO2001085731A1 (en) 2001-11-15
DE60009959D1 (de) 2004-05-19
EP1280804B1 (de) 2004-04-14
DE60009959T2 (de) 2005-03-31
AU2000255635A1 (en) 2001-11-20
CZ295402B6 (cs) 2005-08-17

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Legal Events

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