ATE265525T1 - Verbesserung von trennungsverfahren - Google Patents

Verbesserung von trennungsverfahren

Info

Publication number
ATE265525T1
ATE265525T1 AT99919396T AT99919396T ATE265525T1 AT E265525 T1 ATE265525 T1 AT E265525T1 AT 99919396 T AT99919396 T AT 99919396T AT 99919396 T AT99919396 T AT 99919396T AT E265525 T1 ATE265525 T1 AT E265525T1
Authority
AT
Austria
Prior art keywords
target
sample
separation
microbubbles
layer
Prior art date
Application number
AT99919396T
Other languages
English (en)
Inventor
Alan Cuthbertson
Pal Rongved
Vhaug Dagfinn L
Hege Fjerdingstad
Magne Solbakken
Aslak Godal
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809083.0A external-priority patent/GB9809083D0/en
Priority claimed from GBGB9809085.5A external-priority patent/GB9809085D0/en
Application filed by Amersham Health As filed Critical Amersham Health As
Application granted granted Critical
Publication of ATE265525T1 publication Critical patent/ATE265525T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03D—FLOTATION; DIFFERENTIAL SEDIMENTATION
    • B03D1/00—Flotation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03D—FLOTATION; DIFFERENTIAL SEDIMENTATION
    • B03D1/00—Flotation
    • B03D1/02—Froth-flotation processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03D—FLOTATION; DIFFERENTIAL SEDIMENTATION
    • B03D1/00—Flotation
    • B03D1/14—Flotation machines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03D—FLOTATION; DIFFERENTIAL SEDIMENTATION
    • B03D1/00—Flotation
    • B03D1/14—Flotation machines
    • B03D1/24—Pneumatic
    • B03D1/247—Mixing gas and slurry in a device separate from the flotation tank, i.e. reactor-separator type
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03D—FLOTATION; DIFFERENTIAL SEDIMENTATION
    • B03D2203/00—Specified materials treated by the flotation agents; Specified applications
    • B03D2203/003—Biotechnological applications, e.g. separation or purification of enzymes, hormones, vitamins, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
AT99919396T 1998-04-28 1999-04-28 Verbesserung von trennungsverfahren ATE265525T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9809083.0A GB9809083D0 (en) 1998-04-28 1998-04-28 Improvements in or relating to separation processes
GBGB9809085.5A GB9809085D0 (en) 1998-04-28 1998-04-28 Improvements in or relating to separation processes
PCT/GB1999/001317 WO1999055837A2 (en) 1998-04-28 1999-04-28 Improvements in or relating to separation processes

Publications (1)

Publication Number Publication Date
ATE265525T1 true ATE265525T1 (de) 2004-05-15

Family

ID=26313556

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99919396T ATE265525T1 (de) 1998-04-28 1999-04-28 Verbesserung von trennungsverfahren

Country Status (9)

Country Link
US (1) US20030104359A1 (de)
EP (1) EP1073716B1 (de)
JP (1) JP2002512886A (de)
AT (1) ATE265525T1 (de)
AU (1) AU3719799A (de)
CA (1) CA2326386A1 (de)
DE (1) DE69916822T2 (de)
IL (1) IL139034A0 (de)
WO (1) WO1999055837A2 (de)

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US7838290B2 (en) * 2002-07-25 2010-11-23 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
US7314746B2 (en) * 2002-09-13 2008-01-01 Valentis, Inc. Apparatus and method for preparative scale purification of nucleic acids
AU2003296925A1 (en) * 2002-11-01 2004-06-07 Leucadia Technologies, Inc. Displacement sandwich immuno-pcr
MXPA05007151A (es) 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Polimeros terminados en maleimida hidroliticamente estables.
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
US8076117B2 (en) * 2004-03-18 2011-12-13 Mayo Foundation For Medical Education And Research Microbial biofilm removal methods and systems
JP2005287375A (ja) * 2004-03-31 2005-10-20 Sonopooru:Kk 細胞標識分離方法および細胞標識分離用剤
EP1652569A1 (de) * 2004-11-02 2006-05-03 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Verfahren mit beweglichen Partikeln
EP2302078B1 (de) * 2004-11-03 2015-07-15 Iris Molecular Diagnostics, Inc. Mikrobläschen zur Konzentration mittels Affinitätstrennung
DK1842226T3 (da) * 2004-11-03 2010-10-18 Iris Molecular Diagnostics Inc Homogen analytpåvisning
WO2007004288A1 (ja) * 2005-07-04 2007-01-11 Sonopore, Ltd. 細胞標識分離方法および細胞標識分離用剤
CN1321174C (zh) * 2005-09-28 2007-06-13 哈尔滨工业大学 工业化生物制氢菌种连续流培养及生物制氢系统强化方法
CN103884840A (zh) * 2008-02-21 2014-06-25 艾瑞斯国际有限公司 早期确定前列腺癌治疗后复发的方法
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US9532769B2 (en) 2009-09-04 2017-01-03 The University Of North Carolina At Chapel Hill Systems, methods, and computer readable media for high frequency contrast imaging and image-guided therapeutics
US11175279B2 (en) 2010-05-03 2021-11-16 Creatv Microtech, Inc. Polymer microfilters, devices comprising the same, methods of manufacturing the same, and uses thereof
WO2012048335A2 (en) 2010-10-08 2012-04-12 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
US10195570B2 (en) 2011-01-07 2019-02-05 Creative Micro Tech, Inc. Fabrication of microfilters and nanofilters and their applications
US9731221B2 (en) 2011-05-25 2017-08-15 Cidra Corporate Services, Inc. Apparatus having polymer surfaces having a siloxane functional group
PE20142002A1 (es) 2011-05-25 2014-12-21 Cidra Corporate Services Inc Tecnicas para transportar perlas o burbujas sinteticas en una celda o columna de flotacion
GB201115823D0 (en) 2011-09-13 2011-10-26 Novel Polymer Solutions Ltd Mineral processing
WO2013130794A1 (en) * 2012-02-28 2013-09-06 Cidra Corporate Services Inc. Method and system for floation separation in a magnetically controllable and steerable medium
JP2013180956A (ja) * 2012-02-29 2013-09-12 Sunstar Engineering Inc 殺菌剤組成物
MX370996B (es) 2012-03-30 2020-01-13 Cidra Corporate Services Inc Burbuja polimerica hecha a la medida, dimensionalmente controlada, para la separacion por flotacion.
US9982290B2 (en) 2012-10-04 2018-05-29 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
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JP6557681B2 (ja) * 2014-05-10 2019-08-07 ダイアグノロジックス・エルエルシー 浮力を用いて薬剤を単離または濃縮するためのシステムおよび装置
US11291931B2 (en) 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
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JP6976864B2 (ja) * 2015-12-29 2021-12-08 サーモゲネシス コーポレーション 細胞分離装置、システム、及び方法
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Also Published As

Publication number Publication date
DE69916822T2 (de) 2005-04-21
JP2002512886A (ja) 2002-05-08
AU3719799A (en) 1999-11-16
WO1999055837A2 (en) 1999-11-04
EP1073716B1 (de) 2004-04-28
IL139034A0 (en) 2001-11-25
US20030104359A1 (en) 2003-06-05
CA2326386A1 (en) 1999-11-04
DE69916822D1 (de) 2004-06-03
EP1073716A2 (de) 2001-02-07
WO1999055837A3 (en) 2000-02-10

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