ATE264844T1 - Tetrahydroisochinolinalkanol-derivate und diese enthaltende pharmazeutische zubereitungen - Google Patents
Tetrahydroisochinolinalkanol-derivate und diese enthaltende pharmazeutische zubereitungenInfo
- Publication number
- ATE264844T1 ATE264844T1 AT99901984T AT99901984T ATE264844T1 AT E264844 T1 ATE264844 T1 AT E264844T1 AT 99901984 T AT99901984 T AT 99901984T AT 99901984 T AT99901984 T AT 99901984T AT E264844 T1 ATE264844 T1 AT E264844T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen
- member selected
- alkyl
- arylalkyl
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- VJZFRVXEGROVOC-UHFFFAOYSA-N carbamic acid;1,2,3,4-tetrahydroisoquinoline Chemical compound NC(O)=O.C1=CC=C2CNCCC2=C1 VJZFRVXEGROVOC-UHFFFAOYSA-N 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000005309 thioalkoxy group Chemical group 0.000 abstract 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR1999/000057 WO2000046204A1 (en) | 1999-02-04 | 1999-02-04 | Tetrahydro isoquino linealkanol derivatives and pharmaceutical compositions containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264844T1 true ATE264844T1 (de) | 2004-05-15 |
Family
ID=19570710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99901984T ATE264844T1 (de) | 1999-02-04 | 1999-02-04 | Tetrahydroisochinolinalkanol-derivate und diese enthaltende pharmazeutische zubereitungen |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1149079B1 (de) |
| JP (1) | JP4565747B2 (de) |
| CN (1) | CN1142913C (de) |
| AT (1) | ATE264844T1 (de) |
| AU (1) | AU765198B2 (de) |
| CA (1) | CA2361805A1 (de) |
| DE (1) | DE69916663T2 (de) |
| DK (1) | DK1149079T3 (de) |
| ES (1) | ES2217737T3 (de) |
| PT (1) | PT1149079E (de) |
| WO (1) | WO2000046204A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105461626B (zh) * | 2015-12-17 | 2018-05-08 | 浙江工业大学 | 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用 |
| GB201810486D0 (en) | 2018-06-26 | 2018-08-08 | Imperial Innovations Ltd | Natural killer cells |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2124516C1 (ru) * | 1990-06-27 | 1999-01-10 | Хехст Марион Рассел Инк. | Тетрагидроизохинолинкарбаматы 1,2,3,3а,8,8а-гексагидро-1,3а-8-триметилпирроло (2,3-b)индола, фармацевтическая композиция и способ ингибирования ацетилхолинэстеразы |
| KR0173863B1 (ko) * | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| JP3850920B2 (ja) * | 1995-08-09 | 2006-11-29 | 壽製薬株式会社 | アズレン誘導体およびその製造方法ならびにタキキニン受容体拮抗剤 |
| SE9504618D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Ab | New Compounds |
| SE9600769D0 (sv) * | 1996-02-28 | 1996-02-28 | Astra Ab | Compounds useful as analgesic |
| IT1283637B1 (it) * | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| DK0873308T3 (da) * | 1996-10-10 | 2002-04-22 | Sk Corp | O-Carbamoyl-phenylalaninol-forbindelser og deres farmaceutisk anvendelige salte |
-
1999
- 1999-02-04 AT AT99901984T patent/ATE264844T1/de not_active IP Right Cessation
- 1999-02-04 CN CNB998160393A patent/CN1142913C/zh not_active Expired - Fee Related
- 1999-02-04 CA CA002361805A patent/CA2361805A1/en not_active Abandoned
- 1999-02-04 JP JP2000597274A patent/JP4565747B2/ja not_active Expired - Fee Related
- 1999-02-04 AU AU21889/99A patent/AU765198B2/en not_active Ceased
- 1999-02-04 PT PT99901984T patent/PT1149079E/pt unknown
- 1999-02-04 DK DK99901984T patent/DK1149079T3/da active
- 1999-02-04 DE DE69916663T patent/DE69916663T2/de not_active Expired - Lifetime
- 1999-02-04 EP EP99901984A patent/EP1149079B1/de not_active Expired - Lifetime
- 1999-02-04 ES ES99901984T patent/ES2217737T3/es not_active Expired - Lifetime
- 1999-02-04 WO PCT/KR1999/000057 patent/WO2000046204A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002536364A (ja) | 2002-10-29 |
| ES2217737T3 (es) | 2004-11-01 |
| AU765198B2 (en) | 2003-09-11 |
| AU2188999A (en) | 2000-08-25 |
| CA2361805A1 (en) | 2000-08-10 |
| PT1149079E (pt) | 2004-08-31 |
| DK1149079T3 (da) | 2004-08-16 |
| CN1142913C (zh) | 2004-03-24 |
| EP1149079A1 (de) | 2001-10-31 |
| EP1149079B1 (de) | 2004-04-21 |
| JP4565747B2 (ja) | 2010-10-20 |
| WO2000046204A1 (en) | 2000-08-10 |
| DE69916663D1 (de) | 2004-05-27 |
| CN1334804A (zh) | 2002-02-06 |
| DE69916663T2 (de) | 2005-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |